Found 184 hits of ec50 for UniProtKB: O43525 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50420073
(CHEMBL2047506)Show InChI InChI=1S/C18H13ClN2O2/c19-17-11-8-14(12-20-17)21-18(22)13-6-9-16(10-7-13)23-15-4-2-1-3-5-15/h1-12H,(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 10 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ... |
ACS Med Chem Lett 2: 481-484 (2011)
Article DOI: 10.1021/ml200053x BindingDB Entry DOI: 10.7270/Q2R49RVJ |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50592356
(CHEMBL4458793)Show SMILES Nc1c(F)c(NCc2ccc(cc2)C(F)(F)F)ccc1NC(=O)OC1CC1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 18 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128841 BindingDB Entry DOI: 10.7270/Q2571H05 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465779
(CHEMBL4278049)Show SMILES CS(=O)(=O)c1cccc(c1)[C@H](CO)NC(=O)c1cc(ccc1Oc1ccccc1)S(F)(F)(F)(F)F |r| Show InChI InChI=1S/C22H20F5NO5S2/c1-34(31,32)17-9-5-6-15(12-17)20(14-29)28-22(30)19-13-18(35(23,24,25,26)27)10-11-21(19)33-16-7-3-2-4-8-16/h2-13,20,29H,14H2,1H3,(H,28,30)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 20 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415511
(CHEMBL598553)Show SMILES Cn1c2cc(F)c(F)cc2s\c1=N/NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:14:16:19:23.21.22,THB:21:20:17:23.22.24,21:22:19.20.25:17,24:22:19:25.16.17,24:16:19:23.21.22| Show InChI InChI=1S/C19H21F2N3OS/c1-24-15-5-13(20)14(21)6-16(15)26-18(24)23-22-17(25)19-7-10-2-11(8-19)4-12(3-10)9-19/h5-6,10-12H,2-4,7-9H2,1H3,(H,22,25)/b23-18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415531
(CHEMBL592297)Show SMILES Cn1c2ccc(OC(F)(F)F)cc2sc1=NNC(=O)OC(C)(C)C |w:15.17| Show InChI InChI=1S/C14H16F3N3O3S/c1-13(2,3)23-12(21)19-18-11-20(4)9-6-5-8(7-10(9)24-11)22-14(15,16)17/h5-7H,1-4H3,(H,19,21) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 23 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121052
(CHEMBL3621438)Show InChI InChI=1S/C16H26N4O3S/c1-16(2,3)10-11(21)17-12-13(22-4)18-15(19-14(12)23-5)20-6-8-24-9-7-20/h6-10H2,1-5H3,(H,17,21) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 24 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074 BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415509
(CHEMBL599164)Show SMILES Cn1c2ccc(OC(F)(F)F)cc2s\c1=N/NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:17:19:22:26.24.25,THB:24:23:20:26.25.27,24:25:22.23.28:20,27:25:22:28.19.20,27:19:22:26.24.25| Show InChI InChI=1S/C20H22F3N3O2S/c1-26-15-3-2-14(28-20(21,22)23)7-16(15)29-18(26)25-24-17(27)19-8-11-4-12(9-19)6-13(5-11)10-19/h2-3,7,11-13H,4-6,8-10H2,1H3,(H,24,27)/b25-18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 25 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415502
(CHEMBL598126)Show SMILES Cn1c2ccccc2s\c1=N/NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:12:14:17:21.19.20,THB:19:18:15:21.20.22,19:20:17.18.23:15,22:20:17:23.14.15,22:14:17:21.19.20| Show InChI InChI=1S/C19H23N3OS/c1-22-15-4-2-3-5-16(15)24-18(22)21-20-17(23)19-9-12-6-13(10-19)8-14(7-12)11-19/h2-5,12-14H,6-11H2,1H3,(H,20,23)/b21-18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 27 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415516
(CHEMBL599374)Show SMILES Cn1c2ccc(OC(F)(F)F)cc2s\c1=N/NC(=O)C1CCCCC1 Show InChI InChI=1S/C16H18F3N3O2S/c1-22-12-8-7-11(24-16(17,18)19)9-13(12)25-15(22)21-20-14(23)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,20,23)/b21-15- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415507
