BindingDB PrimarySearch

Found 25 hits of ic50 for UniProtKB: O95382
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM523902 (2-amino-N-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM523902 (2-amino-N-[1-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6.46	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM523865 (2-amino-5-methyl-N-[1-(5-methyl-7H-pyrrolo[2,3-d]p...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.32	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM523862 (2-amino-5-fluoro-N-[1-(5-methyl-7H-pyrrolo[2,3-d]p...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description IMAP technology provides a homogeneous assay applicable to a wide variety of kinases, phosphatases, and phosphodiesterases without regard for substra...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM523901 (2-amino-5-chloro-N-[1-(5-methyl-7H-pyrrolo[2,3-d]p...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM523862 (2-amino-5-fluoro-N-[1-(5-methyl-7H-pyrrolo[2,3-d]p...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	19.5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description ASK1 and ASK2 biochemical activities were also quantified using AlphaScreen technology which measures the degree of phosphorylation of a protein subs...				Citation and Details BindingDB Entry DOI: 10.7270/Q2W95DB4
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	90.8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human MEKK6 using MBP as substrate by [gamma-33P]-ATP assay				Citation and Details Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551987 (CHEMBL4763562) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	201	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50552003 (CHEMBL4764071) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	264	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	475	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of human MEKK6 using MBP as substrate by [gamma-33P]-ATP assay				Eur J Med Chem 161: 456-467 (2019) Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50334268 (CHEMBL1642655 \| CHEMBL2205637 \| N-(6-(1H-imidazol-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	510	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Pharmaceutical Company Limited Curated by ChEMBL					Assay Description Inhibition of ASK2				Bioorg Med Chem Lett 22: 7326-9 (2012) Article DOI: 10.1016/j.bmcl.2012.10.084 BindingDB Entry DOI: 10.7270/Q2M32WXV
Takeda Pharmaceutical Company Limited Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551995 (CHEMBL4759182) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	742	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551972 (CHEMBL4776637) Show SMILES CC(C)n1cnnc1-c1cccc(NC(=O)Nc2ccccn2)n1 Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551992 (CHEMBL4751918) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.48E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551988 (CHEMBL4749551) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551989 (CHEMBL4795965) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551977 (CHEMBL4744931) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.78E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50552004 (CHEMBL4753203) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551994 (CHEMBL4750857) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.91E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551993 (CHEMBL4778358) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.86E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50551998 (CHEMBL4740051) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.99E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50552007 (CHEMBL4796925) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.29E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50212258 (GS-4997 \| Selonsertib) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.25E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50552006 (CHEMBL4752034) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 6 (Homo sapiens (Human))	BDBM50552005 (CHEMBL4761865) Show SMILES Show InChI	KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ASK2 (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112277 BindingDB Entry DOI: 10.7270/Q2GQ72D2
TBA					More data for this Ligand-Target Pair