Compile Data Set for Download or QSAR

Found 1589 hits of ki for UniProtKB: P39748   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Flap endonuclease 1 (Homo sapiens (Human))	BDBM337621 (5-{2-Fluoro-4-[2-tetrahydro-2H- pyran-4-ylsulfonyl...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(nc1S(=O)(=O)C1CCOCC1)C(F)(F)F Show InChI InChI=1S/C21H18F4N4O3S/c22-16-9-12(1-2-15(16)17-10-28-19(26)11-27-17)14-3-4-18(21(23,24)25)29-20(14)33(30,31)13-5-7-32-8-6-13/h1-4,9-11,13H,5-8H2,(H2,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167060 (US9073876, 146 | US9732093, Compound 146) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(N)nc(Cc3ccccc3)n2)c1F Show InChI InChI=1S/C25H23FN6O/c26-24-18(19-13-30-21(28)14-29-19)10-9-17(16-7-4-8-16)25(24)33-23-12-20(27)31-22(32-23)11-15-5-2-1-3-6-15/h1-3,5-6,9-10,12-14,16H,4,7-8,11H2,(H2,28,30)(H2,27,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167060 (US9073876, 146 | US9732093, Compound 146) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2cc(N)nc(Cc3ccccc3)n2)c1F Show InChI InChI=1S/C25H23FN6O/c26-24-18(19-13-30-21(28)14-29-19)10-9-17(16-7-4-8-16)25(24)33-23-12-20(27)31-22(32-23)11-15-5-2-1-3-6-15/h1-3,5-6,9-10,12-14,16H,4,7-8,11H2,(H2,28,30)(H2,27,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM169403 (US9079866, 808 | US9745328, Compound 808 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1cccnc1S(=O)(=O)C1CCCCC1 Show InChI InChI=1S/C21H21FN4O2S/c22-18-11-14(8-9-17(18)19-12-26-20(23)13-25-19)16-7-4-10-24-21(16)29(27,28)15-5-2-1-3-6-15/h4,7-13,15H,1-3,5-6H2,(H2,23,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM337627 (5-(4-{2-[(1,1-Dioxidotetrahydra-2H- thiopyran-4-yl...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(nc1S(=O)(=O)C1CCS(=O)(=O)CC1)C(F)(F)F Show InChI InChI=1S/C21H18F4N4O4S2/c22-16-9-12(1-2-15(16)17-10-28-19(26)11-27-17)14-3-4-18(21(23,24)25)29-20(14)35(32,33)13-5-7-34(30,31)8-6-13/h1-4,9-11,13H,5-8H2,(H2,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167191 (US9073876, 272 | US9732093, Compound 272) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nc(N)c3ccccc3n2)c1F Show InChI InChI=1S/C22H19FN6O/c23-19-14(17-10-27-18(24)11-26-17)9-8-13(12-4-3-5-12)20(19)30-22-28-16-7-2-1-6-15(16)21(25)29-22/h1-2,6-12H,3-5H2,(H2,24,27)(H2,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167191 (US9073876, 272 | US9732093, Compound 272) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nc(N)c3ccccc3n2)c1F Show InChI InChI=1S/C22H19FN6O/c23-19-14(17-10-27-18(24)11-26-17)9-8-13(12-4-3-5-12)20(19)30-22-28-16-7-2-1-6-15(16)21(25)29-22/h1-2,6-12H,3-5H2,(H2,24,27)(H2,25,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM169201 (US9079866, 602 | US9745328, Compound 602 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 Show InChI InChI=1S/C26H18F2N6/c27-21-9-15(5-7-19(21)23-11-33-25(29)13-31-23)17-3-1-2-4-18(17)16-6-8-20(22(28)10-16)24-12-34-26(30)14-32-24/h1-14H,(H2,29,33)(H2,30,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM169405 (US9079866, 810 | US9745328, Compound 810 