(CHEMBL604937)Show SMILES Cn1c2ccc(F)cc2s\c1=N/NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:13:15:18:22.20.21,THB:20:19:16:22.21.23,20:21:18.19.24:16,23:21:18:24.15.16,23:15:18:22.20.21| Show InChI InChI=1S/C19H22FN3OS/c1-23-15-3-2-14(20)7-16(15)25-18(23)22-21-17(24)19-8-11-4-12(9-19)6-13(5-11)10-19/h2-3,7,11-13H,4-6,8-10H2,1H3,(H,21,24)/b22-18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 28 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415529
(CHEMBL589898)Show SMILES Cn1c2ccc(OC(F)(F)F)cc2sc1=NNC(=O)OC1CCCC1 |w:15.17| Show InChI InChI=1S/C15H16F3N3O3S/c1-21-11-7-6-10(24-15(16,17)18)8-12(11)25-13(21)19-20-14(22)23-9-4-2-3-5-9/h6-9H,2-5H2,1H3,(H,20,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 29 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50420077
(CHEMBL2047511)Show InChI InChI=1S/C18H12ClFN2O2/c19-17-9-7-13(11-21-17)22-18(23)12-6-8-16(15(20)10-12)24-14-4-2-1-3-5-14/h1-11H,(H,22,23) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 30 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ... |
ACS Med Chem Lett 2: 481-484 (2011)
Article DOI: 10.1021/ml200053x BindingDB Entry DOI: 10.7270/Q2R49RVJ |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50254401
(CHEMBL4093377)Show InChI InChI=1S/C13H8ClF3N4/c14-11-4-2-8(6-18-11)19-12-9-3-1-7(13(15,16)17)5-10(9)20-21-12/h1-6H,(H2,19,20,21) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, U.K.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/3 (unknown origin) |
ACS Med Chem Lett 8: 666-671 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00140 BindingDB Entry DOI: 10.7270/Q2C24ZWG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50254387
(CHEMBL4062193)Show InChI InChI=1S/C13H7F5N4O/c14-8-2-1-6(3-9(8)15)20-12-11-10(21-22-12)4-7(5-19-11)23-13(16,17)18/h1-5H,(H2,20,21,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 37 | n/a | n/a | n/a | n/a |
Pfizer Worldwide Medicinal Chemistry, Neuroscience and Pain Research Unit, Portway Building, Granta Park, Great Abington, Cambridgeshire CB21 6GS, U.K.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/3 (unknown origin) |
ACS Med Chem Lett 8: 666-671 (2017)
Article DOI: 10.1021/acsmedchemlett.7b00140 BindingDB Entry DOI: 10.7270/Q2C24ZWG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50120996
(CHEMBL3621449)Show SMILES COC1CCN(CC1)c1nc(OC)c(NC(=O)CCC2CCCC2)c(OC)n1 Show InChI InChI=1S/C20H32N4O4/c1-26-15-10-12-24(13-11-15)20-22-18(27-2)17(19(23-20)28-3)21-16(25)9-8-14-6-4-5-7-14/h14-15H,4-13H2,1-3H3,(H,21,25) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074 BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465781
(CHEMBL4276984)Show SMILES C[C@H](NC(=O)c1cc(ccc1Oc1ccccc1)C(F)(F)F)c1cccc(c1)S(C)(=O)=O |r| Show InChI InChI=1S/C23H20F3NO4S/c1-15(16-7-6-10-19(13-16)32(2,29)30)27-22(28)20-14-17(23(24,25)26)11-12-21(20)31-18-8-4-3-5-9-18/h3-15H,1-2H3,(H,27,28)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465775
(CHEMBL1703636)Show SMILES Cc1cc(C)c(NC(=O)C2CC3CCC2C3)c(C)c1 |TLB:7:9:15:13.12| Show InChI InChI=1S/C17H23NO/c1-10-6-11(2)16(12(3)7-10)18-17(19)15-9-13-4-5-14(15)8-13/h6-7,13-15H,4-5,8-9H2,1-3H3,(H,18,19) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415521
