Found 415 hits of ic50 data for polymerid = 50005946,7978 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121523
(CHEMBL3616742)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C191H300N46O60/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-144(246)216-131(187(289)290)60-65-143(245)200-72-75-292-78-82-296-102-149(251)202-74-77-294-80-83-297-103-150(252)201-73-76-293-79-81-295-101-148(250)199-69-42-41-51-126(170(272)219-130(63-68-153(257)258)171(273)224-135(86-115-45-34-32-35-46-115)176(278)235-158(109(11)20-2)184(286)213-112(14)163(265)221-137(89-118-92-205-123-50-40-39-49-121(118)123)174(276)223-133(85-106(5)6)175(277)233-156(107(7)8)182(284)220-125(53-44-71-204-190(196)197)166(268)206-94-145(247)214-124(52-43-70-203-189(194)195)165(267)209-97-155(261)262)217-162(264)111(13)211-161(263)110(12)212-169(271)129(59-64-142(193)244)215-146(248)95-207-167(269)127(61-66-151(253)254)218-172(274)132(84-105(3)4)222-173(275)134(88-117-55-57-120(243)58-56-117)225-179(281)139(98-238)228-181(283)141(100-240)229-183(285)157(108(9)10)234-178(280)138(91-154(259)260)226-180(282)140(99-239)230-186(288)160(114(16)242)236-177(279)136(87-116-47-36-33-37-48-116)227-185(287)159(113(15)241)232-147(249)96-208-168(270)128(62-67-152(255)256)231-188(291)191(17,18)237-164(266)122(192)90-119-93-198-104-210-119/h32-37,39-40,45-50,55-58,92-93,104-114,122,124-141,156-160,205,238-243H,19-31,38,41-44,51-54,59-91,94-103,192H2,1-18H3,(H2,193,244)(H,198,210)(H,199,250)(H,200,245)(H,201,252)(H,202,251)(H,206,268)(H,207,269)(H,208,270)(H,209,267)(H,211,263)(H,212,271)(H,213,286)(H,214,247)(H,215,248)(H,216,246)(H,217,264)(H,218,274)(H,219,272)(H,220,284)(H,221,265)(H,222,275)(H,223,276)(H,224,273)(H,225,281)(H,226,282)(H,227,287)(H,228,283)(H,229,285)(H,230,288)(H,231,291)(H,232,249)(H,233,277)(H,234,280)(H,235,278)(H,236,279)(H,237,266)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,289,290)(H4,194,195,203)(H4,196,197,204)/t109-,110-,111-,112-,113+,114+,122-,124-,125-,126-,127-,128-,129-,130-,131+,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM559792
(WO2022109182, Example 23)Show SMILES OC(=O)c1cc(F)c2nc(CN3CCN(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| WIPO WO2022109182
| n/a | n/a | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
GLP-1R activation by small molecule agonists is quantified by measuring cAMP increase in CHO cells stably expressing GLP-1R (MultiSpan product # C126... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q27D2ZC6 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50120380
(CHEMBL3616743)Show SMILES CCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C187H293N45O57/c1-19-21-22-23-24-25-26-27-28-29-30-31-32-33-40-56-141(241)211-128(183(283)284)62-67-140(240)196-74-76-286-78-81-289-100-146(246)197-75-77-287-79-80-288-99-145(245)195-71-44-43-53-123(166(266)214-127(65-70-149(251)252)167(267)219-132(84-112-47-36-34-37-48-112)172(272)230-154(106(11)20-2)180(280)208-109(14)159(259)216-134(87-115-90-200-120-52-42-41-51-118(115)120)170(270)218-130(83-103(5)6)171(271)228-152(104(7)8)178(278)215-122(55-46-73-199-186(192)193)162(262)201-92-142(242)209-121(54-45-72-198-185(190)191)161(261)204-95-151(255)256)212-158(258)108(13)206-157(257)107(12)207-165(265)126(61-66-139(189)239)210-143(243)93-202-163(263)124(63-68-147(247)248)213-168(268)129(82-102(3)4)217-169(269)131(86-114-57-59-117(238)60-58-114)220-175(275)136(96-233)223-177(277)138(98-235)224-179(279)153(105(9)10)229-174(274)135(89-150(253)254)221-176(276)137(97-234)225-182(282)156(111(16)237)231-173(273)133(85-113-49-38-35-39-50-113)222-181(281)155(110(15)236)227-144(244)94-203-164(264)125(64-69-148(249)250)226-184(285)187(17,18)232-160(260)119(188)88-116-91-194-101-205-116/h34-39,41-42,47-52,57-60,90-91,101-111,119,121-138,152-156,200,233-238H,19-33,40,43-46,53-56,61-89,92-100,188H2,1-18H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,262)(H,202,263)(H,203,264)(H,204,261)(H,206,257)(H,207,265)(H,208,280)(H,209,242)(H,210,243)(H,211,241)(H,212,258)(H,213,268)(H,214,266)(H,215,278)(H,216,259)(H,217,269)(H,218,270)(H,219,267)(H,220,275)(H,221,276)(H,222,281)(H,223,277)(H,224,279)(H,225,282)(H,226,285)(H,227,244)(H,228,271)(H,229,274)(H,230,272)(H,231,273)(H,232,260)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,283,284)(H4,190,191,198)(H4,192,193,199)/t106-,107-,108-,109-,110+,111+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM559790
(WO2022109182, Example 21)Show SMILES OC(=O)c1cc(F)c2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| WIPO WO2022109182
| n/a | n/a | 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
GLP-1R activation by small molecule agonists is quantified by measuring cAMP increase in CHO cells stably expressing GLP-1R (MultiSpan product # C126... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q27D2ZC6 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121399