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1cccnc1S(=O)(=O)C1CCCC1 Show InChI InChI=1S/C20H19FN4O2S/c21-17-10-13(7-8-16(17)18-11-25-19(22)12-24-18)15-6-3-9-23-20(15)28(26,27)14-4-1-2-5-14/h3,6-12,14H,1-2,4-5H2,(H2,22,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM169421 (US9079866, 826 | US9745328, Compound 826 | US98848...) Show SMILES CC(C)S(=O)(=O)c1ncccc1-c1ccc(c(F)c1)-c1cnc2[nH]ccc2c1 Show InChI InChI=1S/C21H18FN3O2S/c1-13(2)28(26,27)21-18(4-3-8-24-21)14-5-6-17(19(22)11-14)16-10-15-7-9-23-20(15)25-12-16/h3-13H,1-2H3,(H,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM337603 (4-{[4'-(5-Aminopyrazin-2-yl)-3'- fluorobiphenyl-2-...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1Oc1ccc(cc1)C(O)=O Show InChI InChI=1S/C23H16FN3O3/c24-19-11-15(7-10-18(19)20-12-27-22(25)13-26-20)17-3-1-2-4-21(17)30-16-8-5-14(6-9-16)23(28)29/h1-13H,(H2,25,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM169270 (US9079866, 675 | US9745328, Compound 675 | US98848...) Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1cnc(c(F)c1)-c1cnc(N)nc1 Show InChI InChI=1S/C19H20FN5O2S/c1-19(2,3)25-28(26,27)16-7-5-4-6-14(16)12-8-15(20)17(22-9-12)13-10-23-18(21)24-11-13/h4-11,25H,1-3H3,(H2,21,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167005 (US9073876, 91 | US9732093, Compound 91) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2cccs2)c1F Show InChI InChI=1S/C22H18FN5OS/c23-20-15(17-11-27-19(24)12-26-17)7-6-14(13-3-1-4-13)21(20)29-22-25-9-8-16(28-22)18-5-2-10-30-18/h2,5-13H,1,3-4H2,(H2,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167188 (US9073876, 269 | US9732093, Compound 269) Show SMILES CNc1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C20H21FN6O/c1-11-8-17(27-20(23-2)26-11)28-19-13(12-4-3-5-12)6-7-14(18(19)21)15-9-25-16(22)10-24-15/h6-10,12H,3-5H2,1-2H3,(H2,22,25)(H,23,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167188 (US9073876, 269 | US9732093, Compound 269) Show SMILES CNc1nc(C)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C20H21FN6O/c1-11-8-17(27-20(23-2)26-11)28-19-13(12-4-3-5-12)6-7-14(18(19)21)15-9-25-16(22)10-24-15/h6-10,12H,3-5H2,1-2H3,(H2,22,25)(H,23,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM169465 (US9079866, 109 | US9745328, Compound 109 | US98848...) Show SMILES CC(C)[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r| Show InChI InChI=1S/C21H23FN4O3S/c1-13(2)19(12-27)26-30(28,29)20-6-4-3-5-15(20)14-7-8-16(17(22)9-14)18-10-25-21(23)11-24-18/h3-11,13,19,26-27H,12H2,1-2H3,(H2,23,25)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168730 (US9079866, 116 | US9745328, Compound 116 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H](CO)Cc1ccccc1 |r| Show InChI InChI=1S/C25H23FN4O3S/c26-22-13-18(10-11-21(22)23-14-29-25(27)15-28-23)20-8-4-5-9-24(20)34(32,33)30-19(16-31)12-17-6-2-1-3-7-17/h1-11,13-15,19,30-31H,12,16H2,(H2,27,29)/t19-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM47234 (US9079866, 117 | US9745328, Compound 117 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NC[C@H](O)c1ccccc1 |r| Show InChI