(CHEMBL609624)Show SMILES Cn1c2ccc(OC(F)(F)F)cc2s\c1=N/NC(=O)CC1CCCC1 Show InChI InChI=1S/C16H18F3N3O2S/c1-22-12-7-6-11(24-16(17,18)19)9-13(12)25-15(22)21-20-14(23)8-10-4-2-3-5-10/h6-7,9-10H,2-5,8H2,1H3,(H,20,23)/b21-15- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 44 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415526
(CHEMBL591302)Show SMILES Cn1c2ccc(OC(F)(F)F)cc2s\c1=N/NC(=O)c1ccc(F)cc1 Show InChI InChI=1S/C16H11F4N3O2S/c1-23-12-7-6-11(25-16(18,19)20)8-13(12)26-15(23)22-21-14(24)9-2-4-10(17)5-3-9/h2-8H,1H3,(H,21,24)/b22-15- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 44 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415520
(CHEMBL599376)Show SMILES Cn1c2ccc(OC(F)(F)F)cc2s\c1=N/NC(=O)CC(C)(C)C Show InChI InChI=1S/C15H18F3N3O2S/c1-14(2,3)8-12(22)19-20-13-21(4)10-6-5-9(7-11(10)24-13)23-15(16,17)18/h5-7H,8H2,1-4H3,(H,19,22)/b20-13- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 49 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121053
(CHEMBL3621439)Show SMILES COc1nc(nc(OC)c1NC(=O)CC(C)(C)C)N1CCC(F)(F)CC1 Show InChI InChI=1S/C17H26F2N4O3/c1-16(2,3)10-11(24)20-12-13(25-4)21-15(22-14(12)26-5)23-8-6-17(18,19)7-9-23/h6-10H2,1-5H3,(H,20,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074 BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465773
(CHEMBL4277250)Show SMILES OC[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1cccc(c1)C(F)(F)F |r| Show InChI InChI=1S/C22H22F5NO2/c23-21(24)10-9-17(14-5-2-1-3-6-14)18(12-21)20(30)28-19(13-29)15-7-4-8-16(11-15)22(25,26)27/h1-8,11,17-19,29H,9-10,12-13H2,(H,28,30)/t17-,18+,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50513734
(CHEMBL4516269)Show SMILES FC(F)(F)c1ccc(cc1)-c1c(NC(=O)CCC2CCCC2)nn2cccnc12 Show InChI InChI=1S/C21H21F3N4O/c22-21(23,24)16-9-7-15(8-10-16)18-19(27-28-13-3-12-25-20(18)28)26-17(29)11-6-14-4-1-2-5-14/h3,7-10,12-14H,1-2,4-6,11H2,(H,26,27,29) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.007 BindingDB Entry DOI: 10.7270/Q2Q52SZP |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50513737
(CHEMBL4549421)Show SMILES Cc1cc(C)n2nc(NC(=O)CC(C)(C)C)c(-c3ccc(F)c(C)c3)c2n1 Show InChI InChI=1S/C21H25FN4O/c1-12-9-15(7-8-16(12)22)18-19(24-17(27)11-21(4,5)6)25-26-14(3)10-13(2)23-20(18)26/h7-10H,11H2,1-6H3,(H,24,25,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.007 BindingDB Entry DOI: 10.7270/Q2Q52SZP |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415506
(CHEMBL599781)Show SMILES Cn1c2cc(ccc2s\c1=N/NC(=O)C12CC3CC(CC(C3)C1)C2)C(F)(F)F |TLB:12:14:17:21.19.20,THB:19:18:15:21.20.22,19:20:17.18.23:15,22:20:17:23.14.15,22:14:17:21.19.20| Show InChI InChI=1S/C20H22F3N3OS/c1-26-15-7-14(20(21,22)23)2-3-16(15)28-18(26)25-24-17(27)19-8-11-4-12(9-19)6-13(5-11)10-19/h2-3,7,11-13H,4-6,8-10H2,1H3,(H,24,27)/b25-18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 53 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50595542
(CHEMBL5204124)Show SMILES CC(C)(C)CC(=O)Nc1ccc(NCc2ccc(cc2)C(F)(F)F)c(F)c1N | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00911 BindingDB Entry DOI: 10.7270/Q2X92GB4 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50339281
(5-(2,6-Dichloro-5-fluoropyridin-3-yl)-3-phenyl-2-(...)Show SMILES Fc1cc(c(Cl)nc1Cl)-c1cc(=O)n2[nH]c(c(-c3ccccc3)c2n1)C(F)(F)F Show InChI InChI=1S/C18H8Cl2F4N4O/c19-15-9(6-10(21)16(20)26-15)11-7-12(29)28-17(25-11)13(8-4-2-1-3-5-8)14(27-28)18(22,23)24/h1-7,27H | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Hebei Medical University
