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Compile Data Set for Download or QSAR

Found 106 hits of ic50 for UniProtKB: Q15046   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390557
PNG
(CHEMBL2069346)
Show SMILES FC(F)(F)c1ccnc(Nc2cccc(n2)-c2cccc(c2)N2CCNCC2)c1
Show InChI InChI=1S/C21H20F3N5/c22-21(23,24)16-7-8-26-20(14-16)28-19-6-2-5-18(27-19)15-3-1-4-17(13-15)29-11-9-25-10-12-29/h1-8,13-14,25H,9-12H2,(H,26,27,28)
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n/an/a 0.600n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.860n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390556
PNG
(CHEMBL2069345)
Show SMILES FC(F)(F)c1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCNCC2)c1
Show InChI InChI=1S/C20H19F3N6/c21-20(22,23)15-5-7-25-18(13-15)28-17-3-1-2-16(27-17)14-4-6-26-19(12-14)29-10-8-24-9-11-29/h1-7,12-13,24H,8-11H2,(H,25,27,28)
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n/an/a 1.80n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390568
PNG
(CHEMBL2069358)
Show SMILES O=C(Cc1cccnc1)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C25H25N9O/c35-25(12-18-2-1-4-27-16-18)31-20-14-21(32-22(15-20)33-23-17-28-6-7-29-23)19-3-5-30-24(13-19)34-10-8-26-9-11-34/h1-7,13-17,26H,8-12H2,(H2,29,31,32,33,35)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390560
PNG
(CHEMBL2069349)
Show SMILES Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C18H20N8/c19-14-10-15(24-16(11-14)25-17-12-21-3-4-22-17)13-1-2-23-18(9-13)26-7-5-20-6-8-26/h1-4,9-12,20H,5-8H2,(H3,19,22,24,25)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390561
PNG
(CHEMBL2069350)
Show SMILES CNc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C19H22N8/c1-20-15-11-16(25-17(12-15)26-18-13-22-4-5-23-18)14-2-3-24-19(10-14)27-8-6-21-7-9-27/h2-5,10-13,21H,6-9H2,1H3,(H2,20,23,25,26)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390563
PNG
(CHEMBL2069352)
Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)C1CCNCC1
Show InChI InChI=1S/C24H29N9O/c34-24(17-1-4-25-5-2-17)30-19-14-20(31-21(15-19)32-22-16-27-7-8-28-22)18-3-6-29-23(13-18)33-11-9-26-10-12-33/h3,6-8,13-17,25-26H,1-2,4-5,9-12H2,(H2,28,30,31,32,34)
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n/an/a 4n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50249539
PNG
(5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...)
Show SMILES COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3ncnc3c2C(N)=O)cc(OC)c1 |r|
Show InChI InChI=1S/C20H26N8O3/c1-30-12-7-11(8-13(9-12)31-2)25-18-16(17(22)29)19-23-10-24-28(19)20(27-18)26-15-6-4-3-5-14(15)21/h7-10,14-15,25H,3-6,21H2,1-2H3,(H2,22,29)(H,26,27)/t14-,15+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390564
PNG
(CHEMBL2069353)
Show SMILES CC(=O)N1CCC(CC1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C26H31N9O2/c1-18(36)34-10-3-19(4-11-34)26(37)31-21-15-22(32-23(16-21)33-24-17-28-6-7-29-24)20-2-5-30-25(14-20)35-12-8-27-9-13-35/h2,5-7,14-17,19,27H,3-4,8-13H2,1H3,(H2,29,31,32,33,37)
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n/an/a 5n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390566
PNG
(CHEMBL2069355)
Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1cccnc1
Show InChI InChI=1S/C24H23N9O/c34-24(18-2-1-4-26-15-18)30-19-13-20(31-21(14-19)32-22-16-27-6-7-28-22)17-3-5-29-23(12-17)33-10-8-25-9-11-33/h1-7,12-16,25H,8-11H2,(H2,28,30,31,32,34)
