Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA polymerase beta (Rattus norvegicus) | BDBM50241570 ((24E)-3beta-hydroxy-7,24-euphadien-26-oic acid | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of rat recombinant DNA polymerase beta after 20 mins by uncompetitive inhibition assay in presence of activated calf thymus DNA and 0.1 mg... | J Nat Prod 63: 1356-60 (2000) BindingDB Entry DOI: 10.7270/Q2X066S2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50109030 (4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 4.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer dose | Bioorg Med Chem Lett 12: 287-90 (2002) BindingDB Entry DOI: 10.7270/Q2K936TC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50448689 (CHEMBL3127730) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kobe Gakuin University Curated by ChEMBL | Assay Description Competitive inhibition of recombinant rat DNA polymerase beta using poly(dA)/oligo(dT)18 as substrate by Lineweaver-Burk plot analysis | Bioorg Med Chem 22: 1070-6 (2014) Article DOI: 10.1016/j.bmc.2013.12.038 BindingDB Entry DOI: 10.7270/Q22V2HMW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50109030 (4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of nucleotide substrate c... | Bioorg Med Chem Lett 12: 287-90 (2002) BindingDB Entry DOI: 10.7270/Q2K936TC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50250426 ((+)-Myristinin A | CHEMBL465365) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Activity of rat recombinant DNA polymerase beta using variable levels of DNA template-primer | J Nat Prod 68: 1625-8 (2005) Article DOI: 10.1021/np058064g BindingDB Entry DOI: 10.7270/Q2Q2400B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50448689 (CHEMBL3127730) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.16E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kobe Gakuin University Curated by ChEMBL | Assay Description Noncompetitive inhibition of recombinant rat DNA polymerase beta using dTTP as substrate by Lineweaver-Burk plot analysis | Bioorg Med Chem 22: 1070-6 (2014) Article DOI: 10.1016/j.bmc.2013.12.038 BindingDB Entry DOI: 10.7270/Q22V2HMW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50250427 ((+)-Myristinin D | CHEMBL448072) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Activity of rat recombinant DNA polymerase beta using variable levels of DNA template-primer | J Nat Prod 68: 1625-8 (2005) Article DOI: 10.1021/np058064g BindingDB Entry DOI: 10.7270/Q2Q2400B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50109029 (4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer dose | Bioorg Med Chem Lett 12: 287-90 (2002) BindingDB Entry DOI: 10.7270/Q2K936TC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50241570 ((24E)-3beta-hydroxy-7,24-euphadien-26-oic acid | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of rat recombinant DNA polymerase beta after 20 mins by noncompetitive inhibition assay in presence of activated calf thymus DNA and 0.1 m... | J Nat Prod 63: 1356-60 (2000) BindingDB Entry DOI: 10.7270/Q2X066S2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50109029 (4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.01E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Tokyo University of Science Curated by ChEMBL | Assay Description Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of template primer dose | Bioorg Med Chem Lett 12: 287-90 (2002) BindingDB Entry DOI: 10.7270/Q2K936TC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50241570 ((24E)-3beta-hydroxy-7,24-euphadien-26-oic acid | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of rat recombinant DNA polymerase beta after 20 mins by uncompetitive inhibition assay in presence of [3H]dTTP and 0.1 mg/mL BSA | J Nat Prod 63: 1356-60 (2000) BindingDB Entry DOI: 10.7270/Q2X066S2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA polymerase beta (Rattus norvegicus) | BDBM50241570 ((24E)-3beta-hydroxy-7,24-euphadien-26-oic acid | C...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 8.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Virginia Curated by ChEMBL | Assay Description Inhibition of rat recombinant DNA polymerase beta after 20 mins by noncompetitive inhibition assay in presence of [3H]dTTP and 0.1 mg/mL BSA | J Nat Prod 63: 1356-60 (2000) BindingDB Entry DOI: 10.7270/Q2X066S2 | |||||||||||
More data for this Ligand-Target Pair |