InChI=1S/C24H21FN4O3S/c25-20-12-17(10-11-19(20)21-13-28-24(26)15-27-21)18-8-4-5-9-23(18)33(31,32)29-14-22(30)16-6-2-1-3-7-16/h1-13,15,22,29-30H,14H2,(H2,26,28)/t22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM283245 (4'-(5-aminopyrazin-2-yl)-3'-fluoro-N-((1S,2S)- 1-h...) Show SMILES C[C@@H]([C@@H](O)c1ccccc1)N(C)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r| Show InChI InChI=1S/C26H25FN4O3S/c1-17(26(32)18-8-4-3-5-9-18)31(2)35(33,34)24-11-7-6-10-20(24)19-12-13-21(22(27)14-19)23-15-30-25(28)16-29-23/h3-17,26,32H,1-2H3,(H2,28,30)/t17-,26+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168733 (US9079866, 120 | US9079866, 162 | US9745328, Compo...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H]1CCCC[C@@H]1O |r| Show InChI InChI=1S/C22H23FN4O3S/c23-17-11-14(9-10-16(17)19-12-26-22(24)13-25-19)15-5-1-4-8-21(15)31(29,30)27-18-6-2-3-7-20(18)28/h1,4-5,8-13,18,20,27-28H,2-3,6-7H2,(H2,24,26)/t18-,20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM283248 ((trans)-4'-(5-Aminopyrazin-2-yl)-3'-fluoro-N-[2- (...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@H]1CCCC[C@@H]1CO |r| Show InChI InChI=1S/C23H25FN4O3S/c24-19-11-15(9-10-18(19)21-12-27-23(25)13-26-21)17-6-2-4-8-22(17)32(30,31)28-20-7-3-1-5-16(20)14-29/h2,4,6,8-13,16,20,28-29H,1,3,5,7,14H2,(H2,25,27)/t16-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168735 (US9079866, 122 | US9745328, Compound 122 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H]1CCCC[C@@H]1CO |r| Show InChI InChI=1S/C23H25FN4O3S/c24-19-11-15(9-10-18(19)21-12-27-23(25)13-26-21)17-6-2-4-8-22(17)32(30,31)28-20-7-3-1-5-16(20)14-29/h2,4,6,8-13,16,20,28-29H,1,3,5,7,14H2,(H2,25,27)/t16-,20-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168739 (US9079866, 128 | US9745328, Compound 128 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCc2[nH]ncc2C1 Show InChI InChI=1S/C22H19FN6O2S/c23-18-9-14(5-6-17(18)20-11-26-22(24)12-25-20)16-3-1-2-4-21(16)32(30,31)29-8-7-19-15(13-29)10-27-28-19/h1-6,9-12H,7-8,13H2,(H2,24,26)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168743 (US9079866, 133 | US9745328, Compound 133 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NCCCCCCO Show InChI InChI=1S/C22H25FN4O3S/c23-19-13-16(9-10-18(19)20-14-26-22(24)15-25-20)17-7-3-4-8-21(17)31(29,30)27-11-5-1-2-6-12-28/h3-4,7-10,13-15,27-28H,1-2,5-6,11-12H2,(H2,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168744 (US9079866, 134 | US9745328, Compound 134 | US98848...) Show SMILES N[C@H]1CC[C@H](CC1)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r,wU:4.7,1.0,(-6.16,-5.33,;-5.39,-4,;-6.16,-2.67,;-5.39,-1.33,;-3.85,-1.33,;-3.08,-2.67,;-3.85,-4,;-3.08,,;-3.85,1.33,;-5.18,.56,;-2.52,2.1,;-4.62,2.67,;-6.16,2.67,;-6.93,4,;-6.16,5.33,;-4.62,5.33,;-3.85,4,;-2.31,4,;-1.54,5.33,;,5.33,;.77,4,;,2.67,;.77,1.33,;-1.54,2.67,;2.31,4,;3.08,5.33,;4.62,5.33,;5.39,4,;6.93,4,;4.62,2.67,;3.08,2.67,)| Show InChI InChI=1S/C22H24FN5O2S/c23-19-11-14(5-10-18(19)20-12-27-22(25)13-26-20)17-3-1-2-4-21(17)31(29,30)28-16-8-6-15(24)7-9-16/h1-5,10-13,15-16,28H,6-9,24H2,(H2,25,27)/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM283262 ((S)-(1-{[4'-(5-Aminopyrazin-2-yl)-3'- fluorobiphen...