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Compile Data Set for Download or QSAR

Found 117 hits of ic50 for UniProtKB: P19525   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308051
PNG
(US10011593, Ex. 3 | US9650366, 3)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H20ClF3N8O2S/c26-19-4-2-16(11-18(19)25(27,28)29)33-24(39)32-15-3-5-20-13(8-15)10-21(40-20)17-9-14(12-31-22(17)30)23-34-36-37(35-23)6-1-7-38/h2-5,8-12,38H,1,6-7H2,(H2,30,31)(H2,32,33,39)
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n/an/a 39n/an/an/an/an/an/a



Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308056
PNG
(US10011593, Ex. 6 | US9650366, 6)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3cc(cc(c3)C(F)(F)F)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C26H20F6N8O2S/c27-25(28,29)15-9-16(26(30,31)32)11-18(10-15)36-24(42)35-17-2-3-20-13(6-17)8-21(43-20)19-7-14(12-34-22(19)33)23-37-39-40(38-23)4-1-5-41/h2-3,6-12,41H,1,4-5H2,(H2,33,34)(H2,35,36,42)
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n/an/a 66n/an/an/an/an/an/a



Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 69n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...

US Patent US10669265 (2020)


BindingDB Entry DOI: 10.7270/Q20R9SFZ
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 69n/an/an/an/an/an/a



Amgen



Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...

J Med Chem 50: 3515-27 (2007)


BindingDB Entry DOI: 10.7270/Q2DB8465
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM364980
PNG
(6-amino-5-{5-[({[4-chloro-3- (trifluoromethyl)phen...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19ClF3N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-14(4-6-19(12)37-20)31-23(35)32-15-3-5-18(25)17(10-15)24(26,27)28/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 69n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...

US Patent US10633373 (2020)


BindingDB Entry DOI: 10.7270/Q2Z60S37
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308055
PNG
(US10011593, Ex. 5 | US9650366, 5)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3cc(F)cc(c3)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H20F4N8O2S/c26-16-9-15(25(27,28)29)10-18(11-16)33-24(39)32-17-2-3-20-13(6-17)8-21(40-20)19-7-14(12-31-22(19)30)23-34-36-37(35-23)4-1-5-38/h2-3,6-12,38H,1,4-5H2,(H2,30,31)(H2,32,33,39)
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Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308057
PNG
(US10011593, Ex. 8 | US9650366, 8)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1nnn(CCO)n1
Show InChI InChI=1S/C24H18ClF3N8O2S/c25-18-3-1-15(10-17(18)24(26,27)28)32-23(38)31-14-2-4-19-12(7-14)9-20(39-19)16-8-13(11-30-21(16)29)22-33-35-36(34-22)5-6-37/h1-4,7-11,37H,5-6H2,(H2,29,30)(H2,31,32,38)
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n/an/a 82n/an/an/an/an/an/a



Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308054
PNG
(US10011593, Ex. 4 | US9650366, 4)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(F)c(c3)C(F)(F)F)ccc2s1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H20F4N8O2S/c26-19-4-2-16(11-18(19)25(27,28)29)33-24(39)32-15-3-5-20-13(8-15)10-21(40-20)17-9-14(12-31-22(17)30)23-34-36-37(35-23)6-1-7-38/h2-5,8-12,38H,1,6-7H2,(H2,30,31)(H2,32,33,39)
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Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50442163
PNG
(CHEMBL2441346)
Show SMILES Cc1cc(C)n(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1
Show InChI InChI=1S/C22H22FN7O/c1-12-8-13(2)30(27-12)10-18(31)29-7-6-15-17(29)5-4-14(20(15)23)16-9-28(3)22-19(16)21(24)25-11-26-22/h4-5,8-9,11H,6-7,10H2,1-3H3,(H2,24,25,26)
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n/an/a 99n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylation

ACS Med Chem Lett 4: 964-8 (2013)


