BindingDB PrimarySearch

Found 3025 hits of ic50 for UniProtKB: Q9UQD0
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM50240277 (CHEMBL4061793) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.0600	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00218 BindingDB Entry DOI: 10.7270/Q2C2514T
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM50240278 (CHEMBL4062780) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Nav1.6 alpha expressed in HEK293 cells incubated for 5 mins with 6 consecutive train pulses to -10 mV at 0.1 Hz and holding poten...				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00218 BindingDB Entry DOI: 10.7270/Q2C2514T
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM630994 ((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5- chl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621932 ((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5- chl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621933 ((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5- chl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM630994 ((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5- chl...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71381 (US9546164, 440 \| US9694002, 440) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.300	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621910 ((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5-chlo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621911 ((S)-N-((R or S)-(3- chloro-4- fluorophenyl)(5-chlo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621824 ((S)-N-((R or S)-(4- chlorophenyl)(4- fluoro-3-(tri...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM630957 ((S)-N-((R or S)-(4- chlorophenyl)(4- fluoro-3-(tri...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621909 ((S)-N-(bis(3-chloro-4- fluorophenyl)methyl)- 2-oxo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621909 ((S)-N-(bis(3-chloro-4- fluorophenyl)methyl)- 2-oxo...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	0.700	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM50118514 (CHEMBL3617063 \| US9481677, 38) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of full length human Nav1.6 channel expressed in HEK cells co-expressing human sodium channel subunit beta1 at holding potential -35 mV by...				ACS Med Chem Lett 7: 277-82 (2016) Article DOI: 10.1021/acsmedchemlett.5b00447 BindingDB Entry DOI: 10.7270/Q2J1052W
Xenon Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71340 (US9546164, 411 \| US9694002, 411) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM526220 (4-((2-(azetidin-1-ylmethyl)benzyl)amino)-3-chloro-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US10662184 (2020) BindingDB Entry DOI: 10.7270/Q2MK6GZP
Xenon Pharmaceuticals Inc. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM526223 (4-((2-(azetidin-1-ylmethyl)benzyl)amino)-2,6-diflu...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM161329 (US10087143, Compound 114 \| US10738009, Compound 11...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars		n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details BindingDB Entry DOI: 10.7270/Q2TM7G2M
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Xenon Pharmaceuticals Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				US Patent US10815229 (2020) BindingDB Entry DOI: 10.7270/Q2MS3WTS
Xenon Pharmaceuticals Inc. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (Nay's), and...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2HM5BRC
St. Jude Research Hospital					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM374028 ((S)-4-((1-benzylpyrrolidin-3-yl)(methyl)amino)-2,6...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Sodium currents were measured using the patch clamp technique in the whole-cell configuration using either a PatchXpress automated voltage clamp or m...				Citation and Details BindingDB Entry DOI: 10.7270/Q2XS5ZK1
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM526223 (4-((2-(azetidin-1-ylmethyl)benzyl)amino)-2,6-diflu...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and...				Citation and Details BindingDB Entry DOI: 10.7270/Q2QF8X18
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621868 ((S)-N-((R or S)-(3- chloro-2,4- difluorophenyl)(5-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621868 ((S)-N-((R or S)-(3- chloro-2,4- difluorophenyl)(5-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621822 ((S)-N-((R or S)-(3- choro-4-fluoro- phenyl)(2-(1- ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621816 ((4S)-N-[((R or S)-5- chloro-6-cyclo- propylpyridin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621746 (BDBM621803 \| US11802122, Example 7A \| US2023031252...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM630953 ((S)-N-((R or S)-(3- choro-4-fluoro- phenyl)(2-(1- ...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM630941 ((4S)-N-[((R or S)-5- chloro-6-cyclo- propylpyridin...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621746 (BDBM621803 \| US11802122, Example 7A \| US2023031252...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM190233 (US9174999, Table 1, Compound 1) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
SiteOne Therapeutics Curated by ChEMBL					Assay Description Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assay				J Med Chem 62: 8695-8710 (2019) Article DOI: 10.1021/acs.jmedchem.8b01906 BindingDB Entry DOI: 10.7270/Q2M90CZD
SiteOne Therapeutics Curated by ChEMBL					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM50597018 (CHEMBL5182397) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00144 BindingDB Entry DOI: 10.7270/Q2SX6J73
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621869 ((S)-N-((R)-3-chloro-4-(trifluoromethoxy)phenyl)(5-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621859 ((S)-N-((R)-(3-chloro-2,4-difluorophenyl)(6-(2,2,2-...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM631047 ((S)—N—((R)-3-chloro-4-(trifluoromethoxy)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM631027 ((S)—N—((R)-(3-chloro-2,4-difluorophenyl)...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71351 (US9546164, 422 \| US9694002, 422) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71341 (US9546164, 412 \| US9694002, 412) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71193 (US9546164, 300 \| US9694002, 300) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71101 (US9546164, 236 \| US9694002, 236) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621743 (BDBM621800 \| US11802122, Example 5A \| US2023031252...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM621743 (BDBM621800 \| US11802122, Example 5A \| US2023031252...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71063 (US9546164, 208 \| US9694002, 208) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM70878 (US9546164, 52 \| US9694002, 52) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.60	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71055 (US9546164, 202 \| US9694002, 202) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 8 subunit alpha (Homo sapiens (Human))	BDBM631055 ((S)—N—((R)-(3-chloro-4-(trifluoromethoxy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem		n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM71062 (US9546164, 207 \| US9694002, 207) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM70836 (US9694002, 23) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair
Sodium channel protein type 1/10/11/2/3/4/5/8/9 subunit alpha (Homo sapiens (Human))	BDBM70848 (US9694002, 29) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.4	25
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description Binding of this radioligand was preformed in 5 mL borosilicate glass test tubes at room temperature. Binding was initiated by adding membranes to inc...				US Patent US9694002 (2017) BindingDB Entry DOI: 10.7270/Q24B2ZFG
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					More data for this Ligand-Target Pair

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