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Compile Data Set for Download or QSAR

Found 118 hits of ic50 for UniProtKB: P10608   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50223424
PNG
(CHEMBL280151)
Show SMILES CC(C)NCC(c1ccc(O)c(O)c1)S(O)(=O)=O
PDB
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n/an/a 0.00000900n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 24: 1258-60 (1981)


BindingDB Entry DOI: 10.7270/Q27W6FDS
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50029050
PNG
((-)-(R)-epinephrine | (-)-3,4-dihydroxy-alpha-((me...)
Show SMILES CNC[C@H](O)c1ccc(O)c(O)c1 |r|
Show InChI InChI=1S/C9H13NO3/c1-10-5-9(13)6-2-3-7(11)8(12)4-6/h2-4,9-13H,5H2,1H3/t9-/m0/s1
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n/an/a 0.0000290n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 24: 1258-60 (1981)


BindingDB Entry DOI: 10.7270/Q27W6FDS
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50223422
PNG
(CHEMBL22195)
Show SMILES CNCC(c1ccc(O)c(O)c1)S(O)(=O)=O
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n/an/a 0.000110n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 24: 1258-60 (1981)


BindingDB Entry DOI: 10.7270/Q27W6FDS
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50223423
PNG
(CHEMBL22352)
Show SMILES NCC(c1ccc(O)c(O)c1)S(O)(=O)=O
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n/an/a 0.000130n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 24: 1258-60 (1981)


BindingDB Entry DOI: 10.7270/Q27W6FDS
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM25392
PNG
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Show SMILES CC(C)NCC(O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
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n/an/a 0.100n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of spontaneous contractions in isolated rat uterus


J Med Chem 46: 105-12 (2002)


Article DOI: 10.1021/jm020177z
BindingDB Entry DOI: 10.7270/Q2BP03J1
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212981
PNG
(CHEMBL543099 | SR-59062A)
Show SMILES Cl.CCOC(=O)CCc1ccc2CC[C@H](Cc2c1)NC[C@H](O)c1cccc(Cl)c1 |r|
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n/an/a 0.900n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212980
PNG
(CHEMBL553039 | SR-58997A)
Show SMILES Cl.CCOC(=O)CCc1ccc2CC[C@@H](Cc2c1)NC[C@H](O)c1cccc(Cl)c1 |r|
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n/an/a 1.10n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50226969
PNG
(CHEMBL39915)
Show SMILES CC(C)(Cc1ccccc1)NCC(O)c1ccc(O)c2nc(O)ccc12
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n/an/a 3.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 30: 1563-6 (1987)


BindingDB Entry DOI: 10.7270/Q2HM5BPG
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212977
PNG
(AMIBEGRON HYDROCHLORIDE | Amibegron HCl | SR-58611...)
Show SMILES Cl.CCOC(=O)COc1ccc2CC[C@@H](Cc2c1)NC[C@H](O)c1cccc(Cl)c1 |r|
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n/an/a 3.5n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50226968
PNG
(CHEMBL287883)
Show SMILES CC(C)(Cc1ccc(NC(=O)CBr)cc1)NCC(O)c1ccc(O)c2nc(O)ccc12
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n/an/a 5.30n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 30: 1563-6 (1987)


BindingDB Entry DOI: 10.7270/Q2HM5BPG
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50226971
PNG
(CHEMBL41605)
Show SMILES CC(C)(Cc1ccc(I)cc1)NCC(O)c1ccc(O)c2nc(O)ccc12
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n/an/a 7.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 30: 1563-6 (1987)


BindingDB Entry DOI: 10.7270/Q2HM5BPG
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM50002133
PNG
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Show SMILES C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1
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n/an/a 9.10n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of spontaneous contractions in isolated rat uterus


J Med Chem 46: 105-12 (2002)


Article DOI: 10.1021/jm020177z
BindingDB Entry DOI: 10.7270/Q2BP03J1
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM50002133
PNG
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Show SMILES C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1
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n/an/a 9.12n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction


J Med Chem 44: 1436-45 (2001)


