Compile Data Set for Download or QSAR

Found 11 hits of ic50 for UniProtKB: O35240   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50259583 (3-amino-5-(biphenyl-3-yl)-N-(diaminomethylene)pyra...) Show SMILES NC(=N)NC(=O)c1ncc(nc1N)-c1cccc(c1)-c1ccccc1 Show InChI InChI=1S/C18H16N6O/c19-16-15(17(25)24-18(20)21)22-10-14(23-16)13-8-4-7-12(9-13)11-5-2-1-3-6-11/h1-10H,(H2,19,23)(H4,20,21,24,25)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	950	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 assessed as inhibition of peak current by patch clamp electrophisiology				Bioorg Med Chem Lett 19: 2514-8 (2009) Article DOI: 10.1016/j.bmcl.2009.03.029 BindingDB Entry DOI: 10.7270/Q2MK6CS6
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50157090 (6-(2-(1-isopropyl-2-methyl-1,2,3,4-tetrahydroisoqu...) Show SMILES CC(C)C1N(C)CCc2ccc(cc12)C1CC1c1ccc2cc(ccc2c1)C(N)=N Show InChI InChI=1S/C27H31N3/c1-16(2)26-25-14-21(7-4-17(25)10-11-30(26)3)24-15-23(24)20-8-5-19-13-22(27(28)29)9-6-18(19)12-20/h4-9,12-14,16,23-24,26H,10-11,15H2,1-3H3,(H3,28,29)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of ASIC3 in rat DRG neurons				J Med Chem 56: 593-624 (2013) Article DOI: 10.1021/jm3011433 BindingDB Entry DOI: 10.7270/Q23B61GZ
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50074922 ((+-)-2-fluoro-alpha-methyl-4-biphenylacetic acid |...) Show SMILES CC(C(O)=O)c1ccc(c(F)c1)-c1ccccc1 Show InChI InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	2.29E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50250133 (Butibufen) Show SMILES CCC(C(O)=O)c1ccc(CC(C)C)cc1 Show InChI InChI=1S/C14H20O2/c1-4-13(14(15)16)12-7-5-11(6-8-12)9-10(2)3/h5-8,10,13H,4,9H2,1-3H3,(H,15,16)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	2.88E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50250130 (CHEMBL4083814) Show SMILES CC(C)Cc1ccc(cc1)C(O)=O Show InChI InChI=1S/C11H14O2/c1-8(2)7-9-3-5-10(6-4-9)11(12)13/h3-6,8H,7H2,1-2H3,(H,12,13)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.02E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50169047 ((S)-2-(4-Isobutyl-phenyl)-propionic acid | (S)-2-(...) Show SMILES CC(C)Cc1ccc(cc1)[C@H](C)C(O)=O |r| Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.09E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50169044 ((-)-ibuprofen | (2R)-2-(4-isobutylphenyl)propanoic...) Show SMILES CC(C)Cc1ccc(cc1)[C@@H](C)C(O)=O Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	3.89E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50295285 ((4-Isobutyl-phenyl)-acetic acid | 2-(4-isobutylphe...) Show SMILES CC(C)Cc1ccc(CC(O)=O)cc1 Show InChI InChI=1S/C12H16O2/c1-9(2)7-10-3-5-11(6-4-10)8-12(13)14/h3-6,9H,7-8H2,1-2H3,(H,13,14)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.17E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50009859 ((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...) Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	5.13E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50250131 (CHEMBL190275) Show SMILES CC(C(O)=O)c1ccc(C)cc1 Show InChI InChI=1S/C10H12O2/c1-7-3-5-9(6-4-7)8(2)10(11)12/h3-6,8H,1-2H3,(H,11,12)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.08E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair
Acid-sensing ion channel 3 (Rattus norvegicus)	BDBM50250132 (CHEMBL4080879) Show SMILES CC(C)Cc1ccc(cc1)C(F)C(O)=O Show InChI InChI=1S/C12H15FO2/c1-8(2)7-9-3-5-10(6-4-9)11(13)12(14)15/h3-6,8,11H,7H2,1-2H3,(H,14,15)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.91E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Inhibition of rat ASIC3 receptor expressed in xenopus lavies oocytes assessed as inhibition of pH 6.4-gated currents by two electrode voltage clamp				J Med Chem 60: 8192-8200 (2017) Article DOI: 10.1021/acs.jmedchem.7b01072 BindingDB Entry DOI: 10.7270/Q2N58PSV
					More data for this Ligand-Target Pair