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1[C@H](CO)Cc2ccccc12 |r| Show InChI InChI=1S/C25H21FN4O3S/c26-21-12-16(9-10-20(21)22-13-29-25(27)14-28-22)19-6-2-4-8-24(19)34(32,33)30-18(15-31)11-17-5-1-3-7-23(17)30/h1-10,12-14,18,31H,11,15H2,(H2,27,29)/t18-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168746 (US9079866, 136 | US9745328, Compound 136 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N(CCO)C1CCCCC1 Show InChI InChI=1S/C24H27FN4O3S/c25-21-14-17(10-11-20(21)22-15-28-24(26)16-27-22)19-8-4-5-9-23(19)33(31,32)29(12-13-30)18-6-2-1-3-7-18/h4-5,8-11,14-16,18,30H,1-3,6-7,12-13H2,(H2,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168750 (US9079866, 140 | US9745328, Compound 140 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N(C1CC1)C1CCOCC1 Show InChI InChI=1S/C24H25FN4O3S/c25-21-13-16(5-8-20(21)22-14-28-24(26)15-27-22)19-3-1-2-4-23(19)33(30,31)29(17-6-7-17)18-9-11-32-12-10-18/h1-5,8,13-15,17-18H,6-7,9-12H2,(H2,26,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168751 (US9079866, 141 | US9745328, Compound 141 | US98848...) Show SMILES CC(C)N(CCO)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 Show InChI InChI=1S/C21H23FN4O3S/c1-14(2)26(9-10-27)30(28,29)20-6-4-3-5-16(20)15-7-8-17(18(22)11-15)19-12-25-21(23)13-24-19/h3-8,11-14,27H,9-10H2,1-2H3,(H2,23,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168754 (US9079866, 147 | US9745328, Compound 147 | US98848...) Show SMILES CC(CO)(CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 Show InChI InChI=1S/C20H21FN4O4S/c1-20(11-26,12-27)25-30(28,29)18-5-3-2-4-14(18)13-6-7-15(16(21)8-13)17-9-24-19(22)10-23-17/h2-10,25-27H,11-12H2,1H3,(H2,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM60476 (US9079866, 150 | US9745328, Compound 150 | US98848...) Show SMILES CC(C)(C)[C@H](CO)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 |r| Show InChI InChI=1S/C22H25FN4O3S/c1-22(2,3)20(13-28)27-31(29,30)19-7-5-4-6-15(19)14-8-9-16(17(23)10-14)18-11-26-21(24)12-25-18/h4-12,20,27-28H,13H2,1-3H3,(H2,24,26)/t20-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168757 (US9079866, 151 | US9745328, Compound 151 | US98848...) Show SMILES CC(C)(C)OC(=O)NCCNS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 Show InChI InChI=1S/C23H26FN5O4S/c1-23(2,3)33-22(30)26-10-11-29-34(31,32)20-7-5-4-6-16(20)15-8-9-17(18(24)12-15)19-13-28-21(25)14-27-19/h4-9,12-14,29H,10-11H2,1-3H3,(H2,25,28)(H,26,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168640 (US9079866, 13 | US9745328, Compound 13) Show SMILES CC(C)(NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F Show InChI InChI=1S/C20H18F4N4O2S/c1-19(2,20(22,23)24)28-31(29,30)17-6-4-3-5-13(17)12-7-8-14(15(21)9-12)16-10-27-18(25)11-26-16/h3-11,28H,1-2H3,(H2,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM60470 (BDBM168646 | US9079866, 127 | US9745328, Compound ...) Show SMILES C[C@@H](NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F |r| Show InChI InChI=1S/C19H16F4N4O2S/c1-11(19(21,22)23)27-30(28,29)17-5-3-2-4-13(17)12-6-7-14(15(20)8-12)16-9-26-18(24)10-25-16/h2-11,27H,1H3,(H2,24,26)/t11-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168648 (US9079866, 22 | US9079866, 23 | US9745328, Compoun...