Compile Data Set for Download or QSAR

Found 57 hits of ec50 for UniProtKB: Q00613   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50071058 ((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,1...) Show SMILES C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O |r,c:15,17| Show InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,30-31H,1,9-14,16H2,2-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296067 (3-(benzo[d]thiazol-2-yl)-1-isobutyl-6-methylpyrimi...) Show SMILES CC(C)Cn1nc(nc2c1nc(=O)n(C)c2=O)-c1nc2ccccc2s1 Show InChI InChI=1S/C17H16N6O2S/c1-9(2)8-23-14-12(16(24)22(3)17(25)20-14)19-13(21-23)15-18-10-6-4-5-7-11(10)26-15/h4-7,9H,8H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296062 (1-butyl-6-methyl-3-(thiazol-2-yl)pyrimido[5,4-e][1...) Show SMILES CCCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1nccs1 Show InChI InChI=1S/C13H14N6O2S/c1-3-4-6-19-10-8(12(20)18(2)13(21)16-10)15-9(17-19)11-14-5-7-22-11/h5,7H,3-4,6H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296066 (3-(benzo[d]thiazol-2-yl)-1-isopentyl-6-methylpyrim...) Show SMILES CC(C)CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1nc2ccccc2s1 Show InChI InChI=1S/C18H18N6O2S/c1-10(2)8-9-24-15-13(17(25)23(3)18(26)21-15)20-14(22-24)16-19-11-6-4-5-7-12(11)27-16/h4-7,10H,8-9H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296064 (1-butyl-6-methyl-3-(quinolin-2-yl)pyrimido[5,4-e][...) Show SMILES CCCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc2ccccc2n1 Show InChI InChI=1S/C19H18N6O2/c1-3-4-11-25-17-15(18(26)24(2)19(27)22-17)21-16(23-25)14-10-9-12-7-5-6-8-13(12)20-14/h5-10H,3-4,11H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296065 (3-(benzo[d]thiazol-2-yl)-1-butyl-6-methylpyrimido[...) Show SMILES CCCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1nc2ccccc2s1 Show InChI InChI=1S/C17H16N6O2S/c1-3-4-9-23-14-12(16(24)22(2)17(25)20-14)19-13(21-23)15-18-10-7-5-6-8-11(10)26-15/h5-8H,3-4,9H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50071058 ((2R,4aS,6aS,12bR,14aS,14bR)-10-Hydroxy-2,4a,6a,9,1...) Show SMILES C[C@]12CC[C@](C)(C[C@H]1[C@]1(C)CC[C@]3(C)C(=CC=c4c3cc(O)c(O)c4=C)[C@@]1(C)CC2)C(O)=O |r,c:15,17| Show InChI InChI=1S/C29H38O4/c1-17-18-7-8-21-27(4,19(18)15-20(30)23(17)31)12-14-29(6)22-16-26(3,24(32)33)10-9-25(22,2)11-13-28(21,29)5/h7-8,15,22,30-31H,1,9-14,16H2,2-6H3,(H,32,33)/t22-,25-,26-,27+,28-,29+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human HeLa cells assessed as granule formation pretreated for 3 hrs by immunocytochemical staining				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296068 (3-(benzo[d]thiazol-2-yl)-1-benzyl-6-methylpyrimido...) Show SMILES Cn1c(=O)nc2n(Cc3ccccc3)nc(nc2c1=O)-c1nc2ccccc2s1 Show InChI InChI=1S/C20H14N6O2S/c1-25-19(27)15-17(23-20(25)28)26(11-12-7-3-2-4-8-12)24-16(22-15)18-21-13-9-5-6-10-14(13)29-18/h2-10H,11H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50468274 (CHEMBL4282794) Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)CCNC(=O)CCNC(=O)c1ccc(C(O)=O)c(c1)C1C2C=CC(=O)C=C2Oc2cc(O)ccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(N)=O |r,c:118,122| Show InChI InChI=1S/C100H140N24O38S/c1-44(2)27-59(83(104)143)114-94(154)64(35-74(103)130)119-98(158)69(41-125)124-97(157)68(39-81(141)142)120-88(148)58(22-26-163-8)111-84(144)47(7)109-89(149)66(37-79(137)138)121-90(150)60(28-45(3)4)116-92(152)62(31-49-40-105-43-108-49)117-96(156)67(38-80(139)140)122-99(159)70(42-126)123-91(151)61(29-46(5)6)115-87(147)57(18-19-77(133)134)113-93(153)63(34-73(102)129)118-86(146)56(11-9-10-23-101)112-95(155)65(36-78(135)136)110-76(132)21-24-106-75(131)20-25-107-85(145)48-12-15-52(100(160)161)55(30-48)82-53-16-13-50(127)32-71(53)162-72-33-51(128)14-17-54(72)82/h12-17,30,32-33,40,43-47,53,56-70,82,125-126,128H,9-11,18-29,31,34-39,41-42,101H2,1-8H3,(H2,102,129)(H2,103,130)(H2,104,143)(H,105,108)(H,106,131)(H,107,145)(H,109,149)(H,110,132)(H,111,144)(H,112,155)(H,113,153)(H,114,154)(H,115,147)(H,116,152)(H,117,156)(H,118,146)(H,119,158)(H,120,148)(H,121,150)(H,122,159)(H,123,151)(H,124,157)(H,133,134)(H,135,136)(H,137,138)(H,139,140)(H,141,142)(H,160,161)/t47-,53?,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a
University of California at San Francisco Curated by ChEMBL					Assay Description Binding affinity to recombinant human HSF1 monomer expressed in Escherichia coli BL21 (DE3) after 15 mins by fluorescence polarization assay				Bioorg Med Chem 26: 5299-5306 (2018) Article DOI: 10.1016/j.bmc.2018.04.018 BindingDB Entry DOI: 10.7270/Q2805593
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM31044 (1-Ethyl-6-methyl-3-thiophen-2-yl-1H-pyrimido[5,4-e...) Show SMILES CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1cccs1 Show InChI InChI=1S/C12H11N5O2S/c1-3-17-10-8(11(18)16(2)12(19)14-10)13-9(15-17)7-5-4-6-20-7/h4-6H,3H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296061 (1-butyl-3-(1H-imidazol-2-yl)-6-methylpyrimido[5,4-...) Show SMILES CCCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ncc[nH]1 Show InChI InChI=1S/C13H15N7O2/c1-3-4-7-20-11-8(12(21)19(2)13(22)17-11)16-10(18-20)9-14-5-6-15-9/h5-6H,3-4,7H2,1-2H3,(H,14,15)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	7.70E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50468274 (CHEMBL4282794) Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(O)=O)NC(=O)CCNC(=O)CCNC(=O)c1ccc(C(O)=O)c(c1)C1C2C=CC(=O)C=C2Oc2cc(O)ccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(N)=O |r,c:118,122| Show InChI InChI=1S/C100H140N24O38S/c1-44(2)27-59(83(104)143)114-94(154)64(35-74(103)130)119-98(158)69(41-125)124-97(157)68(39-81(141)142)120-88(148)58(22-26-163-8)111-84(144)47(7)109-89(149)66(37-79(137)138)121-90(150)60(28-45(3)4)116-92(152)62(31-49-40-105-43-108-49)117-96(156)67(38-80(139)140)122-99(159)70(42-126)123-91(151)61(29-46(5)6)115-87(147)57(18-19-77(133)134)113-93(153)63(34-73(102)129)118-86(146)56(11-9-10-23-101)112-95(155)65(36-78(135)136)110-76(132)21-24-106-75(131)20-25-107-85(145)48-12-15-52(100(160)161)55(30-48)82-53-16-13-50(127)32-71(53)162-72