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Compile Data Set for Download or QSAR

Found 8 hits of ic50 data for polymerid = 50005668   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily D member 2


(Rattus norvegicus)
BDBM50121975
PNG
((6-Methoxy-quinolin-4-yl)-(5-vinyl-1-aza-bicyclo[2...)
Show SMILES COc1ccc2nccc([C@H](O)[C@H]3C[C@@H]4CCN3C[C@@H]4C=C)c2c1 |r,THB:20:19:12.13:16.15,10:12:18.19:16.15|
Show InChI InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19+,20-/m0/s1
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n/an/a 2.20E+3n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv4.2 by patch-clamp method


J Med Chem 50: 2818-41 (2007)


Article DOI: 10.1021/jm0604528
BindingDB Entry DOI: 10.7270/Q29Z95QZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily D member 2


(Rattus norvegicus)
BDBM50213095
PNG
((1S,2S)-1-(1-Naphthalenethoxy)-2-(3-ketopyrrolidin...)
Show SMILES O=C1CCN(C1)[C@H]1CCCC[C@@H]1OCCc1cccc2ccccc12
Show InChI InChI=1S/C22H27NO2/c24-19-12-14-23(16-19)21-10-3-4-11-22(21)25-15-13-18-8-5-7-17-6-1-2-9-20(17)18/h1-2,5-9,21-22H,3-4,10-16H2/t21-,22-/m0/s1
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n/an/a 9.00E+3n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv4.2 by patch-clamp method


J Med Chem 50: 2818-41 (2007)


Article DOI: 10.1021/jm0604528
BindingDB Entry DOI: 10.7270/Q29Z95QZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily D member 2


(Rattus norvegicus)
BDBM50131434
PNG
(CHEMBL652 | FLECAINIDE | N-(piperidin-2-ylmethyl)-...)
Show SMILES FC(F)(F)COc1ccc(OCC(F)(F)F)c(c1)C(=O)NCC1CCCCN1
Show InChI InChI=1S/C17H20F6N2O3/c18-16(19,20)9-27-12-4-5-14(28-10-17(21,22)23)13(7-12)15(26)25-8-11-3-1-2-6-24-11/h4-5,7,11,24H,1-3,6,8-10H2,(H,25,26)
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n/an/a 1.01E+4n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv4.2 by patch-clamp method


J Med Chem 50: 2818-41 (2007)


Article DOI: 10.1021/jm0604528
BindingDB Entry DOI: 10.7270/Q29Z95QZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily D member 2


(Rattus norvegicus)
BDBM50213093
PNG
((1R,2R)-1-(1-naphthalenethoxy)-2-(3-ketopyrrolidin...)
Show SMILES O=C1CCN(C1)[C@@H]1CCCC[C@H]1OCCc1cccc2ccccc12
Show InChI InChI=1S/C22H27NO2/c24-19-12-14-23(16-19)21-10-3-4-11-22(21)25-15-13-18-8-5-7-17-6-1-2-9-20(17)18/h1-2,5-9,21-22H,3-4,10-16H2/t21-,22-/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv4.2 by patch-clamp method


J Med Chem 50: 2818-41 (2007)


Article DOI: 10.1021/jm0604528
BindingDB Entry DOI: 10.7270/Q29Z95QZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily D member 2


(Rattus norvegicus)
BDBM50213094
PNG
((1R,2R)-1-(3,4-dichlorophenethoxy)-2-(4-morpholiny...)
Show SMILES Clc1ccc(CCO[C@@H]2CCCC[C@H]2N2CCOCC2)cc1Cl
Show InChI InChI=1S/C18H25Cl2NO2/c19-15-6-5-14(13-16(15)20)7-10-23-18-4-2-1-3-17(18)21-8-11-22-12-9-21/h5-6,13,17-18H,1-4,7-12H2/t17-,18-/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv4.2 by patch-clamp method


J Med Chem 50: 2818-41 (2007)


Article DOI: 10.1021/jm0604528
BindingDB Entry DOI: 10.7270/Q29Z95QZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily D member 2


(Rattus norvegicus)
BDBM50213093
PNG
((1R,2R)-1-(1-naphthalenethoxy)-2-(3-ketopyrrolidin...)
Show SMILES O=C1CCN(C1)[C@@H]1CCCC[C@H]1OCCc1cccc2ccccc12
Show InChI InChI=1S/C22H27NO2/c24-19-12-14-23(16-19)21-10-3-4-11-22(21)25-15-13-18-8-5-7-17-6-1-2-9-20(17)18/h1-2,5-9,21-22H,3-4,10-16H2/t21-,22-/m1/s1
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n/an/a 1.10E+4n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv4.2 by patch-clamp method


J Med Chem 50: 2818-41 (2007)


Article DOI: 10.1021/jm0604528
BindingDB Entry DOI: 10.7270/Q29Z95QZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily D member 2


(Rattus norvegicus)
BDBM50213092
PNG
((1R,2R)-1-(1-naphthalenethoxy)-2-(4-morpholinyl)cy...)
Show SMILES C(Cc1cccc2ccccc12)O[C@@H]1CCCC[C@H]1N1CCOCC1
Show InChI InChI=1S/C22H29NO2/c1-2-9-20-18(6-1)7-5-8-19(20)12-15-25-22-11-4-3-10-21(22)23-13-16-24-17-14-23/h1-2,5-9,21-22H,3-4,10-17H2/t21-,22-/m1/s1
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n/an/a 1.70E+4n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv4.2 by patch-clamp method


J Med Chem 50: 2818-41 (2007)


Article DOI: 10.1021/jm0604528
BindingDB Entry DOI: 10.7270/Q29Z95QZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily D member 2


(Rattus norvegicus)
BDBM50017662
PNG
(2-(Diethylamino)-2',6'-acetoxylidide | 2-(Diethyla...)
Show SMILES CCN(CC)CC(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
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n/an/a 1.21E+6n/an/an/an/an/an/a



Cardiome Pharma Corporation

Curated by ChEMBL


Assay Description
Inhibition of rat potassium channel Kv4.2 by patch-clamp method


J Med Chem 50: 2818-41 (2007)


Article DOI: 10.1021/jm0604528
BindingDB Entry DOI: 10.7270/Q29Z95QZ
More data for this
Ligand-Target Pair