Compile Data Set for Download or QSAR

Found 108 hits of ic50 for UniProtKB: P16499   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
O43924/P16499/P18545/P35913/P51160/Q13956 (Homo sapiens (Human))	BDBM50492928 (CHEMBL2414311) Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCC[C@H]1C(O)=O |r| Show InChI InChI=1S/C21H26BrN3O6S/c1-4-10-31-16-8-7-13(32(29,30)25-9-5-6-15(25)21(27)28)11-14(16)19-23-18(12(2)3)17(22)20(26)24-19/h7-8,11-12,15H,4-6,9-10H2,1-3H3,(H,27,28)(H,23,24,26)/t15-/m0/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.20	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of PDE6 (unknown origin)				Bioorg Med Chem Lett 23: 4944-7 (2013) Article DOI: 10.1016/j.bmcl.2013.06.062 BindingDB Entry DOI: 10.7270/Q2VM4G6K
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300972 (7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCc2cnccn2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C23H25N7O3/c1-3-9-33-10-8-30-20-11-18(16-4-5-21(32-2)27-12-16)26-15-19(20)29-22(23(30)31)28-14-17-13-24-6-7-25-17/h4-7,11-13,15H,3,8-10,14H2,1-2H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
O43924/P16499/P18545/P35913/P51160/Q13956 (Homo sapiens (Human))	BDBM50399897 (CHEMBL2180942) Show SMILES CCCOc1ccc(cc1-c1nc(C(C)C)c(Br)c(=O)[nH]1)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C21H29BrN4O4S/c1-5-12-30-17-7-6-15(31(28,29)26-10-8-25(4)9-11-26)13-16(17)20-23-19(14(2)3)18(22)21(27)24-20/h6-7,13-14H,5,8-12H2,1-4H3,(H,23,24,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of PDE6 (unknown origin)				Bioorg Med Chem Lett 23: 4944-7 (2013) Article DOI: 10.1016/j.bmcl.2013.06.062 BindingDB Entry DOI: 10.7270/Q2VM4G6K
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300964 (CHEMBL584270 | rac-7-(6-methoxypyridin-3-yl)-1-(2-...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC2CCCO2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C23H29N5O4/c1-3-9-31-11-8-28-20-12-18(16-6-7-21(30-2)25-13-16)24-15-19(20)27-22(23(28)29)26-14-17-5-4-10-32-17/h6-7,12-13,15,17H,3-5,8-11,14H2,1-2H3,(H,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300962 (3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCCOCC)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C22H29N5O4/c1-4-10-31-12-9-27-19-13-17(16-6-7-20(29-3)25-14-16)24-15-18(19)26-21(22(27)28)23-8-11-30-5-2/h6-7,13-15H,4-5,8-12H2,1-3H3,(H,23,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.30	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
O43924/P16499/P18545/P35913/P51160/Q13956 (Homo sapiens (Human))	BDBM14390 (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114170 BindingDB Entry DOI: 10.7270/Q2RX9H3Q
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300953 (3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxyp...) Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1 |r,wU:16.16,wD:19.20,(24.97,-.51,;23.64,-1.28,;23.64,-2.82,;22.3,-3.59,;22.3,-5.13,;20.97,-5.9,;20.97,-7.44,;22.3,-8.21,;23.62,-7.45,;24.95,-8.21,;24.95,-9.75,;23.62,-10.52,;22.3,-9.75,;20.97,-10.52,;19.62,-9.75,;18.29,-10.51,;16.96,-9.74,;15.63,-10.51,;14.29,-9.73,;14.3,-8.19,;12.97,-7.41,;15.64,-7.43,;16.97,-8.2,;19.64,-8.21,;18.31,-7.44,;26.28,-7.43,;27.61,-8.2,;28.94,-7.43,;28.94,-5.89,;30.27,-5.11,;31.61,-5.87,;27.59,-5.12,;26.27,-5.9,)| Show InChI InChI=1S/C24H31N5O4/c1-3-11-33-12-10-29-21-13-19(16-4-9-22(32-2)26-14-16)25-15-20(21)28-23(24(29)31)27-17-5-7-18(30)8-6-17/h4,9,13-15,17-18,30H,3,5-8,10-12H2,1-2H3,(H,27,28)/t17-,18-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
