Compile Data Set for Download or QSAR

Found 11 hits of ic50 for UniProtKB: P10070   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50241296 (CHEMBL245412 | Zerumbone) Show SMILES C\C1=C/CC(C)(C)\C=C\C(=O)\C(C)=C\CC1 |c:1,t:7,12| Show InChI InChI=1S/C15H22O/c1-12-6-5-7-13(2)14(16)9-11-15(3,4)10-8-12/h7-9,11H,5-6,10H2,1-4H3/b11-9+,12-8+,13-7+	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of Gli2-mediated transcription expressed in human PANC1 cells				J Med Chem 52: 3829-45 (2009) Article DOI: 10.1021/jm801420y BindingDB Entry DOI: 10.7270/Q22N536M
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM2581 (3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...) Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21 Show InChI InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of Gli2-mediated transcription expressed in human PANC1 cells				J Med Chem 52: 3829-45 (2009) Article DOI: 10.1021/jm801420y BindingDB Entry DOI: 10.7270/Q22N536M
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50240964 (11-hydroxy-2,3,8,9-tetrahydro-1H-indolo[2,3-a]pyrr...) Show SMILES Oc1ccc2c(c1)[nH]c1c3[nH]c4ccccc4c3c3CNC(=O)c3c21 Show InChI InChI=1S/C20H13N3O2/c24-9-5-6-11-14(7-9)23-19-16(11)17-12(8-21-20(17)25)15-10-3-1-2-4-13(10)22-18(15)19/h1-7,22-24H,8H2,(H,21,25)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of Gli2-mediated transcription expressed in human PANC1 cells				J Med Chem 52: 3829-45 (2009) Article DOI: 10.1021/jm801420y BindingDB Entry DOI: 10.7270/Q22N536M
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50240682 (2,10-dihydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-...) Show SMILES Oc1ccc2c(c1)[nH]c1c3[nH]c4cc(O)ccc4c3c3C(=O)NC(=O)c3c21 Show InChI InChI=1S/C20H11N3O4/c24-7-1-3-9-11(5-7)21-17-13(9)15-16(20(27)23-19(15)26)14-10-4-2-8(25)6-12(10)22-18(14)17/h1-6,21-22,24-25H,(H,23,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of Gli2-mediated transcription expressed in human PANC1 cells				J Med Chem 52: 3829-45 (2009) Article DOI: 10.1021/jm801420y BindingDB Entry DOI: 10.7270/Q22N536M
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50240978 (2,3-dihydroxy-6,7,12,13-tetrahydro-5H-indolo[2,3-a...) Show SMILES Oc1cc2[nH]c3c4[nH]c5ccccc5c4c4C(=O)NC(=O)c4c3c2cc1O Show InChI InChI=1S/C20H11N3O4/c24-11-5-8-10(6-12(11)25)22-18-14(8)16-15(19(26)23-20(16)27)13-7-3-1-2-4-9(7)21-17(13)18/h1-6,21-22,24-25H,(H,23,26,27)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of Gli2-mediated transcription expressed in human PANC1 cells				J Med Chem 52: 3829-45 (2009) Article DOI: 10.1021/jm801420y BindingDB Entry DOI: 10.7270/Q22N536M
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50293858 ((S)-2-(3-Benzoylphenyl)-N,N-bis(4-hydroxyphenethyl...) Show SMILES C[C@H](C(=O)N(CCc1ccc(O)cc1)CCc1ccc(O)cc1)c1cccc(c1)C(=O)c1ccccc1 |r| Show InChI InChI=1S/C32H31NO4/c1-23(27-8-5-9-28(22-27)31(36)26-6-3-2-4-7-26)32(37)33(20-18-24-10-14-29(34)15-11-24)21-19-25-12-16-30(35)17-13-25/h2-17,22-23,34-35H,18-21H2,1H3/t23-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of exogenously transfected human Gli2 deltaN-mediated transcriptional activity in mouse C3H10T1/2 cells after 24 hrs by luciferase reporte...				J Med Chem 52: 4277-87 (2009) Article DOI: 10.1021/jm900106f BindingDB Entry DOI: 10.7270/Q2QJ7H9J