BindingDB Entry DOI: 10.7270/Q2Q52QVH
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50367137
PNG
(CHEMBL1203891)
Show SMILES OCCCCN1CCN(CC1)C1CC(c2ccc(F)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C23H28F2N2O/c24-18-5-3-17(4-6-18)21-16-23(22-15-19(25)7-8-20(21)22)27-12-10-26(11-13-27)9-1-2-14-28/h3-8,15,21,23,28H,1-2,9-14,16H2
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n/an/a 19n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 935-47 (1983)


BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212979
PNG
(CHEMBL543333)
Show SMILES Cl.CCOC(=O)CCc1ccc2CCC(Cc2c1)NCC(O)c1cccc(Cl)c1
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n/an/a 21n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50226970
PNG
(CHEMBL41255)
Show SMILES CC(C)(Cc1ccc(N)cc1)NCC(O)c1ccc(O)c2nc(O)ccc12
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n/an/a 22n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 30: 1563-6 (1987)


BindingDB Entry DOI: 10.7270/Q2HM5BPG
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM97162
PNG
(MLS002153782 | RITODRINE | RITODRINE HYDROCHLORIDE...)
Show SMILES C[C@H](NCCc1ccc(O)cc1)[C@H](O)c1ccc(O)cc1
Show InChI InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m0/s1
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n/an/a 24.0n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction


J Med Chem 44: 1436-45 (2001)


BindingDB Entry DOI: 10.7270/Q2Q52QVH
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cells


J Med Chem 25: 680-4 (1982)


BindingDB Entry DOI: 10.7270/Q24X59ZB
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50367137
PNG
(CHEMBL1203891)
Show SMILES OCCCCN1CCN(CC1)C1CC(c2ccc(F)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C23H28F2N2O/c24-18-5-3-17(4-6-18)21-16-23(22-15-19(25)7-8-20(21)22)27-12-10-26(11-13-27)9-1-2-14-28/h3-8,15,21,23,28H,1-2,9-14,16H2
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n/an/a 30n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 935-47 (1983)


BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM50002132
PNG
((4-{(R)-2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethyl...)
Show SMILES COC(=O)COc1ccc(C[C@@H](C)NC[C@H](O)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C20H24ClNO4/c1-14(22-12-19(23)16-4-3-5-17(21)11-16)10-15-6-8-18(9-7-15)26-13-20(24)25-2/h3-9,11,14,19,22-23H,10,12-13H2,1-2H3/t14-,19+/m1/s1
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n/an/a 30n/an/an/an/an/an/a



American Cyanamid Company

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity towards Beta-2 adrenergic receptor in rat soleus membrane by displacing (-)-isoproterenol (50 microM)


J Med Chem 35: 3081-4 (1992)


BindingDB Entry DOI: 10.7270/Q2PR7TWN
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50020240
PNG
(1-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-4-meth...)
Show SMILES CN1CCN(CC1)C1CC(c2ccc(F)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C20H22F2N2/c1-23-8-10-24(11-9-23)20-13-18(14-2-4-15(21)5-3-14)17-7-6-16(22)12-19(17)20/h2-7,12,18,20H,8-11,13H2,1H3
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n/an/a 32n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 935-47 (1983)


BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50020240
PNG
(1-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-4-meth...)
Show SMILES CN1CCN(CC1)C1CC(c2ccc(F)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C20H22F2N2/c1-23-8-10-24(11-9-23)20-13-18(14-2-4-15(21)5-3-14)17-7-6-16(22)12-19(17)20/h2-7,12,18,20H,8-11,13H2,1H3
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n/an/a 45n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 935-47 (1983)


BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212977
PNG
(AMIBEGRON HYDROCHLORIDE | Amibegron HCl | SR-58611...)
Show SMILES Cl.CCOC(=O)COc1ccc2CC[C@@H](Cc2c1)NC[C@H](O)c1cccc(Cl)c1 |r|
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n/an/a 47n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM50409479
PNG
(CHEMBL32933)
Show SMILES C[C@H](NCCc1ccc(NCC(O)=O)cc1Cl)[C@H](O)c1ccc(O)cc1
Show InChI InChI=1S/C19H23ClN2O4/c1-12(19(26)14-3-6-16(23)7-4-14)21-9-8-13-2-5-15(10-17(13)20)22-11-18(24)25/h2-7,10,12,19,21-23,26H,8-9,11H2,1H3,(H,24,25)/t12-,19-/m0/s1
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n/an/a 61.7n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction


J Med Chem 44: 1436-45 (2001)


BindingDB Entry DOI: 10.7270/Q2Q52QVH
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212978
PNG
(CHEMBL541542)
Show SMILES Cl.CCOC(=O)c1ccc2CCC(Cc2c1)NCC(O)c1cccc(Cl)c1
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n/an/a 90n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50020240
PNG
(1-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-4-meth...)
Show SMILES CN1CCN(CC1)C1CC(c2ccc(F)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C20H22F2N2/c1-23-8-10-24(11-9-23)20-13-18(14-2-4-15(21)5-3-14)17-7-6-16(22)12-19(17)20/h2-7,12,18,20H,8-11,13H2,1H3
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n/an/a 97n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 935-47 (1983)


BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM25392
PNG
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Show SMILES CC(C)NCC(O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
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n/an/a 100n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells


J Med Chem 25: 680-4 (1982)


BindingDB Entry DOI: 10.7270/Q24X59ZB
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50026951
PNG
((cis) 2-{4-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-y...)
Show SMILES OCCN1CCN(CC1)C1CC(c2ccc(F)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(20-13-17(23)5-6-18(19)20)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 140n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 935-47 (1983)


BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50026951
PNG
((cis) 2-{4-[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-y...)
Show SMILES OCCN1CCN(CC1)C1CC(c2ccc(F)cc12)c1ccc(F)cc1
Show InChI InChI=1S/C21H24F2N2O/c22-16-3-1-15(2-4-16)19-14-21(20-13-17(23)5-6-18(19)20)25-9-7-24(8-10-25)11-12-26/h1-6,13,19,21,26H,7-12,14H2
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n/an/a 150n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 935-47 (1983)


BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212978
PNG
(CHEMBL541542)
Show SMILES Cl.CCOC(=O)c1ccc2CCC(Cc2c1)NCC(O)c1cccc(Cl)c1
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n/an/a 185n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM50409484
PNG
(CHEMBL32470)
Show SMILES C[C@H](NCCc1ccc(cc1)N(CC(O)=O)Cc1ccccc1)[C@H](O)c1ccc(O)cc1
Show InChI InChI=1S/C26H30N2O4/c1-19(26(32)22-9-13-24(29)14-10-22)27-16-15-20-7-11-23(12-8-20)28(18-25(30)31)17-21-5-3-2-4-6-21/h2-14,19,26-27,29,32H,15-18H2,1H3,(H,30,31)/t19-,26-/m0/s1
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n/an/a 251n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction


J Med Chem 44: 1436-45 (2001)


BindingDB Entry DOI: 10.7270/Q2Q52QVH
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM50409476
PNG
(CHEMBL289670)
Show SMILES C[C@H](NCCc1ccc(cc1)N(CC(O)=O)CC(O)=O)[C@H](O)c1ccc(O)cc1
Show InChI InChI=1S/C21H26N2O6/c1-14(21(29)16-4-8-18(24)9-5-16)22-11-10-15-2-6-17(7-3-15)23(12-19(25)26)13-20(27)28/h2-9,14,21-22,24,29H,10-13H2,1H3,(H,25,26)(H,27,28)/t14-,21-/m0/s1
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n/an/a 282n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction


J Med Chem 44: 1436-45 (2001)


BindingDB Entry DOI: 10.7270/Q2Q52QVH
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212980
PNG
(CHEMBL553039 | SR-58997A)
Show SMILES Cl.CCOC(=O)CCc1ccc2CC[C@@H](Cc2c1)NC[C@H](O)c1cccc(Cl)c1 |r|
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n/an/a 319n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM25392
PNG
(4-[1-hydroxy-2-(isopropylamino)ethyl]pyrocatechol;...)
Show SMILES CC(C)NCC(O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C11H17NO3/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8/h3-5,7,11-15H,6H2,1-2H3
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n/an/a 325n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 30: 1563-6 (1987)


