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Compile Data Set for Download or QSAR

Found 70 hits of affinity data for UniProtKB/TrEMBL: O60607   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50095027
PNG
((2,3-Dimethoxy-phenyl)-{1-[2-(4-fluoro-phenyl)-eth...)
Show SMILES COc1cccc([C@H](O)C2CCN(CCc3ccc(F)cc3)CC2)c1OC |r|
Show InChI InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1
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1.06E+3n/an/an/an/an/an/an/an/a



Merck Sharp and Dohme

Curated by ChEMBL


Assay Description
Binding affinity at Voltage-gated potassium channel


J Med Chem 44: 477-501 (2001)


BindingDB Entry DOI: 10.7270/Q24Q7VQH
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50371391
PNG
(SENICAPOC)
Show SMILES NC(=O)C(c1ccccc1)(c1ccc(F)cc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated K channel 7.1 (unknown origin)


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395464
PNG
(CHEMBL2164048)
Show SMILES CC[C@H](C(=O)Nc1ccccc1N1CCCC1)c1ccccc1 |r|
Show InChI InChI=1S/C20H24N2O/c1-2-17(16-10-4-3-5-11-16)20(23)21-18-12-6-7-13-19(18)22-14-8-9-15-22/h3-7,10-13,17H,2,8-9,14-15H2,1H3,(H,21,23)/t17-/m0/s1
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n/an/a 2.92E+3n/an/an/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Antagonist activity at KCNQ1 expressed in CHO cells incubated for 3 mins by automated patch clamp assay


J Med Chem 55: 6975-9 (2012)


Article DOI: 10.1021/jm300700v
BindingDB Entry DOI: 10.7270/Q2KD2017
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50395399
PNG
(CHEMBL2165063)
Show SMILES COc1ccc2ncc(=O)n(CCN3CCC(CC3)NCc3ccc4OCC(=O)Nc4n3)c2c1
Show InChI InChI=1S/C24H28N6O4/c1-33-18-3-4-19-20(12-18)30(23(32)14-26-19)11-10-29-8-6-16(7-9-29)25-13-17-2-5-21-24(27-17)28-22(31)15-34-21/h2-5,12,14,16,25H,6-11,13,15H2,1H3,(H,27,28,31)
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n/an/a 3.50E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of potassium channel IKs (unknown origin)


Bioorg Med Chem 22: 5392-409 (2014)


Article DOI: 10.1016/j.bmc.2014.07.040
BindingDB Entry DOI: 10.7270/Q2VQ3480
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50023582
PNG
(CHEMBL3355575)
Show SMILES [H][C@@]1(CC[C@@H](CC1)NCc1ccc2OCC(=O)Nc2n1)[C@@H](N)Cn1c2cc(OC)cnc2ccc1=O |r,wU:20.23,wD:4.7,1.0,(9.66,-8.53,;8.34,-7.77,;7,-7.01,;7,-5.46,;8.33,-4.69,;9.67,-5.46,;9.67,-6.99,;8.33,-3.15,;9.66,-2.38,;11,-3.14,;10.99,-4.69,;12.32,-5.46,;13.65,-4.69,;14.99,-5.46,;16.33,-4.68,;16.33,-3.13,;17.66,-2.36,;14.98,-2.36,;13.65,-3.14,;12.31,-2.38,;8.35,-9.3,;9.68,-10.07,;7.02,-10.08,;7.03,-11.62,;5.69,-12.41,;4.36,-11.64,;3.03,-12.41,;1.7,-11.65,;.36,-12.42,;3.03,-13.96,;4.36,-14.73,;5.7,-13.96,;7.04,-14.73,;8.38,-13.95,;8.38,-12.4,;9.71,-11.62,)|
Show InChI InChI=1/C25H30N6O4/c1-34-18-10-21-20(28-12-18)7-9-24(33)31(21)13-19(26)15-2-4-16(5-3-15)27-11-17-6-8-22-25(29-17)30-23(32)14-35-22/h6-10,12,15-16,19,27H,2-5,11,13-14,26H2,1H3,(H,29,30,32)/t15-,16-,19-/s2
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n/an/a>3.33E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of potassium channel IKs (unknown origin)


