Found 30 hits of ic50 for UniProtKB: Q9NY91 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50342885
((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1 |r| Show InChI InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+,21-,22-/m0/s1 | Reactome pathway
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| Article
PubMed
| n/a | n/a | 0.877 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr |
J Med Chem 54: 2952-60 (2011)
Article DOI: 10.1021/jm200049r
BindingDB Entry DOI: 10.7270/Q2NZ880H |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50342887
((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)ph...)Show SMILES COc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1 |r| Show InChI InChI=1S/C21H23ClO7/c1-27-15-5-2-12(3-6-15)8-13-9-14(4-7-16(13)22)21-19(26)17(24)18(25)20(10-23,29-21)11-28-21/h2-7,9,17-19,23-26H,8,10-11H2,1H3/t17-,18-,19+,20-,21-/m0/s1 | Reactome pathway
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| CHEMBL
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PC sid
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| Article
PubMed
| n/a | n/a | 0.882 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr |
J Med Chem 54: 2952-60 (2011)
Article DOI: 10.1021/jm200049r
BindingDB Entry DOI: 10.7270/Q2NZ880H |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50342889
((1S,2S,3S,4R,5S)-1-(Hydroxymethyl)-5-[3-(4-methoxy...)Show SMILES COc1ccc(Cc2cc(ccc2C)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1 |r| Show InChI InChI=1S/C22H26O7/c1-13-3-6-16(10-15(13)9-14-4-7-17(27-2)8-5-14)22-20(26)18(24)19(25)21(11-23,29-22)12-28-22/h3-8,10,18-20,23-26H,9,11-12H2,1-2H3/t18-,19-,20+,21-,22-/m0/s1 | Reactome pathway
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| Article
PubMed
| n/a | n/a | 1.07 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr |
J Med Chem 54: 2952-60 (2011)
Article DOI: 10.1021/jm200049r
BindingDB Entry DOI: 10.7270/Q2NZ880H |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50342888
((1S,2S,3S,4R,5S)-5-[3-(4-Ethoxybenzyl)-4-methylphe...)Show SMILES CCOc1ccc(Cc2cc(ccc2C)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@H]3O)cc1 |r| Show InChI InChI=1S/C23H28O7/c1-3-28-18-8-5-15(6-9-18)10-16-11-17(7-4-14(16)2)23-21(27)19(25)20(26)22(12-24,30-23)13-29-23/h4-9,11,19-21,24-27H,3,10,12-13H2,1-2H3/t19-,20-,21+,22-,23-/m0/s1 | Reactome pathway
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| CHEMBL
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PC sid
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| Article
PubMed
| n/a | n/a | 1.11 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr |
J Med Chem 54: 2952-60 (2011)
Article DOI: 10.1021/jm200049r
BindingDB Entry DOI: 10.7270/Q2NZ880H |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM20880
((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show InChI InChI=1S/C21H25ClO6/c1-2-27-15-6-3-12(4-7-15)9-14-10-13(5-8-16(14)22)21-20(26)19(25)18(24)17(11-23)28-21/h3-8,10,17-21,23-26H,2,9,11H2,1H3/t17-,18-,19+,20-,21+/m1/s1 | Reactome pathway
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| Article
PubMed
| n/a | n/a | 1.35 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting |
Bioorg Med Chem Lett 21: 3759-63 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.063
BindingDB Entry DOI: 10.7270/Q2NC61KM |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM20878
((2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-{2-[(4-methox...)Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 Show InChI InChI=1S/C20H24O7/c1-25-14-8-6-12(7-9-14)10-13-4-2-3-5-15(13)26-20-19(24)18(23)17(22)16(11-21)27-20/h2-9,16-24H,10-11H2,1H3/t16-,17-,18+,19-,20-/m1/s1 | Reactome pathway
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PC sid
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| Article
PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50313368
((6S,7R,8R,9S)-6-(3-(4-methoxybenzyl)-4-methylpheny...)Show SMILES COc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(COC3)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C22H26O6/c1-13-3-6-15(10-16(13)9-14-4-7-17(26-2)8-5-14)20-18(23)19(24)21(25)22(28-20)11-27-12-22/h3-8,10,18-21,23-25H,9,11-12H2,1-2H3/t18-,19-,20+,21+/m1/s1 | Reactome pathway