Curated by ChEMBL
| Assay Description Activation of KCNQ2/Q3 expressed in CHO cells by atomic absorption Rb'+ efflux assay |
Eur J Med Chem 46: 934-43 (2011)
Article DOI: 10.1016/j.ejmech.2011.01.010 BindingDB Entry DOI: 10.7270/Q2TM7BDF |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121054
(CHEMBL3621440)Show InChI InChI=1S/C17H28N4O4/c1-17(2,3)11-12(22)18-13-14(23-4)19-16(20-15(13)24-5)21-7-6-9-25-10-8-21/h6-11H2,1-5H3,(H,18,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 62 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074 BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415517
(CHEMBL599375)Show InChI InChI=1S/C15H16F3N3O2S/c1-21-11-7-6-10(23-15(16,17)18)8-12(11)24-14(21)20-19-13(22)9-4-2-3-5-9/h6-9H,2-5H2,1H3,(H,19,22)/b20-14- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 62 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121055
(CHEMBL3621441)Show InChI InChI=1S/C17H28N4O3/c1-17(2,3)11-12(22)18-13-14(23-4)19-16(20-15(13)24-5)21-9-7-6-8-10-21/h6-11H2,1-5H3,(H,18,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 64 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074 BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50420079
(CHEMBL2047513)Show SMILES Fc1ccc(cc1)S(=O)(=O)c1ccc(cc1F)C(=O)Nc1ccc(Cl)nc1 Show InChI InChI=1S/C18H11ClF2N2O3S/c19-17-8-4-13(10-22-17)23-18(24)11-1-7-16(15(21)9-11)27(25,26)14-5-2-12(20)3-6-14/h1-10H,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
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Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ... |
ACS Med Chem Lett 2: 481-484 (2011)
Article DOI: 10.1021/ml200053x BindingDB Entry DOI: 10.7270/Q2R49RVJ |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50513725
(CHEMBL4584469)Show SMILES Cc1cc(C)n2nc(NC(=O)CCC3CCCC3)c(-c3ccc(F)c(C)c3)c2n1 Show InChI InChI=1S/C23H27FN4O/c1-14-12-18(9-10-19(14)24)21-22(26-20(29)11-8-17-6-4-5-7-17)27-28-16(3)13-15(2)25-23(21)28/h9-10,12-13,17H,4-8,11H2,1-3H3,(H,26,27,29) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.007 BindingDB Entry DOI: 10.7270/Q2Q52SZP |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50513733
(CHEMBL4460237)Show SMILES Cc1cc(C)n2nc(NC(=O)CC3CCCC3)c(-c3ccc(F)c(C)c3)c2n1 Show InChI InChI=1S/C22H25FN4O/c1-13-10-17(8-9-18(13)23)20-21(25-19(28)12-16-6-4-5-7-16)26-27-15(3)11-14(2)24-22(20)27/h8-11,16H,4-7,12H2,1-3H3,(H,25,26,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 70 | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.007 BindingDB Entry DOI: 10.7270/Q2Q52SZP |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465782
(CHEMBL4280414)Show SMILES CS(=O)(=O)c1cccc(CNC(=O)c2cc(ccc2Oc2ccccc2)S(F)(F)(F)(F)F)c1 Show InChI InChI=1S/C21H18F5NO4S2/c1-32(29,30)17-9-5-6-15(12-17)14-27-21(28)19-13-18(33(22,23,24,25)26)10-11-20(19)31-16-7-3-2-4-8-16/h2-13H,14H2,1H3,(H,27,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50513740
(CHEMBL4455848)Show SMILES Cc1cnc2c(c(NC(=O)CCC3CCCC3)nn2c1)-c1ccc(F)c(C)c1 Show InChI InChI=1S/C22H25FN4O/c1-14-12-24-22-20(17-8-9-18(23)15(2)11-17)21(26-27(22)13-14)25-19(28)10-7-16-5-3-4-6-16/h8-9,11-13,16H,3-7,10H2,1-2H3,(H,25,26,28) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.007 BindingDB Entry DOI: 10.7270/Q2Q52SZP |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50420063