Bioorg Med Chem 22: 5392-409 (2014)


Article DOI: 10.1016/j.bmc.2014.07.040
BindingDB Entry DOI: 10.7270/Q2VQ3480
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50023589
PNG
(CHEMBL3355573)
Show SMILES [H][C@@]1(CC[C@@H](CC1)NCc1ncc2OCC(=O)Nc2n1)[C@@H](N)Cn1c2cc(F)ccc2ncc1=O |r,wU:20.23,wD:4.7,1.0,(25.26,-46.78,;23.93,-46.02,;22.6,-45.26,;22.59,-43.72,;23.93,-42.94,;25.26,-43.71,;25.27,-45.24,;23.92,-41.4,;25.26,-40.63,;26.59,-41.4,;26.58,-42.95,;27.92,-43.71,;29.25,-42.94,;30.58,-43.71,;31.92,-42.94,;31.92,-41.39,;33.25,-40.62,;30.58,-40.61,;29.24,-41.39,;27.91,-40.63,;23.94,-47.56,;25.28,-48.32,;22.61,-48.34,;22.62,-49.88,;21.29,-50.66,;19.95,-49.9,;18.62,-50.67,;17.29,-49.9,;18.62,-52.21,;19.96,-52.98,;21.29,-52.22,;22.63,-52.99,;23.98,-52.21,;23.97,-50.65,;25.3,-49.88,)|
Show InChI InChI=1/C23H26FN7O3/c24-14-3-6-17-18(7-14)31(22(33)10-27-17)11-16(25)13-1-4-15(5-2-13)26-9-20-28-8-19-23(29-20)30-21(32)12-34-19/h3,6-8,10,13,15-16,26H,1-2,4-5,9,11-12,25H2,(H,28,29,30,32)/t13-,15-,16-/s2
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n/an/a>3.33E+5n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Inhibition of potassium channel IKs (unknown origin)


Bioorg Med Chem 22: 5392-409 (2014)


Article DOI: 10.1016/j.bmc.2014.07.040
BindingDB Entry DOI: 10.7270/Q2VQ3480
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50339281
PNG
(5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(...)
Show SMILES Fc1cc(c(Cl)nc1Cl)-c1cc(=O)n2[nH]c(c(-c3ccccc3)c2n1)C(F)(F)F
Show InChI InChI=1S/C18H8Cl2F4N4O/c19-15-9(6-10(21)16(20)26-15)11-7-12(29)28-17(25-11)13(8-4-2-1-3-5-8)14(27-28)18(22,23)24/h1-7,27H
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n/an/an/an/a 4.93E+4n/an/an/an/a



Hebei Medical University

Curated by ChEMBL


Assay Description
Activation of KCNQ1 expressed in HEK293 cells by atomic absorption Rb'+ efflux assay


Eur J Med Chem 46: 934-43 (2011)