Article DOI: 10.1021/ml400228e
BindingDB Entry DOI: 10.7270/Q24X597X
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347876
PNG
(CHEMBL1802782)
Show SMILES CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2c(C)[nH]c3ccc(Cl)cc23)cc1
Show InChI InChI=1S/C24H25ClN6/c1-16-23(20-15-17(25)3-8-21(20)27-16)22-9-10-26-24(29-22)28-18-4-6-19(7-5-18)31-13-11-30(2)12-14-31/h3-10,15,27H,11-14H2,1-2H3,(H,26,28,29)
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n/an/a 100n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347891
PNG
(CHEMBL1802629)
Show SMILES Cc1[nH]c2ccccc2c1-c1ccnc(Nc2cccnc2)n1
Show InChI InChI=1S/C18H15N5/c1-12-17(14-6-2-3-7-15(14)21-12)16-8-10-20-18(23-16)22-13-5-4-9-19-11-13/h2-11,21H,1H3,(H,20,22,23)
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n/an/a 100n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50466038
PNG
(CHEMBL4281823)
Show SMILES CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H22F3N5O2/c1-2-32-13-19(22-23(29)30-14-31-24(22)32)16-6-7-20-17(12-16)8-9-33(20)21(34)11-15-4-3-5-18(10-15)35-25(26,27)28/h3-7,10,12-14H,2,8-9,11H2,1H3,(H2,29,30,31)
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n/an/a 116n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...

Citation and Details
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308050
PNG
(US10011593, Ex. 2 | US9650366, 2)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1nn[nH]n1
Show InChI InChI=1S/C22H14ClF3N8OS/c23-16-3-1-13(8-15(16)22(24,25)26)30-21(35)29-12-2-4-17-10(5-12)7-18(36-17)14-6-11(9-28-19(14)27)20-31-33-34-32-20/h1-9H,(H2,27,28)(H2,29,30,35)(H,31,32,33,34)
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n/an/a 140n/an/an/an/an/an/a



Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347926
PNG
(CHEMBL1802778)
Show SMILES Cc1[nH]c2ccccc2c1-c1ccnc(Nc2ccc(F)cc2)n1
Show InChI InChI=1S/C19H15FN4/c1-12-18(15-4-2-3-5-16(15)22-12)17-10-11-21-19(24-17)23-14-8-6-13(20)7-9-14/h2-11,22H,1H3,(H,21,23,24)
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Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308060
PNG
(US10011593, Ex. 11 | US9650366, 11)
Show SMILES Nc1ncc(cc1C#Cc1cccc(NC(=O)Nc2ccc(Cl)c(c2)C(F)(F)F)c1)-c1nnn(CCCO)n1
Show InChI InChI=1S/C25H20ClF3N8O2/c26-21-8-7-19(13-20(21)25(27,28)29)33-24(39)32-18-4-1-3-15(11-18)5-6-16-12-17(14-31-22(16)30)23-34-36-37(35-23)9-2-10-38/h1,3-4,7-8,11-14,38H,2,9-10H2,(H2,30,31)(H2,32,33,39)
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n/an/a 158n/an/an/an/an/an/a



Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 167n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...

US Patent US10669265 (2020)


BindingDB Entry DOI: 10.7270/Q20R9SFZ
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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Allergan, Inc.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...

US Patent US10633373 (2020)


BindingDB Entry DOI: 10.7270/Q2Z60S37
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM364984
PNG
(6-amino-N-[dimethyl(oxido)- lambda4-sulfanylidene]...)
Show SMILES CS(C)(=O)=NC(=O)c1cnc(N)c(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H19F4N5O3S2/c1-38(2,36)33-22(34)13-8-16(21(29)30-11-13)20-9-12-7-15(4-6-19(12)37-20)31-23(35)32-18-10-14(24(26,27)28)3-5-17(18)25/h3-11H,1-2H3,(H2,29,30)(H2,31,32,35)
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n/an/a 167n/an/an/an/an/an/a



Amgen



Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...

J Med Chem 50: 3515-27 (2007)


BindingDB Entry DOI: 10.7270/Q2DB8465
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50466038
PNG
(CHEMBL4281823)
Show SMILES CCn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(OC(F)(F)F)c2)c2c(N)ncnc12
Show InChI InChI=1S/C25H22F3N5O2/c1-2-32-13-19(22-23(29)30-14-31-24(22)32)16-6-7-20-17(12-16)8-9-33(20)21(34)11-15-4-3-5-18(10-15)35-25(26,27)28/h3-7,10,12-14H,2,8-9,11H2,1H3,(H2,29,30,31)
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n/an/a 210n/an/an/an/an/an/a



Sichuan University/Collaborative Innovation Center of Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of recombinant human PKR (252 to end residues) using RSRSRSRSRSRSRS as substrate after 40 mins in presence of [gamma-33P]-ATP by scintilla...

