Found 18 hits of ic50 data for polymerid = 50003971 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Gachon University
Curated by ChEMBL
| Assay Description
Inhibition of human STK25 using MBP as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 163: 453-480 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.037
BindingDB Entry DOI: 10.7270/Q2TQ650N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Gachon University
Curated by ChEMBL
| Assay Description
Inhibition of human STK25 using MBP as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 163: 453-480 (2019)
Article DOI: 10.1016/j.ejmech.2018.11.037
BindingDB Entry DOI: 10.7270/Q2TQ650N |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida
Curated by ChEMBL
| Assay Description
Inhibition of human STK25 using MBP as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052
BindingDB Entry DOI: 10.7270/Q2W380MT |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB
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| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of human STK25 using MBP as substrate by [gamma-33P]-ATP assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2018.02.022
BindingDB Entry DOI: 10.7270/Q2DJ5KB8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM212293
(US9290507, I-13)Show SMILES Cc1ccc(cc1-n1cc(nn1)-c1cncc(c1)N1CCOCC1)C(=O)Nc1cc(n[nH]1)C(C)(C)C Show InChI InChI=1S/C26H30N8O2/c1-17-5-6-18(25(35)28-24-13-23(30-31-24)26(2,3)4)12-22(17)34-16-21(29-32-34)19-11-20(15-27-14-19)33-7-9-36-10-8-33/h5-6,11-16H,7-10H2,1-4H3,(H2,28,30,31,35) | PDB
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TBA
| Assay Description
Binding affinity towards rat beta adrenergic receptor from lung membranes. |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM50148921
(CHEMBL3770443)Show SMILES CNc1ncc2cc(-c3ccc(cc3Cl)-c3cccc(C)n3)c(=O)n(C[C@H]3OC[C@H](N)CO3)c2n1 |r,wU:26.27,wD:29.31,(-5.08,.92,;-4.02,1.54,;-2.68,.77,;-2.68,-.77,;-1.33,-1.54,;,-.77,;1.33,-1.54,;2.66,-.77,;4,-1.54,;3.99,-3.08,;5.33,-3.85,;6.66,-3.08,;6.66,-1.54,;5.33,-.77,;5.33,.46,;7.99,-3.86,;9.33,-3.09,;10.66,-3.86,;10.66,-5.4,;9.32,-6.17,;9.32,-7.4,;7.99,-5.4,;2.66,.77,;3.73,1.38,;1.33,1.54,;1.33,3.08,;2.67,3.85,;2.68,5.39,;4.01,6.15,;5.34,5.38,;6.41,5.99,;5.34,3.84,;4,3.07,;,.77,;-1.33,1.54,)| Show InChI InChI=1S/C25H25ClN6O3/c1-14-4-3-5-21(30-14)15-6-7-18(20(26)9-15)19-8-16-10-29-25(28-2)31-23(16)32(24(19)33)11-22-34-12-17(27)13-35-22/h3-10,17,22H,11-13,27H2,1-2H3,(H,28,29,31)/t17-,22- | PDB
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Genentech
Curated by ChEMBL
| Assay Description
Inhibition of human recombinant YSK1 |
ACS Med Chem Lett 6: 1241-6 (2015)
Article DOI: 10.1021/acsmedchemlett.5b00398
BindingDB Entry DOI: 10.7270/Q2MP554V |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | CHEMBL5276146
Show SMILES CCCCN(CC(O)=O)C(=O)C(CCCNC(N)=N)NS(=O)(=O)c1cccc2CCCCc12 Show InChI InChI=1S/C22H35N5O5S/c1-2-3-14-27(15-20(28)29)21(30)18(11-7-13-25-22(23)24)26-33(31,32)19-12-6-9-16-8-4-5-10-17(16)19/h6,9,12,18,26H,2-5,7-8,10-11,13-15H2,1H3,(H,28,29)(H4,23,24,25) | PDB
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TBA
| Assay Description