O43924/P16499/P18545/P35913/P51160/Q13956 (Homo sapiens (Human))	BDBM50126469 ((6R,12aR)-6-Benzo[1,3]dioxol-5-yl-2-((R)-1-propyl-...) Show SMILES CCCN1CC[C@H](C1)N1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O Show InChI InChI=1S/C28H30N4O4/c1-2-10-30-11-9-18(14-30)31-15-25(33)32-22(28(31)34)13-20-19-5-3-4-6-21(19)29-26(20)27(32)17-7-8-23-24(12-17)36-16-35-23/h3-8,12,18,22,27,29H,2,9-11,13-16H2,1H3/t18-,22-,27-/m1/s1	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibitory activity against phosphodiesterase 6 (PDE6) obtained from canine or bovine retina				Bioorg Med Chem Lett 13: 1425-8 (2003) BindingDB Entry DOI: 10.7270/Q2GM86N6
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50296256 (7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H32N6O4/c1-3-11-33-14-10-30-21-15-19(18-4-5-22(32-2)27-16-18)26-17-20(21)28-23(24(30)31)25-6-7-29-8-12-34-13-9-29/h4-5,15-17H,3,6-14H2,1-2H3,(H,25,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
O43924/P16499/P18545/P35913/P51160/Q13956 (Homo sapiens (Human))	BDBM14776 (2-{2-ethoxy-5-[(4-ethylpiperazine-1-)sulfonyl]phen...) Show SMILES CCCc1nc(C)c2n1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(CC)CC1 Show InChI InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Monash University (Parkville Campus) Curated by ChEMBL					Assay Description Inhibition of human phosphodiesterase 6				J Med Chem 48: 3449-62 (2005) Article DOI: 10.1021/jm040217u BindingDB Entry DOI: 10.7270/Q21G0N2H
					More data for this Ligand-Target Pair				3D Structure (crystal)
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300970 (7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCc2ccccn2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H26N6O3/c1-3-11-33-12-10-30-21-13-19(17-7-8-22(32-2)27-14-17)26-16-20(21)29-23(24(30)31)28-15-18-6-4-5-9-25-18/h4-9,13-14,16H,3,10-12,15H2,1-2H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300987 (3-(3-hydroxypropylamino)-7-(6-methoxypyridin-3-yl)...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCCCO)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C21H27N5O4/c1-3-10-30-11-8-26-18-12-16(15-5-6-19(29-2)24-13-15)23-14-17(18)25-20(21(26)28)22-7-4-9-27/h5-6,12-14,27H,3-4,7-11H2,1-2H3,(H,22,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300952 (3-(trans-4-hydroxycyclohexylamino)-7-(6-methoxypyr...) Show SMILES CCCOCCn1c2cc(cnc2nc(N[C@H]2CC[C@H](O)CC2)c1=O)-c1ccc(OC)nc1 |r,wU:16.16,wD:19.20,(3.98,.08,;2.65,-.69,;2.65,-2.23,;1.32,-3,;1.32,-4.54,;-.02,-5.31,;-.02,-6.85,;1.31,-7.63,;2.64,-6.86,;3.96,-7.62,;3.97,-9.17,;2.64,-9.93,;1.31,-9.17,;-.02,-9.93,;-1.36,-9.16,;-2.7,-9.93,;-4.03,-9.15,;-5.37,-9.93,;-6.7,-9.15,;-6.69,-7.6,;-8.02,-6.82,;-5.35,-6.84,;-4.03,-7.62,;-1.35,-7.63,;-2.68,-6.86,;5.29,-6.85,;6.63,-7.62,;7.96,-6.84,;7.95,-5.3,;9.28,-4.53,;10.62,-5.29,;6.61,-4.54,;5.28,-5.31,)| Show InChI InChI=1S/C24H31N5O4/c1-3-11-33-12-10-29-20-13-17(16-4-9-21(32-2)25-14-16)15-26-22(20)28-23(24(29)31)27-18-5-7-19(30)8-6-18/h4,9,13-15,18-19,30H,3,5-8,10-12H2,1-2H3,(H,26,27,28)/t18-,19-	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300983 (7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCN(C)CC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C25H33N7O4/c1-4-12-36-13-11-32-21-14-19(18-5-6-22(35-3)27-15-18)26-16-20(21)29-24(25(32)34)28-17-23(33)31-9-7-30(2)8-10-31/h5-6,14-16H,4,7-13,17H2,1-3H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300989 ((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...) Show SMILES CCCOCCn1c2cc(ncc2nc(NC[C@H](C)O)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-18-10-16(15-5-6-19(29-3)23-12-15)22-13-17(18)25-20(21(26)28)24-11-14(2)27/h5-6,10,12-14,27H,4,7-9,11H2,1-3H3,(H,24,25)/t14-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300991 ((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...) Show SMILES