J Med Chem 61: 11398-11414 (2018)


Article DOI: 10.1021/acs.jmedchem.8b01652
BindingDB Entry DOI: 10.7270/Q2377CDJ
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50230828
PNG
(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)
Show SMILES NC(=O)Nc1sc(cc1C(N)=O)-c1ccc(F)cc1
Show InChI InChI=1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
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n/an/a 250n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50173832
PNG
(4-(3-chloro-4-fluorophenylamino)-6-(pyridin-3-ylme...)
Show SMILES Fc1ccc(Nc2c(cnc3cnc(NCc4cccnc4)cc23)C#N)cc1Cl
Show InChI InChI=1S/C21H14ClFN6/c22-17-6-15(3-4-18(17)23)29-21-14(8-24)11-26-19-12-28-20(7-16(19)21)27-10-13-2-1-5-25-9-13/h1-7,9,11-12H,10H2,(H,26,29)(H,27,28)
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Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50396536
PNG
(CHEMBL2171122)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(Cl)c2)c2c(N)ncnc12
Show InChI InChI=1S/C23H20ClN5O/c1-28-12-18(21-22(25)26-13-27-23(21)28)15-5-6-19-16(11-15)7-8-29(19)20(30)10-14-3-2-4-17(24)9-14/h2-6,9,11-13H,7-8,10H2,1H3,(H2,25,26,27)
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n/an/a 291n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PKR assessed as EIF2AK2 phosphorylation

J Med Chem 55: 7193-207 (2012)


Article DOI: 10.1021/jm300713s
BindingDB Entry DOI: 10.7270/Q2222VWP
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347887
PNG
(CHEMBL1802769)
Show SMILES Cc1[nH]c2ccccc2c1-c1ccnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H15ClN4/c1-12-18(15-7-2-3-8-16(15)22-12)17-9-10-21-19(24-17)23-14-6-4-5-13(20)11-14/h2-11,22H,1H3,(H,21,23,24)
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Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308063
PNG
(US10011593, Ex. 14 | US9650366, 14)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1cnccn1
Show InChI InChI=1S/C25H16ClF3N6OS/c26-19-3-1-16(10-18(19)25(27,28)29)35-24(36)34-15-2-4-21-13(7-15)9-22(37-21)17-8-14(11-33-23(17)30)20-12-31-5-6-32-20/h1-12H,(H2,30,33)(H2,34,35,36)
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n/an/a 301n/an/an/an/an/an/a



Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		CHEMBL5271785
PNG
Show SMILES NCCCC[C@H](OP(O)(=O)CCCCc1ccc(F)cc1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C21H32FN2O6P/c22-17-11-9-16(10-12-17)6-2-4-15-31(28,29)30-19(8-1-3-13-23)20(25)24-14-5-7-18(24)21(26)27/h9-12,18-19H,1-8,13-15,23H2,(H,26,27)(H,28,29)/t18-,19-/m0/s1
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n/an/a 306n/an/an/an/an/an/a


TBA

Assay Description
In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...

Citation and Details
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50442162
PNG
(CHEMBL2441342)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2F)C(=O)Cc2cccc(n2)C(F)(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C23H18F4N6O/c1-32-10-15(19-21(28)29-11-30-22(19)32)13-5-6-16-14(20(13)24)7-8-33(16)18(34)9-12-3-2-4-17(31-12)23(25,26)27/h2-6,10-11H,7-9H2,1H3,(H2,28,29,30)
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n/an/a 359n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylation

ACS Med Chem Lett 4: 964-8 (2013)


Article DOI: 10.1021/ml400228e
BindingDB Entry DOI: 10.7270/Q24X597X
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		CHEMBL5266620
PNG
Show SMILES CC(=O)NCCCC[C@H](OP(O)(=O)CCCCc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C23H35N2O7P/c1-18(26)24-15-7-5-14-21(22(27)25-16-9-13-20(25)23(28)29)32-33(30,31)17-8-6-12-19-10-3-2-4-11-19/h2-4,10-11,20-21H,5-9,12-17H2,1H3,(H,24,26)(H,28,29)(H,30,31)/t20-,21-/m0/s1
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TBA

Assay Description
In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...