Binding affinity towards rat beta adrenergic receptor from lung membranes. |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | CHEMBL5276146
Show SMILES CCCCN(CC(O)=O)C(=O)C(CCCNC(N)=N)NS(=O)(=O)c1cccc2CCCCc12 Show InChI InChI=1S/C22H35N5O5S/c1-2-3-14-27(15-20(28)29)21(30)18(11-7-13-25-22(23)24)26-33(31,32)19-12-6-9-16-8-4-5-10-17(16)19/h6,9,12,18,26H,2-5,7-8,10-11,13-15H2,1H3,(H,28,29)(H4,23,24,25) | PDB
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TBA
| Assay Description
Binding affinity towards rat beta adrenergic receptor from lung membranes. |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM50243388
(AT-9283 | US10981896, Compound AT9283)Show SMILES O=C(NC1CC1)Nc1c[nH]nc1-c1nc2cc(CN3CCOCC3)ccc2[nH]1 Show InChI InChI=1S/C19H23N7O2/c27-19(21-13-2-3-13)24-16-10-20-25-17(16)18-22-14-4-1-12(9-15(14)23-18)11-26-5-7-28-8-6-26/h1,4,9-10,13H,2-3,5-8,11H2,(H,20,25)(H,22,23)(H2,21,24,27) | PDB
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TBA
| Assay Description
Binding affinity towards rat beta adrenergic receptor from lung membranes. |
Citation and Details
|
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | CHEMBL5278528
Show SMILES CCCCN(CC(O)=O)C(=O)C(CCCNC(N)=N)NS(=O)(=O)c1ccc2ccc(C)cc2c1 Show InChI InChI=1S/C23H33N5O5S/c1-3-4-12-28(15-21(29)30)22(31)20(6-5-11-26-23(24)25)27-34(32,33)19-10-9-17-8-7-16(2)13-18(17)14-19/h7-10,13-14,20,27H,3-6,11-12,15H2,1-2H3,(H,29,30)(H4,24,25,26) | PDB
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TBA
| Assay Description
Binding affinity towards rat beta adrenergic receptor from heart membranes. |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | CHEMBL5286173
Show SMILES Cc1ccc2ccc(cc2c1)S(=O)(=O)NC(CCCNC(N)=N)C(=O)N(CC1CCCO1)CC(O)=O Show InChI InChI=1S/C24H33N5O6S/c1-16-6-7-17-8-9-20(13-18(17)12-16)36(33,34)28-21(5-2-10-27-24(25)26)23(32)29(15-22(30)31)14-19-4-3-11-35-19/h6-9,12-13,19,21,28H,2-5,10-11,14-15H2,1H3,(H,30,31)(H4,25,26,27) | PDB
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| | n/a | n/a | 865 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity towards rat beta adrenergic receptor from lung membranes. |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | CHEMBL5279218
Show SMILES COCCN(CC(O)=O)C(=O)C(CCCNC(N)=N)NS(=O)(=O)c1cccc2c(OC)cccc12 Show InChI InChI=1S/C22H31N5O7S/c1-33-13-12-27(14-20(28)29)21(30)17(8-5-11-25-22(23)24)26-35(31,32)19-10-4-6-15-16(19)7-3-9-18(15)34-2/h3-4,6-7,9-10,17,26H,5,8,11-14H2,1-2H3,(H,28,29)(H4,23,24,25) | PDB
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| | n/a | n/a | 5.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Binding affinity towards rat beta adrenergic receptor from lung membranes. |
Citation and Details
|
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM50135286
(CHEMBL3745885)Show SMILES Cn1c2nc(Nc3ccc4[nH]ccc4c3)ncc2cc(c1=O)S(=O)(=O)c1ccc(F)cc1F Show InChI InChI=1S/C22H15F2N5O3S/c1-29-20-13(9-19(21(29)30)33(31,32)18-5-2-14(23)10-16(18)24)11-26-22(28-20)27-15-3-4-17-12(8-15)6-7-25-17/h2-11,25H,1H3,(H,26,27,28) | PDB
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| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Icahn School of Medicine at Mount Sinai