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n/an/a 6n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390567
PNG
(CHEMBL2069357)
Show SMILES Cc1cc(C(=O)Nc2cc(Nc3cnccn3)nc(c2)-c2ccnc(c2)N2CCNCC2)n(C)n1
Show InChI InChI=1S/C24H26N10O/c1-16-11-20(33(2)32-16)24(35)29-18-13-19(30-21(14-18)31-22-15-26-5-6-27-22)17-3-4-28-23(12-17)34-9-7-25-8-10-34/h3-6,11-15,25H,7-10H2,1-2H3,(H2,27,29,30,31,35)
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n/an/a 7n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465346
PNG
(CHEMBL4286991)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@]2(CO)C(O)=O)C(C)C |r|
Show InChI InChI=1S/C20H28O3/c1-13(2)14-5-7-16-15(11-14)6-8-17-19(16,3)9-4-10-20(17,12-21)18(22)23/h5,7,11,13,17,21H,4,6,8-10,12H2,1-3H3,(H,22,23)/t17-,19-,20-/m1/s1
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n/an/a 7.20n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390569
PNG
(CHEMBL2069359)
Show SMILES OC(=O)c1ccc(cc1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C26H24N8O3/c35-25(17-1-3-18(4-2-17)26(36)37)31-20-14-21(32-22(15-20)33-23-16-28-7-8-29-23)19-5-6-30-24(13-19)34-11-9-27-10-12-34/h1-8,13-16,27H,9-12H2,(H,36,37)(H2,29,31,32,33,35)
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n/an/a 8n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390562
PNG
(CHEMBL2069351)
Show SMILES Oc1ccc(CNc2cc(Nc3cnccn3)nc(c2)-c2ccnc(c2)N2CCNCC2)cc1
Show InChI InChI=1S/C25H26N8O/c34-21-3-1-18(2-4-21)16-30-20-14-22(31-23(15-20)32-24-17-27-7-8-28-24)19-5-6-29-25(13-19)33-11-9-26-10-12-33/h1-8,13-15,17,26,34H,9-12,16H2,(H2,28,30,31,32)
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n/an/a 8n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50059889
PNG
((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20?,26-,28+/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50249254
PNG
(5-((1S,2R)-2-aminocyclohexylamino)-7-(3,5-dimethox...)
Show SMILES COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3cnnc3c2C(N)=O)cc(OC)c1 |r|
Show InChI InChI=1S/C20H26N8O3/c1-30-12-7-11(8-13(9-12)31-2)24-18-16(17(22)29)19-27-23-10-28(19)20(26-18)25-15-6-4-3-5-14(15)21/h7-10,14-15,24H,3-6,21H2,1-2H3,(H2,22,29)(H,25,26)/t14-,15+/m1/s1
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n/an/a 9n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390573
PNG
(CHEMBL2069356)
Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1cncnc1
Show InChI InChI=1S/C23H22N10O/c34-23(17-12-26-15-27-13-17)30-18-10-19(31-20(11-18)32-21-14-25-3-4-28-21)16-1-2-29-22(9-16)33-7-5-24-6-8-33/h1-4,9-15,24H,5-8H2,(H2,28,30,31,32,34)
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n/an/a 9n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50249253
PNG
(5-(2-Aminoethylamino)-7-(3,5-dimethoxyphenylamino)...)
Show SMILES COc1cc(Nc2nc(NCCN)n3cnnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C16H20N8O3/c1-26-10-5-9(6-11(7-10)27-2)21-14-12(13(18)25)15-23-20-8-24(15)16(22-14)19-4-3-17/h5-8,21H,3-4,17H2,1-2H3,(H2,18,25)(H,19,22)
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n/an/a 9n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390571
PNG
(CHEMBL2069360)
Show SMILES OC(=O)c1ccc(cn1)C(=O)Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1
