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Compile Data Set for Download or QSAR

Found 29 hits of ki for UniProtKB: Q64737   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GAR transformylase


(Mus musculus)
BDBM50280415
PNG
((R)-2-{4-[3-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-p...)
Show SMILES Nc1nc2NCC(CCCc3ccc(cc3)C(=O)N[C@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C22H27N5O6/c23-22-26-18-15(20(31)27-22)10-13(11-24-18)3-1-2-12-4-6-14(7-5-12)19(30)25-16(21(32)33)8-9-17(28)29/h4-7,13,16H,1-3,8-11H2,(H,25,30)(H,28,29)(H,32,33)(H4,23,24,26,27,31)
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0.0000190n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against glycinamide ribonucleotide formyltransferase (GARFT) from L1210 murine leukemic cells


Bioorg Med Chem Lett 2: 339-342 (1992)


Article DOI: 10.1016/S0960-894X(01)80214-6
BindingDB Entry DOI: 10.7270/Q2RF5TXV
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM22590
PNG
((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Show SMILES Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15+/m1/s1
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0.000120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against glycinamide ribonucleotide formyltransferase (GARFT) from L1210 murine leukemic cells


Bioorg Med Chem Lett 2: 339-342 (1992)


Article DOI: 10.1016/S0960-894X(01)80214-6
BindingDB Entry DOI: 10.7270/Q2RF5TXV
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50280414
PNG
((R)-2-[4-(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyri...)
Show SMILES Nc1nc2NCC(Cc3ccc(cc3)C(=O)N[C@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C20H23N5O6/c21-20-24-16-13(18(29)25-20)8-11(9-22-16)7-10-1-3-12(4-2-10)17(28)23-14(19(30)31)5-6-15(26)27/h1-4,11,14H,5-9H2,(H,23,28)(H,26,27)(H,30,31)(H4,21,22,24,25,29)
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0.000630n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against glycinamide ribonucleotide formyltransferase (GARFT) from L1210 murine leukemic cells


Bioorg Med Chem Lett 2: 339-342 (1992)


Article DOI: 10.1016/S0960-894X(01)80214-6
BindingDB Entry DOI: 10.7270/Q2RF5TXV
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50005868
PNG
(2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...)
Show SMILES Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCP(O)(O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C19H25N6O7P/c20-19-24-15-13(17(27)25-19)7-10(9-22-15)8-21-12-3-1-11(2-4-12)16(26)23-14(18(28)29)5-6-33(30,31)32/h1-4,10,14,21H,5-9H2,(H,23,26)(H,28,29)(H2,30,31,32)(H4,20,22,24,25,27)
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47n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells


J Med Chem 35: 1578-88 (1992)


BindingDB Entry DOI: 10.7270/Q2028S6J
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM22590
PNG
((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Show SMILES Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15+/m1/s1
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60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cells


Bioorg Med Chem Lett 7: 453-456 (1997)


Article DOI: 10.1016/S0960-894X(97)00041-3
BindingDB Entry DOI: 10.7270/Q2HT2PB2
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024475
PNG
(2-{4-[(2-Amino-4-oxo-1,4,5,6,7,8-hexahydro-quinazo...)
Show SMILES Nc1nc2CCC(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C21H25N5O6/c22-21-25-15-6-1-11(9-14(15)19(30)26-21)10-23-13-4-2-12(3-5-13)18(29)24-16(20(31)32)7-8-17(27)28/h2-5,11,16,23H,1,6-10H2,(H,24,29)(H,27,28)(H,31,32)(H3,22,25,26,30)
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65n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
In vitro inhibition of mouse GAR transformylase


J Med Chem 35: 1578-88 (1992)