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| CHEMBL
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UniChem
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| Article
PubMed
| n/a | n/a | 6.98 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr |
J Med Chem 54: 2952-60 (2011)
Article DOI: 10.1021/jm200049r
BindingDB Entry DOI: 10.7270/Q2NZ880H |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351435
(CHEMBL1819489)Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(cc2)C2CC2)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C23H28O5/c24-13-18-12-20(22(26)23(27)21(18)25)28-19-4-2-1-3-17(19)11-14-5-7-15(8-6-14)16-9-10-16/h1-8,16,18,20-27H,9-13H2/t18-,20-,21-,22+,23+/m1/s1 | Reactome pathway
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM20875
(1-(2,4-dihydroxy-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihyd...)Show SMILES OC[C@H]1O[C@@H](Oc2cc(O)cc(O)c2C(=O)CCc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O Show InChI InChI=1S/C21H24O10/c22-9-16-18(27)19(28)20(29)21(31-16)30-15-8-12(24)7-14(26)17(15)13(25)6-3-10-1-4-11(23)5-2-10/h1-2,4-5,7-8,16,18-24,26-29H,3,6,9H2/t16-,18-,19+,20-,21-/m1/s1 | Reactome pathway
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| Article
PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351439
(CHEMBL1819492)Show SMILES CSc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C21H26O5S/c1-27-16-8-6-13(7-9-16)10-14-4-2-3-5-17(14)26-18-11-15(12-22)19(23)21(25)20(18)24/h2-9,15,18-25H,10-12H2,1H3/t15-,18-,19-,20+,21+/m1/s1 | Reactome pathway
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| CHEMBL
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PC sid
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| Article
PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351432
(CHEMBL1819486)Show SMILES CCc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C22H28O5/c1-2-14-7-9-15(10-8-14)11-16-5-3-4-6-18(16)27-19-12-17(13-23)20(24)22(26)21(19)25/h3-10,17,19-26H,2,11-13H2,1H3/t17-,19-,20-,21+,22+/m1/s1 | Reactome pathway
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PC sid
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| Article
PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351436
(CHEMBL1819490)Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(C=C)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C22H26O5/c1-2-14-7-9-15(10-8-14)11-16-5-3-4-6-18(16)27-19-12-17(13-23)20(24)22(26)21(19)25/h2-10,17,19-26H,1,11-13H2/t17-,19-,20-,21+,22+/m1/s1 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351437
(CHEMBL1819491)Show SMILES COc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C21H26O6/c1-26-16-8-6-13(7-9-16)10-14-4-2-3-5-17(14)27-18-11-15(12-22)19(23)21(25)20(18)24/h2-9,15,18-25H,10-12H2,1H3/t15-,18-,19-,20+,21+/m1/s1 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50342886
((1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-methoxybenzyl)-p...)Show SMILES COc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@@H]3O)cc1 |r| Show InChI InChI=1S/C21H23ClO7/c1-27-15-5-2-12(3-6-15)8-13-9-14(4-7-16(13)22)21-19(26)17(24)18(25)20(10-23,29-21)11-28-21/h2-7,9,17-19,23-26H,8,10-11H2,1H3/t17-,18-,19-,20-,21-/m0/s1 | Reactome pathway
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PC sid
UniChem
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| Article
PubMed
| n/a | n/a | 43.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr |
J Med Chem 54: 2952-60 (2011)
Article DOI: 10.1021/jm200049r
BindingDB Entry DOI: 10.7270/Q2NZ880H |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351431
(CHEMBL1819485)Show SMILES Cc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C21H26O5/c1-13-6-8-14(9-7-13)10-15-4-2-3-5-17(15)26-18-11-16(12-22)19(23)21(25)20(18)24/h2-9,16,18-25H,10-12H2,1H3/t16-,18-,19-,20+,21+/m1/s1 | Reactome pathway
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UniChem