Show InChI InChI=1S/C25H23N9O3/c35-24(17-1-2-19(25(36)37)30-14-17)31-18-12-20(32-21(13-18)33-22-15-27-5-6-28-22)16-3-4-29-23(11-16)34-9-7-26-8-10-34/h1-6,11-15,26H,7-10H2,(H,36,37)(H2,28,31,32,33,35)
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n/an/a 10n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465342
PNG
(CHEMBL4293812)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(CC(=O)OC)C(O)=O)C(C)=C |r|
Show InChI InChI=1S/C22H28O4/c1-14(2)15-6-8-17-16(12-15)7-9-18-21(17,3)10-5-11-22(18,20(24)25)13-19(23)26-4/h6,8,12,18H,1,5,7,9-11,13H2,2-4H3,(H,24,25)/t18-,21-,22+/m1/s1
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n/an/a 11n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390552
PNG
(CHEMBL2069341)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCNCC2)c1
Show InChI InChI=1S/C20H22N6/c1-15-5-7-22-19(13-15)25-18-4-2-3-17(24-18)16-6-8-23-20(14-16)26-11-9-21-10-12-26/h2-8,13-14,21H,9-12H2,1H3,(H,22,24,25)
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n/an/a 14n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465348
PNG
(CHEMBL4292650)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(CC(=O)OC)C(O)=O)C(C)C |r|
Show InChI InChI=1S/C22H30O4/c1-14(2)15-6-8-17-16(12-15)7-9-18-21(17,3)10-5-11-22(18,20(24)25)13-19(23)26-4/h6,8,12,14,18H,5,7,9-11,13H2,1-4H3,(H,24,25)/t18-,21-,22+/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390555
PNG
(CHEMBL2069344)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCCNCC2)c1
Show InChI InChI=1S/C21H24N6/c1-16-6-9-23-20(14-16)26-19-5-2-4-18(25-19)17-7-10-24-21(15-17)27-12-3-8-22-11-13-27/h2,4-7,9-10,14-15,22H,3,8,11-13H2,1H3,(H,23,25,26)
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n/an/a 27n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50143600
PNG
(CHEBI:29571 | Dehydroabietic Acid)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(C)C(O)=O)C(C)C |r|
Show InChI InChI=1S/C20H28O2/c1-13(2)14-6-8-16-15(12-14)7-9-17-19(16,3)10-5-11-20(17,4)18(21)22/h6,8,12-13,17H,5,7,9-11H2,1-4H3,(H,21,22)/t17-,19-,20-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390565
PNG
(CHEMBL2069354)
Show SMILES O=C(Nc1cc(Nc2cnccn2)nc(c1)-c1ccnc(c1)N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C25H24N8O/c34-25(18-4-2-1-3-5-18)30-20-15-21(31-22(16-20)32-23-17-27-8-9-28-23)19-6-7-29-24(14-19)33-12-10-26-11-13-33/h1-9,14-17,26H,10-13H2,(H2,28,30,31,32,34)
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n/an/a 28n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465345
PNG
(18-Oxoferruginol | acs.jmedchem.1c00409_ST.768)
Show SMILES [H][C@@]12CCc3cc(C(C)C)c(O)cc3[C@@]1(C)CCC[C@@]2(C)C=O |r|
Show InChI InChI=1S/C20H28O2/c1-13(2)15-10-14-6-7-18-19(3,12-21)8-5-9-20(18,4)16(14)11-17(15)22/h10-13,18,22H,5-9H2,1-4H3/t18-,19-,20+/m0/s1
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n/an/a 34n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50126419
PNG
(CHEMBL282342 | N*1*-[7-(4-Dimethylamino-phenyl)-[1...)
Show SMILES CN(C)c1ccc(cc1)-c1cc2ncccc2c(NCCCCN)n1
Show InChI InChI=1S/C20H25N5/c1-25(2)16-9-7-15(8-10-16)18-14-19-17(6-5-13-22-19)20(24-18)23-12-4-3-11-21/h5-10,13-14H,3-4,11-12,21H2,1-2H3,(H,23,24)
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n/an/a 34n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of SYK