BindingDB Entry DOI: 10.7270/Q2028S6J
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50367875
PNG
(CHEMBL607957)
Show SMILES Nc1nc2ccc(CN(C(=O)CSCC(=O)NC3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c3ccc(cc3)C(=O)N[C@H](CCC(O)=O)C(O)=O)cc2c(=O)[nH]1 |r|
Show InChI InChI=1S/C30H35N6O15PS/c31-30-33-18-6-1-14(9-17(18)27(44)35-30)10-36(16-4-2-15(3-5-16)26(43)32-19(29(45)46)7-8-23(39)40)22(38)13-53-12-21(37)34-28-25(42)24(41)20(51-28)11-50-52(47,48)49/h1-6,9,19-20,24-25,28,41-42H,7-8,10-13H2,(H,32,43)(H,34,37)(H,39,40)(H,45,46)(H2,47,48,49)(H3,31,33,35,44)/t19-,20-,24-,25-,28?/m1/s1
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>100n/an/an/an/an/an/an/an/a



Pennsylvania State University

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant against GAR TFase in mice


J Med Chem 32: 937-40 (1989)


BindingDB Entry DOI: 10.7270/Q2RX9CN7
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50003896
PNG
((DDATHF) 5,10-Dideazatetrahydrofolic acid2-{4-[2-(...)
Show SMILES Nc1nc2NCC(CCc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cells


Bioorg Med Chem Lett 7: 453-456 (1997)


Article DOI: 10.1016/S0960-894X(97)00041-3
BindingDB Entry DOI: 10.7270/Q2HT2PB2
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM22590
PNG
((2S)-2-[(4-{2-[(6R)-2-amino-4-oxo-1H,4H,5H,6H,7H,8...)
Show SMILES Nc1nc2NC[C@H](CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C21H25N5O6/c22-21-25-17-14(19(30)26-21)9-12(10-23-17)2-1-11-3-5-13(6-4-11)18(29)24-15(20(31)32)7-8-16(27)28/h3-6,12,15H,1-2,7-10H2,(H,24,29)(H,27,28)(H,31,32)(H4,22,23,25,26,30)/t12-,15+/m1/s1
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120n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the inhibition of trifunctional Glycinamide ribonucleotide formyltransferase isolated from murine L1210 cells.


Bioorg Med Chem Lett 3: 2657-2660 (1993)


Article DOI: 10.1016/S0960-894X(01)80736-8
BindingDB Entry DOI: 10.7270/Q2R49QPW
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50291133
PNG
(2-{(S)-4-[2-(8-Amino-6-oxo-2,3,4,5,6,7-hexahydro-1...)
Show SMILES Nc1cc2NCCC(CCc3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)Cc2c(O)n1 |r|
Show InChI InChI=1S/C23H28N4O6/c24-19-12-18-16(22(31)27-19)11-14(9-10-25-18)2-1-13-3-5-15(6-4-13)21(30)26-17(23(32)33)7-8-20(28)29/h3-6,12,14,17,25H,1-2,7-11H2,(H,26,30)(H,28,29)(H,32,33)(H3,24,27,31)/t14?,17-/m0/s1
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147n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested in vitro for its inhibition of trifunctional glycinamide ribonucleotide formyltransferase (GARFT) isolated from murine L1210 leukemia cells


Bioorg Med Chem Lett 7: 453-456 (1997)


Article DOI: 10.1016/S0960-894X(97)00041-3
BindingDB Entry DOI: 10.7270/Q2HT2PB2
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50005865
PNG
(2-{4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-pyrido[...)
Show SMILES Nc1nc2NCC(CNc3ccc(cc3)C(=O)NC(CCS(O)(=O)=O)C(O)=O)Cc2c(=O)[nH]1
Show InChI InChI=1S/C19H24N6O7S/c20-19-24-15-13(17(27)25-19)7-10(9-22-15)8-21-12-3-1-11(2-4-12)16(26)23-14(18(28)29)5-6-33(30,31)32/h1-4,10,14,21H,5-9H2,(H,23,26)(H,28,29)(H,30,31,32)(H4,20,22,24,25,27)
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190n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
In vitro inhibition of Glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells


J Med Chem 35: 1578-88 (1992)