Article DOI: 10.1016/j.ejmech.2011.01.010
BindingDB Entry DOI: 10.7270/Q2TM7BDF
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390867
PNG
(CHEMBL2070959)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C(F)(F)F)n1 |r|
Show InChI InChI=1S/C23H22F3N3O4S2/c1-33-17-9-5-15(6-10-17)19-14-34-22(27-19)28-21(30)20-4-2-3-13-29(20)35(31,32)18-11-7-16(8-12-18)23(24,25)26/h5-12,14,20H,2-4,13H2,1H3,(H,27,28,30)/t20-/m1/s1
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n/an/an/an/a 1.71E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390868
PNG
(CHEMBL2070960)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2OC)n1 |r|
Show InChI InChI=1S/C23H25N3O5S2/c1-30-17-12-10-16(11-13-17)18-15-32-23(24-18)25-22(27)19-7-5-6-14-26(19)33(28,29)21-9-4-3-8-20(21)31-2/h3-4,8-13,15,19H,5-7,14H2,1-2H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 1.78E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390869
PNG
(CHEMBL2070961)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(OC)c2)n1 |r|
Show InChI InChI=1S/C23H25N3O5S2/c1-30-17-11-9-16(10-12-17)20-15-32-23(24-20)25-22(27)21-8-3-4-13-26(21)33(28,29)19-7-5-6-18(14-19)31-2/h5-7,9-12,14-15,21H,3-4,8,13H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a 810n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390870
PNG
(CHEMBL2070962)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc3OCOc3c2)n1 |r|
Show InChI InChI=1S/C23H23N3O6S2/c1-30-16-7-5-15(6-8-16)18-13-33-23(24-18)25-22(27)19-4-2-3-11-26(19)34(28,29)17-9-10-20-21(12-17)32-14-31-20/h5-10,12-13,19H,2-4,11,14H2,1H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 780n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390871
PNG
(CHEMBL2070963)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2C#N)n1 |r|
Show InChI InChI=1S/C23H22N4O4S2/c1-31-18-11-9-16(10-12-18)19-15-32-23(25-19)26-22(28)20-7-4-5-13-27(20)33(29,30)21-8-3-2-6-17(21)14-24/h2-3,6,8-12,15,20H,4-5,7,13H2,1H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390872
PNG
(CHEMBL2070964)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(c2)C#N)n1 |r|
Show InChI InChI=1S/C23H22N4O4S2/c1-31-18-10-8-17(9-11-18)20-15-32-23(25-20)26-22(28)21-7-2-3-12-27(21)33(29,30)19-6-4-5-16(13-19)14-24/h4-6,8-11,13,15,21H,2-3,7,12H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a 880n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390873
PNG
(CHEMBL2070965)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(cc2)C#N)n1 |r|
Show InChI InChI=1S/C23H22N4O4S2/c1-31-18-9-7-17(8-10-18)20-15-32-23(25-20)26-22(28)21-4-2-3-13-27(21)33(29,30)19-11-5-16(14-24)6-12-19/h5-12,15,21H,2-4,13H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a 1.63E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390874
PNG
(CHEMBL2070966)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(F)c2)n1 |r|
Show InChI InChI=1S/C22H22FN3O4S2/c1-30-17-10-8-15(9-11-17)19-14-31-22(24-19)25-21(27)20-7-2-3-12-26(20)32(28,29)18-6-4-5-16(23)13-18/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.16E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390875
PNG
(CHEMBL2070967)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2)n1 |r|
Show InChI InChI=1S/C22H22FN3O4S2/c1-30-17-9-5-15(6-10-17)19-14-31-22(24-19)25-21(27)20-4-2-3-13-26(20)32(28,29)18-11-7-16(23)8-12-18/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.03E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390876
PNG
(CHEMBL2070968)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccccc2Cl)n1 |r|
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-16-11-9-15(10-12-16)18-14-31-22(24-18)25-21(27)19-7-4-5-13-26(19)32(28,29)20-8-3-2-6-17(20)23/h2-3,6,8-12,14,19H,4-5,7,13H2,1H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a 730n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390877
PNG
(CHEMBL2070969)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(Cl)c2)n1 |r|