(CHEMBL2046680)Show InChI InChI=1S/C12H7Cl2FN2O/c13-9-3-1-7(5-10(9)15)12(18)17-8-2-4-11(14)16-6-8/h1-6H,(H,17,18) | PDB
UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ... |
ACS Med Chem Lett 2: 481-484 (2011)
Article DOI: 10.1021/ml200053x BindingDB Entry DOI: 10.7270/Q2R49RVJ |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50420078
(CHEMBL2047512)Show InChI InChI=1S/C18H11ClF2N2OS/c19-17-8-4-13(10-22-17)23-18(24)11-1-7-16(15(21)9-11)25-14-5-2-12(20)3-6-14/h1-10H,(H,23,24) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ... |
ACS Med Chem Lett 2: 481-484 (2011)
Article DOI: 10.1021/ml200053x BindingDB Entry DOI: 10.7270/Q2R49RVJ |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465772
(CHEMBL4288317)Show SMILES CS(=O)(=O)c1cccc(c1)[C@H](CO)NC(=O)c1cc(ccc1Oc1ccccc1)C(F)(F)F |r| Show InChI InChI=1S/C23H20F3NO5S/c1-33(30,31)18-9-5-6-15(12-18)20(14-28)27-22(29)19-13-16(23(24,25)26)10-11-21(19)32-17-7-3-2-4-8-17/h2-13,20,28H,14H2,1H3,(H,27,29)/t20-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 80 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415504
(CHEMBL596909)Show SMILES Cn1c2c(cccc2s\c1=N/NC(=O)C12CC3CC(CC(C3)C1)C2)C(F)(F)F |TLB:12:14:17:21.19.20,THB:19:18:15:21.20.22,19:20:17.18.23:15,22:20:17:23.14.15,22:14:17:21.19.20| Show InChI InChI=1S/C20H22F3N3OS/c1-26-16-14(20(21,22)23)3-2-4-15(16)28-18(26)25-24-17(27)19-8-11-5-12(9-19)7-13(6-11)10-19/h2-4,11-13H,5-10H2,1H3,(H,24,27)/b25-18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 91 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415530
(CHEMBL602305)Show SMILES CC(C)OC(=O)NN=c1sc2cc(OC(F)(F)F)ccc2n1C |w:7.6| Show InChI InChI=1S/C13H14F3N3O3S/c1-7(2)21-12(20)18-17-11-19(3)9-5-4-8(6-10(9)23-11)22-13(14,15)16/h4-7H,1-3H3,(H,18,20) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 95 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415510
(CHEMBL591203)Show SMILES Cn1c2cccc(F)c2s\c1=N/NC(=O)C12CC3CC(CC(C3)C1)C2 |TLB:13:15:18:22.20.21,THB:20:19:16:22.21.23,20:21:18.19.24:16,23:21:18:24.15.16,23:15:18:22.20.21| Show InChI InChI=1S/C19H22FN3OS/c1-23-15-4-2-3-14(20)16(15)25-18(23)22-21-17(24)19-8-11-5-12(9-19)7-13(6-11)10-19/h2-4,11-13H,5-10H2,1H3,(H,21,24)/b22-18- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 98 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50485659
(CHEMBL2147030)Show SMILES Cc1cnc2c(Cc3ccc(F)cc3)c(NC(=O)CC3CCCC3)nn2c1 Show InChI InChI=1S/C21H23FN4O/c1-14-12-23-21-18(10-16-6-8-17(22)9-7-16)20(25-26(21)13-14)24-19(27)11-15-4-2-3-5-15/h6-9,12-13,15H,2-5,10-11H2,1H3,(H,24,25,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/Q3 |
ACS Med Chem Lett 3: 608-9 (2012)
Article DOI: 10.1021/ml300154z BindingDB Entry DOI: 10.7270/Q26Q2137 |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465774
(CHEMBL4287894)Show SMILES OC[C@H](NC(=O)[C@H]1CC(F)(F)CC[C@@H]1c1ccccc1)c1cccc(Cl)c1 |r| Show InChI InChI=1S/C21H22ClF2NO2/c22-16-8-4-7-15(11-16)19(13-26)25-20(27)18-12-21(23,24)10-9-17(18)14-5-2-1-3-6-14/h1-8,11,17-19,26H,9-10,12-13H2,(H,25,27)/t17-,18+,19+/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50415525
(CHEMBL589667)Show SMILES Cn1c2ccc(OC(F)(F)F)cc2s\c1=N/NC(=O)c1cccc(F)c1 Show InChI InChI=1S/C16H11F4N3O2S/c1-23-12-6-5-11(25-16(18,19)20)8-13(12)26-15(23)22-21-14(24)9-3-2-4-10(17)7-9/h2-8H,1H3,(H,21,24)/b22-15- | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
Icagen, Inc.