CCCOCCn1c2cc(ncc2nc(NC[C@@H](C)O)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-18-10-16(15-5-6-19(29-3)23-12-15)22-13-17(18)25-20(21(26)28)24-11-14(2)27/h5-6,10,12-14,27H,4,7-9,11H2,1-3H3,(H,24,25)/t14-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300976 (2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)NC)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C21H26N6O4/c1-4-8-31-9-7-27-17-10-15(14-5-6-19(30-3)24-11-14)23-12-16(17)26-20(21(27)29)25-13-18(28)22-2/h5-6,10-12H,4,7-9,13H2,1-3H3,(H,22,28)(H,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300980 (7-(6-methoxypyridin-3-yl)-3-(2-morpholino-2-oxoeth...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCOCC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H30N6O5/c1-3-9-34-12-8-30-20-13-18(17-4-5-21(33-2)26-14-17)25-15-19(20)28-23(24(30)32)27-16-22(31)29-6-10-35-11-7-29/h4-5,13-15H,3,6-12,16H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300948 ((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...) Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H](C)CO)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-18-10-16(15-5-6-19(29-3)23-11-15)22-12-17(18)25-20(21(26)28)24-14(2)13-27/h5-6,10-12,14,27H,4,7-9,13H2,1-3H3,(H,24,25)/t14-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300950 ((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...) Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@@H](C)CO)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-18-10-16(15-5-6-19(29-3)23-11-15)22-12-17(18)25-20(21(26)28)24-14(2)13-27/h5-6,10-12,14,27H,4,7-9,13H2,1-3H3,(H,24,25)/t14-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300951 ((R)-3-(1-hydroxybutan-2-ylamino)-7-(6-methoxypyrid...) Show SMILES CCCOCCn1c2cc(ncc2nc(N[C@H](CC)CO)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C22H29N5O4/c1-4-9-31-10-8-27-19-11-17(15-6-7-20(30-3)24-12-15)23-13-18(19)26-21(22(27)29)25-16(5-2)14-28/h6-7,11-13,16,28H,4-5,8-10,14H2,1-3H3,(H,25,26)/t16-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300971 (7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...) Show SMILES CCCOCCn1c2cc(cnc2nc(NCc2cnccn2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C23H25N7O3/c1-3-9-33-10-8-30-19-11-17(16-4-5-20(32-2)26-12-16)13-27-21(19)29-22(23(30)31)28-15-18-14-24-6-7-25-18/h4-7,11-14H,3,8-10,15H2,1-2H3,(H,27,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300978 (3-(2-(4-hydroxypiperidin-1-yl)-2-oxoethylamino)-7-...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCC(O)CC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C25H32N6O5/c1-3-11-36-12-10-31-21-13-19(17-4-5-22(35-2)27-14-17)26-15-20(21)29-24(25(31)34)28-16-23(33)30-8-6-18(32)7-9-30/h4-5,13-15,18,32H,3,6-12,16H2,1-2H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300960 (3-(2-hydroxyethylamino)-7-(6-methoxypyridin-3-yl)-...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCCO)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C20H25N5O4/c1-3-9-29-10-7-25-17-11-15(14-4-5-18(28-2)23-12-14)22-13-16(17)24-19(20(25)27)21-6-8-26/h4-5,11-13,26H,3,6-10H2,1-2H3,(H,21,24)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM480487 (US10626113, Compound D | US10899756, Compound D) Show SMILES CCc1cc(cc2c(NCc3ccc(OC)c(Cl)c3)c3CN(C)CCc3nc12)C#N Show InChI InChI=1S/C24H25ClN4O/c1-4-17-9-16(12-26)10-18-23(17)28-21-7-8-29(2)14-19(21)24(18)27-13-15-5-6-22(30-3)20(25)11-15/h5-6,9-11H,4,7-8,13-14H2,1-3H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Columbia University in the City of New York US Patent					Assay Description A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...				US Patent US10899756 (2021) BindingDB Entry DOI: 10.7270/Q2RN3C0P
					More data for this Ligand-Target Pair