BindingDB Entry DOI: 10.7270/Q2028S6J
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50073753
PNG
((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)
Show SMILES C[C@](CCC(O)=O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)o1)C(O)=O
Show InChI InChI=1S/C20H26N6O6/c1-20(18(30)31,7-6-14(27)28)26-17(29)13-5-4-11(32-13)3-2-10-8-12-15(21)24-19(22)25-16(12)23-9-10/h4-5,10H,2-3,6-9H2,1H3,(H,26,29)(H,27,28)(H,30,31)(H5,21,22,23,24,25)/t10?,20-/m1/s1
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710n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzyme


Bioorg Med Chem Lett 9: 75-8 (1999)


BindingDB Entry DOI: 10.7270/Q2SX6CCT
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024464
PNG
(2-{4-[Acetyl-(2-amino-4-oxo-3,4-dihydro-quinazolin...)
Show SMILES CC(=O)N(Cc1ccc2nc(N)[nH]c(=O)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Show InChI InChI=1S/C23H23N5O7/c1-12(29)28(11-13-2-7-17-16(10-13)21(33)27-23(24)26-17)15-5-3-14(4-6-15)20(32)25-18(22(34)35)8-9-19(30)31/h2-7,10,18H,8-9,11H2,1H3,(H,25,32)(H,30,31)(H,34,35)(H3,24,26,27,33)
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1.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50002471
PNG
(5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,4a,5,6,7,8-octa...)
Show SMILES NCCCC(NC(=O)c1ccc(NCC2CNc3nc(N)[nH]c(=O)c3C2)cc1)C(O)=O
Show InChI InChI=1S/C20H27N7O4/c21-7-1-2-15(19(30)31)25-17(28)12-3-5-13(6-4-12)23-9-11-8-14-16(24-10-11)26-20(22)27-18(14)29/h3-6,11,15,23H,1-2,7-10,21H2,(H,25,28)(H,30,31)(H4,22,24,26,27,29)
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1.40E+3n/an/an/an/an/an/an/an/a



Medical University of South Carolina

Curated by ChEMBL


Assay Description
potent inhibitor of GAR Tfase obtained from porcine


J Med Chem 35: 2002-6 (1992)


BindingDB Entry DOI: 10.7270/Q2X9297Q
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50006906
PNG
(2-{4-[(2-Amino-4-hydroxy-quinazolin-6-ylmethyl)-am...)
Show SMILES Nc1nc2ccc(CNc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C21H21N5O6/c22-21-25-15-6-1-11(9-14(15)19(30)26-21)10-23-13-4-2-12(3-5-13)18(29)24-16(20(31)32)7-8-17(27)28/h1-6,9,16,23H,7-8,10H2,(H,24,29)(H,27,28)(H,31,32)(H3,22,25,26,30)
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2.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024465
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES Nc1nc2ccc(CN(CC(=O)c3ccccc3)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C29H27N5O7/c30-29-32-22-11-6-17(14-21(22)27(39)33-29)15-34(16-24(35)18-4-2-1-3-5-18)20-9-7-19(8-10-20)26(38)31-23(28(40)41)12-13-25(36)37/h1-11,14,23H,12-13,15-16H2,(H,31,38)(H,36,37)(H,40,41)(H3,30,32,33,39)
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3.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50002471
PNG
(5-Amino-2-{4-[(2-amino-4-oxo-2,3,4,4a,5,6,7,8-octa...)
Show SMILES NCCCC(NC(=O)c1ccc(NCC2CNc3nc(N)[nH]c(=O)c3C2)cc1)C(O)=O
Show InChI InChI=1S/C20H27N7O4/c21-7-1-2-15(19(30)31)25-17(28)12-3-5-13(6-4-12)23-9-11-8-14-16(24-10-11)26-20(22)27-18(14)29/h3-6,11,15,23H,1-2,7-10,21H2,(H,25,28)(H,30,31)(H4,22,24,26,27,29)
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3.70E+3n/an/an/an/an/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
In vitro inhibition of glycinamide ribonucleotide formyltransferase from L1210 murine leukemia cells