-33-51(128)14-17-54(72)82/h12-17,30,32-33,40,43-47,53,56-70,82,125-126,128H,9-11,18-29,31,34-39,41-42,101H2,1-8H3,(H2,102,129)(H2,103,130)(H2,104,143)(H,105,108)(H,106,131)(H,107,145)(H,109,149)(H,110,132)(H,111,144)(H,112,155)(H,113,153)(H,114,154)(H,115,147)(H,116,152)(H,117,156)(H,118,146)(H,119,158)(H,120,148)(H,121,150)(H,122,159)(H,123,151)(H,124,157)(H,133,134)(H,135,136)(H,137,138)(H,139,140)(H,141,142)(H,160,161)/t47-,53?,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,82?/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	>8.00E+3	n/a	n/a	n/a	n/a
University of California at San Francisco Curated by ChEMBL					Assay Description Binding affinity to recombinant human HSF1 monomer delta LZ1-3 mutant expressed in Escherichia coli BL21 (DE3) after 15 mins by fluorescence polariza...				Bioorg Med Chem 26: 5299-5306 (2018) Article DOI: 10.1016/j.bmc.2018.04.018 BindingDB Entry DOI: 10.7270/Q2805593
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296051 (1-butyl-6-methyl-3-(5-methylthiophen-2-yl)-5,7-dio...) Show SMILES CCCCn1nc(-c2ccc(C)s2)[n+]([O-])c2c1nc(=O)n(C)c2=O Show InChI InChI=1S/C15H17N5O3S/c1-4-5-8-19-13-11(14(21)18(3)15(22)16-13)20(23)12(17-19)10-7-6-9(2)24-10/h6-7H,4-5,8H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296052 (1-butyl-6-methyl-3-(5-methylfuran-2-yl)pyrimido[5,...) Show SMILES CCCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(C)o1 Show InChI InChI=1S/C15H17N5O3/c1-4-5-8-20-13-11(14(21)19(3)15(22)17-13)16-12(18-20)10-7-6-9(2)23-10/h6-7H,4-5,8H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296053 (1-butyl-6-methyl-3-(5-methylfuran-2-yl)-5,7-dioxo-...) Show SMILES CCCCn1nc(-c2ccc(C)o2)[n+]([O-])c2c1nc(=O)n(C)c2=O Show InChI InChI=1S/C15H17N5O4/c1-4-5-8-19-13-11(14(21)18(3)15(22)16-13)20(23)12(17-19)10-7-6-9(2)24-10/h6-7H,4-5,8H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296056 (1-ethyl-3-(furan-2-yl)-6-methylpyrimido[5,4-e][1,2...) Show SMILES CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccco1 Show InChI InChI=1S/C12H11N5O3/c1-3-17-10-8(11(18)16(2)12(19)14-10)13-9(15-17)7-5-4-6-20-7/h4-6H,3H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296072 (1-ethyl-6-methyl-3-(5-methylthiophen-2-yl)-5,7-dio...) Show SMILES CCn1nc(-c2ccc(C)s2)[n+]([O-])c2c1nc(=O)n(C)c2=O Show InChI InChI=1S/C13H13N5O3S/c1-4-17-11-9(12(19)16(3)13(20)14-11)18(21)10(15-17)8-6-5-7(2)22-8/h5-6H,4H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295793 (CHEMBL551057 | N-(2-hydroxy-3-(piperidin-1-yl)prop...) Show SMILES OC(CO\N=C(/Cl)c1nc2c(ccc3ccccc23)o1)CN1CCCCC1 Show InChI InChI=1S/C20H22ClN3O3/c21-19(23-26-13-15(25)12-24-10-4-1-5-11-24)20-22-18-16-7-3-2-6-14(16)8-9-17(18)27-20/h2-3,6-9,15,25H,1,4-5,10-13H2/b23-19-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.21E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295804 (CHEMBL564532 | N-(3-((cyclopropylmethyl)(isopropyl...) Show SMILES CC(C)N(CC(O)CO\N=C(/Cl)c1nc2ccccc2o1)CC1CC1 Show InChI