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Compile Data Set for Download or QSAR

Found 30 hits of non-affinity data for polymerid = 50003206   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23773
PNG
((2R)-2-amino-3-[(diphenylmethyl)sulfanyl]propanoic...)
Show SMILES N[C@@H](CSC(c1ccccc1)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C16H17NO2S/c17-14(16(18)19)11-20-15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14-15H,11,17H2,(H,18,19)/t14-/m0/s1
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23835
PNG
((2R)-2-acetamido-3-[(9-phenyl-9H-fluoren-9-yl)sulf...)
Show SMILES CC(=O)N[C@@H](CSC1(c2ccccc2-c2ccccc12)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C24H21NO3S/c1-16(26)25-22(23(27)28)15-29-24(17-9-3-2-4-10-17)20-13-7-5-11-18(20)19-12-6-8-14-21(19)24/h2-14,22H,15H2,1H3,(H,25,26)(H,27,28)/t22-/m0/s1
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23783
PNG
((bromodiphenylmethyl)benzene | Triphenylmethyl-con...)
Show SMILES BrC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H15Br/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23784
PNG
(CHEMBL118166 | Triphenylmethyl-containing compound...)
Show SMILES OC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H16O/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,20H
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23785
PNG
((methoxydiphenylmethyl)benzene | Triphenylmethyl-c...)
Show SMILES COC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H18O/c1-21-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19/h2-16H,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23786
PNG
(Triphenylmethyl-containing compound, 15 | tripheny...)
Show SMILES NC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H17N/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H,20H2
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23787
PNG
((1,1-diphenylethyl)benzene | Triphenylmethyl-conta...)
Show SMILES CC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H18/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19/h2-16H,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23788
PNG
((1,1-diphenylpropyl)benzene | Triphenylmethyl-cont...)
Show SMILES CCC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20/c1-2-21(18-12-6-3-7-13-18,19-14-8-4-9-15-19)20-16-10-5-11-17-20/h3-17H,2H2,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23789
PNG
(2-methyl-4,4,4-triphenylbutan-2-ol | Triphenylmeth...)
Show SMILES CC(C)(O)CC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H24O/c1-22(2,24)18-23(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21/h3-17,24H,18H2,1-2H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23790
PNG
(4-(triphenylmethyl)aniline | Triphenylmethyl-conta...)
Show SMILES Nc1ccc(cc1)C(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H21N/c26-24-18-16-23(17-19-24)25(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-19H,26H2
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23791
PNG
(Triphenylmethyl-containing compound, 20 | tripheny...)
Show SMILES SC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H16S/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,20H
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23792
PNG
(Triphenylmethyl-containing compound, 21 | [(ethyls...)
Show SMILES CCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20S/c1-2-22-21(18-12-6-3-7-13-18,19-14-8-4-9-15-19)20-16-10-5-11-17-20/h3-17H,2H2,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23793
PNG
(Triphenylmethyl-containing compound, 22 | [(benzyl...)
Show SMILES C(SC(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H22S/c1-5-13-22(14-6-1)21-27-26(23-15-7-2-8-16-23,24-17-9-3-10-18-24)25-19-11-4-12-20-25/h1-20H,21H2
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23794
PNG
(1-[(triphenylmethyl)sulfanyl]ethan-1-one | Triphen...)
Show SMILES CC(=O)SC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H18OS/c1-17(22)23-21(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16H,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23795
PNG
(Triphenylmethyl-containing compound, 24 | {[(2-chl...)
Show SMILES ClCCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H19ClS/c22-16-17-23-21(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15H,16-17H2
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23796
PNG
(4-[(triphenylmethyl)sulfanyl]butan-2-one | Triphen...)
Show SMILES CC(=O)CCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H22OS/c1-19(24)17-18-25-23(20-11-5-2-6-12-20,21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16H,17-18H2,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23797
PNG
(2-[(triphenylmethyl)sulfanyl]ethan-1-ol | Tripheny...)
Show SMILES OCCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20OS/c22-16-17-23-21(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15,22H,16-17H2
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23798
PNG
(1-methyl-2-[(triphenylmethyl)sulfanyl]benzene | Tr...)
Show SMILES Cc1ccccc1SC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H22S/c1-21-13-11-12-20-25(21)27-26(22-14-5-2-6-15-22,23-16-7-3-8-17-23)24-18-9-4-10-19-24/h2-20H,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23800
PNG
(Triphenylmethyl-containing compound, 29 | methyl 2...)