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H]1CCc2ccccc12 |r| Show InChI InChI=1S/C25H21FN4O2S/c26-21-13-17(9-11-20(21)23-14-29-25(27)15-28-23)19-7-3-4-8-24(19)33(31,32)30-22-12-10-16-5-1-2-6-18(16)22/h1-9,11,13-15,22,30H,10,12H2,(H2,27,29)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168649 (US9079866, 26 | US9745328, Compound 26 | US9884878...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)Nc1ccccc1 Show InChI InChI=1S/C22H17FN4O2S/c23-19-12-15(10-11-18(19)20-13-26-22(24)14-25-20)17-8-4-5-9-21(17)30(28,29)27-16-6-2-1-3-7-16/h1-14,27H,(H2,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168670 (US9079866, 47 | US9745328, Compound 47 | US9884878...) Show SMILES CCN(CC)S(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 Show InChI InChI=1S/C20H21FN4O2S/c1-3-25(4-2)28(26,27)19-8-6-5-7-15(19)14-9-10-16(17(21)11-14)18-12-24-20(22)13-23-18/h5-13H,3-4H2,1-2H3,(H2,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168673 (US9079866, 50 | US9745328, Compound 50 | US9884878...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCCC(F)(F)C1 Show InChI InChI=1S/C21H19F3N4O2S/c22-17-10-14(6-7-16(17)18-11-27-20(25)12-26-18)15-4-1-2-5-19(15)31(29,30)28-9-3-8-21(23,24)13-28/h1-2,4-7,10-12H,3,8-9,13H2,(H2,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168678 (US9079866, 55 | US9745328, Compound 55 | US9884878...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCC(O)(CC1)C(F)(F)F Show InChI InChI=1S/C22H20F4N4O3S/c23-17-11-14(5-6-16(17)18-12-29-20(27)13-28-18)15-3-1-2-4-19(15)34(32,33)30-9-7-21(31,8-10-30)22(24,25)26/h1-6,11-13,31H,7-10H2,(H2,27,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168691 (US9079866, 68 | US9745328, Compound 68 | US9884878...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCC(CO)CC1 Show InChI InChI=1S/C22H23FN4O3S/c23-19-11-16(5-6-18(19)20-12-26-22(24)13-25-20)17-3-1-2-4-21(17)31(29,30)27-9-7-15(14-28)8-10-27/h1-6,11-13,15,28H,7-10,14H2,(H2,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168692 (US9079866, 69 | US9745328, Compound 69 | US9884878...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N1CCC(CCO)CC1 Show InChI InChI=1S/C23H25FN4O3S/c24-20-13-17(5-6-19(20)21-14-27-23(25)15-26-21)18-3-1-2-4-22(18)32(30,31)28-10-7-16(8-11-28)9-12-29/h1-6,13-16,29H,7-12H2,(H2,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168701 (US9079866, 78 | US9745328, Compound 78 | US9884878...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)N[C@@H](CO)[C@@H](O)c1ccccc1 |r| Show InChI InChI=1S/C25H23FN4O4S/c26-20-12-17(10-11-19(20)21-13-29-24(27)14-28-21)18-8-4-5-9-23(18)35(33,34)30-22(15-31)25(32)16-6-2-1-3-7-16/h1-14,22,25,30-32H,15H2,(H2,27,29)/t22-,25-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168631 (US9079866, 4 | US9745328, Compound 4 | US9884878, ...) Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1 Show InChI InChI=1S/C20H21FN4O2S/c1-20(2,3)25-28(26,27)18-7-5-4-6-14(18)13-8-9-15(16(21)10-13)17-11-24-19(22)12-23-17/h4-12,25H,1-3H3,(H2,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168633 (US9079866, 6 | US9745328, Compound 6 | US9884878, ...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccccc1S(=O)(=O)NC1CCCCC1 Show InChI InChI=1S/C22H23FN4O2S/c23-19-12-15(10-11-18(19)20-13-26-22(24)14-25-20)17-8-4-5-9-21(17)30(28,29)27-16-6-2-1-3-7-16/h4-5,8-14,16,27H,1-3,6-7H2,(H2,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM168635 (US9079866, 8 | US9745328, Compound 8 | US9884878, ...) Show SMILES CC(NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)cn1)C(F)(F)F Show InChI InChI=1S/C19H16F4N4O2S/c1-11(19(21,22)23)27-30(28,29)17-5-3-2-4-13(17)12-6-7-14(15(20)8-12)16-9-26-18(24)10-25-16/h2-11,27H,1H3,(H2,24,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167001 (US9073876, 87 | US9732093, Compound 87) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2ccccc2)c1F Show InChI InChI=1S/C24H20FN5O/c25-22-18(20-13-29-21(26)14-28-20)10-9-17(15-7-4-8-15)23(22)31-24-27-12-11-19(30-24)16-5-2-1-3-6-16/h1-3,5-6,9-15H,4,7-8H2,(H2,26,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167005 (US9073876, 91 | US9732093, Compound 91) Show SMILES Nc1cnc(cn1)-c1ccc(C2CCC2)c(Oc2nccc(n2)-c2cccs2)c1F Show InChI InChI=1S/C22H18FN5OS/c23-20-15(17-11-27-19(24)12-26-17)7-6-14(13-3-1-4-13)21(20)29-22-25-9-8-16(28-22)18-5-2-10-30-18/h2,5-13H,1,3-4H2,(H2,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM167014 (US9073876, 100 | US9732093, Compound 100) Show SMILES COc1nc(N)cc(Oc2c(F)c(ccc2C2CCC2)-c2cnc(N)cn2)n1 Show InChI InChI=1S/C19H19FN6O2/c1-27-19-25-14(21)7-16(26-19)28-18-11(10-3-2-4-10)5-6-12(17(18)20)13-8-24-15(22)9-23-13/h5-10H,2-4H2,1H3,(H2,22,24)(H2,21,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9732093 (2017) BindingDB Entry DOI: 10.7270/Q2NV9MCX
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM169155 (US9079866, 556 | US9745328, Compound 556 | US98848...) Show SMILES Nc1cnc(cn1)-c1ccc(cc1F)-c1ccc(cc1Oc1nccc(N)n1)C(F)(F)F Show InChI InChI=1S/C21H14F4N6O/c22-15-7-11(1-3-14(15)16-9-30-19(27)10-29-16)13-4-2-12(21(23,24)25)8-17(13)32-20-28-6-5-18(26)31-20/h1-10H,(H2,27,30)(H2,26,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair
Flap endonuclease 1 (Homo sapiens (Human))	BDBM169033 (US9079866, 434 | US9745328, Compound 434 | US98848...) Show SMILES CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(c(F)c1)-c1cnc(N)c(n1)C#N Show InChI InChI=1S/C21H20FN5O2S/c1-21(2,3)27-30(28,29)19-7-5-4-6-14(19)13-8-9-15(16(22)10-13)18-12-25-20(24)17(11-23)26-18/h4-10,12,27H,1-3H3,(H2,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description The FLAP binding assay is performed in HTRF format (homogeneous time resolved fluorescence). FLAP-containing membranes (1 μg/well final for huma...				US Patent US9745328 (2017) BindingDB Entry DOI: 10.7270/Q2H13446
					More data for this Ligand-Target Pair

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