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50321859 (2-(3-Benzoylphenyl)-N-(1H-indol-5-yl)-N-propylprop...) Show SMILES CCCN(C(=O)C(C)c1cccc(c1)C(=O)c1ccccc1)c1ccc2[nH]ccc2c1 Show InChI InChI=1S/C27H26N2O2/c1-3-16-29(24-12-13-25-22(18-24)14-15-28-25)27(31)19(2)21-10-7-11-23(17-21)26(30)20-8-5-4-6-9-20/h4-15,17-19,28H,3,16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of human Gli2 expressed in mouse C3H10T1/2 cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter ge...				Bioorg Med Chem 18: 4801-11 (2011) Article DOI: 10.1016/j.bmc.2010.05.001 BindingDB Entry DOI: 10.7270/Q23R0TTT
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50293859 ((S)-2-(3-Benzoylphenyl)-N-(4-hydroxyphenethyl)-N-p...) Show SMILES CCCN(CCc1ccc(O)cc1)C(=O)[C@@H](C)c1cccc(c1)C(=O)c1ccccc1 |r| Show InChI InChI=1S/C27H29NO3/c1-3-17-28(18-16-21-12-14-25(29)15-13-21)27(31)20(2)23-10-7-11-24(19-23)26(30)22-8-5-4-6-9-22/h4-15,19-20,29H,3,16-18H2,1-2H3/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.39E+4	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of exogenously transfected human Gli2 deltaN-mediated transcriptional activity in mouse C3H10T1/2 cells after 24 hrs by luciferase reporte...				J Med Chem 52: 4277-87 (2009) Article DOI: 10.1021/jm900106f BindingDB Entry DOI: 10.7270/Q2QJ7H9J
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50321858 (2-(3-Benzoylphenyl)-N-(1H-indol-6-yl)-N-propylprop...) Show SMILES CCCN(C(=O)C(C)c1cccc(c1)C(=O)c1ccccc1)c1ccc2cc[nH]c2c1 Show InChI InChI=1S/C27H26N2O2/c1-3-16-29(24-13-12-20-14-15-28-25(20)18-24)27(31)19(2)22-10-7-11-23(17-22)26(30)21-8-5-4-6-9-21/h4-15,17-19,28H,3,16H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of human Gli2 expressed in mouse C3H10T1/2 cells assessed as inhibition of transcriptional activity after 24 hrs by luciferase reporter ge...				Bioorg Med Chem 18: 4801-11 (2011) Article DOI: 10.1016/j.bmc.2010.05.001 BindingDB Entry DOI: 10.7270/Q23R0TTT
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50293860 ((S)-2-(3-Benzoylphenyl)-N-(3,4-dihydroxyphenethyl)...) Show SMILES C[C@H](C(=O)NCCc1ccc(O)c(O)c1)c1cccc(Oc2ccccc2)c1 |r| Show InChI InChI=1S/C23H23NO4/c1-16(23(27)24-13-12-17-10-11-21(25)22(26)14-17)18-6-5-9-20(15-18)28-19-7-3-2-4-8-19/h2-11,14-16,25-26H,12-13H2,1H3,(H,24,27)/t16-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.94E+4	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of exogenously transfected human Gli2 deltaN-mediated transcriptional activity in mouse C3H10T1/2 cells after 24 hrs by luciferase reporte...				J Med Chem 52: 4277-87 (2009) Article DOI: 10.1021/jm900106f BindingDB Entry DOI: 10.7270/Q2QJ7H9J
					More data for this Ligand-Target Pair
Zinc finger protein GLI2 (Homo sapiens (Human))	BDBM50293861 ((S)-2-(3-Benzoylphenyl)-N-(4-hydroxyphenethyl)prop...) Show SMILES C[C@H](C(=O)NCCc1ccc(O)cc1)c1cccc(c1)C(=O)c1ccccc1 |r| Show InChI InChI=1S/C24H23NO3/c1-17(24(28)25-15-14-18-10-12-22(26)13-11-18)20-8-5-9-21(16-20)23(27)19-6-3-2-4-7-19/h2-13,16-17,26H,14-15H2,1H3,(H,25,28)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.52E+4	n/a	n/a	n/a	n/a	n/a	n/a
St Jude Children's Research Hospital Curated by ChEMBL					Assay Description Inhibition of exogenously transfected human Gli2 deltaN-mediated transcriptional activity in mouse C3H10T1/2 cells after 24 hrs by luciferase reporte...				J Med Chem 52: 4277-87 (2009) Article DOI: 10.1021/jm900106f BindingDB Entry DOI: 10.7270/Q2QJ7H9J
					More data for this Ligand-Target Pair