(CHEMBL3616764)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C187H291N43O59/c1-18-106(10)155(181(280)206-109(13)160(259)214-134(87-115-90-198-120-51-40-39-50-118(115)120)171(270)216-130(83-103(4)5)172(271)226-153(104(6)7)179(278)213-122(52-41-43-71-188)163(262)199-92-142(240)207-121(54-45-73-197-186(191)192)162(261)202-95-152(255)256)228-173(272)132(84-112-46-33-31-34-47-112)217-168(267)127(65-70-150(251)252)212-167(266)123(53-42-44-72-194-145(243)99-288-80-79-287-77-75-196-146(244)100-289-81-78-286-76-74-195-140(238)67-62-128(184(283)284)209-141(239)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-56-147(245)246)210-159(258)108(12)204-158(257)107(11)205-166(265)126(61-66-139(190)237)208-143(241)93-200-164(263)124(63-68-148(247)248)211-169(268)129(82-102(2)3)215-170(269)131(86-114-57-59-117(236)60-58-114)218-176(275)136(96-231)221-178(277)138(98-233)222-180(279)154(105(8)9)227-175(274)135(89-151(253)254)219-177(276)137(97-232)223-183(282)157(111(15)235)229-174(273)133(85-113-48-35-32-36-49-113)220-182(281)156(110(14)234)225-144(242)94-201-165(264)125(64-69-149(249)250)224-185(285)187(16,17)230-161(260)119(189)88-116-91-193-101-203-116/h31-36,39-40,46-51,57-60,90-91,101-111,119,121-138,153-157,198,231-236H,18-30,37-38,41-45,52-56,61-89,92-100,188-189H2,1-17H3,(H2,190,237)(H,193,203)(H,194,243)(H,195,238)(H,196,244)(H,199,262)(H,200,263)(H,201,264)(H,202,261)(H,204,257)(H,205,265)(H,206,280)(H,207,240)(H,208,241)(H,209,239)(H,210,258)(H,211,268)(H,212,266)(H,213,278)(H,214,259)(H,215,269)(H,216,270)(H,217,267)(H,218,275)(H,219,276)(H,220,281)(H,221,277)(H,222,279)(H,223,282)(H,224,285)(H,225,242)(H,226,271)(H,227,274)(H,228,272)(H,229,273)(H,230,260)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,283,284)(H4,191,192,197)/t106-,107-,108-,109-,110+,111+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,153-,154-,155-,156-,157-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121405
(CHEMBL3616767)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C191H300N44O59/c1-18-109(10)158(185(285)210-112(13)163(263)219-138(91-118-94-203-123-53-40-39-52-121(118)123)175(275)221-134(87-106(4)5)176(276)231-156(107(6)7)183(283)218-125(54-41-44-74-192)166(266)204-96-146(245)211-124(57-47-77-202-190(196)197)165(265)206-98-155(259)260)233-177(277)136(88-115-48-33-31-34-49-115)222-172(272)131(68-73-153(255)256)216-169(269)126(55-42-45-75-193)213-162(262)111(12)208-161(261)110(11)209-168(268)129(64-69-143(195)242)215-170(270)127(56-43-46-76-199-148(247)102-293-84-83-292-81-79-201-149(248)103-294-85-82-291-80-78-200-144(243)70-65-132(188(288)289)212-145(244)58-37-29-27-25-23-21-19-20-22-24-26-28-30-38-59-150(249)250)214-171(271)130(67-72-152(253)254)217-173(273)133(86-105(2)3)220-174(274)135(90-117-60-62-120(241)63-61-117)223-180(280)140(99-236)226-182(282)142(101-238)227-184(284)157(108(8)9)232-179(279)139(93-154(257)258)224-181(281)141(100-237)228-187(287)160(114(15)240)234-178(278)137(89-116-50-35-32-36-51-116)225-186(286)159(113(14)239)230-147(246)97-205-167(267)128(66-71-151(251)252)229-189(290)191(16,17)235-164(264)122(194)92-119-95-198-104-207-119/h31-36,39-40,48-53,60-63,94-95,104-114,122,124-142,156-160,203,236-241H,18-30,37-38,41-47,54-59,64-93,96-103,192-194H2,1-17H3,(H2,195,242)(H,198,207)(H,199,247)(H,200,243)(H,201,248)(H,204,266)(H,205,267)(H,206,265)(H,208,261)(H,209,268)(H,210,285)(H,211,245)(H,212,244)(H,213,262)(H,214,271)(H,215,270)(H,216,269)(H,217,273)(H,218,283)(H,219,263)(H,220,274)(H,221,275)(H,222,272)(H,223,280)(H,224,281)(H,225,286)(H,226,282)(H,227,284)(H,228,287)(H,229,290)(H,230,246)(H,231,276)(H,232,279)(H,233,277)(H,234,278)(H,235,264)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,288,289)(H4,196,197,202)/t109-,110-,111-,112-,113+,114+,122-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,156-,157-,158-,159-,160-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM559789
(2-[[4-[6-[(4-cyano-2-fluoro-phenyl)methoxy]-5-fluo...)Show SMILES OC(=O)c1cc(F)c2nc(CN3CCC(CC3)c3ccc(F)c(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| WIPO WO2022109182
| n/a | n/a | 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
GLP-1R activation by small molecule agonists is quantified by measuring cAMP increase in CHO cells stably expressing GLP-1R (MultiSpan product # C126... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q27D2ZC6 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121527
(CHEMBL3616718)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C152H230N42O47/c1-18-77(10)120(146(238)171-80(13)125(217)178-104(60-86-63-163-91-36-26-25-35-89(86)91)136(228)180-100(56-74(4)5)137(229)190-118(75(6)7)144(236)177-93(39-30-54-162-151(158)159)128(220)164-65-110(202)172-92(38-29-53-161-150(156)157)127(219)167-68-117(213)214)192-138(230)102(57-83-31-21-19-22-32-83)181-133(225)98(47-51-115(209)210)176-132(224)94(37-27-28-52-153)174-124(216)79(12)169-123(215)78(11)170-131(223)97(44-48-109(155)201)173-111(203)66-165-129(221)95(45-49-113(205)206)175-134(226)99(55-73(2)3)179-135(227)101(59-85-40-42-88(200)43-41-85)182-141(233)106(69-195)185-143(235)108(71-197)186-145(237)119(76(8)9)191-140(232)105(62-116(211)212)183-142(234)107(70-196)187-148(240)122(82(15)199)193-139(231)103(58-84-33-23-20-24-34-84)184-147(239)121(81(14)198)189-112(204)67-166-130(222)96(46-50-114(207)208)188-149(241)152(16,17)194-126(218)90(154)61-87-64-160-72-168-87/h19-26,31-36,40-43,63-64,72-82,90,92-108,118-122,163,195-200H,18,27-30,37-39,44-62,65-71,153-154H2,1-17H3,(H2,155,201)(H,160,168)(H,164,220)(H,165,221)(H,166,222)(H,167,219)(H,169,215)(H,170,223)(H,171,238)(H,172,202)(H,173,203)(H,174,216)(H,175,226)(H,176,224)(H,177,236)(H,178,217)(H,179,227)(H,180,228)(H,181,225)(H,182,233)(H,183,234)(H,184,239)(H,185,235)(H,186,237)(H,187,240)(H,188,241)(H,189,204)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,194,218)(H,205,206)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,156,157,161)(H4,158,159,162)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,118-,119-,120-,121-,122-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121402