J Med Chem 51: 7898-914 (2008)


Article DOI: 10.1021/jm8011036
BindingDB Entry DOI: 10.7270/Q2WS8T4C
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50249319
PNG
(2-(2-aminoethylamino)-4-(3-(trifluoromethyl)phenyl...)
Show SMILES NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1
Show InChI InChI=1S/C14H15F3N6O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23)
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n/an/a 41n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390559
PNG
(CHEMBL2069348)
Show SMILES C1CN(CCN1)c1cccc(c1)-c1cccc(Nc2cnccn2)n1
Show InChI InChI=1S/C19H20N6/c1-3-15(13-16(4-1)25-11-9-20-10-12-25)17-5-2-6-18(23-17)24-19-14-21-7-8-22-19/h1-8,13-14,20H,9-12H2,(H,22,23,24)
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n/an/a 43n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465347
PNG
(CHEBI:52486 | POMIFERIN A)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(C)CO)C(C)C |r|
Show InChI InChI=1S/C20H30O/c1-14(2)15-6-8-17-16(12-15)7-9-18-19(3,13-21)10-5-11-20(17,18)4/h6,8,12,14,18,21H,5,7,9-11,13H2,1-4H3/t18-,19-,20+/m0/s1
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n/an/a 46n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465338
PNG
(15-Hydroxydehydroabietic Acid | CHEMBL598566)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(C)C(O)=O)C(C)(C)O |r|
Show InChI InChI=1S/C20H28O3/c1-18(2,23)14-7-8-15-13(12-14)6-9-16-19(15,3)10-5-11-20(16,4)17(21)22/h7-8,12,16,23H,5-6,9-11H2,1-4H3,(H,21,22)/t16-,19-,20-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50263121
PNG
(CHEMBL472840 | cis-5-(2-Aminocyclohexylamino)-7-(3...)
Show SMILES COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3nc(nc3c2C(N)=O)-c2ccccc2Cl)cc(OC)c1 |r|
Show InChI InChI=1S/C26H29ClN8O3/c1-37-15-11-14(12-16(13-15)38-2)30-24-21(22(29)36)25-32-23(17-7-3-4-8-18(17)27)34-35(25)26(33-24)31-20-10-6-5-9-19(20)28/h3-4,7-8,11-13,19-20,30H,5-6,9-10,28H2,1-2H3,(H2,29,36)(H,31,33)/t19-,20+/m1/s1
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n/an/a 50n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390558
PNG
(CHEMBL2069347)
Show SMILES C1CN(CCN1)c1cc(ccn1)-c1cccc(Nc2cnccn2)n1
Show InChI InChI=1S/C18H19N7/c1-2-15(23-16(3-1)24-17-13-20-6-7-21-17)14-4-5-22-18(12-14)25-10-8-19-9-11-25/h1-7,12-13,19H,8-11H2,(H,21,23,24)
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n/an/a 62n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50426528
PNG
(CHEMBL2323633)
Show SMILES COc1ccc(Nc2nc(nc3scnc23)N2CCCC(C2)C(=O)Nc2ccc(nc2)C(O)=O)cc1OC
Show InChI InChI=1S/C25H25N7O5S/c1-36-18-8-6-15(10-19(18)37-2)28-21-20-23(38-13-27-20)31-25(30-21)32-9-3-4-14(12-32)22(33)29-16-5-7-17(24(34)35)26-11-16/h5-8,10-11,13-14H,3-4,9,12H2,1-2H3,(H,29,33)(H,34,35)(H,28,30,31)
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n/an/a 65n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Gst-tagged Syk expressed in sf9 cells

ACS Med Chem Lett 4: 18-9 (2013)


Article DOI: 10.1021/ml300405d
BindingDB Entry DOI: 10.7270/Q24B32NS
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50426527
PNG
(CHEMBL2323632)
Show SMILES COc1ccc(Nc2nc(nc3scnc23)N2CCCC(C2)C(=O)Nc2ccc(C(O)=O)c(O)c2)cc1OC
Show InChI InChI=1S/C26H26N6O6S/c1-37-19-8-6-16(11-20(19)38-2)28-22-21-24(39-13-27-21)31-26(30-22)32-9-3-4-14(12-32)23(34)29-15-5-7-17(25(35)36)18(33)10-15/h5-8,10-11,13-14,33H,3-4,9,12H2,1-2H3,(H,29,34)(H,35,36)(H,28,30,31)
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n/an/a 71n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Gst-tagged Syk expressed in sf9 cells

ACS Med Chem Lett 4: 18-9 (2013)


Article DOI: 10.1021/ml300405d
BindingDB Entry DOI: 10.7270/Q24B32NS
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50426530
PNG
(CHEMBL2323635)
Show SMILES CNC(=O)c1ccc(NC(=O)c2cccc(c2)-c2nc(Nc3ccc(OC)c(OC)c3)c3ncsc3n2)cc1
Show InChI InChI=1S/C28H24N6O4S/c1-29-26(35)16-7-9-19(10-8-16)32-27(36)18-6-4-5-17(13-18)24-33-25(23-28(34-24)39-15-30-23)31-20-11-12-21(37-2)22(14-20)38-3/h4-15H,1-3H3,(H,29,35)(H,32,36)(H,31,33,34)
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n/an/a 71n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Gst-tagged Syk expressed in sf9 cells

ACS Med Chem Lett 4: 18-9 (2013)


Article DOI: 10.1021/ml300405d
BindingDB Entry DOI: 10.7270/Q24B32NS
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50426525
PNG
(CHEMBL2323631)
Show SMILES COc1ccc(Nc2nc(nc3scnc23)-c2cccc(CO)c2)cc1OC
Show InChI InChI=1S/C20H18N4O3S/c1-26-15-7-6-14(9-16(15)27-2)22-19-17-20(28-11-21-17)24-18(23-19)13-5-3-4-12(8-13)10-25/h3-9,11,25H,10H2,1-2H3,(H,22,23,24)
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n/an/a 79n/an/an/an/an/an/a



Therachem Research Medilab (India) Pvt. Ltd.

