Found 17 hits of ic50 for UniProtKB: Q8IY84 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | KEGG
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| n/a | n/a | 91.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human NIM1 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | KEGG
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| n/a | n/a | 129 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description
Inhibition of human NIM1 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50585188
(CHEMBL5086901)Show SMILES Cc1nn(CC(F)(F)F)cc1Nc1ncc(C2CC2)c(NCCc2c[nH]cn2)n1 | KEGG
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| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of full length recombinant human NIM1 using KKKVSRSGLYRSPSMPENLNRPR as substrate incubated for 40 mins in presence of [gamma-33P-ATP] by r... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00440
BindingDB Entry DOI: 10.7270/Q27S7SND |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50048362
(CHEMBL3309995)Show InChI InChI=1S/C17H14N6O2/c18-10-2-3-11-12(7-10)20-15(23-16(11)21-17(19)22-23)6-9-1-4-13-14(5-9)25-8-24-13/h1-5,7H,6,8,18H2,(H2,19,22) | KEGG
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Nerviano Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 (unknown origin) |
Bioorg Med Chem 22: 4135-50 (2014)
Article DOI: 10.1016/j.bmc.2014.05.056
BindingDB Entry DOI: 10.7270/Q2S46TMD |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50048364
(CHEMBL3309997)Show InChI InChI=1S/C19H17N5O3/c25-7-1-6-20-13-3-4-14-15(9-13)23-18(24-19(14)21-10-22-24)12-2-5-16-17(8-12)27-11-26-16/h2-5,8-10,20,25H,1,6-7,11H2 | KEGG
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| Article
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 (unknown origin) |
Bioorg Med Chem 22: 4135-50 (2014)
Article DOI: 10.1016/j.bmc.2014.05.056
BindingDB Entry DOI: 10.7270/Q2S46TMD |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50048365
(CHEMBL3309998)Show InChI InChI=1S/C19H18N6O3/c20-19-23-18-13-3-2-12(21-5-6-26)9-14(13)22-17(25(18)24-19)8-11-1-4-15-16(7-11)28-10-27-15/h1-4,7,9,21,26H,5-6,8,10H2,(H2,20,24) | KEGG
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Nerviano Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 (unknown origin) |
Bioorg Med Chem 22: 4135-50 (2014)
Article DOI: 10.1016/j.bmc.2014.05.056
BindingDB Entry DOI: 10.7270/Q2S46TMD |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50048374
(CHEMBL3310151)Show SMILES CN1CCN(CC1)c1cc(F)c2c3nc(N)nn3c(Cc3ccc4OCOc4c3)nc2c1 Show InChI InChI=1S/C22H22FN7O2/c1-28-4-6-29(7-5-28)14-10-15(23)20-16(11-14)25-19(30-21(20)26-22(24)27-30)9-13-2-3-17-18(8-13)32-12-31-17/h2-3,8,10-11H,4-7,9,12H2,1H3,(H2,24,27) | KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 (unknown origin) |
Bioorg Med Chem 22: 4135-50 (2014)
Article DOI: 10.1016/j.bmc.2014.05.056
BindingDB Entry DOI: 10.7270/Q2S46TMD |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM138348
(US8877944, 99)Show SMILES NC(=O)c1cc(F)cc2CN(C3CCN(CC3)C3CCC(F)(F)CC3)C(=O)c12 Show InChI InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27) | KEGG
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Nerviano Medical Sciences Srl
Curated by ChEMBL
| Assay Description
Inhibition of human NIM1 |
J Med Chem 58: 6875-98 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00680
BindingDB Entry DOI: 10.7270/Q2JD4ZKF |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM158154
(US10081622, Compound 11 | US10370379, Entrectinib ...)Show SMILES CN1CCN(CC1)c1ccc(C(=O)Nc2n[nH]c3ccc(Cc4cc(F)cc(F)c4)cc23)c(NC2CCOCC2)c1 Show InChI InChI=1S/C31H34F2N6O2/c1-38-8-10-39(11-9-38)25-3-4-26(29(19-25)34-24-6-12-41-13-7-24)31(40)35-30-27-17-20(2-5-28(27)36-37-30)14-21-15-22(32)18-23(33)16-21/h2-5,15-19,24,34H,6-14H2,1H3,(H2,35,36,37,40) | KEGG
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Nerviano Medical Sciences Srl
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 (unknown origin) in presence of gamma33-ATP |
J Med Chem 59: 3392-408 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00064
BindingDB Entry DOI: 10.7270/Q27M09TG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50327912