Citation and Details
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM365353
PNG
(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-16(4-6-20(13)36-21)30-23(34)31-17-3-5-19(25)18(10-17)24(26,27)28/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 390n/an/an/an/an/an/a



Amgen



Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...

J Med Chem 50: 3515-27 (2007)


BindingDB Entry DOI: 10.7270/Q2DB8465
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM365353
PNG
(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-16(4-6-20(13)36-21)30-23(34)31-17-3-5-19(25)18(10-17)24(26,27)28/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 390n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...

US Patent US10633373 (2020)


BindingDB Entry DOI: 10.7270/Q2Z60S37
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM365353
PNG
(5-{5-[({[4-chloro-3- (trifluoromethyl)phenyl]amino...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18ClF3N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-16(4-6-20(13)36-21)30-23(34)31-17-3-5-19(25)18(10-17)24(26,27)28/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 390n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...

US Patent US10669265 (2020)


BindingDB Entry DOI: 10.7270/Q20R9SFZ
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		CHEMBL5267979
PNG
Show SMILES CC(C)C[C@H](OP(O)(=O)CCCCc1ccccc1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C21H32NO6P/c1-16(2)15-19(20(23)22-13-8-12-18(22)21(24)25)28-29(26,27)14-7-6-11-17-9-4-3-5-10-17/h3-5,9-10,16,18-19H,6-8,11-15H2,1-2H3,(H,24,25)(H,26,27)/t18-,19-/m0/s1
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TBA

Assay Description
In vitro inhibitory activity against beta-2 adrenergic receptor was measured by the inhibition of isoproterenol-induced relaxation of PGF2-alpha cont...

Citation and Details
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM365352
PNG
(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 551n/an/an/an/an/an/a



Allergan, Inc.

US Patent


Assay Description
PKR: Commercially available recombinant human GST-PKR (1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2, 10 mM KCl, 10...

US Patent US10633373 (2020)


BindingDB Entry DOI: 10.7270/Q2Z60S37
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM365352
PNG
(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)
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n/an/a 551n/an/an/an/an/an/a



ALLERGAN, INC.

US Patent


Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...

US Patent US10669265 (2020)


BindingDB Entry DOI: 10.7270/Q20R9SFZ
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM365352
PNG
(N-[dimethyl(oxido)-lambda4- sulfanylidene]-5-{5-[(...)
Show SMILES CS(C)(=O)=NC(=O)c1cncc(c1)-c1cc2cc(NC(=O)Nc3cc(ccc3F)C(F)(F)F)ccc2s1
Show InChI InChI=1S/C24H18F4N4O3S2/c1-37(2,35)32-22(33)15-7-14(11-29-12-15)21-9-13-8-17(4-6-20(13)36-21)30-23(34)31-19-10-16(24(26,27)28)3-5-18(19)25/h3-12H,1-2H3,(H2,30,31,34)
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Amgen



Assay Description
Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, pH 7.2...

J Med Chem 50: 3515-27 (2007)


BindingDB Entry DOI: 10.7270/Q2DB8465
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308062
PNG
(US10011593, Ex. 13 | US9650366, 13)
Show SMILES Nc1ncc(cc1-c1cc2cc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)ccc2s1)-c1ncccn1
Show InChI InChI=1S/C25H16ClF3N6OS/c26-19-4-2-16(11-18(19)25(27,28)29)35-24(36)34-15-3-5-20-13(8-15)10-21(37-20)17-9-14(12-33-22(17)30)23-31-6-1-7-32-23/h1-12H,(H2,30,33)(H2,34,35,36)
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n/an/a 558n/an/an/an/an/an/a



Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347889
PNG
(CHEMBL1802630)
Show SMILES Cc1[nH]c2ccccc2c1-c1ccnc(Nc2ccc(Cl)cc2)n1
Show InChI InChI=1S/C19H15ClN4/c1-12-18(15-4-2-3-5-16(15)22-12)17-10-11-21-19(24-17)23-14-8-6-13(20)7-9-14/h2-11,22H,1H3,(H,21,23,24)
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n/an/a 600n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM7401
PNG
((2 Z,3 E)-6-Bromoindirubin-3 -oxime | (3E)-6-bromo...)
Show SMILES Brc1ccc2C(C(=O)Nc2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 600n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50396534
PNG
(CHEMBL2171124)
Show SMILES Cn1cc(-c2ccc3N(CCc3c2)C(=O)Cc2cccc(c2)C(F)(F)F)c2c(N)ncnc12
Show InChI InChI=1S/C24H20F3N5O/c1-31-12-18(21-22(28)29-13-30-23(21)31)15-5-6-19-16(11-15)7-8-32(19)20(33)10-14-3-2-4-17(9-14)24(25,26)27/h2-6,9,11-13H,7-8,10H2,1H3,(H2,28,29,30)
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n/an/a 696n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PKR assessed as EIF2AK2 phosphorylation

J Med Chem 55: 7193-207 (2012)


Article DOI: 10.1021/jm300713s
BindingDB Entry DOI: 10.7270/Q2222VWP
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM308049
PNG
(US10011593, Ex. 1 | US9650366, 1)
Show SMILES FC(F)(F)c1cc(NC(=O)Nc2ccc3sc(cc3c2)-c2cncc(c2)-c2nn[nH]n2)ccc1Cl
Show InChI InChI=1S/C22H13ClF3N7OS/c23-17-3-1-15(8-16(17)22(24,25)26)29-21(34)28-14-2-4-18-11(6-14)7-19(35-18)12-5-13(10-27-9-12)20-30-32-33-31-20/h1-10H,(H2,28,29,34)(H,30,31,32,33)
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n/an/a 727n/an/an/an/an/an/a



Vertex



Assay Description
PKR: Commercially available recombinant human GST-PKR (SignalChem, Canada; 1.5 uM-2 uM stock) is diluted to 500 nM in assay buffer (20 mM Tris-HCl, p...

J Med Chem 52: 6362-8 (2009)


BindingDB Entry DOI: 10.7270/Q24J0HGV
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347920
PNG
(CHEMBL1802486)
Show SMILES O=C1NCc2c1c1c3ccccc3n3C4CCC(O4)n4c5ccccc5c2c4c13
Show InChI InChI=1S/C24H17N3O2/c28-24-21-14(11-25-24)19-12-5-1-3-7-15(12)26-17-9-10-18(29-17)27-16-8-4-2-6-13(16)20(21)23(27)22(19)26/h1-8,17-18H,9-11H2,(H,25,28)
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n/an/a 750n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50442166
PNG
(CHEMBL2441340)
Show SMILES Cc1cccc(CC(=O)N2CCc3c2ccc(-c2cn(C)c4ncnc(N)c24)c3F)n1
Show InChI InChI=1S/C23H21FN6O/c1-13-4-3-5-14(28-13)10-19(31)30-9-8-16-18(30)7-6-15(21(16)24)17-11-29(2)23-20(17)22(25)26-12-27-23/h3-7,11-12H,8-10H2,1-2H3,(H2,25,26,27)
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n/an/a 905n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PKR (unknown origin) assessed as EIF2AK2 phosphorylation

ACS Med Chem Lett 4: 964-8 (2013)


Article DOI: 10.1021/ml400228e
BindingDB Entry DOI: 10.7270/Q24X597X
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50396531
PNG
(CHEMBL2171132)
Show SMILES Cn1cc(cn1)-c1cnc(N)c2c(csc12)-c1ccc2N(CCc2c1)C(=O)Cc1ccccc1
Show InChI InChI=1S/C27H23N5OS/c1-31-15-20(13-30-31)21-14-29-27(28)25-22(16-34-26(21)25)18-7-8-23-19(12-18)9-10-32(23)24(33)11-17-5-3-2-4-6-17/h2-8,12-16H,9-11H2,1H3,(H2,28,29)
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n/an/a 978n/an/an/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Inhibition of PKR assessed as EIF2AK2 phosphorylation