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| Article
PubMed
| n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50345019
((2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(3-(4-(pent-2...)Show SMILES CC\C=C\COc1ccc(Cc2cccc(c2)[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C24H30O6/c1-2-3-4-12-29-19-10-8-16(9-11-19)13-17-6-5-7-18(14-17)24-23(28)22(27)21(26)20(15-25)30-24/h3-11,14,20-28H,2,12-13,15H2,1H3/b4-3+/t20-,21-,22+,23-,24+/m1/s1 | Reactome pathway
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| CHEMBL
PC cid
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UniChem
Similars
| Article
PubMed
| n/a | n/a | 59.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting |
Bioorg Med Chem Lett 21: 3759-63 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.063
BindingDB Entry DOI: 10.7270/Q2NC61KM |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50345022
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricycl...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCCCCCOc3ccc(Cc2c1)cc3 |r| Show InChI InChI=1S/C25H32O6/c26-15-21-22(27)23(28)24(29)25(31-21)18-9-8-17-5-3-1-2-4-12-30-20-10-6-16(7-11-20)13-19(17)14-18/h6-11,14,21-29H,1-5,12-13,15H2/t21-,22-,23+,24-,25+/m1/s1 | Reactome pathway
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 81.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting |
Bioorg Med Chem Lett 21: 3759-63 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.063
BindingDB Entry DOI: 10.7270/Q2NC61KM |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50345020
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(15-oxa-tricycl...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCC\C=C\COc3ccc(Cc2c1)cc3 |r,t:19| Show InChI InChI=1S/C25H30O6/c26-15-21-22(27)23(28)24(29)25(31-21)18-9-8-17-5-3-1-2-4-12-30-20-10-6-16(7-11-20)13-19(17)14-18/h2,4,6-11,14,21-29H,1,3,5,12-13,15H2/b4-2+/t21-,22-,23+,24-,25+/m1/s1 | Reactome pathway
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| n/a | n/a | 89.6 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting |
Bioorg Med Chem Lett 21: 3759-63 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.063
BindingDB Entry DOI: 10.7270/Q2NC61KM |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50342884
((1S,2S,3S,4S,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)-ph...)Show SMILES CCOc1ccc(Cc2cc(ccc2Cl)[C@]23OC[C@](CO)(O2)[C@@H](O)[C@H](O)[C@@H]3O)cc1 |r| Show InChI InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27)18(25)19(26)21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20-,21-,22-/m0/s1 | Reactome pathway
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| n/a | n/a | 89.9 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hr |
J Med Chem 54: 2952-60 (2011)
Article DOI: 10.1021/jm200049r
BindingDB Entry DOI: 10.7270/Q2NZ880H |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50345023
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricycl...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCCCCCCOc3ccc(Cc2c1)cc3 |r| Show InChI InChI=1S/C26H34O6/c27-16-22-23(28)24(29)25(30)26(32-22)19-10-9-18-6-4-2-1-3-5-13-31-21-11-7-17(8-12-21)14-20(18)15-19/h7-12,15,22-30H,1-6,13-14,16H2/t22-,23-,24+,25-,26+/m1/s1 | Reactome pathway
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| n/a | n/a | 99.7 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting |
Bioorg Med Chem Lett 21: 3759-63 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.063
BindingDB Entry DOI: 10.7270/Q2NC61KM |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50345021
((2R,3S,4R,5R,6S)-2-Hydroxymethyl-6-(16-oxa-tricycl...)Show SMILES OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)c1ccc2CCCC\C=C\COc3ccc(Cc2c1)cc3 |r,t:20| Show InChI InChI=1S/C26H32O6/c27-16-22-23(28)24(29)25(30)26(32-22)19-10-9-18-6-4-2-1-3-5-13-31-21-11-7-17(8-12-21)14-20(18)15-19/h3,5,7-12,15,22-30H,1-2,4,6,13-14,16H2/b5-3+/t22-,23-,24+,25-,26+/m1/s1 | Reactome pathway
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| n/a | n/a | 103 | n/a | n/a | n/a | n/a | n/a | n/a |