(CHEMBL3616772)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C193H303N49O60/c1-18-108(10)158(184(291)217-111(13)163(270)226-137(89-117-92-209-122-51-40-39-50-120(117)122)174(281)228-133(85-105(4)5)175(282)238-156(106(6)7)182(289)225-124(54-44-74-207-191(198)199)166(273)211-94-145(252)218-123(53-43-73-206-190(196)197)165(272)210-96-147(254)221-130(187(294)295)52-41-42-72-203-149(256)101-301-82-81-300-79-77-205-150(257)102-302-83-80-299-78-76-204-143(250)68-63-131(188(296)297)220-144(251)56-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-151(258)259)240-176(283)135(86-114-46-33-31-34-47-114)229-171(278)129(66-71-154(264)265)224-170(277)125(55-45-75-208-192(200)201)222-162(269)110(12)215-161(268)109(11)216-169(276)128(62-67-142(195)249)219-146(253)95-212-167(274)126(64-69-152(260)261)223-172(279)132(84-104(2)3)227-173(280)134(88-116-58-60-119(248)61-59-116)230-179(286)139(98-243)233-181(288)141(100-245)234-183(290)157(107(8)9)239-178(285)138(91-155(266)267)231-180(287)140(99-244)235-186(293)160(113(15)247)241-177(284)136(87-115-48-35-32-36-49-115)232-185(292)159(112(14)246)237-148(255)97-213-168(275)127(65-70-153(262)263)236-189(298)193(16,17)242-164(271)121(194)90-118-93-202-103-214-118/h31-36,39-40,46-51,58-61,92-93,103-113,121,123-141,156-160,209,243-248H,18-30,37-38,41-45,52-57,62-91,94-102,194H2,1-17H3,(H2,195,249)(H,202,214)(H,203,256)(H,204,250)(H,205,257)(H,210,272)(H,211,273)(H,212,274)(H,213,275)(H,215,268)(H,216,276)(H,217,291)(H,218,252)(H,219,253)(H,220,251)(H,221,254)(H,222,269)(H,223,279)(H,224,277)(H,225,289)(H,226,270)(H,227,280)(H,228,281)(H,229,278)(H,230,286)(H,231,287)(H,232,292)(H,233,288)(H,234,290)(H,235,293)(H,236,298)(H,237,255)(H,238,282)(H,239,285)(H,240,283)(H,241,284)(H,242,271)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,266,267)(H,294,295)(H,296,297)(H4,196,197,206)(H4,198,199,207)(H4,200,201,208)/t108-,109-,110-,111-,112+,113+,121-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121518
(CHEMBL428139)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O |wU:119.121,95.99,89.93,105.111,142.150,8.16,195.200,134.137,69.74,28.34,210.215,223.228,156.159,164.169,167.172,42.43,176.180,2.2,wD:113.117,123.133,101.103,203.208,4.4,181.184,77.87,19.25,47.53,60.66,37.38,151.154,(42.46,-37.33,;42.37,-38.87,;40.99,-39.57,;39.7,-38.74,;40.89,-41.1,;42.2,-41.97,;43.56,-41.27,;43.68,-39.74,;44.87,-42.13,;44.77,-43.67,;43.39,-44.36,;42.09,-43.51,;40.71,-44.19,;40.63,-45.74,;41.92,-46.56,;43.3,-45.88,;46.26,-41.41,;48.15,-38.22,;50.19,-38.22,;47.05,-35.91,;45.48,-36.01,;44.58,-34.7,;43,-34.7,;42.23,-33.32,;42.2,-36.08,;47.71,-34.5,;46.82,-33.25,;45.29,-33.35,;47.5,-31.88,;49.02,-31.71,;49.9,-33.02,;51.45,-32.86,;52.3,-34.13,;53.88,-34.01,;46.61,-30.57,;47.28,-29.18,;48.81,-29.04,;46.4,-27.9,;44.85,-28.05,;47.1,-26.52,;46.18,-25.27,;44.66,-25.37,;46.88,-23.89,;48.41,-23.75,;45.97,-22.6,;46.65,-21.19,;48.2,-21.08,;45.79,-19.94,;44.22,-20.08,;43.56,-21.45,;42.02,-21.57,;41.15,-20.3,;41.38,-22.93,;46.44,-18.58,;45.53,-17.27,;44.01,-17.37,;46.23,-15.88,;45.34,-14.62,;46.02,-13.23,;47.54,-13.1,;45.15,-11.97,;43.61,-12.08,;42.91,-13.45,;41.38,-13.59,;40.52,-12.3,;40.73,-14.97,;45.81,-10.56,;44.94,-9.3,;43.4,-9.41,;45.62,-7.92,;47.14,-7.76,;47.99,-9.02,;47.37,-10.45,;49.57,-8.92,;44.71,-6.63,;45.37,-5.25,;46.93,-5.14,;44.5,-3.99,;43,-4.11,;42.31,-5.49,;43.19,-6.74,;42.53,-8.16,;40.99,-8.27,;40.3,-9.63,;40.07,-6.99,;40.77,-5.6,;45.15,-2.58,;44.28,-1.32,;43.19,-2.21,;44.97,.09,;46.51,.19,;47.37,-1.06,;44.05,1.35,;42.74,.58,;42.74,-.96,;41.38,1.35,;41.38,2.88,;42.74,3.65,;40.07,.58,;38.72,1.35,;38.72,2.88,;37.4,.58,;36.05,1.35,;34.73,.58,;34.73,-.96,;33.4,1.35,;33.4,2.88,;34.73,3.65,;36.05,2.88,;34.73,5.21,;32.06,.58,;30.7,1.35,;30.7,2.88,;29.39,.58,;29.39,-.96,;30.7,-1.72,;28.01,1.35,;26.72,.58,;26.72,-.96,;25.34,1.35,;24.03,.58,;22.71,1.35,;22.71,2.88,;21.34,.58,;21.34,-.96,;22.71,-1.72,;24.03,-.96,;25.34,-1.72,;25.34,-3.24,;24.03,-4.06,;22.71,-3.24,;20.04,1.35,;18.69,.58,;18.69,-.96,;17.34,1.35,;16,.58,;14.66,1.35,;14.66,2.88,;13.31,.58,;11.99,1.35,;10.66,.58,;10.66,-.96,;9.3,1.35,;9.3,2.88,;10.66,3.65,;10.66,5.21,;9.3,5.97,;11.99,5.97,;7.98,.58,;6.63,1.35,;6.63,2.88,;5.32,.58,;5.32,-.96,;3.97,1.35,;2.61,.58,;2.61,-.96,;1.3,1.35,;-.02,.58,;1.3,2.88,;2.61,3.65,;4.03,3.04,;5.09,4.18,;4.29,5.54,;2.79,5.21,;17.34,2.88,;16,3.65,;18.69,3.65,;25.34,2.88,;24.03,3.65,;26.72,3.65,;37.4,-.96,;36.05,-1.72,;38.72,-1.72,;39.51,-41.81,;39.42,-43.34,;38.22,-40.98,;36.86,-41.69,;36.79,-43.21,;35.55,-40.81,;35.64,-39.3,;34.19,-41.52,;32.88,-40.66,;32.98,-39.14,;31.68,-38.27,;30.24,-38.81,;29.25,-37.61,;30.14,-36.35,;29.72,-34.87,;30.8,-33.77,;32.32,-34.17,;32.71,-35.65,;31.62,-36.77,;31.52,-41.36,;31.41,-42.91,;30.21,-40.54,;28.83,-41.24,;28.76,-42.74,;27.37,-43.45,;27.31,-44.97,;26.09,-42.6,;27.52,-40.38,;27.62,-38.81,;26.16,-41.08,;24.85,-40.23,;24.97,-38.71,;23.66,-37.83,;26.33,-37.99,;23.49,-40.94,;23.42,-42.46,;22.22,-40.07,;20.82,-40.78,;20.71,-42.3,;19.35,-43.02,;19.28,-44.54,;17.91,-45.25,;17.83,-46.77,;19.51,-39.93,;19.62,-38.38,;18.15,-40.65,;16.87,-39.79,;15.48,-40.49,;15.41,-42.03,;14.17,-39.63,;12.81,-40.33,;12.72,-41.87,;11.36,-42.58,;11.27,-44.1,;9.89,-44.8,;9.8,-46.34,;8.44,-47.05,;11.1,-47.16,;11.5,-39.5,;11.6,-37.94,;10.17,-40.21,;8.86,-39.35,;7.45,-40.07,;6.14,-39.2,;7.38,-41.57,)| Show InChI