J Med Chem 55: 7193-207 (2012)


Article DOI: 10.1021/jm300713s
BindingDB Entry DOI: 10.7270/Q2222VWP
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50301356
PNG
(CHEMBL585927 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)
Show SMILES CNc1ccn(-c2ccccc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)cn1
Show InChI InChI=1S/C29H25N5O5/c1-30-21-12-14-34(18-7-5-4-6-8-18)29(36)27(21)28(35)33-26-10-9-19(17-32-26)39-23-11-13-31-22-16-25(38-3)24(37-2)15-20(22)23/h4-17,30H,1-3H3,(H,32,33,35)
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n/an/a>1.00E+3n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of PKR

Bioorg Med Chem Lett 19: 4924-8 (2009)


Article DOI: 10.1016/j.bmcl.2009.07.084
BindingDB Entry DOI: 10.7270/Q2N017G2
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347886
PNG
(CHEMBL1802771)
Show SMILES Cc1[nH]c2ccccc2c1-c1ccnc(Nc2ccc(F)c(F)c2)n1
Show InChI InChI=1S/C19H14F2N4/c1-11-18(13-4-2-3-5-16(13)23-11)17-8-9-22-19(25-17)24-12-6-7-14(20)15(21)10-12/h2-10,23H,1H3,(H,22,24,25)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347927
PNG
(CHEMBL1802623)
Show SMILES COc1ccc2[nH]c(C)c(-c3ccnc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H22N4O/c1-12-18(15-11-14(24-2)7-8-16(15)21-12)17-9-10-20-19(23-17)22-13-5-3-4-6-13/h7-11,13,21H,3-6H2,1-2H3,(H,20,22,23)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347902
PNG
(CHEMBL1802616)
Show SMILES COCCCNc1nccc(n1)-c1c(C)[nH]c2ccccc12
Show InChI InChI=1S/C17H20N4O/c1-12-16(13-6-3-4-7-14(13)20-12)15-8-10-19-17(21-15)18-9-5-11-22-2/h3-4,6-8,10,20H,5,9,11H2,1-2H3,(H,18,19,21)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM6878
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3n ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=S)Nc1c(F)cccc1F
Show InChI InChI=1S/C15H13F2N7O2S2/c16-10-2-1-3-11(17)12(10)21-15(27)24-13(18)22-14(23-24)20-8-4-6-9(7-5-8)28(19,25)26/h1-7H,(H,21,27)(H2,19,25,26)(H3,18,20,22,23)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347924
PNG
(CHEMBL1802728)
Show SMILES CCN(CC)C(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1
Show InChI InChI=1S/C23H30N6O2/c1-3-29(4-2)22(30)17-10-12-18(13-11-17)26-23-27-20-19(24-15-25-20)21(28-23)31-14-16-8-6-5-7-9-16/h10-13,15-16H,3-9,14H2,1-2H3,(H2,24,25,26,27,28)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347905
PNG
(CHEMBL1802613)
Show SMILES CSc1cccc(c1)N=CC1C(=O)Nc2ccccc12 |w:9.10|
Show InChI InChI=1S/C16H14N2OS/c1-20-12-6-4-5-11(9-12)17-10-14-13-7-2-3-8-15(13)18-16(14)19/h2-10,14H,1H3,(H,18,19)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
Interferon-induced, double-stranded RNA-activated protein kinase


(Homo sapiens (Human))		BDBM50347885
PNG
(CHEMBL1802773)
Show SMILES Cc1[nH]c2ccc(Cl)cc2c1-c1ccnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C19H14Cl2N4/c1-11-18(15-10-13(21)5-6-16(15)23-11)17-7-8-22-19(25-17)24-14-4-2-3-12(20)9-14/h2-10,23H,1H3,(H,22,24,25)
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n/an/a 2.50E+3n/an/an/an/an/an/a



Weill Cornell Medical College

Curated by ChEMBL


Assay Description
Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay

Bioorg Med Chem Lett 21: 4108-14 (2011)


Article DOI: 10.1016/j.bmcl.2011.04.149
BindingDB Entry DOI: 10.7270/Q2KK9C4H
More data for this
Ligand-Target Pair
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