BindingDB Entry DOI: 10.7270/Q2HM5BPG
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212979
PNG
(CHEMBL543333)
Show SMILES Cl.CCOC(=O)CCc1ccc2CCC(Cc2c1)NCC(O)c1cccc(Cl)c1
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n/an/a 350n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212981
PNG
(CHEMBL543099 | SR-59062A)
Show SMILES Cl.CCOC(=O)CCc1ccc2CC[C@H](Cc2c1)NC[C@H](O)c1cccc(Cl)c1 |r|
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n/an/a 480n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50212977
PNG
(AMIBEGRON HYDROCHLORIDE | Amibegron HCl | SR-58611...)
Show SMILES Cl.CCOC(=O)COc1ccc2CC[C@@H](Cc2c1)NC[C@H](O)c1cccc(Cl)c1 |r|
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n/an/a 499n/an/an/an/an/an/a


TBA



Citation and Details

BindingDB Entry DOI: 10.7270/Q2W09846
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM25756
PNG
((2R,3R)-2,3-dihydroxysuccinic acid;1-(isopropylami...)
Show SMILES COCCc1ccc(OCC(O)CNC(C)C)cc1
Show InChI InChI=1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for beta2-adrenergic blocking effect by measuring the ability to inhibit the relaxing effect of epinephrine on the isolated tracheal muscle of...


Bioorg Med Chem Lett 7: 1273-1274 (1997)


Article DOI: 10.1016/S0960-894X(97)00207-2
BindingDB Entry DOI: 10.7270/Q2SX6D7F
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50224296
PNG
(CHEMBL161974)
Show SMILES CC(C)NCC(O)c1ccc(O)c(O)c1F
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n/an/a 500n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cells


J Med Chem 25: 680-4 (1982)


BindingDB Entry DOI: 10.7270/Q24X59ZB
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM50122649
PNG
((2-Chloro-4-{2-[2-hydroxy-2-(4-hydroxy-phenyl)-1-m...)
Show SMILES CCOC(=O)COc1ccc(CCNC(C)C(O)c2ccc(O)cc2)cc1Cl
Show InChI InChI=1S/C21H26ClNO5/c1-3-27-20(25)13-28-19-9-4-15(12-18(19)22)10-11-23-14(2)21(26)16-5-7-17(24)8-6-16/h4-9,12,14,21,23-24,26H,3,10-11,13H2,1-2H3
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n/an/a 520n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Inhibition of spontaneous contractions in isolated rat uterus


J Med Chem 46: 105-12 (2002)


Article DOI: 10.1021/jm020177z
BindingDB Entry DOI: 10.7270/Q2BP03J1
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50224297
PNG
(CHEMBL158865)
Show SMILES CC(C)NCC(O)c1cc(O)c(O)c(F)c1
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n/an/a 600n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of H-Ras-mediated farnesylation expressed in mouse NIH3T3 cells


J Med Chem 25: 680-4 (1982)


BindingDB Entry DOI: 10.7270/Q24X59ZB
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus)
BDBM50409470
PNG
(CHEMBL32532)
Show SMILES C[C@H](NCCc1ccc(NCC(O)=O)cc1)[C@H](O)c1ccc(O)cc1
Show InChI InChI=1S/C19H24N2O4/c1-13(19(25)15-4-8-17(22)9-5-15)20-11-10-14-2-6-16(7-3-14)21-12-18(23)24/h2-9,13,19-22,25H,10-12H2,1H3,(H,23,24)/t13-,19-/m0/s1
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n/an/a 646n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity towards beta-2 adrenoceptor. Mean concentration required to produce 50% inhibition of uterine contraction


J Med Chem 44: 1436-45 (2001)


BindingDB Entry DOI: 10.7270/Q2Q52QVH
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50002012
PNG
((trans) 2-{4-[3-(4-Fluoro-phenyl)-6-trifluoromethy...)
Show SMILES OCCN1CCN(CC1)C1CC(c2ccc(cc12)C(F)(F)F)c1ccc(F)cc1
Show InChI InChI=1S/C22H24F4N2O/c23-17-4-1-15(2-5-17)19-14-21(28-9-7-27(8-10-28)11-12-29)20-13-16(22(24,25)26)3-6-18(19)20/h1-6,13,19,21,29H,7-12,14H2
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n/an/a 660n/an/an/an/an/an/a