J Med Chem 35: 1578-88 (1992)


BindingDB Entry DOI: 10.7270/Q2028S6J
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024468
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES Nc1nc2ccc(CN(CC(O)=O)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C23H23N5O8/c24-23-26-16-6-1-12(9-15(16)21(34)27-23)10-28(11-19(31)32)14-4-2-13(3-5-14)20(33)25-17(22(35)36)7-8-18(29)30/h1-6,9,17H,7-8,10-11H2,(H,25,33)(H,29,30)(H,31,32)(H,35,36)(H3,24,26,27,34)
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5.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50008294
PNG
(2-(4-(((2-amino-4-oxo-1,4-dihydroquinazolin-6-yl)m...)
Show SMILES Nc1nc2ccc(CN(CC#C)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H23N5O6/c1-2-11-29(13-14-3-8-18-17(12-14)22(33)28-24(25)27-18)16-6-4-15(5-7-16)21(32)26-19(23(34)35)9-10-20(30)31/h1,3-8,12,19H,9-11,13H2,(H,26,32)(H,30,31)(H,34,35)(H3,25,27,28,33)
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6.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024466
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES Nc1nc2ccc(CN(Cc3c[nH]c(=O)[nH]c3=O)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C26H25N7O8/c27-25-30-18-6-1-13(9-17(18)23(38)31-25)11-33(12-15-10-28-26(41)32-22(15)37)16-4-2-14(3-5-16)21(36)29-19(24(39)40)7-8-20(34)35/h1-6,9-10,19H,7-8,11-12H2,(H,29,36)(H,34,35)(H,39,40)(H3,27,30,31,38)(H2,28,32,37,41)
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7.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024467
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES Nc1nc2ccc(CN(CC3CC3)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C25H27N5O6/c26-25-28-19-8-3-15(11-18(19)23(34)29-25)13-30(12-14-1-2-14)17-6-4-16(5-7-17)22(33)27-20(24(35)36)9-10-21(31)32/h3-8,11,14,20H,1-2,9-10,12-13H2,(H,27,33)(H,31,32)(H,35,36)(H3,26,28,29,34)
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8.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50073752
PNG
((R)-2-({5-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrid...)
Show SMILES C[C@](CCC(O)=O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)s1)C(O)=O
Show InChI InChI=1S/C20H26N6O5S/c1-20(18(30)31,7-6-14(27)28)26-17(29)13-5-4-11(32-13)3-2-10-8-12-15(21)24-19(22)25-16(12)23-9-10/h4-5,10H,2-3,6-9H2,1H3,(H,26,29)(H,27,28)(H,30,31)(H5,21,22,23,24,25)/t10?,20-/m1/s1
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9.20E+3n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzyme


Bioorg Med Chem Lett 9: 75-8 (1999)