InChI=1S/C18H24ClN3O3/c1-12(2)22(9-13-7-8-13)10-14(23)11-24-21-17(19)18-20-15-5-3-4-6-16(15)25-18/h3-6,12-14,23H,7-11H2,1-2H3/b21-17-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296069 (3-(benzo[d]thiazol-2-yl)-1-(4-fluorobenzyl)-6-meth...) Show SMILES Cn1c(=O)nc2n(Cc3ccc(F)cc3)nc(nc2c1=O)-c1nc2ccccc2s1 Show InChI InChI=1S/C20H13FN6O2S/c1-26-19(28)15-17(24-20(26)29)27(10-11-6-8-12(21)9-7-11)25-16(23-15)18-22-13-4-2-3-5-14(13)30-18/h2-9H,10H2,1H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296070 (1-butyl-6-methyl-3-phenylpyrimido[5,4-e][1,2,4]tri...) Show SMILES CCCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccccc1 Show InChI InChI=1S/C16H17N5O2/c1-3-4-10-21-14-12(15(22)20(2)16(23)18-14)17-13(19-21)11-8-6-5-7-9-11/h5-9H,3-4,10H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.48E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296059 (1-butyl-6-methyl-5,7-dioxo-3-(1H-pyrrol-2-yl)-1,5,...) Show SMILES CCCCn1nc(-c2ccc[nH]2)[n+]([O-])c2c1nc(=O)n(C)c2=O Show InChI InChI=1S/C14H16N6O3/c1-3-4-8-19-12-10(13(21)18(2)14(22)16-12)20(23)11(17-19)9-6-5-7-15-9/h5-7,15H,3-4,8H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.49E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295781 (CHEMBL554525 | N-(3-(tert-butyl(isopropyl)amino)-2...) Show SMILES CC(C)N(CC(O)CO\N=C(/Cl)c1nc2ccccc2o1)C(C)(C)C Show InChI InChI=1S/C18H26ClN3O3/c1-12(2)22(18(3,4)5)10-13(23)11-24-21-16(19)17-20-14-8-6-7-9-15(14)25-17/h6-9,12-13,23H,10-11H2,1-5H3/b21-16-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.66E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296050 (1-butyl-6-methyl-3-(5-methylthiophen-2-yl)pyrimido...) Show SMILES CCCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(C)s1 Show InChI InChI=1S/C15H17N5O2S/c1-4-5-8-20-13-11(14(21)19(3)15(22)17-13)16-12(18-20)10-7-6-9(2)23-10/h6-7H,4-5,8H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.68E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296071 (1-ethyl-6-methyl-3-(5-methylthiophen-2-yl)pyrimido...) Show SMILES CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc(C)s1 Show InChI InChI=1S/C13H13N5O2S/c1-4-18-11-9(12(19)17(3)13(20)15-11)14-10(16-18)8-6-5-7(2)21-8/h5-6H,4H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.73E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295788 (CHEMBL561119 | N-(3-(3,5-dimethylpiperidin-1-yl)-2...) Show SMILES CC1CC(C)CN(CC(O)CO\N=C(/Cl)c2nc3ccccc3o2)C1 Show InChI InChI=1S/C18H24ClN3O3/c1-12-7-13(2)9-22(8-12)10-14(23)11-24-21-17(19)18-20-15-5-3-4-6-16(15)25-18/h3-6,12-14,23H,7-11H2,1-2H3/b21-17-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.74E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295800 (7-fluoro-N-(2-hydroxy-3-(piperidin-1-yl)propoxy)be...) Show SMILES OC(CO\N=C(/Cl)c1nc2cccc(F)c2o1)CN1CCCCC1 Show InChI InChI=1S/C16H19ClFN3O3/c17-15(16-19-13-6-4-5-12(18)14(13)24-16)20-23-10-11(22)9-21-7-2-1-3-8-21/h4-6,11,22H,1-3,7-10H2/b20-15-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.85E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295801 (4-fluoro-N-(2-hydroxy-3-(piperidin-1-yl)propoxy)be...) Show SMILES OC(CO\N=C(/Cl)c1nc2c(F)cccc2o1)CN1CCCCC1 Show InChI InChI=1S/C16H19ClFN3O3/c17-15(16-19-14-12(18)5-4-6-13(14)24-16)20-23-10-11(22)9-21-7-2-1-3-8-21/h4-6,11,22H,1-3,7-10H2/b20-15-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.02E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296055 (1-ethyl-6-methyl-3-(5-methylfuran-2-yl)-5,7-dioxo-...) Show SMILES CCn1nc(-c2ccc(C)o2)[n+]([O-])c2c1nc(=O)n(C)c2=O Show InChI InChI=1S/C13H13N5O4/c1-4-17-11-9(12(19)16(3)13(20)14-11)18(21)10(15-17)8-6-5-7(2)22-8/h5-6H,4H2,1-3H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.06E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295784 (CHEMBL560657 | N-(3-(dibutylamino)-2-hydroxypropox...) Show SMILES CCCCN(CCCC)CC(O)CO\N=C(/Cl)c1nc2ccccc2o1 Show InChI InChI=1S/C19H28ClN3O3/c1-3-5-11-23(12-6-4-2)13-15(24)14-25-22-18(20)19-21-16-9-7-8-10-17(16)26-19/h7-10,15,24H,3-6,11-14H2,1-2H3/b22-18-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.09E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295797 (5-chloro-N-(2-hydroxy-3-(piperidin-1-yl)propoxy)be...) Show SMILES OC(CO\N=C(/Cl)c1nc2cc(Cl)ccc2o1)CN1CCCCC1 Show InChI InChI=1S/C16H19Cl2N3O3/c17-11-4-5-14-13(8-11)19-16(24-14)15(18)20-23-10-12(22)9-21-6-2-1-3-7-21/h4-5,8,12,22H,1-3,6-7,9-10H2/b20-15-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.09E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295805 (CHEMBL560380 | N-(3-((3-fluoropropyl)(isopropyl)am...) Show SMILES CC(C)N(CCCF)CC(O)CO\N=C(/Cl)c1nc2ccccc2o1 Show InChI InChI=1S/C17H23ClFN3O3/c1-12(2)22(9-5-8-19)10-13(23)11-24-21-16(18)17-20-14-6-3-4-7-15(14)25-17/h3-4,6-7,12-13,23H,5,8-11H2,1-2H3/b21-16-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.28E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295796 (6-chloro-N-(2-hydroxy-3-(piperidin-1-yl)propoxy)be...) Show SMILES OC(CO\N=C(/Cl)c1nc2ccc(Cl)cc2o1)CN1CCCCC1 Show InChI InChI=1S/C16H19Cl2N3O3/c17-11-4-5-13-14(8-11)24-16(19-13)15(18)20-23-10-12(22)9-21-6-2-1-3-7-21/h4-5,8,12,22H,1-3,6-7,9-10H2/b20-15-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.29E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295783 (CHEMBL549427 | N-(3-(ethyl(propyl)amino)-2-hydroxy...) Show SMILES CCCN(CC)CC(O)CO\N=C(/Cl)c1nc2ccccc2o1 Show InChI InChI=1S/C16H22ClN3O3/c1-3-9-20(4-2)10-12(21)11-22-19-15(17)16-18-13-7-5-6-8-14(13)23-16/h5-8,12,21H,3-4,9-11H2,1-2H3/b19-15-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295785 (CHEMBL552321 | N-(3-(dipropylamino)-2-hydroxypropo...) Show SMILES CCCN(CCC)CC(O)CO\N=C(/Cl)c1nc2ccccc2o1 Show InChI InChI=1S/C17H24ClN3O3/c1-3-9-21(10-4-2)11-13(22)12-23-20-16(18)17-19-14-7-5-6-8-15(14)24-17/h5-8,13,22H,3-4,9-12H2,1-2H3/b20-16-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.39E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295807 ((S)-N-(2-hydroxy-3-(isopropyl(propyl)amino)propoxy...) Show SMILES CCCN(C[C@H](O)CO\N=C(/Cl)c1nc2ccccc2o1)C(C)C |r| Show InChI