Found 6 hits of ki data for polymerid = 50004363 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alkaline phosphatase, tissue-nonspecific isozyme
(Homo sapiens (Human)) | BDBM50299523
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3 | PDB
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UniProtKB/SwissProt
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 340 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description Inhibition of TNAP using CDP-star as substrate by non-competitive Lineweaver-Burk plot |
J Med Chem 52: 6919-25 (2009)
Article DOI: 10.1021/jm900383s BindingDB Entry DOI: 10.7270/Q2WS8T9M |
More data for this Ligand-Target Pair | |
Alkaline phosphatase, tissue-nonspecific isozyme
(Homo sapiens (Human)) | BDBM50299523
(2,5-Dimethoxy-N-(quinolin-3-yl)benzenesulfonamide ...)Show InChI InChI=1S/C17H16N2O4S/c1-22-14-7-8-16(23-2)17(10-14)24(20,21)19-13-9-12-5-3-4-6-15(12)18-11-13/h3-11,19H,1-2H3 | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 590 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description Inhibition of TNAP using DEA as substrate by non-competitive Lineweaver-Burk plot |
J Med Chem 52: 6919-25 (2009)
Article DOI: 10.1021/jm900383s BindingDB Entry DOI: 10.7270/Q2WS8T9M |
More data for this Ligand-Target Pair | |
Alkaline phosphatase, tissue-nonspecific isozyme
(Homo sapiens (Human)) | BDBM50241179
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1 | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description Inhibition of TNSALP (unknown origin) |
Bioorg Med Chem Lett 19: 222-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.107 BindingDB Entry DOI: 10.7270/Q2CR5T64 |
More data for this Ligand-Target Pair | |
Alkaline phosphatase, tissue-nonspecific isozyme
(Homo sapiens (Human)) | BDBM50241179
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1 | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a | 9.8 | n/a |
Universit£ de Lyon
Curated by ChEMBL
| Assay Description Inhibition of human tissue non-specific alkaline phosphatase at pH 9.8 |
Bioorg Med Chem 17: 7290-300 (2009)
Article DOI: 10.1016/j.bmc.2009.08.048 BindingDB Entry DOI: 10.7270/Q2VM4CB4 |
More data for this Ligand-Target Pair | |
Alkaline phosphatase, tissue-nonspecific isozyme
(Homo sapiens (Human)) | BDBM10847
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9) | PDB
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 8.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Medical Research
Curated by ChEMBL
| Assay Description Inhibition of TNSALP (unknown origin) |
Bioorg Med Chem Lett 19: 222-5 (2008)
Article DOI: 10.1016/j.bmcl.2008.10.107 BindingDB Entry DOI: 10.7270/Q2CR5T64 |
More data for this Ligand-Target Pair | |
Alkaline phosphatase, tissue-nonspecific isozyme
(Homo sapiens (Human)) | BDBM50241179
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1 | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 9.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ Claude Bernard-Lyon 1
Curated by ChEMBL
| Assay Description Inhibition of recombinant TNAP |
Bioorg Med Chem Lett 21: 2297-301 (2011)
Article DOI: 10.1016/j.bmcl.2011.02.089 BindingDB Entry DOI: 10.7270/Q2V988CR |
More data for this Ligand-Target Pair | |