Found 6 hits of ki for UniProtKB: P03962 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Orotidine 5'-phosphate decarboxylase
(Saccharomyces cerevisiae) | BDBM50199178
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)Show SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O |r| Show InChI InChI=1S/C9H13N2O10P/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(21-8)2-20-22(17,18)19/h1,3,6-8,13-15H,2H2,(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 0.00880 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University Health Network
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisia uridine 5'-monophosphate synthase |
Bioorg Med Chem 18: 4032-41 (2010)
Article DOI: 10.1016/j.bmc.2010.04.017 BindingDB Entry DOI: 10.7270/Q24T6KBX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Orotidine 5'-phosphate decarboxylase
(Saccharomyces cerevisiae) | BDBM50199178
(1-beta-D-ribofuranosyl(3H)pyrimidine-2,4,6-trione ...)Show SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1c(O)cc(=O)[nH]c1=O |r| Show InChI InChI=1S/C9H13N2O10P/c12-4-1-5(13)11(9(16)10-4)8-7(15)6(14)3(21-8)2-20-22(17,18)19/h1,3,6-8,13-15H,2H2,(H,10,12,16)(H2,17,18,19)/t3-,6-,7-,8-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 0.00900 | -15.1 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
University Health Network
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisia uridine 5'-monophosphate synthase after overnight incubation at room temperature by VP-ITC microcalorimetry |
Bioorg Med Chem 18: 4032-41 (2010)
Article DOI: 10.1016/j.bmc.2010.04.017 BindingDB Entry DOI: 10.7270/Q24T6KBX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Orotidine 5'-phosphate decarboxylase
(Saccharomyces cerevisiae) | BDBM50378784
(CHEMBL1164953)Show SMILES NC(=O)c1[nH]nc([C@@H]2O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]2O)c1O |r| Show InChI InChI=1S/C9H14N3O9P/c10-9(16)4-6(14)3(11-12-4)8-7(15)5(13)2(21-8)1-20-22(17,18)19/h2,5,7-8,13-15H,1H2,(H2,10,16)(H,11,12)(H2,17,18,19)/t2-,5-,7-,8+/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
| Article PubMed
| 5 | -11.3 | n/a | n/a | n/a | n/a | n/a | n/a | 25 |
University Health Network
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisia uridine 5'-monophosphate synthase after overnight incubation at room temperature by VP-ITC microcalorimetry |
Bioorg Med Chem 18: 4032-41 (2010)
Article DOI: 10.1016/j.bmc.2010.04.017 BindingDB Entry DOI: 10.7270/Q24T6KBX |
More data for this Ligand-Target Pair | |
Orotidine 5'-phosphate decarboxylase
(Saccharomyces cerevisiae) | BDBM21340
(6-aza-UMP | C6-Uridine Derivative, 18 | {[(2R,3S,4...)Show SMILES O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1ncc(=O)[nH]c1=O |r| Show InChI InChI=1S/C8H12N3O9P/c12-4-1-9-11(8(15)10-4)7-6(14)5(13)3(20-7)2-19-21(16,17)18/h1,3,5-7,13-14H,2H2,(H,10,12,15)(H2,16,17,18)/t3-,5-,6-,7-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto
Curated by ChEMBL
| Assay Description Inhibition of Saccharomyces cerevisiae ODCase at 25 degreeC by competitive binding assay |
J Med Chem 49: 4937-45 (2006)
Article DOI: 10.1021/jm060202r BindingDB Entry DOI: 10.7270/Q2J9676J |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Orotidine 5'-phosphate decarboxylase
(Saccharomyces cerevisiae) | BDBM47402
(2-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ncc(=O)[nH]c1=O Show InChI InChI=1S/C8H11N3O6/c12-2-3-5(14)6(15)7(17-3)11-8(16)10-4(13)1-9-11/h1,3,5-7,12,14-15H,2H2,(H,10,13,16)/t3-,5-,6-,7-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 64 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cardiff University
Curated by ChEMBL
| Assay Description Inhibition of yeast ODCase |
Bioorg Med Chem 26: 551-565 (2018)
Article DOI: 10.1016/j.bmc.2017.11.037 BindingDB Entry DOI: 10.7270/Q2639SBX |
More data for this Ligand-Target Pair | |
Orotidine 5'-phosphate decarboxylase
(Saccharomyces cerevisiae) | BDBM50231945
(CHEMBL253328 | xanthosine-5'-monophosphate disodiu...)Show SMILES O[C@@H]1[C@@H](COP([O-])([O-])=O)O[C@H]([C@@H]1O)n1cnc2c1[nH]c(=O)[nH]c2=O Show InChI InChI=1S/C10H13N4O9P/c15-5-3(1-22-24(19,20)21)23-9(6(5)16)14-2-11-4-7(14)12-10(18)13-8(4)17/h2-3,5-6,9,15-16H,1H2,(H2,19,20,21)(H2,12,13,17,18)/p-2/t3-,5-,6-,9-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toronto General Research Institute
Curated by ChEMBL
| Assay Description Inhibition of yeast ODCase |
J Med Chem 51: 432-8 (2008)
Article DOI: 10.1021/jm700968x BindingDB Entry DOI: 10.7270/Q2FT8MW2 |
More data for this Ligand-Target Pair | 3D Structure (docked) |