Curated by ChEMBL
| Assay Description
Inhibition of human STK25 using MBP substrate |
Bioorg Med Chem 24: 521-44 (2016)
Article DOI: 10.1016/j.bmc.2015.11.045
BindingDB Entry DOI: 10.7270/Q24Q7WT8 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM50519662
(CHEMBL4438748)Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1cccc(NC(=O)COc2ccc3c(c2)occc3=O)c1 Show InChI InChI=1S/C26H23N3O5/c1-29(2)20-8-6-17(7-9-20)26(32)28-19-5-3-4-18(14-19)27-25(31)16-34-21-10-11-22-23(30)12-13-33-24(22)15-21/h3-15H,16H2,1-2H3,(H,27,31)(H,28,32) | PDB
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TBA
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human STK25 (1 to 308 residues) using RLGRDKYKTLRQI as substrate incubated for 40 mins in presence of [gamma33P]ATP by radi... |
J Med Chem 62: 10691-10710 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01143
BindingDB Entry DOI: 10.7270/Q2MC93FG |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM50501882
(CHEMBL4446361)Show SMILES Fc1cccc(NC(=O)CC(=O)Nc2ccc3c(\C=C\c4ccccn4)n[nH]c3c2)c1 Show InChI InChI=1S/C23H18FN5O2/c24-15-4-3-6-17(12-15)26-22(30)14-23(31)27-18-7-9-19-20(28-29-21(19)13-18)10-8-16-5-1-2-11-25-16/h1-13H,14H2,(H,26,30)(H,27,31)(H,28,29)/b10-8+ | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of wild-type human partial length STK25 (V14 to H295 residues) expressed in bacterial expression system after 1 hr by Z-LYTE assay |
J Med Chem 62: 5006-5024 (2019)
Article DOI: 10.1021/acs.jmedchem.9b00176
BindingDB Entry DOI: 10.7270/Q2P84G4P |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM50577328
(CHEMBL4875188)Show SMILES COc1ccccc1C1=C(Nc2cccc(c2)C#N)C(=O)NC1=O |c:9| | PDB
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TBA
| Assay Description
Inhibition of NanoLuc-fused YSK1 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01579
BindingDB Entry DOI: 10.7270/Q2ST7TPK |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM8226
(3-[(3-chlorophenyl)amino]-4-(2-methoxyphenyl)-2,5-...)Show SMILES COc1ccccc1C1=C(Nc2cccc(Cl)c2)C(=O)NC1=O |c:9| Show InChI InChI=1S/C17H13ClN2O3/c1-23-13-8-3-2-7-12(13)14-15(17(22)20-16(14)21)19-11-6-4-5-10(18)9-11/h2-9H,1H3,(H2,19,20,21,22) | PDB
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| n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of NanoLuc-fused YSK1 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01579
BindingDB Entry DOI: 10.7270/Q2ST7TPK |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase 25
(Homo sapiens (Human)) | BDBM50537742
(CHEMBL4634634 | US11179389, Compound 1-14)Show SMILES C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1 |r| Show InChI InChI=1S/C19H23N7O/c1-12-6-15(12)19(27)26-5-4-25(10-13(26)2)17-9-21-16(7-20)18(23-17)14-8-22-24(3)11-14/h8-9,11-13,15H,4-6,10H2,1-3H3/t12-,13-,15-/m1/s1 | PDB
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant full length human GST-tagged YSK1 expressed in baculovirus expression system using serine/threonine-7 peptide as substrate ... |
Bioorg Med Chem Lett 30: (2020)
Article DOI: 10.1016/j.bmcl.2019.126715
BindingDB Entry DOI: 10.7270/Q2HM5CZG |
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