(3-(4-Morpholin-4-yl-benzoylamino)-1H-thieno[3,2-c]...)Show SMILES O=C(N[C@H](CN1CCCC1)c1ccccc1)c1cc2n[nH]c(NC(=O)c3ccc(cc3)N3CCOCC3)c2s1 |r| Show InChI InChI=1S/C29H32N6O3S/c36-28(21-8-10-22(11-9-21)35-14-16-38-17-15-35)31-27-26-23(32-33-27)18-25(39-26)29(37)30-24(19-34-12-4-5-13-34)20-6-2-1-3-7-20/h1-3,6-11,18,24H,4-5,12-17,19H2,(H,30,37)(H2,31,32,33,36)/t24-/m1/s1 | KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences-Oncology
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 |
Bioorg Med Chem 18: 7113-20 (2010)
Article DOI: 10.1016/j.bmc.2010.07.048
BindingDB Entry DOI: 10.7270/Q2Q240GM |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50343559
(1-(2-HYDROXYETHYL)-8-[[5-(4-METHYLPIPERAZIN-1-YL)-...)Show SMILES CN1CCN(CC1)c1ccc(OC(F)(F)F)c(Nc2ncc3CCc4c(nn(CCO)c4-c3n2)C(N)=O)c1 Show InChI InChI=1S/C24H27F3N8O3/c1-33-6-8-34(9-7-33)15-3-5-18(38-24(25,26)27)17(12-15)30-23-29-13-14-2-4-16-20(22(28)37)32-35(10-11-36)21(16)19(14)31-23/h3,5,12-13,36H,2,4,6-11H2,1H3,(H2,28,37)(H,29,30,31) | KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences srl
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 assessed as [33P]gamma-ATP incorporation into substrate after 60 mins by gamma counting |
Bioorg Med Chem Lett 21: 2969-74 (2011)
Article DOI: 10.1016/j.bmcl.2011.03.054
BindingDB Entry DOI: 10.7270/Q27M088W |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM27344
(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)Show InChI InChI=1S/C12H11N3O/c16-12-9-7-11(8-1-4-13-5-2-8)15-10(9)3-6-14-12/h1-2,4-5,7,15H,3,6H2,(H,14,16) | KEGG
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Nerviano Medical Sciences Oncology
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 |
Nat Chem Biol 4: 357-65 (2008)
Article DOI: 10.1038/nchembio.90
BindingDB Entry DOI: 10.7270/Q2DV1KVK |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50519662
(CHEMBL4438748)Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 Show InChI InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32) | KEGG
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human NIM1 using KKKVSRSGLYRSP as substrate measured after 40 mins in presence of [gamma33P]ATP by radiometric ... |
J Med Chem 62: 10691-10710 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01143
BindingDB Entry DOI: 10.7270/Q2MC93FG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50048357
(CHEMBL3309990)Show InChI InChI=1S/C17H12FN5O2/c18-10-2-1-3-11-15(10)16-21-17(19)22-23(16)14(20-11)7-9-4-5-12-13(6-9)25-8-24-12/h1-6H,7-8H2,(H2,19,22) | KEGG
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Nerviano Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 (unknown origin) |
Bioorg Med Chem 22: 4135-50 (2014)
Article DOI: 10.1016/j.bmc.2014.05.056
BindingDB Entry DOI: 10.7270/Q2S46TMD |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50329427
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20) | KEGG
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Nerviano Medical Sciences Srl
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 |
J Med Chem 53: 7296-315 (2010)
Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50021626
(CHEMBL3298400)Show SMILES CC(C)(C)CNC(=O)CC1CNC(=O)c2cc(cn12)-c1ccsc1 Show InChI InChI=1S/C18H23N3O2S/c1-18(2,3)11-20-16(22)7-14-8-19-17(23)15-6-13(9-21(14)15)12-4-5-24-10-12/h4-6,9-10,14H,7-8,11H2,1-3H3,(H,19,23)(H,20,22) | KEGG
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Nerviano Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 (unknown origin) |
Bioorg Med Chem 21: 7364-80 (2013)
Article DOI: 10.1016/j.bmc.2013.09.054
BindingDB Entry DOI: 10.7270/Q23F4R7S |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase NIM1
(Homo sapiens (Human)) | BDBM50021618
(CHEMBL3297762 | US9145418, 2)Show SMILES CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cccc(Cl)c2)C2CCCCC2)CC1 |r| Show InChI InChI=1S/C28H38ClN5O2/c1-32-10-12-33(13-11-32)19-25(20-6-3-2-4-7-20)31-27(35)16-24-17-30-28(36)26-15-22(18-34(24)26)21-8-5-9-23(29)14-21/h5,8-9,14-15,18,20,24-25H,2-4,6-7,10-13,16-17,19H2,1H3,(H,30,36)(H,31,35)/t24-,25+/m0/s1 | KEGG
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Nerviano Medical Sciences
Curated by ChEMBL
| Assay Description
Inhibition of NIM1 (unknown origin) |
Bioorg Med Chem 21: 7364-80 (2013)
Article DOI: 10.1016/j.bmc.2013.09.054
BindingDB Entry DOI: 10.7270/Q23F4R7S |
More data for this
Ligand-Target Pair | |
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