InChI=1S/C151H228N40O47/c1-17-77(10)121(148(236)169-81(14)127(215)177-105(60-87-63-160-92-36-25-24-35-90(87)92)138(226)179-101(56-74(4)5)139(227)188-119(75(6)7)146(234)176-94(37-26-28-52-152)130(218)161-65-111(199)170-93(39-30-54-159-151(156)157)129(217)164-68-118(210)211)190-140(228)103(57-84-31-20-18-21-32-84)180-135(223)99(47-51-116(206)207)175-134(222)95(38-27-29-53-153)172-125(213)79(12)166-124(212)78(11)168-133(221)98(44-48-110(155)198)171-112(200)66-162-132(220)97(46-50-115(204)205)174-136(224)100(55-73(2)3)178-137(225)102(59-86-40-42-89(197)43-41-86)181-143(231)107(69-192)184-145(233)109(71-194)185-147(235)120(76(8)9)189-142(230)106(62-117(208)209)182-144(232)108(70-193)186-150(238)123(83(16)196)191-141(229)104(58-85-33-22-19-23-34-85)183-149(237)122(82(15)195)187-113(201)67-163-131(219)96(45-49-114(202)203)173-126(214)80(13)167-128(216)91(154)61-88-64-158-72-165-88/h18-25,31-36,40-43,63-64,72-83,91,93-109,119-123,160,192-197H,17,26-30,37-39,44-62,65-71,152-154H2,1-16H3,(H2,155,198)(H,158,165)(H,161,218)(H,162,220)(H,163,219)(H,164,217)(H,166,212)(H,167,216)(H,168,221)(H,169,236)(H,170,199)(H,171,200)(H,172,213)(H,173,214)(H,174,224)(H,175,222)(H,176,234)(H,177,215)(H,178,225)(H,179,226)(H,180,223)(H,181,231)(H,182,232)(H,183,237)(H,184,233)(H,185,235)(H,186,238)(H,187,201)(H,188,227)(H,189,230)(H,190,228)(H,191,229)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H4,156,157,159)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121526
(CHEMBL3616762)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C189H295N45O59/c1-18-107(10)156(182(284)210-110(13)161(263)218-135(88-116-91-202-121-52-42-41-51-119(116)121)172(274)220-131(84-104(4)5)173(275)230-154(105(6)7)180(282)217-123(55-46-74-201-188(194)195)164(266)203-93-143(244)211-122(54-45-73-200-187(192)193)163(265)206-96-153(259)260)232-174(276)133(85-113-47-35-33-36-48-113)221-169(271)128(66-71-151(255)256)216-168(270)124(53-43-44-72-197-146(247)100-292-81-80-291-78-76-199-147(248)101-293-82-79-290-77-75-198-141(242)68-63-129(185(287)288)213-142(243)56-39-31-29-27-25-23-21-19-20-22-24-26-28-30-32-40-57-148(249)250)214-160(262)109(12)208-159(261)108(11)209-167(269)127(62-67-140(191)241)212-144(245)94-204-165(267)125(64-69-149(251)252)215-170(272)130(83-103(2)3)219-171(273)132(87-115-58-60-118(240)61-59-115)222-177(279)137(97-235)225-179(281)139(99-237)226-181(283)155(106(8)9)231-176(278)136(90-152(257)258)223-178(280)138(98-236)227-184(286)158(112(15)239)233-175(277)134(86-114-49-37-34-38-50-114)224-183(285)157(111(14)238)229-145(246)95-205-166(268)126(65-70-150(253)254)228-186(289)189(16,17)234-162(264)120(190)89-117-92-196-102-207-117/h33-38,41-42,47-52,58-61,91-92,102-112,120,122-139,154-158,202,235-240H,18-32,39-40,43-46,53-57,62-90,93-101,190H2,1-17H3,(H2,191,241)(H,196,207)(H,197,247)(H,198,242)(H,199,248)(H,203,266)(H,204,267)(H,205,268)(H,206,265)(H,208,261)(H,209,269)(H,210,284)(H,211,244)(H,212,245)(H,213,243)(H,214,262)(H,215,272)(H,216,270)(H,217,282)(H,218,263)(H,219,273)(H,220,274)(H,221,271)(H,222,279)(H,223,280)(H,224,285)(H,225,281)(H,226,283)(H,227,286)(H,228,289)(H,229,246)(H,230,275)(H,231,278)(H,232,276)(H,233,277)(H,234,264)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,287,288)(H4,192,193,200)(H4,194,195,201)/t107-,108-,109-,110-,111+,112+,120-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,154-,155-,156-,157-,158-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121508
(CHEMBL3616774)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C180H280N44O56/c1-16-102(10)150(176(274)202-105(13)155(253)210-129(82-111-85-193-116-48-38-37-47-114(111)116)166(264)212-125(78-99(4)5)167(265)221-148(100(6)7)174(272)209-118(51-42-68-192-180(185)186)158(256)195-88-137(234)203-117(50-41-67-191-179(183)184)157(255)198-91-147(249)250)223-168(266)127(79-108-43-31-29-32-44-108)213-163(261)123(61-65-145(245)246)208-162(260)119(49-39-40-66-188-140(237)95-279-75-74-278-72-70-190-141(238)96-280-76-73-277-71-69-189-135(232)52-35-27-25-23-21-19-17-18-20-22-24-26-28-36-53-142(239)240)206-154(252)104(12)200-153(251)103(11)201-161(259)122(58-62-134(182)231)205-138(235)89-196-160(258)121(60-64-144(243)244)207-164(262)124(77-98(2)3)211-165(263)126(81-110-54-56-113(230)57-55-110)214-171(269)131(92-225)217-173(271)133(94-227)218-175(273)149(101(8)9)222-170(268)130(84-146(247)248)215-172(270)132(93-226)219-178(276)152(107(15)229)224-169(267)128(80-109-45-33-30-34-46-109)216-177(275)151(106(14)228)220-139(236)90-197-159(257)120(59-63-143(241)242)204-136(233)87-194-156(254)115(181)83-112-86-187-97-199-112/h29-34,37-38,43-48,54-57,85-86,97-107,115,117-133,148-152,193,225-230H,16-28,35-36,39-42,49-53,58-84,87-96,181H2,1-15H3,(H2,182,231)(H,187,199)(H,188,237)(H,189,232)(H,190,238)(H,194,254)(H,195,256)(H,196,258)(H,197,257)(H,198,255)(H,200,251)(H,201,259)(H,202,274)(H,203,234)(H,204,233)(H,205,235)(H,206,252)(H,207,262)(H,208,260)(H,209,272)(H,210,253)(H,211,263)(H,212,264)(H,213,261)(H,214,269)(H,215,270)(H,216,275)(H,217,271)(H,218,273)(H,219,276)(H,220,236)(H,221,265)(H,222,268)(H,223,266)(H,224,267)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H4,183,184,191)(H4,185,186,192)/t102-,103-,104-,105-,106+,107+,115-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,148-,149-,150-,151-,152-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121401