Curated by ChEMBL


Assay Description
Inhibition of human Gst-tagged Syk expressed in sf9 cells

ACS Med Chem Lett 4: 18-9 (2013)


Article DOI: 10.1021/ml300405d
BindingDB Entry DOI: 10.7270/Q24B32NS
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50263119
PNG
(CHEMBL478642 | cis-5-(2-Aminocyclohexylamino)-7-(3...)
Show SMILES COc1cc(Nc2nc(N[C@H]3CCCC[C@H]3N)n3nc(nc3c2C(N)=O)-c2ccccc2)cc(OC)c1 |r|
Show InChI InChI=1S/C26H30N8O3/c1-36-17-12-16(13-18(14-17)37-2)29-24-21(22(28)35)25-31-23(15-8-4-3-5-9-15)33-34(25)26(32-24)30-20-11-7-6-10-19(20)27/h3-5,8-9,12-14,19-20,29H,6-7,10-11,27H2,1-2H3,(H2,28,35)(H,30,32)/t19-,20+/m1/s1
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n/an/a 83n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465343
PNG
(CHEMBL4279751)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@]2(CO)C(O)=O)C(C)=C |r|
Show InChI InChI=1S/C20H26O3/c1-13(2)14-5-7-16-15(11-14)6-8-17-19(16,3)9-4-10-20(17,12-21)18(22)23/h5,7,11,17,21H,1,4,6,8-10,12H2,2-3H3,(H,22,23)/t17-,19-,20-/m1/s1
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n/an/a 85n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390570
PNG
(CHEMBL2069337)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cccc(NCCN)c2)c1
Show InChI InChI=1S/C19H21N5/c1-14-8-10-22-19(12-14)24-18-7-3-6-17(23-18)15-4-2-5-16(13-15)21-11-9-20/h2-8,10,12-13,21H,9,11,20H2,1H3,(H,22,23,24)
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n/an/a 91n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465344
PNG
(CHEMBL4294902)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@]2(CO)C(O)=O)C(C)=O |r|
Show InChI InChI=1S/C19H24O4/c1-12(21)13-4-6-15-14(10-13)5-7-16-18(15,2)8-3-9-19(16,11-20)17(22)23/h4,6,10,16,20H,3,5,7-9,11H2,1-2H3,(H,22,23)/t16-,18-,19-/m1/s1
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n/an/a>100n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465341
PNG
(CHEMBL4289234)
Show SMILES [H][C@@]12CCc3cc(O)ccc3[C@@]1(C)CCC[C@@]2(CC(=O)OC)C(O)=O |r|
Show InChI InChI=1S/C19H24O5/c1-18-8-3-9-19(17(22)23,11-16(21)24-2)15(18)7-4-12-10-13(20)5-6-14(12)18/h5-6,10,15,20H,3-4,7-9,11H2,1-2H3,(H,22,23)/t15-,18-,19+/m1/s1
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n/an/a>100n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465339
PNG
(CHEMBL4285076)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(CC(=O)OC)C(O)=O)C(C)(C)O |r|
Show InChI InChI=1S/C22H30O5/c1-20(2,26)15-7-8-16-14(12-15)6-9-17-21(16,3)10-5-11-22(17,19(24)25)13-18(23)27-4/h7-8,12,17,26H,5-6,9-11,13H2,1-4H3,(H,24,25)/t17-,21-,22+/m1/s1
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n/an/a>100n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50465340
PNG
(CHEMBL4278579)
Show SMILES [H][C@@]12CCc3cc(ccc3[C@@]1(C)CCC[C@@]2(CC(=O)OC)C(O)=O)C(C)=O |r|
Show InChI InChI=1S/C21H26O5/c1-13(22)14-5-7-16-15(11-14)6-8-17-20(16,2)9-4-10-21(17,19(24)25)12-18(23)26-3/h5,7,11,17H,4,6,8-10,12H2,1-3H3,(H,24,25)/t17-,20-,21+/m1/s1
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n/an/a>100n/an/an/an/an/an/a



Yunnan University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin) by mobility shift assay

J Nat Prod 81: 998-1006 (2018)