TBA

Curated by ChEMBL




J Med Chem 26: 935-47 (1983)


BindingDB Entry DOI: 10.7270/Q2JH3MR6
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50045874
PNG
(2-[2-(4-Iodo-phenyl)-1H-indol-3-yl]-N,N-dipropyl-a...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(I)cc1
Show InChI InChI=1S/C22H25IN2O/c1-3-13-25(14-4-2)21(26)15-19-18-7-5-6-8-20(18)24-22(19)16-9-11-17(23)12-10-16/h5-12,24H,3-4,13-15H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL




J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50045882
PNG
(2-[5-Chloro-2-(4-chloro-phenyl)-1H-indol-3-yl]-N,N...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccc(Cl)cc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C28H36Cl2N2O/c1-3-5-7-9-17-32(18-10-8-6-4-2)27(33)20-25-24-19-23(30)15-16-26(24)31-28(25)21-11-13-22(29)14-12-21/h11-16,19,31H,3-10,17-18,20H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL




J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50045860
PNG
(CHEMBL327273 | N-Decyl-2-(2-phenyl-1H-indol-3-yl)-...)
Show SMILES CCCCCCCCCCNC(=O)Cc1c([nH]c2ccccc12)-c1ccccc1
Show InChI InChI=1S/C26H34N2O/c1-2-3-4-5-6-7-8-14-19-27-25(29)20-23-22-17-12-13-18-24(22)28-26(23)21-15-10-9-11-16-21/h9-13,15-18,28H,2-8,14,19-20H2,1H3,(H,27,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL




J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50045854
PNG
(3-(4,5-Dihydro-1H-imidazol-2-ylmethyl)-2-phenyl-1H...)
Show SMILES C(C1=NCCN1)c1c([nH]c2ccccc12)-c1ccccc1 |t:1|
Show InChI InChI=1S/C18H17N3/c1-2-6-13(7-3-1)18-15(12-17-19-10-11-20-17)14-8-4-5-9-16(14)21-18/h1-9,21H,10-12H2,(H,19,20)
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Mayo Foundation for Medical Education and Research

Curated by ChEMBL




J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50045877
PNG
(2-(2-(4-fluorophenyl)-1H-indol-3-yl)-N,N-dihexylac...)
Show SMILES CCCCCCN(CCCCCC)C(=O)Cc1c([nH]c2ccccc12)-c1ccc(F)cc1
Show InChI InChI=1S/C28H37FN2O/c1-3-5-7-11-19-31(20-12-8-6-4-2)27(32)21-25-24-13-9-10-14-26(24)30-28(25)22-15-17-23(29)18-16-22/h9-10,13-18,30H,3-8,11-12,19-21H2,1-2H3
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Mayo Foundation for Medical Education and Research

Curated by ChEMBL




J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50045889
PNG
(2-(5-Chloro-2-thiophen-2-yl-1H-indol-3-yl)-N,N-dip...)
Show SMILES CCCN(CCC)C(=O)Cc1c([nH]c2ccc(Cl)cc12)-c1cccs1
Show InChI InChI=1S/C20H23ClN2OS/c1-3-9-23(10-4-2)19(24)13-16-15-12-14(21)7-8-17(15)22-20(16)18-6-5-11-25-18/h5-8,11-12,22H,3-4,9-10,13H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL




J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
Adrenergic receptor beta


(Rattus norvegicus (Rat))
BDBM50045856
PNG
(2-[1-(4-Bromo-benzyl)-1H-indol-3-yl]-N,N-dipropyl-...)
Show SMILES CCCN(CCC)C(=O)Cc1cn(Cc2ccc(Br)cc2)c2ccccc12
Show InChI InChI=1S/C23H27BrN2O/c1-3-13-25(14-4-2)23(27)15-19-17-26(22-8-6-5-7-21(19)22)16-18-9-11-20(24)12-10-18/h5-12,17H,3-4,13-16H2,1-2H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Mayo Foundation for Medical Education and Research

Curated by ChEMBL




J Med Chem 36: 2908-20 (1993)


BindingDB Entry DOI: 10.7270/Q2C24VGV
More data for this
Ligand-Target Pair
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