InChI=1S/C17H24ClN3O3/c1-4-9-21(12(2)3)10-13(22)11-23-20-16(18)17-19-14-7-5-6-8-15(14)24-17/h5-8,12-13,22H,4,9-11H2,1-3H3/b20-16-/t13-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.41E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296058 (1-ethyl-6-methyl-5,7-dioxo-3-(1H-pyrrol-2-yl)-1,5,...) Show SMILES CCn1nc(-c2ccc[nH]2)[n+]([O-])c2c1nc(=O)n(C)c2=O Show InChI InChI=1S/C12H12N6O3/c1-3-17-10-8(11(19)16(2)12(20)14-10)18(21)9(15-17)7-5-4-6-13-7/h4-6,13H,3H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.47E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295782 (CHEMBL558309 | N-(3-(diisopropylamino)-2-hydroxypr...) Show SMILES CC(C)N(CC(O)CO\N=C(/Cl)c1nc2ccccc2o1)C(C)C Show InChI InChI=1S/C17H24ClN3O3/c1-11(2)21(12(3)4)9-13(22)10-23-20-16(18)17-19-14-7-5-6-8-15(14)24-17/h5-8,11-13,22H,9-10H2,1-4H3/b20-16-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.55E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295786 (CHEMBL552320 | N-(3-(diethylamino)-2-hydroxypropox...) Show SMILES CCN(CC)CC(O)CO\N=C(/Cl)c1nc2ccccc2o1 Show InChI InChI=1S/C15H20ClN3O3/c1-3-19(4-2)9-11(20)10-21-18-14(16)15-17-12-7-5-6-8-13(12)22-15/h5-8,11,20H,3-4,9-10H2,1-2H3/b18-14-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.71E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50414476 (CHEMBL2021569) Show SMILES CCCN(C[C@H](O)CC\C=C(/Cl)c1nc2ccccc2o1)C(C)C |r| Show InChI InChI=1S/C19H27ClN2O2/c1-4-12-22(14(2)3)13-15(23)8-7-9-16(20)19-21-17-10-5-6-11-18(17)24-19/h5-6,9-11,14-15,23H,4,7-8,12-13H2,1-3H3/b16-9-/t15-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.86E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295806 (CHEMBL561724 | N-(2-hydroxy-3-((2-hydroxyethyl)(is...) Show SMILES CC(C)N(CCO)CC(O)CO\N=C(/Cl)c1nc2ccccc2o1 Show InChI InChI=1S/C16H22ClN3O4/c1-11(2)20(7-8-21)9-12(22)10-23-19-15(17)16-18-13-5-3-4-6-14(13)24-16/h3-6,11-12,21-22H,7-10H2,1-2H3/b19-15-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.87E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295802 (6-fluoro-N-(2-hydroxy-3-(piperidin-1-yl)propoxy)be...) Show SMILES OC(CO\N=C(/Cl)c1nc2ccc(F)cc2o1)CN1CCCCC1 Show InChI InChI=1S/C16H19ClFN3O3/c17-15(16-19-13-5-4-11(18)8-14(13)24-16)20-23-10-12(22)9-21-6-2-1-3-7-21/h4-5,8,12,22H,1-3,6-7,9-10H2/b20-15-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.94E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295798 (CHEMBL550653 | N-(2-hydroxy-3-(piperidin-1-yl)prop...) Show SMILES Cc1ccc2nc(oc2c1)C(\Cl)=N\OCC(O)CN1CCCCC1 Show InChI InChI=1S/C17H22ClN3O3/c1-12-5-6-14-15(9-12)24-17(19-14)16(18)20-23-11-13(22)10-21-7-3-2-4-8-21/h5-6,9,13,22H,2-4,7-8,10-11H2,1H3/b20-16-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.10E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50414475 (CHEMBL2021570) Show SMILES CCCN(C[C@@H](O)CC\C=C(/Cl)c1nc2ccccc2o1)C(C)C |r| Show InChI InChI=1S/C19H27ClN2O2/c1-4-12-22(14(2)3)13-15(23)8-7-9-16(20)19-21-17-10-5-6-11-18(17)24-19/h5-6,9-11,14-15,23H,4,7-8,12-13H2,1-3H3/b16-9-/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.19E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295787 (CHEMBL557917 | N-(3-(2,6-dimethylpiperidin-1-yl)-2...) Show SMILES CC1CCCC(C)N1CC(O)CO\N=C(/Cl)c1nc2ccccc2o1 Show InChI InChI=1S/C18H24ClN3O3/c1-12-6-5-7-13(2)22(12)10-14(23)11-24-21-17(19)18-20-15-8-3-4-9-16(15)25-18/h3-4,8-9,12-14,23H,5-7,10-11H2,1-2H3/b21-17-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.24E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296057 (1-ethyl-6-methyl-3-(1H-pyrrol-2-yl)pyrimido[5,4-e]...) Show SMILES CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ccc[nH]1 Show InChI InChI=1S/C12H12N6O2/c1-3-18-10-8(11(19)17(2)12(20)15-10)14-9(16-18)7-5-4-6-13-7/h4-6,13H,3H2,1-2H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296060 (1-ethyl-3-(1H-imidazol-2-yl)-6-methylpyrimido[5,4-...) Show SMILES CCn1nc(nc2c1nc(=O)n(C)c2=O)-c1ncc[nH]1 Show InChI InChI=1S/C11H11N7O2/c1-3-18-9-6(10(19)17(2)11(20)15-9)14-8(16-18)7-12-4-5-13-7/h4-5H,3H2,1-2H3,(H,12,13)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	3.98E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50296063 (3-(1H-benzo[d]imidazol-2-yl)-1-butyl-6-methylpyrim...) Show SMILES CCCCn1nc(nc2c1nc(=O)n(C)c2=O)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C17H17N7O2/c1-3-4-9-24-15-12(16(25)23(2)17(26)21-15)20-14(22-24)13-18-10-7-5-6-8-11(10)19-13/h5-8H,3-4,9H2,1-2H3,(H,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.08E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Amplification of HSF1 transcriptional activity in human heat shock-induced HeLa cells assessed as granule formation treated 1 hr before heat shock ch...				Bioorg Med Chem Lett 19: 4303-7 (2009) Article DOI: 10.1016/j.bmcl.2009.05.073 BindingDB Entry DOI: 10.7270/Q2HD7VPC
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295794 (6-(N,N-dimethylsulfamoyl)-N-(2-hydroxy-3-(piperidi...) Show SMILES CN(C)S(=O)(=O)c1ccc2nc(oc2c1)C(\Cl)=N\OCC(O)CN1CCCCC1 Show InChI InChI=1S/C18H25ClN4O5S/c1-22(2)29(25,26)14-6-7-15-16(10-14)28-18(20-15)17(19)21-27-12-13(24)11-23-8-4-3-5-9-23/h6-7,10,13,24H,3-5,8-9,11-12H2,1-2H3/b21-17-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	4.16E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair
Heat shock factor protein 1 (Homo sapiens (Human))	BDBM50295799 (CHEMBL564701 | N-(2-hydroxy-3-(piperidin-1-yl)prop...) Show SMILES Cc1ccc2oc(nc2c1)C(\Cl)=N\OCC(O)CN1CCCCC1 Show InChI InChI=1S/C17H22ClN3O3/c1-12-5-6-15-14(9-12)19-17(24-15)16(18)20-23-11-13(22)10-21-7-3-2-4-8-21/h5-6,9,13,22H,2-4,7-8,10-11H2,1H3/b20-16-	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.16E+4	n/a	n/a	n/a	n/a
CytRx Corporation Curated by ChEMBL					Assay Description Transcriptional activation of HSF1 in heat shock stress-induced human HeLa cells assessed as granule formation treated 1 hr before heat shock challen...				Bioorg Med Chem Lett 19: 3128-35 (2009) Article DOI: 10.1016/j.bmcl.2009.03.011 BindingDB Entry DOI: 10.7270/Q23B605H
					More data for this Ligand-Target Pair

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