Article DOI: 10.1021/acs.jnatprod.7b01082
BindingDB Entry DOI: 10.7270/Q2P84FK3
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390554
PNG
(CHEMBL2069343)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(c2)N2CCC(N)CC2)c1
Show InChI InChI=1S/C21H24N6/c1-15-5-9-23-20(13-15)26-19-4-2-3-18(25-19)16-6-10-24-21(14-16)27-11-7-17(22)8-12-27/h2-6,9-10,13-14,17H,7-8,11-12,22H2,1H3,(H,23,25,26)
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n/an/a 114n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50263120
PNG
(CHEMBL475882 | cis-5-(2-Aminocyclohexylamino)-7-(3...)
Show SMILES COc1cccc(c1)-c1nc2c(C(N)=O)c(Nc3cc(OC)cc(OC)c3)nc(N[C@H]3CCCC[C@H]3N)n2n1 |r|
Show InChI InChI=1S/C27H32N8O4/c1-37-17-8-6-7-15(11-17)24-32-26-22(23(29)36)25(30-16-12-18(38-2)14-19(13-16)39-3)33-27(35(26)34-24)31-21-10-5-4-9-20(21)28/h6-8,11-14,20-21,30H,4-5,9-10,28H2,1-3H3,(H2,29,36)(H,31,33)/t20-,21+/m1/s1
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n/an/a 120n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50510261
PNG
(CHEMBL4590082)
Show SMILES Cc1cnc(Nc2ccc(cc2)N2CCOCC2)nc1-c1cc2CN(CCc2o1)C(=O)CC#N
Show InChI InChI=1S/C25H26N6O3/c1-17-15-27-25(28-19-2-4-20(5-3-19)30-10-12-33-13-11-30)29-24(17)22-14-18-16-31(23(32)6-8-26)9-7-21(18)34-22/h2-5,14-15H,6-7,9-13,16H2,1H3,(H,27,28,29)
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n/an/a 140n/an/an/an/an/an/a



Central China Normal University

Curated by ChEMBL


Assay Description
Inhibition of SYK (unknown origin)

Bioorg Med Chem 27: 2592-2597 (2019)


Article DOI: 10.1016/j.bmc.2019.03.048
BindingDB Entry DOI: 10.7270/Q25D8W5B
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50263040
PNG
(5-(2-Amino-2-methylpropylamino)-7-(3,5-dimethoxyph...)
Show SMILES COc1cc(Nc2nc(NCC(C)(C)N)n3cnnc3c2C(N)=O)cc(OC)c1
Show InChI InChI=1S/C18H24N8O3/c1-18(2,20)8-21-17-24-15(13(14(19)27)16-25-22-9-26(16)17)23-10-5-11(28-3)7-12(6-10)29-4/h5-7,9,23H,8,20H2,1-4H3,(H2,19,27)(H,21,24)
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n/an/a 150n/an/an/an/an/an/a



Kissei Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Inhibition of human Syk

Bioorg Med Chem 16: 7347-57 (2008)


Article DOI: 10.1016/j.bmc.2008.06.017
BindingDB Entry DOI: 10.7270/Q2HQ3ZP6
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390548
PNG
(CHEMBL2069340)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2cccc(CCN)c2)c1
Show InChI InChI=1S/C19H20N4/c1-14-9-11-21-19(12-14)23-18-7-3-6-17(22-18)16-5-2-4-15(13-16)8-10-20/h2-7,9,11-13H,8,10,20H2,1H3,(H,21,22,23)
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n/an/a 160n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
Lysine--tRNA ligase


(Homo sapiens (Human))		BDBM50390549
PNG
(CHEMBL2069336)
Show SMILES Cc1ccnc(Nc2cccc(n2)-c2ccnc(NCCN)c2)c1
Show InChI InChI=1S/C18H20N6/c1-13-5-8-21-18(11-13)24-16-4-2-3-15(23-16)14-6-9-20-17(12-14)22-10-7-19/h2-6,8-9,11-12H,7,10,19H2,1H3,(H,20,22)(H,21,23,24)
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n/an/a 200n/an/an/an/an/an/a



Rhône-Poulenc Rorer

Curated by ChEMBL


Assay Description
Inhibition of human recombinant full-length Syk using poly-GT as substrate after 40 mins by radioactive filtration assay

Bioorg Med Chem Lett 22: 5419-23 (2012)


Article DOI: 10.1016/j.bmcl.2012.07.045
BindingDB Entry DOI: 10.7270/Q2416Z4V
More data for this
Ligand-Target Pair
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