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-17-10-8-15(9-11-17)19-14-31-22(24-19)25-21(27)20-7-2-3-12-26(20)32(28,29)18-6-4-5-16(23)13-18/h4-6,8-11,13-14,20H,2-3,7,12H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 1.41E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390878
PNG
(CHEMBL2070970)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(Cl)cc2)n1 |r|
Show InChI InChI=1S/C22H22ClN3O4S2/c1-30-17-9-5-15(6-10-17)19-14-31-22(24-19)25-21(27)20-4-2-3-13-26(20)32(28,29)18-11-7-16(23)8-12-18/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 420n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390879
PNG
(CHEMBL2070971)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(Cl)c2Cl)n1 |r|
Show InChI InChI=1S/C22H21Cl2N3O4S2/c1-31-15-10-8-14(9-11-15)17-13-32-22(25-17)26-21(28)18-6-2-3-12-27(18)33(29,30)19-7-4-5-16(23)20(19)24/h4-5,7-11,13,18H,2-3,6,12H2,1H3,(H,25,26,28)/t18-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390880
PNG
(CHEMBL2070972)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(F)cc2Cl)n1 |r|
Show InChI InChI=1S/C22H21ClFN3O4S2/c1-31-16-8-5-14(6-9-16)18-13-32-22(25-18)26-21(28)19-4-2-3-11-27(19)33(29,30)20-10-7-15(24)12-17(20)23/h5-10,12-13,19H,2-4,11H2,1H3,(H,25,26,28)/t19-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390881
PNG
(CHEMBL2070973)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cc(Cl)ccc2F)n1 |r|
Show InChI InChI=1S/C22H21ClFN3O4S2/c1-31-16-8-5-14(6-9-16)18-13-32-22(25-18)26-21(28)19-4-2-3-11-27(19)33(29,30)20-12-15(23)7-10-17(20)24/h5-10,12-13,19H,2-4,11H2,1H3,(H,25,26,28)/t19-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390882
PNG
(CHEMBL2070974)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccc(F)c2C)n1 |r|
Show InChI InChI=1S/C23H24FN3O4S2/c1-15-18(24)6-5-8-21(15)33(29,30)27-13-4-3-7-20(27)22(28)26-23-25-19(14-32-23)16-9-11-17(31-2)12-10-16/h5-6,8-12,14,20H,3-4,7,13H2,1-2H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390883
PNG
(CHEMBL2070975)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)Cc2ccccc2Cl)n1 |r|
Show InChI InChI=1S/C23H24ClN3O4S2/c1-31-18-11-9-16(10-12-18)20-14-32-23(25-20)26-22(28)21-8-4-5-13-27(21)33(29,30)15-17-6-2-3-7-19(17)24/h2-3,6-7,9-12,14,21H,4-5,8,13,15H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390884
PNG
(CHEMBL2070976)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)Cc2ccc(Cl)cc2)n1 |r|
Show InChI InChI=1S/C23H24ClN3O4S2/c1-31-19-11-7-17(8-12-19)20-14-32-23(25-20)26-22(28)21-4-2-3-13-27(21)33(29,30)15-16-5-9-18(24)10-6-16/h5-12,14,21H,2-4,13,15H2,1H3,(H,25,26,28)/t21-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390885
PNG
(CHEMBL2070977)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2nccc3ccccc23)n1 |r|
Show InChI InChI=1S/C25H24N4O4S2/c1-33-19-11-9-18(10-12-19)21-16-34-25(27-21)28-23(30)22-8-4-5-15-29(22)35(31,32)24-20-7-3-2-6-17(20)13-14-26-24/h2-3,6-7,9-14,16,22H,4-5,8,15H2,1H3,(H,27,28,30)/t22-/m1/s1
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n/an/an/an/a 7.97E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390886
PNG
(CHEMBL2070978)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccnc2)n1 |r|
Show InChI InChI=1S/C21H22N4O4S2/c1-29-16-9-7-15(8-10-16)18-14-30-21(23-18)24-20(26)19-6-2-3-12-25(19)31(27,28)17-5-4-11-22-13-17/h4-5,7-11,13-14,19H,2-3,6,12H2,1H3,(H,23,24,26)/t19-/m1/s1
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n/an/an/an/a 1.36E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390887
PNG
(CHEMBL2070979)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cn(C)cn2)n1 |r|
Show InChI InChI=1S/C20H23N5O4S2/c1-24-11-18(21-13-24)31(27,28)25-10-4-3-5-17(25)19(26)23-20-22-16(12-30-20)14-6-8-15(29-2)9-7-14/h6-9,11-13,17H,3-5,10H2,1-2H3,(H,22,23,26)/t17-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390888
PNG
(CHEMBL2070980)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2cccnc2C)n1 |r|