(CHEMBL3616771)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C188H296N48O57/c1-18-106(10)154(180(284)212-109(13)159(263)220-134(87-115-90-204-120-51-40-39-50-118(115)120)170(274)222-130(83-103(4)5)171(275)232-152(104(6)7)178(282)219-122(54-44-72-202-186(193)194)162(266)206-92-141(245)213-121(53-43-71-201-185(191)192)161(265)205-94-143(247)215-128(183(287)288)52-41-42-70-198-145(249)99-292-80-79-291-77-75-200-146(250)100-293-81-78-290-76-74-199-140(244)56-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-147(251)252)234-172(276)132(84-112-46-33-31-34-47-112)223-167(271)127(65-69-150(257)258)218-166(270)123(55-45-73-203-187(195)196)216-158(262)108(12)210-157(261)107(11)211-165(269)126(62-66-139(190)243)214-142(246)93-207-163(267)124(63-67-148(253)254)217-168(272)129(82-102(2)3)221-169(273)131(86-114-58-60-117(242)61-59-114)224-175(279)136(96-237)227-177(281)138(98-239)228-179(283)153(105(8)9)233-174(278)135(89-151(259)260)225-176(280)137(97-238)229-182(286)156(111(15)241)235-173(277)133(85-113-48-35-32-36-49-113)226-181(285)155(110(14)240)231-144(248)95-208-164(268)125(64-68-149(255)256)230-184(289)188(16,17)236-160(264)119(189)88-116-91-197-101-209-116/h31-36,39-40,46-51,58-61,90-91,101-111,119,121-138,152-156,204,237-242H,18-30,37-38,41-45,52-57,62-89,92-100,189H2,1-17H3,(H2,190,243)(H,197,209)(H,198,249)(H,199,244)(H,200,250)(H,205,265)(H,206,266)(H,207,267)(H,208,268)(H,210,261)(H,211,269)(H,212,284)(H,213,245)(H,214,246)(H,215,247)(H,216,262)(H,217,272)(H,218,270)(H,219,282)(H,220,263)(H,221,273)(H,222,274)(H,223,271)(H,224,279)(H,225,280)(H,226,285)(H,227,281)(H,228,283)(H,229,286)(H,230,289)(H,231,248)(H,232,275)(H,233,278)(H,234,276)(H,235,277)(H,236,264)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,287,288)(H4,191,192,201)(H4,193,194,202)(H4,195,196,203)/t106-,107-,108-,109-,110+,111+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121398
(CHEMBL3616480)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C182H284N44O56/c1-18-103(10)150(176(275)203-106(13)155(254)210-130(84-112-87-195-117-50-40-39-49-115(112)117)166(265)212-126(80-100(4)5)167(266)222-148(101(6)7)174(273)209-119(52-43-69-193-180(185)186)158(257)196-89-137(235)204-118(157(256)199-92-147(250)251)51-41-42-68-190-140(238)96-281-77-76-280-74-72-192-141(239)97-282-78-75-279-73-71-191-136(234)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-142(240)241)224-168(267)128(81-109-45-33-31-34-46-109)213-163(262)124(63-67-145(246)247)208-162(261)120(53-44-70-194-181(187)188)206-154(253)105(12)201-153(252)104(11)202-161(260)123(60-64-135(184)233)205-138(236)90-197-159(258)121(61-65-143(242)243)207-164(263)125(79-99(2)3)211-165(264)127(83-111-56-58-114(232)59-57-111)214-171(270)132(93-227)217-173(272)134(95-229)218-175(274)149(102(8)9)223-170(269)131(86-146(248)249)215-172(271)133(94-228)219-178(277)152(108(15)231)225-169(268)129(82-110-47-35-32-36-48-110)216-177(276)151(107(14)230)221-139(237)91-198-160(259)122(62-66-144(244)245)220-179(278)182(16,17)226-156(255)116(183)85-113-88-189-98-200-113/h31-36,39-40,45-50,56-59,87-88,98-108,116,118-134,148-152,195,227-232H,18-30,37-38,41-44,51-55,60-86,89-97,183H2,1-17H3,(H2,184,233)(H,189,200)(H,190,238)(H,191,234)(H,192,239)(H,196,257)(H,197,258)(H,198,259)(H,199,256)(H,201,252)(H,202,260)(H,203,275)(H,204,235)(H,205,236)(H,206,253)(H,207,263)(H,208,261)(H,209,273)(H,210,254)(H,211,264)(H,212,265)(H,213,262)(H,214,270)(H,215,271)(H,216,276)(H,217,272)(H,218,274)(H,219,277)(H,220,278)(H,221,237)(H,222,266)(H,223,269)(H,224,267)(H,225,268)(H,226,255)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H4,185,186,193)(H4,187,188,194)/t103-,104-,105-,106-,107+,108+,116-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,148-,149-,150-,151-,152-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121535
(CHEMBL3616739)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C173H267N43O51/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-129(225)195-116(169(265)266)60-65-128(224)181-69-42-41-51-111(152(248)198-115(63-68-135(233)234)153(249)203-120(74-100-45-34-32-35-46-100)158(254)214-140(94(11)20-2)166(262)192-97(14)145(241)200-122(77-103-80-184-108-50-40-39-49-106(103)108)156(252)202-118(73-91(5)6)157(253)212-138(92(7)8)164(260)199-110(53-44-71-183-172(178)179)148(244)185-82-130(226)193-109(52-43-70-182-171(176)177)147(243)188-85-137(237)238)196-144(240)96(13)190-143(239)95(12)191-151(247)114(59-64-127(175)223)194-131(227)83-186-149(245)112(61-66-133(229)230)197-154(250)117(72-90(3)4)201-155(251)119(76-102-55-57-105(222)58-56-102)204-161(257)124(86-217)207-163(259)126(88-219)208-165(261)139(93(9)10)213-160(256)123(79-136(235)236)205-162(258)125(87-218)209-168(264)142(99(16)221)215-159(255)121(75-101-47-36-33-37-48-101)206-167(263)141(98(15)220)211-132(228)84-187-150(246)113(62-67-134(231)232)210-170(267)173(17,18)216-146(242)107(174)78-104-81-180-89-189-104/h32-37,39-40,45-50,55-58,80-81,89-99,107,109-126,138-142,184,217-222H,19-31,38,41-44,51-54,59-79,82-88,174H2,1-18H3,(H2,175,223)(H,180,189)(H,181,224)(H,185,244)(H,186,245)(H,187,246)(H,188,243)(H,190,239)(H,191,247)(H,192,262)(H,193,226)(H,194,227)(H,195,225)(H,196,240)(H,197,250)(H,198,248)(H,199,260)(H,200,241)(H,201,251)(H,202,252)(H,203,249)(H,204,257)(H,205,258)(H,206,263)(H,207,259)(H,208,261)(H,209,264)(H,210,267)(H,211,228)(H,212,253)(H,213,256)(H,214,254)(H,215,255)(H,216,242)(H,229,230)(H,231,232)(H,233,234)(H,235,236)(H,237,238)(H,265,266)(H4,176,177,182)(H4,178,179,183)/t94-,95-,96-,97-,98+,99+,107-,109-,110-,111-,112-,113-,114-,115-,116+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,138-,139-,140-,141-,142-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.120 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121400
