Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Procathepsin L (Rattus norvegicus) | BDBM50121039 (CHEMBL114410 | [(S)-2-Cyclohexyl-1-((5S,6R)-4,4,7-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121041 (CHEMBL326093 | [(S)-1-((R)-4,7-Dioxo-4-(S)-oxo-4la...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121040 (CHEMBL117928 | [(S)-2-Pyridin-3-yl-1-((5S,6R)-4,4,...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121044 (CHEMBL116041 | [(S)-2-(3-Fluoro-phenyl)-1-((5S,6R)...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121042 (CHEMBL323638 | [(S)-2-Naphthalen-2-yl-1-((5S,6R)-4...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121038 (CHEMBL113706 | [(S)-2-Thiophen-2-yl-1-((5S,6R)-4,4...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121030 (CHEMBL115734 | [(S)-1-((5S,6S)-7-Oxo-4-oxa-1-aza-b...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin L cysteine protease by using Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121043 (CHEMBL323637 | [(S)-1-((R)-4,7-Dioxo-4-(R)-oxo-4la...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 9.60 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121035 (CHEMBL326342 | [(S)-1-((R)-4-(S)-Oxo-7-oxo-4lambda...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121028 (CHEMBL113761 | [(S)-1-((S)-7-Oxo-4-oxa-1-aza-bicyc...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 85 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin L cysteine protease by using Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121031 (CHEMBL419772 | [(S)-2-Methyl-1-((5R,6S)-7-oxo-4-ox...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin L cysteine protease by using Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121029 (CHEMBL116910 | [(S)-((5R,6S)-7-Oxo-4-oxa-1-aza-bic...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 1.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin L cysteine protease by using Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121034 (CHEMBL332025 | [1-((S)-7-Oxo-4-oxa-1-aza-bicyclo[3...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121036 (CHEMBL421054 | [(S)-1-((R)-7-Oxo-4-thia-1-aza-bicy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 6.68E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM25141 (2-cyano-pyrropyrimidine, 7g | 7-[2-(4,4-difluorocy...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis | Assay Description The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor... | J Med Chem 51: 5502-5 (2008) Article DOI: 10.1021/jm800839j BindingDB Entry DOI: 10.7270/Q2125QZR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM25135 (2-cyano-pyrropyrimidine, 7a | 7-(2-cyclohexylethyl...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis | Assay Description The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor... | J Med Chem 51: 5502-5 (2008) Article DOI: 10.1021/jm800839j BindingDB Entry DOI: 10.7270/Q2125QZR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM25134 (2-cyano-pyrropyrimidine, 2 | 7-(2-cyclohexylethyl)...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis | Assay Description The substrate hydrolysis with or without inhibitor was monitored at an excitation wavelength of 360nm and an emission wavelength of 460 nm on a fluor... | J Med Chem 51: 5502-5 (2008) Article DOI: 10.1021/jm800839j BindingDB Entry DOI: 10.7270/Q2125QZR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121037 (CHEMBL323704 | [(S)-2-Phenyl-1-((2S,7R)-5,5,8-trio...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 1.06E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121032 (CHEMBL424441 | [(S)-1-((5R,6S)-7-Oxo-4-oxa-1-aza-b...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description In vitro Inhibitory activity of the compound was determined against Cathepsin L cysteine protease by using Cbz-Phe-Arg-AMC | Bioorg Med Chem Lett 12: 3413-5 (2002) BindingDB Entry DOI: 10.7270/Q2CR5SQF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Procathepsin L (Rattus norvegicus) | BDBM50121033 (CHEMBL115822 | [(S)-2-Phenyl-1-((6R,7R)-5,5,8-trio...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
currently NAEJA Pharmaceutical Inc. Curated by ChEMBL | Assay Description Inhibition of Cbz-Phe-Arg-AMC binding to Cathepsin L cysteine protease | Bioorg Med Chem Lett 12: 3417-9 (2002) BindingDB Entry DOI: 10.7270/Q280520T | |||||||||||
More data for this Ligand-Target Pair |