Green Cross Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells using methyl-alpha-D-glucopyranoside by liquid scintillation counting |
Bioorg Med Chem Lett 21: 3759-63 (2011)
Article DOI: 10.1016/j.bmcl.2011.04.063
BindingDB Entry DOI: 10.7270/Q2NC61KM |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351438
(CHEMBL1817688)Show SMILES CCOc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C22H28O6/c1-2-27-17-9-7-14(8-10-17)11-15-5-3-4-6-18(15)28-19-12-16(13-23)20(24)22(26)21(19)25/h3-10,16,19-26H,2,11-13H2,1H3/t16-,19-,20-,21+,22+/m1/s1 | Reactome pathway
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| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351443
(CHEMBL1819496)Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(cc2)C(F)(F)F)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C21H23F3O5/c22-21(23,24)15-7-5-12(6-8-15)9-13-3-1-2-4-16(13)29-17-10-14(11-25)18(26)20(28)19(17)27/h1-8,14,17-20,25-28H,9-11H2/t14-,17-,18-,19+,20+/m1/s1 | Reactome pathway
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351433
(CHEMBL1819487)Show SMILES CCCc1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C23H30O5/c1-2-5-15-8-10-16(11-9-15)12-17-6-3-4-7-19(17)28-20-13-18(14-24)21(25)23(27)22(20)26/h3-4,6-11,18,20-27H,2,5,12-14H2,1H3/t18-,20-,21-,22+,23+/m1/s1 | Reactome pathway
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| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351434
(CHEMBL1819488)Show SMILES CC(C)c1ccc(Cc2ccccc2O[C@@H]2C[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| Show InChI InChI=1S/C23H30O5/c1-14(2)16-9-7-15(8-10-16)11-17-5-3-4-6-19(17)28-20-12-18(13-24)21(25)23(27)22(20)26/h3-10,14,18,20-27H,11-13H2,1-2H3/t18-,20-,21-,22+,23+/m1/s1 | Reactome pathway
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351442
(CHEMBL1819495)Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(Cl)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C20H23ClO5/c21-15-7-5-12(6-8-15)9-13-3-1-2-4-16(13)26-17-10-14(11-22)18(23)20(25)19(17)24/h1-8,14,17-20,22-25H,9-11H2/t14-,17-,18-,19+,20+/m1/s1 | Reactome pathway
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| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351429
(CHEMBL450044)Show SMILES CCOC(=O)OCC1OC(Oc2ccccc2Cc2ccc(OC)cc2)C(O)C(O)C1O Show InChI InChI=1S/C23H28O9/c1-3-29-23(27)30-13-18-19(24)20(25)21(26)22(32-18)31-17-7-5-4-6-15(17)12-14-8-10-16(28-2)11-9-14/h4-11,18-22,24-26H,3,12-13H2,1-2H3 | Reactome pathway
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| n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351440
(CHEMBL1819493)Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C20H24O6/c21-11-14-10-17(19(24)20(25)18(14)23)26-16-4-2-1-3-13(16)9-12-5-7-15(22)8-6-12/h1-8,14,17-25H,9-11H2/t14-,17-,18-,19+,20+/m1/s1 | Reactome pathway
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| n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351441
(CHEMBL1819494)Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccc(F)cc2)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C20H23FO5/c21-15-7-5-12(6-8-15)9-13-3-1-2-4-16(13)26-17-10-14(11-22)18(23)20(25)19(17)24/h1-8,14,17-20,22-25H,9-11H2/t14-,17-,18-,19+,20+/m1/s1 | Reactome pathway
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| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
Solute carrier family 5 member 4
(Homo sapiens (Human)) | BDBM50351430
(CHEMBL1819484)Show SMILES OC[C@H]1C[C@@H](Oc2ccccc2Cc2ccccc2)[C@H](O)[C@@H](O)[C@@H]1O |r| Show InChI InChI=1S/C20H24O5/c21-12-15-11-17(19(23)20(24)18(15)22)25-16-9-5-4-8-14(16)10-13-6-2-1-3-7-13/h1-9,15,17-24H,10-12H2/t15-,17-,18-,19+,20+/m1/s1 | Reactome pathway
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| n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
Chugai Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description
Inhibition of human SGLT2 expressed in CHO cells assessed as [14C]AMG uptake after 45 mins |
Bioorg Med Chem 19: 5334-41 (2011)
Article DOI: 10.1016/j.bmc.2011.08.005
BindingDB Entry DOI: 10.7270/Q2F1903R |
More data for this
Ligand-Target Pair | |
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