Show InChI InChI=1S/C22H24N4O4S2/c1-15-20(7-5-12-23-15)32(28,29)26-13-4-3-6-19(26)21(27)25-22-24-18(14-31-22)16-8-10-17(30-2)11-9-16/h5,7-12,14,19H,3-4,6,13H2,1-2H3,(H,24,25,27)/t19-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390889
PNG
(CHEMBL2070982)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2C(=O)c2ccccc2)n1 |r|
Show InChI InChI=1S/C23H23N3O3S/c1-29-18-12-10-16(11-13-18)19-15-30-23(24-19)25-21(27)20-9-5-6-14-26(20)22(28)17-7-3-2-4-8-17/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a 8.16E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390890
PNG
(CHEMBL2070983)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2C(=O)c2ccccc2OC)n1 |r|
Show InChI InChI=1S/C24H25N3O4S/c1-30-17-12-10-16(11-13-17)19-15-32-24(25-19)26-22(28)20-8-5-6-14-27(20)23(29)18-7-3-4-9-21(18)31-2/h3-4,7,9-13,15,20H,5-6,8,14H2,1-2H3,(H,25,26,28)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390891
PNG
(CHEMBL2070984)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCCCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C24H27N3O4S2/c1-17-7-13-20(14-8-17)33(29,30)27-15-5-3-4-6-22(27)23(28)26-24-25-21(16-32-24)18-9-11-19(31-2)12-10-18/h7-14,16,22H,3-6,15H2,1-2H3,(H,25,26,28)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390892
PNG
(CHEMBL2070985)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O4S2/c1-15-5-11-18(12-6-15)31(27,28)25-13-3-4-20(25)21(26)24-22-23-19(14-30-22)16-7-9-17(29-2)10-8-16/h5-12,14,20H,3-4,13H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 2.86E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390893
PNG
(CHEMBL2070986)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C21H21N3O4S2/c1-14-3-9-17(10-4-14)30(26,27)24-12-11-19(24)20(25)23-21-22-18(13-29-21)15-5-7-16(28-2)8-6-15/h3-10,13,19H,11-12H2,1-2H3,(H,22,23,25)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390894
PNG
(CHEMBL2070987)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2COCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O5S2/c1-15-3-9-18(10-4-15)32(27,28)25-11-12-30-13-20(25)21(26)24-22-23-19(14-31-22)16-5-7-17(29-2)8-6-16/h3-10,14,20H,11-13H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 4.38E+3n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390895
PNG
(CHEMBL2070988)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CSCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H23N3O4S3/c1-15-3-9-18(10-4-15)32(27,28)25-11-12-30-14-20(25)21(26)24-22-23-19(13-31-22)16-5-7-17(29-2)8-6-16/h3-10,13,20H,11-12,14H2,1-2H3,(H,23,24,26)
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n/an/an/an/a 600n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390896
PNG
(CHEMBL2070989)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)C2CNCCN2S(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C22H24N4O4S2/c1-15-3-9-18(10-4-15)32(28,29)26-12-11-23-13-20(26)21(27)25-22-24-19(14-31-22)16-5-7-17(30-2)8-6-16/h3-10,14,20,23H,11-13H2,1-2H3,(H,24,25,27)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390897
PNG
(CHEMBL2070990)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCN(C2)S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-5-11-20(12-6-16)32(28,29)26-13-3-4-18(14-26)22(27)25-23-24-21(15-31-23)17-7-9-19(30-2)10-8-17/h5-12,15,18H,3-4,13-14H2,1-2H3,(H,24,25,27)/t18-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390897
PNG
(CHEMBL2070990)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCN(C2)S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O4S2/c1-16-5-11-20(12-6-16)32(28,29)26-13-3-4-18(14-26)22(27)25-23-24-21(15-31-23)17-7-9-19(30-2)10-8-17/h5-12,15,18H,3-4,13-14H2,1-2H3,(H,24,25,27)/t18-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390898
PNG
(CHEMBL2070992)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)CCNS(=O)(=O)c2ccc(C)cc2)n1