(CHEMBL3616752)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16,17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,200,233-238H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,239)(H,194,205)(H,195,245)(H,196,240)(H,197,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,270)(H,214,268)(H,215,280)(H,216,261)(H,217,271)(H,218,272)(H,219,269)(H,220,277)(H,221,278)(H,222,283)(H,223,279)(H,224,281)(H,225,284)(H,226,287)(H,227,244)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,190,191,198)(H4,192,193,199)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127+,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.130 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50152769
(CHEMBL410972 | GLP-1(7-36)-NH2 | GLP-17-(7-36) der...)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1cnc[nH]1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(N)=O |r,wU:156.159,142.150,134.137,164.169,119.121,167.172,105.111,95.99,77.87,60.66,47.53,37.38,19.25,4.4,181.184,203.208,wD:151.154,123.133,113.117,101.103,89.93,69.74,42.43,28.34,8.16,2.2,176.180,195.200,210.215,223.228,(82.22,1.34,;82.22,-.2,;83.55,-.98,;84.89,-.21,;83.55,-2.52,;82.22,-3.29,;80.88,-2.53,;80.88,-.98,;79.55,-3.29,;79.55,-4.83,;80.88,-5.61,;82.22,-4.83,;83.55,-5.6,;83.56,-7.14,;82.23,-7.91,;80.89,-7.15,;78.21,-2.53,;76.87,-3.3,;76.87,-4.84,;75.55,-2.53,;75.55,-.99,;76.87,-.21,;76.87,1.33,;75.55,2.1,;78.21,2.09,;74.21,-3.3,;72.88,-2.53,;72.88,-.99,;71.54,-3.3,;71.54,-4.84,;72.88,-5.62,;72.88,-7.16,;74.21,-7.92,;74.21,-9.46,;70.2,-2.54,;68.87,-3.31,;68.87,-4.84,;67.53,-2.54,;67.53,-1,;66.21,-3.31,;64.87,-2.54,;64.87,-1,;63.53,-3.31,;63.53,-4.85,;62.2,-2.55,;60.86,-3.32,;60.86,-4.85,;59.53,-2.55,;59.53,-1.01,;60.86,-.23,;60.86,1.31,;59.52,2.08,;62.19,2.08,;58.19,-3.32,;56.86,-2.55,;56.86,-1.01,;55.53,-3.32,;54.19,-2.56,;52.86,-3.32,;52.86,-4.86,;51.52,-2.56,;51.52,-1.01,;52.86,-.24,;52.86,1.3,;51.51,2.07,;54.18,2.07,;50.19,-3.33,;48.85,-2.56,;48.85,-1.02,;47.51,-3.33,;47.51,-4.87,;48.85,-5.64,;48.85,-7.18,;50.19,-4.87,;46.18,-2.56,;44.85,-3.33,;44.85,-4.87,;43.52,-2.57,;43.52,-1.02,;44.85,-.25,;46.18,-1.02,;47.51,-.24,;47.5,1.3,;48.84,2.06,;46.17,2.06,;44.84,1.29,;42.18,-3.34,;40.84,-2.57,;40.84,-1.03,;39.51,-3.34,;39.51,-4.88,;40.84,-5.65,;38.17,-2.57,;36.84,-3.34,;36.84,-4.88,;35.5,-2.58,;35.5,-1.03,;36.84,-.26,;34.17,-3.35,;32.84,-2.58,;32.84,-1.04,;31.49,-3.35,;30.17,-2.58,;28.82,-3.35,;28.82,-4.89,;27.5,-2.59,;27.5,-1.04,;28.82,-.27,;30.16,-1.04,;28.82,1.28,;26.15,-3.36,;24.83,-2.6,;24.83,-1.05,;23.49,-3.37,;23.49,-4.9,;24.83,-5.68,;22.16,-2.6,;20.82,-3.37,;20.82,-4.91,;19.49,-2.6,;18.14,-3.37,;16.82,-2.61,;16.82,-1.06,;15.47,-3.37,;15.47,-4.91,;16.82,-5.69,;18.15,-4.91,;19.49,-5.68,;19.49,-7.22,;18.15,-7.99,;16.82,-7.23,;14.15,-2.61,;12.81,-3.38,;12.81,-4.92,;11.48,-2.61,;10.14,-3.38,;8.81,-2.62,;8.81,-1.07,;7.47,-3.38,;6.14,-2.62,;4.79,-3.39,;4.79,-4.92,;3.47,-2.62,;3.47,-1.08,;4.79,-.3,;4.79,1.24,;3.47,2.01,;6.13,2.01,;2.13,-3.39,;.8,-2.62,;.8,-1.08,;-.54,-3.39,;-.54,-4.93,;-1.87,-2.63,;-3.21,-3.39,;-3.21,-4.93,;-4.55,-2.63,;-5.87,-3.39,;-4.55,-1.09,;-3.21,-.31,;-1.8,-.94,;-.77,.21,;-1.55,1.55,;-3.05,1.22,;11.48,-1.07,;10.14,-.29,;12.81,-.3,;19.49,-1.05,;18.14,-.28,;20.82,-.28,;31.49,-4.89,;32.84,-5.66,;30.17,-5.66,;84.89,-3.29,;84.89,-4.83,;86.23,-2.52,;87.55,-3.28,;87.55,-4.82,;88.89,-2.52,;88.89,-.96,;90.22,-3.28,;91.56,-2.51,;91.56,-.96,;92.89,-.19,;94.3,-.81,;95.34,.33,;94.56,1.66,;95.03,3.13,;94,4.28,;92.5,3.96,;92.02,2.49,;93.05,1.35,;92.89,-3.28,;92.89,-4.81,;94.23,-2.51,;95.57,-3.27,;95.57,-4.81,;96.9,-5.58,;96.9,-7.12,;98.24,-4.81,;96.9,-2.5,;96.9,-.96,;98.23,-3.26,;99.57,-2.5,;99.57,-.95,;100.9,-.18,;98.23,-.18,;100.9,-3.26,;100.9,-4.8,;102.24,-2.49,;103.57,-3.26,;103.57,-4.8,;104.91,-5.57,;104.91,-7.11,;106.25,-7.88,;106.25,-9.42,;104.91,-2.49,;104.91,-.95,;106.24,-3.26,;107.58,-2.49,;108.91,-3.25,;108.91,-4.79,;110.25,-2.48,;111.58,-3.25,;111.58,-4.79,;112.92,-5.56,;112.92,-7.1,;114.26,-7.87,;114.26,-9.41,;112.92,-10.18,;115.6,-10.18,;112.92,-2.48,;114.25,-3.25,;112.92,-.94,)| Show InChI InChI=1S/C149H226N40O45/c1-17-76(10)119(146(232)167-80(14)126(212)175-104(60-86-63-159-91-36-25-24-35-89(86)91)136(222)177-100(56-73(4)5)137(223)186-117(74(6)7)144(230)174-93(37-26-28-52-150)128(214)160-65-110(197)168-92(122(154)208)39-30-54-158-149(155)156)188-138(224)102(57-83-31-20-18-21-32-83)178-133(219)98(47-51-115(204)205)173-132(218)94(38-27-29-53-151)170-124(210)78(12)164-123(209)77(11)166-131(217)97(44-48-109(153)196)169-111(198)66-161-130(216)96(46-50-114(202)203)172-134(220)99(55-72(2)3)176-135(221)101(59-85-40-42-88(195)43-41-85)179-141(227)106(68-190)182-143(229)108(70-192)183-145(231)118(75(8)9)187-140(226)105(62-116(206)207)180-142(228)107(69-191)184-148(234)121(82(16)194)189-139(225)103(58-84-33-22-19-23-34-84)181-147(233)120(81(15)193)185-112(199)67-162-129(215)95(45-49-113(200)201)171-125(211)79(13)165-127(213)90(152)61-87-64-157-71-163-87/h18-25,31-36,40-43,63-64,71-82,90,92-108,117-121,159,190-195H,17,26-30,37-39,44-62,65-70,150-152H2,1-16H3,(H2,153,196)(H2,154,208)(H,157,163)(H,160,214)(H,161,216)(H,162,215)(H,164,209)(H,165,213)(H,166,217)(H,167,232)(H,168,197)(H,169,198)(H,170,210)(H,171,211)(H,172,220)(H,173,218)(H,174,230)(H,175,212)(H,176,221)(H,177,222)(H,178,219)(H,179,227)(H,180,228)(H,181,233)(H,182,229)(H,183,231)(H,184,234)(H,185,199)(H,186,223)(H,187,226)(H,188,224)(H,189,225)(H,200,201)(H,202,203)(H,204,205)(H,206,207)(H4,155,156,158)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,117-,118-,119-,120-,121-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
ConjuChem Inc.
