Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50505787 (CHEMBL4537998) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG Curated by ChEMBL | Assay Description Antagonist activity at human thyroid stimulating hormone receptor expressed in rat HTC133 cells assessed as reduction in agonist-induced cAMP product... | J Med Chem 62: 10321-10341 (2019) Article DOI: 10.1021/acs.jmedchem.9b01382 BindingDB Entry DOI: 10.7270/Q29P34X6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50071058 ((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,1...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50004441 ((2R,4R)-ketoconazole | 1-acetyl-4-(4-{[(2R,4R)-2-(...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research Curated by ChEMBL | Assay Description Inhibition of cytochrome P450 progesterone 2-alpha-hydroxylase | J Med Chem 35: 2818-25 (1992) BindingDB Entry DOI: 10.7270/Q24Q7SZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50505783 (CHEMBL4458424) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG Curated by ChEMBL | Assay Description Antagonist activity at human thyroid stimulating hormone receptor expressed in rat HTC133 cells assessed as reduction in agonist-induced cAMP product... | J Med Chem 62: 10321-10341 (2019) Article DOI: 10.1021/acs.jmedchem.9b01382 BindingDB Entry DOI: 10.7270/Q29P34X6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50505789 (CHEMBL4471621) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG Curated by ChEMBL | Assay Description Antagonist activity at human thyroid stimulating hormone receptor expressed in rat HTC133 cells assessed as reduction in agonist-induced cAMP product... | J Med Chem 62: 10321-10341 (2019) Article DOI: 10.1021/acs.jmedchem.9b01382 BindingDB Entry DOI: 10.7270/Q29P34X6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50505793 (CHEMBL4593222) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG Curated by ChEMBL | Assay Description Antagonist activity at human thyroid stimulating hormone receptor expressed in rat HTC133 cells assessed as reduction in agonist-induced cAMP product... | J Med Chem 62: 10321-10341 (2019) Article DOI: 10.1021/acs.jmedchem.9b01382 BindingDB Entry DOI: 10.7270/Q29P34X6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50505788 (CHEMBL4449797) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer AG Curated by ChEMBL | Assay Description Antagonist activity at human thyroid stimulating hormone receptor expressed in rat HTC133 cells assessed as reduction in agonist-induced cAMP product... | J Med Chem 62: 10321-10341 (2019) Article DOI: 10.1021/acs.jmedchem.9b01382 BindingDB Entry DOI: 10.7270/Q29P34X6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50004442 ((2S,4S)-ketoconazole | 1-acetyl-4-(4-{[(2S,4S)-2-(...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 3.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research Curated by ChEMBL | Assay Description Inhibition of cytochrome P450 progesterone 2-alpha-hydroxylase | J Med Chem 35: 2818-25 (1992) BindingDB Entry DOI: 10.7270/Q24Q7SZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM31768 (CHEMBL295698 | Ketoconazole | Nizoral | Panfungol) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 8.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research Curated by ChEMBL | Assay Description Inhibition of cytochrome P450 progesterone 15-alpha hydroxylase | J Med Chem 35: 2818-25 (1992) BindingDB Entry DOI: 10.7270/Q24Q7SZT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM50426305 (ARTEMOTIL) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Division of Medicinal& Process Chemistry, Division of Parasitology, Division of Pharmacokinetics and Metabolism, and Sophisticated Analytical Instrument Facility, Central Drug Research Institute Curated by ChEMBL | Assay Description Inhibition of CYP2C11 in rat liver microsome using diclofenac as substrate by HPLC-PDA analysis | ACS Med Chem Lett 4: 165-9 (2013) Article DOI: 10.1021/ml300188t BindingDB Entry DOI: 10.7270/Q2V1264R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2C11 (Rattus norvegicus) | BDBM31768 (CHEMBL295698 | Ketoconazole | Nizoral | Panfungol) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PubMed | n/a | n/a | 1.04E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntex Research Curated by ChEMBL | Assay Description Inhibition of cytochrome P450 progesterone 2-alpha-hydroxylase | J Med Chem 35: 2818-25 (1992) BindingDB Entry DOI: 10.7270/Q24Q7SZT | |||||||||||
More data for this Ligand-Target Pair |