Found 28 hits of ic50 for UniProtKB: Q8N5S9 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572893
(CHEMBL4870467)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1ccnc2[nH]c(nc12)-c1ccccc1 | PDB
Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| Article
PubMed
| n/a | n/a | 29.8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using MBP as substrate by [gamma-33P]-ATP assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8 |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572904
(CHEMBL4857253)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1ccnc(Nc2ccccc2)n1 | PDB
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| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50296011
(2-cyclopentyl-4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin...)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1c[nH]c2ncc(cc12)-c1ccccc1 Show InChI InChI=1S/C25H22N2O2/c28-25(29)20-11-10-18(12-21(20)17-8-4-5-9-17)23-15-27-24-22(23)13-19(14-26-24)16-6-2-1-3-7-16/h1-3,6-7,10-15,17H,4-5,8-9H2,(H,26,27)(H,28,29) | PDB
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| PDB
Article
PubMed
| n/a | n/a | 33 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description
Inhibition of human CAMKK1 using MBP as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM92455
(CHEMBL265470 | STO-609)Show InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24) | PDB
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Dundee
Curated by ChEMBL
| Assay Description
Inhibition of CAMKKalpha in the presence of 20uM ATP |
Biochem J 408: 297-315 (2007)
Article DOI: 10.1042/BJ20070797
BindingDB Entry DOI: 10.7270/Q27082B4 |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50271789
(CHEMBL4125686)Show InChI InChI=1S/C19H18N2O2/c22-19(23)15-8-7-13(10-16(15)12-4-1-2-5-12)17-11-21-18-14(17)6-3-9-20-18/h3,6-12H,1-2,4-5H2,(H,20,21)(H,22,23) | PDB
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| PC cid
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| n/a | n/a | 195 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572890
(CHEMBL4877552)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1cnn2ccc(nc12)-c1ccccc1 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 238 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572900
(CHEMBL4852523) | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 239 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM92455
(CHEMBL265470 | STO-609)Show InChI InChI=1S/C19H10N2O3/c22-18-13-5-3-4-10-11(19(23)24)8-9-12(16(10)13)17-20-14-6-1-2-7-15(14)21(17)18/h1-9H,(H,23,24) | PDB
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| Article
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| n/a | n/a | 381 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description
Inhibition of CaM-KKalpha |
Proc Natl Acad Sci USA 104: 20523-8 (2007)
Checked by Author
Article DOI: 10.1073/pnas.0708800104
BindingDB Entry DOI: 10.7270/Q2DB82RH |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572887
(CHEMBL4875005)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1csc2ncc(cc12)-c1ccccc1 | PDB
Reactome pathway
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 384 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572896
(CHEMBL4862562) | PDB
Reactome pathway
KEGG
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AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 407 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572886
(CHEMBL4866741)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1coc2ncc(cc12)-c1ccccc1 | PDB
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| PC cid
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| Article
PubMed
| n/a | n/a | 961 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572892
(CHEMBL4873692) | PDB
Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572888
(CHEMBL4851892)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1cnn2ccc(cc12)-c1ccccc1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572899
(CHEMBL4877634)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1ccnc2ccc(cc12)-c1ccccc1 | PDB
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572889
(CHEMBL4851925) | PDB
Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572901
(CHEMBL4849143)Show SMILES OC(=O)c1ccc(cc1C1CCCC1)-c1ncnc2ccc(cc12)-c1ccccc1 | PDB
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 2.61E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50559222
(CHEMBL4752776) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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AffyNet
| MCE
PC cid
PC sid
PDB
UniChem
| Article
PubMed
| n/a | n/a | 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 in presence of ATP at Km level |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01174
BindingDB Entry DOI: 10.7270/Q2DB85J2 |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572902
(CHEMBL4878827) | PDB
Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 5.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572898
(CHEMBL4853274) | PDB
Reactome pathway
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | 7.28E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572903
(CHEMBL4876404) | PDB
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| PC cid
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50135286
(CHEMBL3745885)Show SMILES Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F Show InChI InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
| Assay Description
Inhibition of human CAMKK1 using MBP as substrate |
Bioorg Med Chem 24: 521-44 (2016)
Article DOI: 10.1016/j.bmc.2015.11.045
BindingDB Entry DOI: 10.7270/Q24Q7WT8 |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572891
(CHEMBL4869147)Show SMILES Cn1c(cc2c(ccnc12)-c1ccc(C(O)=O)c(c1)C1CCCC1)-c1ccccc1 | PDB
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| PC cid
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50572905
(CHEMBL4857601) | PDB
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| PC cid
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| Article
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human CAMKK1 using CAMKKtide as substrate assessed as residual activity by [gamma-33P]-ATP assay relative to control |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c02274
BindingDB Entry DOI: 10.7270/Q2MG7T9N |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50519662
(CHEMBL4438748)Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 Show InChI InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32) | PDB
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| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human CaMKK1 using calmodulin as substrate incubated for 40 mins in presence of [gamma-33ATP] by radiometric sc... |
J Med Chem 62: 10691-10710 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01143
BindingDB Entry DOI: 10.7270/Q2MC93FG |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50558812
(CHEMBL4755698)Show SMILES Nc1ncnc2n(CC3CCN(CC3)C(=O)C=C)cc(-c3ccc4OCOc4c3)c12 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of CAMKK1 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.ejmech.2017.12.079
BindingDB Entry DOI: 10.7270/Q2P272TR |
More data for this
Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50401152
(CHEMBL2205766)Show SMILES CC(C)(C)NS(=O)(=O)c1cncc(c1)-c1ccn2nc(N)nc2c1 Show InChI InChI=1S/C15H18N6O2S/c1-15(2,3)20-24(22,23)12-6-11(8-17-9-12)10-4-5-21-13(7-10)18-14(16)19-21/h4-9,20H,1-3H3,(H2,16,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | <1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cellzome Ltd
Curated by ChEMBL
| Assay Description
Inhibition of CAMKK1 |
Bioorg Med Chem Lett 22: 4613-8 (2012)
Article DOI: 10.1016/j.bmcl.2012.05.090
BindingDB Entry DOI: 10.7270/Q2HQ412B |
More data for this
Ligand-Target Pair | |
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