O43924/P16499/P18545/P35913/P51160/Q13956 (Homo sapiens (Human))	BDBM50241831 (CHEMBL4062273 | US10626113, Compound M | US1089975...) Show SMILES COc1ccc(CNc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)cc1Cl Show InChI InChI=1S/C23H21ClN4O2/c1-14(29)28-8-7-21-18(13-28)23(17-9-15(11-25)3-5-20(17)27-21)26-12-16-4-6-22(30-2)19(24)10-16/h3-6,9-10H,7-8,12-13H2,1-2H3,(H,26,27)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.bmc.2022.116614 BindingDB Entry DOI: 10.7270/Q21Z48DS
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM480487 (US10626113, Compound D | US10899756, Compound D) Show SMILES CCc1cc(cc2c(NCc3ccc(OC)c(Cl)c3)c3CN(C)CCc3nc12)C#N Show InChI InChI=1S/C24H25ClN4O/c1-4-17-9-16(12-26)10-18-23(17)28-21-7-8-29(2)14-19(21)24(18)27-13-15-5-6-22(30-3)20(25)11-15/h5-6,9-11H,4,7-8,13-14H2,1-3H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2KH0SFD
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50241831 (CHEMBL4062273 | US10626113, Compound M | US1089975...) Show SMILES COc1ccc(CNc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)cc1Cl Show InChI InChI=1S/C23H21ClN4O2/c1-14(29)28-8-7-21-18(13-28)23(17-9-15(11-25)3-5-20(17)27-21)26-12-16-4-6-22(30-2)19(24)10-16/h3-6,9-10H,7-8,12-13H2,1-2H3,(H,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	30.1	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Columbia University in the City of New York US Patent					Assay Description A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...				US Patent US10899756 (2021) BindingDB Entry DOI: 10.7270/Q2RN3C0P
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50241831 (CHEMBL4062273 | US10626113, Compound M | US1089975...) Show SMILES COc1ccc(CNc2c3CN(CCc3nc3ccc(cc23)C#N)C(C)=O)cc1Cl Show InChI InChI=1S/C23H21ClN4O2/c1-14(29)28-8-7-21-18(13-28)23(17-9-15(11-25)3-5-20(17)27-21)26-12-16-4-6-22(30-2)19(24)10-16/h3-6,9-10H,7-8,12-13H2,1-2H3,(H,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	30.1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2KH0SFD
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300963 (7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-((t...) Show SMILES CCCOCCn1c2cc(cnc2nc(NCC2CCOCC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H31N5O4/c1-3-9-32-12-8-29-20-13-19(18-4-5-21(31-2)25-15-18)16-27-22(20)28-23(24(29)30)26-14-17-6-10-33-11-7-17/h4-5,13,15-17H,3,6-12,14H2,1-2H3,(H,26,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300969 (7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)-3-(py...) Show SMILES CCCOCCn1c2cc(cnc2nc(NCc2ccccn2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H26N6O3/c1-3-11-33-12-10-30-20-13-18(17-7-8-21(32-2)26-14-17)15-27-22(20)29-23(24(30)31)28-16-19-6-4-5-9-25-19/h4-9,13-15H,3,10-12,16H2,1-2H3,(H,27,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300977 (7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(pyrrolidin-1...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCCC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H30N6O4/c1-3-11-34-12-10-30-20-13-18(17-6-7-21(33-2)26-14-17)25-15-19(20)28-23(24(30)32)27-16-22(31)29-8-4-5-9-29/h6-7,13-15H,3-5,8-12,16H2,1-2H3,(H,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
O43924/P16499/P18545/P35913/P51160/Q13956 (Homo sapiens (Human))	BDBM14390 (5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...) Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Università di Firenze Curated by ChEMBL					Assay Description Inhibition of PDE6				J Med Chem 49: 5363-71 (2006) Article DOI: 10.1021/jm060265+ BindingDB Entry DOI: 10.7270/Q2GB23PC