Curated by ChEMBL
| Assay Description
Inhibitory concentration against human GLP1 receptor expressed in CHO cell membrane homogenates with 1%DMSO |
Bioorg Med Chem Lett 14: 4395-8 (2004)
Article DOI: 10.1016/j.bmcl.2004.06.066
BindingDB Entry DOI: 10.7270/Q25X28FC |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121394
(CHEMBL3616711)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C151H228N42O47/c1-17-76(10)120(147(238)171-80(14)126(217)179-104(59-86-62-162-91-35-25-24-34-89(86)91)137(228)181-100(55-73(4)5)138(229)190-118(74(6)7)145(236)178-93(38-29-53-161-151(157)158)129(220)163-64-110(201)172-92(37-28-52-160-150(155)156)128(219)166-67-117(212)213)192-139(230)102(56-83-30-20-18-21-31-83)182-134(225)98(46-50-115(208)209)177-133(224)94(36-26-27-51-152)174-124(215)78(12)168-123(214)77(11)170-132(223)97(43-47-109(154)200)173-111(202)65-164-131(222)96(45-49-114(206)207)176-135(226)99(54-72(2)3)180-136(227)101(58-85-39-41-88(199)42-40-85)183-142(233)106(68-194)186-144(235)108(70-196)187-146(237)119(75(8)9)191-141(232)105(61-116(210)211)184-143(234)107(69-195)188-149(240)122(82(16)198)193-140(231)103(57-84-32-22-19-23-33-84)185-148(239)121(81(15)197)189-112(203)66-165-130(221)95(44-48-113(204)205)175-125(216)79(13)169-127(218)90(153)60-87-63-159-71-167-87/h18-25,30-35,39-42,62-63,71-82,90,92-108,118-122,162,194-199H,17,26-29,36-38,43-61,64-70,152-153H2,1-16H3,(H2,154,200)(H,159,167)(H,163,220)(H,164,222)(H,165,221)(H,166,219)(H,168,214)(H,169,218)(H,170,223)(H,171,238)(H,172,201)(H,173,202)(H,174,215)(H,175,216)(H,176,226)(H,177,224)(H,178,236)(H,179,217)(H,180,227)(H,181,228)(H,182,225)(H,183,233)(H,184,234)(H,185,239)(H,186,235)(H,187,237)(H,188,240)(H,189,203)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,155,156,160)(H4,157,158,161)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,118-,119-,120-,121-,122-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.140 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121531
(CHEMBL3616741)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C179H278N44O54/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-134(232)202-121(175(273)274)60-65-133(231)188-72-73-276-74-75-277-93-138(236)187-69-42-41-51-116(158(256)205-120(63-68-141(241)242)159(257)210-125(78-105-45-34-32-35-46-105)164(262)221-146(99(11)20-2)172(270)199-102(14)151(249)207-127(81-108-84-191-113-50-40-39-49-111(108)113)162(260)209-123(77-96(5)6)163(261)219-144(97(7)8)170(268)206-115(53-44-71-190-178(184)185)154(252)192-86-135(233)200-114(52-43-70-189-177(182)183)153(251)195-89-143(245)246)203-150(248)101(13)197-149(247)100(12)198-157(255)119(59-64-132(181)230)201-136(234)87-193-155(253)117(61-66-139(237)238)204-160(258)122(76-95(3)4)208-161(259)124(80-107-55-57-110(229)58-56-107)211-167(265)129(90-224)214-169(267)131(92-226)215-171(269)145(98(9)10)220-166(264)128(83-142(243)244)212-168(266)130(91-225)216-174(272)148(104(16)228)222-165(263)126(79-106-47-36-33-37-48-106)213-173(271)147(103(15)227)218-137(235)88-194-156(254)118(62-67-140(239)240)217-176(275)179(17,18)223-152(250)112(180)82-109-85-186-94-196-109/h32-37,39-40,45-50,55-58,84-85,94-104,112,114-131,144-148,191,224-229H,19-31,38,41-44,51-54,59-83,86-93,180H2,1-18H3,(H2,181,230)(H,186,196)(H,187,236)(H,188,231)(H,192,252)(H,193,253)(H,194,254)(H,195,251)(H,197,247)(H,198,255)(H,199,270)(H,200,233)(H,201,234)(H,202,232)(H,203,248)(H,204,258)(H,205,256)(H,206,268)(H,207,249)(H,208,259)(H,209,260)(H,210,257)(H,211,265)(H,212,266)(H,213,271)(H,214,267)(H,215,269)(H,216,272)(H,217,275)(H,218,235)(H,219,261)(H,220,264)(H,221,262)(H,222,263)(H,223,250)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,273,274)(H4,182,183,189)(H4,184,185,190)/t99-,100-,101-,102-,103+,104+,112-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,144-,145-,146-,147-,148-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121406
(CHEMBL3616713)Show SMILES CCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C188H295N45O57/c1-18-20-21-22-23-24-25-26-27-28-29-30-31-32-33-34-41-57-143(242)213-130(186(285)286)63-68-142(241)197-75-77-287-79-82-290-101-148(247)198-76-78-288-80-81-289-100-147(246)196-72-45-44-54-125(169(268)217-129(66-71-151(252)253)170(269)222-134(85-114-48-37-35-38-49-114)175(274)232-156(107(11)19-2)183(282)210-111(15)162(261)219-136(88-117-91-201-122-53-43-42-52-120(117)122)173(272)221-132(84-104(5)6)174(273)230-154(105(7)8)181(280)218-124(56-47-74-200-188(193)194)165(264)202-93-144(243)211-123(55-46-73-199-187(191)192)164(263)205-96-153(256)257)214-160(259)109(13)207-159(258)108(12)209-168(267)128(62-67-141(190)240)212-145(244)94-203-167(266)127(65-70-150(250)251)216-171(270)131(83-103(3)4)220-172(271)133(87-116-58-60-119(239)61-59-116)223-178(277)138(97-234)226-180(279)140(99-236)227-182(281)155(106(9)10)231-177(276)137(90-152(254)255)224-179(278)139(98-235)228-185(284)158(113(17)238)233-176(275)135(86-115-50-39-36-40-51-115)225-184(283)157(112(16)237)229-146(245)95-204-166(265)126(64-69-149(248)249)215-161(260)110(14)208-163(262)121(189)89-118-92-195-102-206-118/h35-40,42-43,48-53,58-61,91-92,102-113,121,123-140,154-158,201,234-239H,18-34,41,44-47,54-57,62-90,93-101,189H2,1-17H3,(H2,190,240)(H,195,206)(H,196,246)(H,197,241)(H,198,247)(H,202,264)(H,203,266)(H,204,265)(H,205,263)(H,207,258)(H,208,262)(H,209,267)(H,210,282)(H,211,243)(H,212,244)(H,213,242)(H,214,259)(H,215,260)(H,216,270)(H,217,268)(H,218,280)(H,219,261)(H,220,271)(H,221,272)(H,222,269)(H,223,277)(H,224,278)(H,225,283)(H,226,279)(H,227,281)(H,228,284)(H,229,245)(H,230,273)(H,231,276)(H,232,274)(H,233,275)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,285,286)(H4,191,192,199)(H4,193,194,200)/t107-,108-,109-,110-,111-,112+,113+,121-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,154-,155-,156-,157-,158-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.160 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121527