Curated by ChEMBL
| Assay Description Activation of KCNQ2/KCNQ3 expressed in CHO cells by isotopic efflux assay |
J Med Chem 53: 887-96 (2010)
Article DOI: 10.1021/jm901497b BindingDB Entry DOI: 10.7270/Q2BC40TS |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50121056
(CHEMBL3621442)Show SMILES COc1nc(nc(OC)c1NC(=O)CC(C)(C)C)N1CC(F)(F)C1 Show InChI InChI=1S/C15H22F2N4O3/c1-14(2,3)6-9(22)18-10-11(23-4)19-13(20-12(10)24-5)21-7-15(16,17)8-21/h6-8H2,1-5H3,(H,18,22) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 expressed in CHOK1 cells |
Bioorg Med Chem Lett 25: 4941-4 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.074 BindingDB Entry DOI: 10.7270/Q28054FG |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50420082
(CHEMBL2047516)Show InChI InChI=1S/C15H14ClFN2OS/c1-9(2)21-13-5-3-10(7-12(13)17)15(20)19-11-4-6-14(16)18-8-11/h3-9H,1-2H3,(H,19,20) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at KCNQ2/KCNQ3 expressed in CHO cells assessed as increase in KCl-induced 86Rb+ efflux incubated for 10 mins prior to KCl-induction ... |
ACS Med Chem Lett 2: 481-484 (2011)
Article DOI: 10.1021/ml200053x BindingDB Entry DOI: 10.7270/Q2R49RVJ |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50513732
(CHEMBL4448080)Show InChI InChI=1S/C21H24N4O/c26-18(13-12-16-8-3-1-4-9-16)23-20-19(17-10-5-2-6-11-17)21-22-14-7-15-25(21)24-20/h2,5-7,10-11,14-16H,1,3-4,8-9,12-13H2,(H,23,24,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.007 BindingDB Entry DOI: 10.7270/Q2Q52SZP |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50465777
(CHEMBL4288707)Show SMILES C[C@H](NC(=O)c1cc(F)c(F)cc1Oc1ccccc1)c1cccc(c1)S(C)(=O)=O |r| Show InChI InChI=1S/C22H19F2NO4S/c1-14(15-7-6-10-17(11-15)30(2,27)28)25-22(26)18-12-19(23)20(24)13-21(18)29-16-8-4-3-5-9-16/h3-14H,1-2H3,(H,25,26)/t14-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 130 | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Activation of human Kv7.2/7.3 by patch clamp method |
Bioorg Med Chem Lett 28: 3793-3797 (2018)
Article DOI: 10.1016/j.bmcl.2018.09.036 BindingDB Entry DOI: 10.7270/Q28W3H0D |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50513724
(CHEMBL4556856)Show InChI InChI=1S/C20H21FN4O/c21-16-9-7-15(8-10-16)18-19(24-25-13-3-12-22-20(18)25)23-17(26)11-6-14-4-1-2-5-14/h3,7-10,12-14H,1-2,4-6,11H2,(H,23,24,26) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.007 BindingDB Entry DOI: 10.7270/Q2Q52SZP |
More data for this Ligand-Target Pair | |
Potassium voltage-gated channel subfamily KQT member 2/3
(Homo sapiens (Human)) | BDBM50513727
(CHEMBL4466756)Show SMILES Cc1cnc2c(c(NC(=O)CC3CCCC3)nn2c1)-c1ccc(F)c(C)c1 Show InChI InChI=1S/C21H23FN4O/c1-13-11-23-21-19(16-7-8-17(22)14(2)9-16)20(25-26(21)12-13)24-18(27)10-15-5-3-4-6-15/h7-9,11-12,15H,3-6,10H2,1-2H3,(H,24,25,27) | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | n/a | 140 | n/a | n/a | n/a | n/a |
AbbVie Inc.
Curated by ChEMBL
| Assay Description Agonist activity at human KCNQ2/3 expressed in HEK293 cells by FLIPR based thallium influx assay |
Bioorg Med Chem Lett 29: (2019)
Article DOI: 10.1016/j.bmcl.2019.08.007 BindingDB Entry DOI: 10.7270/Q2Q52SZP |
More data for this Ligand-Target Pair | |