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300966 (2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(O)=O)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C20H23N5O5/c1-3-7-30-8-6-25-16-9-14(13-4-5-17(29-2)22-10-13)21-11-15(16)24-19(20(25)28)23-12-18(26)27/h4-5,9-11H,3,6-8,12H2,1-2H3,(H,23,24)(H,26,27)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300990 ((R)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...) Show SMILES CCCOCCn1c2cc(cnc2nc(NC[C@@H](C)O)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-17-10-16(15-5-6-18(29-3)22-12-15)13-24-19(17)25-20(21(26)28)23-11-14(2)27/h5-6,10,12-14,27H,4,7-9,11H2,1-3H3,(H,23,24,25)/t14-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	50	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300988 ((S)-3-(2-hydroxypropylamino)-7-(6-methoxypyridin-3...) Show SMILES CCCOCCn1c2cc(cnc2nc(NC[C@H](C)O)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-17-10-16(15-5-6-18(29-3)22-12-15)13-24-19(17)25-20(21(26)28)23-11-14(2)27/h5-6,10,12-14,27H,4,7-9,11H2,1-3H3,(H,23,24,25)/t14-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	52	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300985 (3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C26H35N7O4/c1-4-13-37-14-12-33-22-15-20(19-6-7-23(36-3)28-16-19)27-17-21(22)30-25(26(33)35)29-18-24(34)32-10-8-31(5-2)9-11-32/h6-7,15-17H,4-5,8-14,18H2,1-3H3,(H,29,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300961 (3-(2-ethoxyethylamino)-7-(6-methoxypyridin-3-yl)-1...) Show SMILES CCCOCCn1c2cc(cnc2nc(NCCOCC)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C22H29N5O4/c1-4-10-31-12-9-27-18-13-17(16-6-7-19(29-3)24-14-16)15-25-20(18)26-21(22(27)28)23-8-11-30-5-2/h6-7,13-15H,4-5,8-12H2,1-3H3,(H,23,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50238860 (CHEMBL4099219) Show SMILES O=c1c2c([nH]c(Cc3ccc4OCOc4c3)c2oc2ccccc12)-c1nccs1 Show InChI InChI=1S/C22H14N2O4S/c25-20-13-3-1-2-4-15(13)28-21-14(24-19(18(20)21)22-23-7-8-29-22)9-12-5-6-16-17(10-12)27-11-26-16/h1-8,10,24H,9,11H2	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Sun Yat-Sen University Curated by ChEMBL					Assay Description Inhibition of PDE6A (484 to 817 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using [3H]cGMP or [3H]cAMP as substrate after 15 m...				J Med Chem 60: 6622-6637 (2017) Article DOI: 10.1021/acs.jmedchem.7b00523 BindingDB Entry DOI: 10.7270/Q23N25NF
					More data for this Ligand-Target Pair
O43924/P16499/P18545/P35913/P51160/Q13956 (Homo sapiens (Human))	BDBM50193586 (7-benzyl-4-isopropyl-9-methyl-2-phenyl-7H-3,3a,5,7...) Show SMILES CC(C)c1nc2c(c(C)nn(Cc3ccccc3)c2=O)c2cc(nn12)-c1ccccc1 Show InChI InChI=1S/C25H23N5O/c1-16(2)24-26-23-22(21-14-20(28-30(21)24)19-12-8-5-9-13-19)17(3)27-29(25(23)31)15-18-10-6-4-7-11-18/h4-14,16H,15H2,1-3H3	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Università di Firenze Curated by ChEMBL					Assay Description Inhibition of PDE6				J Med Chem 49: 5363-71 (2006) Article DOI: 10.1021/jm060265+ BindingDB Entry DOI: 10.7270/Q2GB23PC
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50296257 (7-(6-methoxypyridin-3-yl)-3-(2-morpholinoethylamin...) Show SMILES CCCOCCn1c2cc(cnc2nc(NCCN2CCOCC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H32N6O4/c1-3-11-33-14-10-30-20-15-19(18-4-5-21(32-2)26-16-18)17-27-22(20)28-23(24(30)31)25-6-7-29-8-12-34-13-9-29/h4-5,15-17H,3,6-14H2,1-2H3,(H,25,27,28)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300947 ((R)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...) Show SMILES CCCOCCn1c2cc(cnc2nc(N[C@H](C)CO)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-17-10-16(15-5-6-18(29-3)22-11-15)12-23-19(17)25-20(21(26)28)24-14(2)13-27/h5-6,10-12,14,27H,4,7-9,13H2,1-3H3,(H,23,24,25)/t14-/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300949 ((S)-3-(1-hydroxypropan-2-ylamino)-7-(6-methoxypyri...) Show SMILES CCCOCCn1c2cc(cnc2nc(N[C@@H](C)CO)c1=O)-c1ccc(OC)nc1 |r| Show InChI InChI=1S/C21H27N5O4/c1-4-8-30-9-7-26-17-10-16(15-5-6-18(29-3)22-11-15)12-23-19(17)25-20(21(26)28)24-14(2)13-27/h5-6,10-12,14,27H,4,7-9,13H2,1-3H3,(H,23,24,25)/t14-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300982 (7-(6-methoxypyridin-3-yl)-3-(2-(4-methylpiperazin-...) Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(=O)N2CCN(C)CC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C25H33N7O4/c1-4-12-36-13-11-32-20-14-19(18-5-6-21(35-3)26-15-18)16-27-23(20)29-24(25(32)34)28-17-22(33)31-9-7-30(2)8-10-31/h5-6,14-16H,4,7-13,17H2,1-3H3,(H,27,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300974 (2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(N)=O)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C20H24N6O4/c1-3-7-30-8-6-26-16-9-14(13-4-5-18(29-2)23-10-13)22-11-15(16)25-19(20(26)28)24-12-17(21)27/h4-5,9-11H,3,6-8,12H2,1-2H3,(H2,21,27)(H,24,25)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300968 (2-(7-(6-methoxypyridin-3-yl)-2-oxo-1-(2-propoxyeth...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N(C)C)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C22H28N6O4/c1-5-9-32-10-8-28-18-11-16(15-6-7-19(31-4)24-12-15)23-13-17(18)26-21(22(28)30)25-14-20(29)27(2)3/h6-7,11-13H,5,8-10,14H2,1-4H3,(H,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	87	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300984 (3-(2-(4-ethylpiperazin-1-yl)-2-oxoethylamino)-7-(6...) Show SMILES CCCOCCn1c2cc(cnc2nc(NCC(=O)N2CCN(CC)CC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C26H35N7O4/c1-4-13-37-14-12-33-21-15-20(19-6-7-22(36-3)27-16-19)17-28-24(21)30-25(26(33)35)29-18-23(34)32-10-8-31(5-2)9-11-32/h6-7,15-17H,4-5,8-14,18H2,1-3H3,(H,28,29,30)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	99	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50241837 (CHEMBL4102913 | US10626113, Compound G | US1089975...) Show SMILES COc1ccc(CNc2c3CNCCc3nc3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C21H19ClN4O/c1-27-20-5-3-14(9-17(20)22)11-25-21-15-8-13(10-23)2-4-18(15)26-19-6-7-24-12-16(19)21/h2-5,8-9,24H,6-7,11-12H2,1H3,(H,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
The Trustees of Columbia University in the City of New York US Patent					Assay Description A series of dilutions of the test compounds were prepared with 10% DMSO in assay buffer and 5 μl of the dilution was added to a 50 μl react...				US Patent US10899756 (2021) BindingDB Entry DOI: 10.7270/Q2RN3C0P
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50300981 (7-(6-methoxypyridin-3-yl)-3-(2-oxo-2-(piperazin-1-...) Show SMILES CCCOCCn1c2cc(ncc2nc(NCC(=O)N2CCNCC2)c1=O)-c1ccc(OC)nc1 Show InChI InChI=1S/C24H31N7O4/c1-3-11-35-12-10-31-20-13-18(17-4-5-21(34-2)27-14-17)26-15-19(20)29-23(24(31)33)28-16-22(32)30-8-6-25-7-9-30/h4-5,13-15,25H,3,6-12,16H2,1-2H3,(H,28,29)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Global Research and Development Curated by ChEMBL					Assay Description Inhibition of PDE6				Bioorg Med Chem Lett 19: 5209-13 (2009) Article DOI: 10.1016/j.bmcl.2009.07.019 BindingDB Entry DOI: 10.7270/Q2H41RHV
					More data for this Ligand-Target Pair
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha (Homo sapiens (Human))	BDBM50241837 (CHEMBL4102913 | US10626113, Compound G | US1089975...) Show SMILES COc1ccc(CNc2c3CNCCc3nc3ccc(cc23)C#N)cc1Cl Show InChI InChI=1S/C21H19ClN4O/c1-27-20-5-3-14(9-17(20)22)11-25-21-15-8-13(10-23)2-4-18(15)26-19-6-7-24-12-16(19)21/h2-5,8-9,24H,6-7,11-12H2,1H3,(H,25,26)	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	>100	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2KH0SFD
					More data for this Ligand-Target Pair

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