Show InChI InChI=1S/C20H21N3O4S2/c1-14-3-9-17(10-4-14)29(25,26)21-12-11-19(24)23-20-22-18(13-28-20)15-5-7-16(27-2)8-6-15/h3-10,13,21H,11-12H2,1-2H3,(H,22,23,24)
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390899
PNG
(CHEMBL2070993)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H](NS(=O)(=O)c2ccc(C)cc2)C(C)(C)C)n1 |r|
Show InChI InChI=1S/C23H27N3O4S2/c1-15-6-12-18(13-7-15)32(28,29)26-20(23(2,3)4)21(27)25-22-24-19(14-31-22)16-8-10-17(30-5)11-9-16/h6-14,20,26H,1-5H3,(H,24,25,27)/t20-/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390900
PNG
(CHEMBL2070994)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@H](NS(=O)(=O)c2ccc(C)cc2)C(C)C)n1 |r|
Show InChI InChI=1S/C22H25N3O4S2/c1-14(2)20(25-31(27,28)18-11-5-15(3)6-12-18)21(26)24-22-23-19(13-30-22)16-7-9-17(29-4)10-8-16/h5-14,20,25H,1-4H3,(H,23,24,26)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390901
PNG
(CHEMBL2070995)
Show SMILES COc1ccc(cc1)-c1csc(NC(=O)[C@@H](C)NS(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C20H21N3O4S2/c1-13-4-10-17(11-5-13)29(25,26)23-14(2)19(24)22-20-21-18(12-28-20)15-6-8-16(27-3)9-7-15/h4-12,14,23H,1-3H3,(H,21,22,24)/t14-/m1/s1
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n/an/an/an/a 1.29E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390902
PNG
(CHEMBL2070996)
Show SMILES CC(C)c1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C25H29N3O3S2/c1-17(2)19-9-11-20(12-10-19)22-16-32-25(26-22)27-24(29)23-6-4-5-15-28(23)33(30,31)21-13-7-18(3)8-14-21/h7-14,16-17,23H,4-6,15H2,1-3H3,(H,26,27,29)/t23-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390903
PNG
(CHEMBL2070997)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccccc1 |r|
Show InChI InChI=1S/C22H23N3O3S2/c1-16-10-12-18(13-11-16)30(27,28)25-14-6-5-9-20(25)21(26)24-22-23-19(15-29-22)17-7-3-2-4-8-17/h2-4,7-8,10-13,15,20H,5-6,9,14H2,1H3,(H,23,24,26)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390904
PNG
(CHEMBL2070998)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C22H22FN3O3S2/c1-15-5-11-18(12-6-15)31(28,29)26-13-3-2-4-20(26)21(27)25-22-24-19(14-30-22)16-7-9-17(23)10-8-16/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390905
PNG
(CHEMBL2070999)
Show SMILES Cc1ccc(cc1)-c1csc(NC(=O)[C@H]2CCCCN2S(=O)(=O)c2ccc(C)cc2)n1 |r|
Show InChI InChI=1S/C23H25N3O3S2/c1-16-6-10-18(11-7-16)20-15-30-23(24-20)25-22(27)21-5-3-4-14-26(21)31(28,29)19-12-8-17(2)9-13-19/h6-13,15,21H,3-5,14H2,1-2H3,(H,24,25,27)/t21-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390906
PNG
(CHEMBL2071001)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc(cs1)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C22H22ClN3O3S2/c1-15-5-11-18(12-6-15)31(28,29)26-13-3-2-4-20(26)21(27)25-22-24-19(14-30-22)16-7-9-17(23)10-8-16/h5-12,14,20H,2-4,13H2,1H3,(H,24,25,27)/t20-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390907
PNG
(CHEMBL2071002)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nccs1 |r|
Show InChI InChI=1S/C16H19N3O3S2/c1-12-5-7-13(8-6-12)24(21,22)19-10-3-2-4-14(19)15(20)18-16-17-9-11-23-16/h5-9,11,14H,2-4,10H2,1H3,(H,17,18,20)/t14-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
KCNQ (Kv7) potassium channel


(Homo sapiens (Human))
BDBM50390908
PNG
(CHEMBL2071003)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCC[C@@H]1C(=O)Nc1nc2ccccc2s1 |r|
Show InChI InChI=1S/C20H21N3O3S2/c1-14-9-11-15(12-10-14)28(25,26)23-13-5-4-7-17(23)19(24)22-20-21-16-6-2-3-8-18(16)27-20/h2-3,6,8-12,17H,4-5,7,13H2,1H3,(H,21,22,24)/t17-/m1/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



Vanderbilt University Medical Center

Curated by ChEMBL


Assay Description
Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced thallium influx after 3 mins by patch clamp assay


Bioorg Med Chem Lett 22: 5936-41 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.060
BindingDB Entry DOI: 10.7270/Q25T3MKN
More data for this
Ligand-Target Pair
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