Found 6 hits of ki data for polymerid = 50004239 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein delta homolog 1
(Homo sapiens (Human)) | BDBM50042942
(CHEMBL3355003)Show SMILES CC(C)n1nc(cc1C1CCN(C)CC1)-c1cnc2[nH]cc(c2c1)C(F)(F)F Show InChI InChI=1S/C20H24F3N5/c1-12(2)28-18(13-4-6-27(3)7-5-13)9-17(26-28)14-8-15-16(20(21,22)23)11-25-19(15)24-10-14/h8-13H,4-7H2,1-3H3,(H,24,25) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of DLK (unknown origin) by RT-FRET assay |
ACS Med Chem Lett 6: 11-2 (2015)
Article DOI: 10.1021/ml500347s
BindingDB Entry DOI: 10.7270/Q26W9CQT |
More data for this
Ligand-Target Pair | |
Protein delta homolog 1
(Homo sapiens (Human)) | BDBM50042940
(CHEMBL3355005)Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc2[nH]cc(c2c1)C(F)(F)F)C1COC1 |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 0.400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of DLK (unknown origin) by RT-FRET assay |
ACS Med Chem Lett 6: 11-2 (2015)
Article DOI: 10.1021/ml500347s
BindingDB Entry DOI: 10.7270/Q26W9CQT |
More data for this
Ligand-Target Pair | |
Protein delta homolog 1
(Homo sapiens (Human)) | BDBM4814
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| 6.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of DLK (unknown origin) |
J Med Chem 61: 8078-8087 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00370
BindingDB Entry DOI: 10.7270/Q2G163G3 |
More data for this
Ligand-Target Pair | |
Protein delta homolog 1
(Homo sapiens (Human)) | BDBM50004205
(MK-045 | MK-0457 | TOZASERTIB | US9249124, VX680 |...)Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)[nH]n2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1 Show InChI InChI=1S/C23H28N8OS/c1-15-13-20(29-28-15)25-19-14-21(31-11-9-30(2)10-12-31)27-23(26-19)33-18-7-5-17(6-8-18)24-22(32)16-3-4-16/h5-8,13-14,16H,3-4,9-12H2,1-2H3,(H,24,32)(H2,25,26,27,28,29) | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech
Curated by ChEMBL
| Assay Description
Inhibition of DLK (unknown origin) |
J Med Chem 61: 8078-8087 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00370
BindingDB Entry DOI: 10.7270/Q2G163G3 |
More data for this
Ligand-Target Pair | |
Protein delta homolog 1
(Homo sapiens (Human)) | BDBM50042941
(CHEMBL3355004)Show SMILES CC(C)n1nc(cc1C1CCN(C1)C1COC1)-c1cnc2[nH]cc(F)c2c1 | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of DLK (unknown origin) by RT-FRET assay |
ACS Med Chem Lett 6: 11-2 (2015)
Article DOI: 10.1021/ml500347s
BindingDB Entry DOI: 10.7270/Q26W9CQT |
More data for this
Ligand-Target Pair | |
Protein delta homolog 1
(Homo sapiens (Human)) | BDBM50042939
(CHEMBL3355006)Show SMILES [H][C@@]12CN(C[C@]1([H])[C@H]2c1cc(nn1C(C)C)-c1cnc(N)c2cn[nH]c12)C1COC1 |r| | KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 270 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Therachem Research Medilab (India) Pvt. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of DLK (unknown origin) by RT-FRET assay |
ACS Med Chem Lett 6: 11-2 (2015)
Article DOI: 10.1021/ml500347s
BindingDB Entry DOI: 10.7270/Q26W9CQT |
More data for this
Ligand-Target Pair | |
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