Show SMILES COC(=O)CSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H20O2S/c1-24-21(23)17-25-22(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16H,17H2,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23801
PNG
(Triphenylmethyl-containing compound, 30 | methyl 3...)
Show SMILES COC(=O)CCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H22O2S/c1-25-22(24)17-18-26-23(19-11-5-2-6-12-19,20-13-7-3-8-14-20)21-15-9-4-10-16-21/h2-16H,17-18H2,1H3
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23803
PNG
(3-[(triphenylmethyl)sulfanyl]propan-1-amine | Trip...)
Show SMILES NCCCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H23NS/c23-17-10-18-24-22(19-11-4-1-5-12-19,20-13-6-2-7-14-20)21-15-8-3-9-16-21/h1-9,11-16H,10,17-18,23H2
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23804
PNG
(4-[(triphenylmethyl)sulfanyl]butan-1-amine | Triph...)
Show SMILES NCCCCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H25NS/c24-18-10-11-19-25-23(20-12-4-1-5-13-20,21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1-9,12-17H,10-11,18-19,24H2
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23806
PNG
(3-[(triphenylmethyl)sulfanyl]propanoic acid | Trip...)
Show SMILES OC(=O)CCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H20O2S/c23-21(24)16-17-25-22(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15H,16-17H2,(H,23,24)
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23807
PNG
(2-[(E)-(thiophen-2-ylmethylidene)amino]-3-[(triphe...)
Show SMILES OC(=O)C(CSC(c1ccccc1)(c1ccccc1)c1ccccc1)\N=C\c1cccs1
Show InChI InChI=1S/C27H23NO2S2/c29-26(30)25(28-19-24-17-10-18-31-24)20-32-27(21-11-4-1-5-12-21,22-13-6-2-7-14-22)23-15-8-3-9-16-23/h1-19,25H,20H2,(H,29,30)/b28-19+
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23808
PNG
((2R)-2-acetamido-3-[(triphenylmethyl)sulfanyl]prop...)
Show SMILES CC(=O)N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C24H23NO3S/c1-18(26)25-22(23(27)28)17-29-24(19-11-5-2-6-12-19,20-13-7-3-8-14-20)21-15-9-4-10-16-21/h2-16,22H,17H2,1H3,(H,25,26)(H,27,28)/t22-/m0/s1
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23809
PNG
((2R)-2-[(triphenylmethyl)amino]-3-[(triphenylmethy...)
Show SMILES OC(=O)[C@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(c1ccccc1)(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C41H35NO2S/c43-39(44)38(42-40(32-19-7-1-8-20-32,33-21-9-2-10-22-33)34-23-11-3-12-24-34)31-45-41(35-25-13-4-14-26-35,36-27-15-5-16-28-36)37-29-17-6-18-30-37/h1-30,38,42H,31H2,(H,43,44)/t38-/m0/s1
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23810
PNG
(2-[(diphenylmethyl)amino]-3-[(triphenylmethyl)sulf...)
Show SMILES OC(=O)C(CSC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C35H31NO2S/c37-34(38)32(36-33(27-16-6-1-7-17-27)28-18-8-2-9-19-28)26-39-35(29-20-10-3-11-21-29,30-22-12-4-13-23-30)31-24-14-5-15-25-31/h1-25,32-33,36H,26H2,(H,37,38)
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23811
PNG
((2R)-2-{[(tert-butoxy)carbonyl]amino}-3-[(tripheny...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C27H29NO4S/c1-26(2,3)32-25(31)28-23(24(29)30)19-33-27(20-13-7-4-8-14-20,21-15-9-5-10-16-21)22-17-11-6-12-18-22/h4-18,23H,19H2,1-3H3,(H,28,31)(H,29,30)/t23-/m0/s1
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23834
PNG
((2R)-2-amino-3-{[9-(4-chlorophenyl)-9H-fluoren-9-y...)
Show SMILES N[C@@H](CSC1(c2ccccc2-c2ccccc12)c1ccc(Cl)cc1)C(O)=O |r|
Show InChI InChI=1S/C22H18ClNO2S/c23-15-11-9-14(10-12-15)22(27-13-20(24)21(25)26)18-7-3-1-5-16(18)17-6-2-4-8-19(17)22/h1-12,20H,13,24H2,(H,25,26)/t20-/m0/s1
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n/an/an/an/an/an/an/an/a25



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens (Human))
BDBM23782
PNG
((chlorodiphenylmethyl)benzene | Triphenylmethyl-co...)
Show SMILES ClC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H15Cl/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
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n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
More data for this
Ligand-Target Pair