BindingDB Entry DOI: 10.7270/Q2SX6CCT
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024462
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES Nc1nc2ccc(CN(CCCC#N)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C25H26N6O6/c26-11-1-2-12-31(14-15-3-8-19-18(13-15)23(35)30-25(27)29-19)17-6-4-16(5-7-17)22(34)28-20(24(36)37)9-10-21(32)33/h3-8,13,20H,1-2,9-10,12,14H2,(H,28,34)(H,32,33)(H,36,37)(H3,27,29,30,35)
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1.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50017876
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES CCN(Cc1ccc2nc(N)[nH]c(=O)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Show InChI InChI=1S/C23H25N5O6/c1-2-28(12-13-3-8-17-16(11-13)21(32)27-23(24)26-17)15-6-4-14(5-7-15)20(31)25-18(22(33)34)9-10-19(29)30/h3-8,11,18H,2,9-10,12H2,1H3,(H,25,31)(H,29,30)(H,33,34)(H3,24,26,27,32)
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1.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from the murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024461
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES Nc1nc2ccc(CN(Cc3cccc(F)c3)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C28H26FN5O6/c29-19-3-1-2-16(12-19)14-34(15-17-4-9-22-21(13-17)26(38)33-28(30)32-22)20-7-5-18(6-8-20)25(37)31-23(27(39)40)10-11-24(35)36/h1-9,12-13,23H,10-11,14-15H2,(H,31,37)(H,35,36)(H,39,40)(H3,30,32,33,38)
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1.80E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024463
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES CC(C)N(Cc1ccc2nc(N)[nH]c(=O)c2c1)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Show InChI InChI=1S/C24H27N5O6/c1-13(2)29(12-14-3-8-18-17(11-14)22(33)28-24(25)27-18)16-6-4-15(5-7-16)21(32)26-19(23(34)35)9-10-20(30)31/h3-8,11,13,19H,9-10,12H2,1-2H3,(H,26,32)(H,30,31)(H,34,35)(H3,25,27,28,33)
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1.90E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50281128
PNG
((S)-2-{4-[2-(4-Oxo-3,4,5,6,7,8-hexahydro-pyrido[2,...)
Show SMILES OC(=O)CC[C@H](NC(=O)c1ccc(CCC2CNc3nc[nH]c(=O)c3C2)cc1)C(O)=O
Show InChI InChI=1S/C21H24N4O6/c26-17(27)8-7-16(21(30)31)25-19(28)14-5-3-12(4-6-14)1-2-13-9-15-18(22-10-13)23-11-24-20(15)29/h3-6,11,13,16H,1-2,7-10H2,(H,25,28)(H,26,27)(H,30,31)(H2,22,23,24,29)
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2.70E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for the inhibition of trifunctional Glycinamide ribonucleotide formyltransferase isolated from murine L1210 cells.


Bioorg Med Chem Lett 3: 2657-2660 (1993)


Article DOI: 10.1016/S0960-894X(01)80736-8
BindingDB Entry DOI: 10.7270/Q2R49QPW
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50024469
PNG
(2-{4-[(2-Amino-4-oxo-3,4-dihydro-quinazolin-6-ylme...)
Show SMILES Nc1nc2ccc(CN(CCC(O)=O)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)cc2c(=O)[nH]1
Show InChI InChI=1S/C24H25N5O8/c25-24-27-17-6-1-13(11-16(17)22(35)28-24)12-29(10-9-20(32)33)15-4-2-14(3-5-15)21(34)26-18(23(36)37)7-8-19(30)31/h1-6,11,18H,7-10,12H2,(H,26,34)(H,30,31)(H,32,33)(H,36,37)(H3,25,27,28,35)
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3.20E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of GAR transformylase isolated from murine lymphoma cell line L5178Y


J Med Chem 30: 1254-6 (1987)


BindingDB Entry DOI: 10.7270/Q2VX0FHS
More data for this
Ligand-Target Pair
GAR transformylase


(Mus musculus)
BDBM50073754
PNG
((R)-2-{4-[2-(2,4-Diamino-5,6,7,8-tetrahydro-pyrido...)
Show SMILES C[C@](CCC(O)=O)(NC(=O)c1ccc(CCC2CNc3nc(N)nc(N)c3C2)cc1)C(O)=O
Show InChI InChI=1S/C22H28N6O5/c1-22(20(32)33,9-8-16(29)30)28-19(31)14-6-4-12(5-7-14)2-3-13-10-15-17(23)26-21(24)27-18(15)25-11-13/h4-7,13H,2-3,8-11H2,1H3,(H,28,31)(H,29,30)(H,32,33)(H5,23,24,25,26,27)/t13?,22-/m1/s1
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5.60E+4n/an/an/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against murine glycinamide ribonucleotide formyltransferase (GARFT) enzyme


Bioorg Med Chem Lett 9: 75-8 (1999)


BindingDB Entry DOI: 10.7270/Q2SX6CCT
More data for this
Ligand-Target Pair