(CHEMBL3616718)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C152H230N42O47/c1-18-77(10)120(146(238)171-80(13)125(217)178-104(60-86-63-163-91-36-26-25-35-89(86)91)136(228)180-100(56-74(4)5)137(229)190-118(75(6)7)144(236)177-93(39-30-54-162-151(158)159)128(220)164-65-110(202)172-92(38-29-53-161-150(156)157)127(219)167-68-117(213)214)192-138(230)102(57-83-31-21-19-22-32-83)181-133(225)98(47-51-115(209)210)176-132(224)94(37-27-28-52-153)174-124(216)79(12)169-123(215)78(11)170-131(223)97(44-48-109(155)201)173-111(203)66-165-129(221)95(45-49-113(205)206)175-134(226)99(55-73(2)3)179-135(227)101(59-85-40-42-88(200)43-41-85)182-141(233)106(69-195)185-143(235)108(71-197)186-145(237)119(76(8)9)191-140(232)105(62-116(211)212)183-142(234)107(70-196)187-148(240)122(82(15)199)193-139(231)103(58-84-33-23-20-24-34-84)184-147(239)121(81(14)198)189-112(204)67-166-130(222)96(46-50-114(207)208)188-149(241)152(16,17)194-126(218)90(154)61-87-64-160-72-168-87/h19-26,31-36,40-43,63-64,72-82,90,92-108,118-122,163,195-200H,18,27-30,37-39,44-62,65-71,153-154H2,1-17H3,(H2,155,201)(H,160,168)(H,164,220)(H,165,221)(H,166,222)(H,167,219)(H,169,215)(H,170,223)(H,171,238)(H,172,202)(H,173,203)(H,174,216)(H,175,226)(H,176,224)(H,177,236)(H,178,217)(H,179,227)(H,180,228)(H,181,225)(H,182,233)(H,183,234)(H,184,239)(H,185,235)(H,186,237)(H,187,240)(H,188,241)(H,189,204)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,194,218)(H,205,206)(H,207,208)(H,209,210)(H,211,212)(H,213,214)(H4,156,157,161)(H4,158,159,162)/t77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,118-,119-,120-,121-,122-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50120389
(CHEMBL3616751)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C181H280N44O56/c1-18-100(10)148(174(274)201-103(13)153(253)209-128(82-109-85-193-114-50-40-39-49-112(109)114)164(264)211-124(78-97(4)5)165(265)221-146(98(6)7)172(272)208-116(53-44-72-192-180(186)187)156(256)194-87-136(235)202-115(52-43-71-191-179(184)185)155(255)197-90-145(249)250)223-166(266)126(79-106-45-33-31-34-46-106)212-161(261)121(64-69-143(245)246)207-160(260)117(51-41-42-70-189-139(238)94-281-76-75-280-74-73-190-134(233)66-61-122(177(277)278)204-135(234)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-140(239)240)205-152(252)102(12)199-151(251)101(11)200-159(259)120(60-65-133(183)232)203-137(236)88-195-157(257)118(62-67-141(241)242)206-162(262)123(77-96(2)3)210-163(263)125(81-108-56-58-111(231)59-57-108)213-169(269)130(91-226)216-171(271)132(93-228)217-173(273)147(99(8)9)222-168(268)129(84-144(247)248)214-170(270)131(92-227)218-176(276)150(105(15)230)224-167(267)127(80-107-47-35-32-36-48-107)215-175(275)149(104(14)229)220-138(237)89-196-158(258)119(63-68-142(243)244)219-178(279)181(16,17)225-154(254)113(182)83-110-86-188-95-198-110/h31-36,39-40,45-50,56-59,85-86,95-105,113,115-132,146-150,193,226-231H,18-30,37-38,41-44,51-55,60-84,87-94,182H2,1-17H3,(H2,183,232)(H,188,198)(H,189,238)(H,190,233)(H,194,256)(H,195,257)(H,196,258)(H,197,255)(H,199,251)(H,200,259)(H,201,274)(H,202,235)(H,203,236)(H,204,234)(H,205,252)(H,206,262)(H,207,260)(H,208,272)(H,209,253)(H,210,263)(H,211,264)(H,212,261)(H,213,269)(H,214,270)(H,215,275)(H,216,271)(H,217,273)(H,218,276)(H,219,279)(H,220,237)(H,221,265)(H,222,268)(H,223,266)(H,224,267)(H,225,254)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,277,278)(H4,184,185,191)(H4,186,187,192)/t100-,101-,102-,103-,104+,105+,113-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-,150-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50120381
(CHEMBL3616744)Show SMILES CCCCCCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C189H297N45O57/c1-19-21-22-23-24-25-26-27-28-29-30-31-32-33-34-35-42-58-143(243)213-130(185(285)286)64-69-142(242)198-76-78-288-80-83-291-102-148(248)199-77-79-289-81-82-290-101-147(247)197-73-46-45-55-125(168(268)216-129(67-72-151(253)254)169(269)221-134(86-114-49-38-36-39-50-114)174(274)232-156(108(11)20-2)182(282)210-111(14)161(261)218-136(89-117-92-202-122-54-44-43-53-120(117)122)172(272)220-132(85-105(5)6)173(273)230-154(106(7)8)180(280)217-124(57-48-75-201-188(194)195)164(264)203-94-144(244)211-123(56-47-74-200-187(192)193)163(263)206-97-153(257)258)214-160(260)110(13)208-159(259)109(12)209-167(267)128(63-68-141(191)241)212-145(245)95-204-165(265)126(65-70-149(249)250)215-170(270)131(84-104(3)4)219-171(271)133(88-116-59-61-119(240)62-60-116)222-177(277)138(98-235)225-179(279)140(100-237)226-181(281)155(107(9)10)231-176(276)137(91-152(255)256)223-178(278)139(99-236)227-184(284)158(113(16)239)233-175(275)135(87-115-51-40-37-41-52-115)224-183(283)157(112(15)238)229-146(246)96-205-166(266)127(66-71-150(251)252)228-186(287)189(17,18)234-162(262)121(190)90-118-93-196-103-207-118/h36-41,43-44,49-54,59-62,92-93,103-113,121,123-140,154-158,202,235-240H,19-35,42,45-48,55-58,63-91,94-102,190H2,1-18H3,(H2,191,241)(H,196,207)(H,197,247)(H,198,242)(H,199,248)(H,203,264)(H,204,265)(H,205,266)(H,206,263)(H,208,259)(H,209,267)(H,210,282)(H,211,244)(H,212,245)(H,213,243)(H,214,260)(H,215,270)(H,216,268)(H,217,280)(H,218,261)(H,219,271)(H,220,272)(H,221,269)(H,222,277)(H,223,278)(H,224,283)(H,225,279)(H,226,281)(H,227,284)(H,228,287)(H,229,246)(H,230,273)(H,231,276)(H,232,274)(H,233,275)(H,234,262)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,192,193,200)(H4,194,195,201)/t108-,109-,110-,111-,112+,113+,121-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,154-,155-,156-,157-,158-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121518
(CHEMBL428139)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O |wU:119.121,95.99,89.93,105.111,142.150,8.16,195.200,134.137,69.74,28.34,210.215,223.228,156.159,164.169,167.172,42.43,176.180,2.2,wD:113.117,123.133,101.103,203.208,4.4,181.184,77.87,19.25,47.53,60.66,37.38,151.154,(42.46,-37.33,;42.37,-38.87,;40.99,-39.57,;39.7,-38.74,;40.89,-41.1,;42.2,-41.97,;43.56,-41.27,;43.68,-39.74,;44.87,-42.13,;44.77,-43.67,;43.39,-44.36,;42.09,-43.51,;40.71,-44.19,;40.63,-45.74,;41.92,-46.56,;43.3,-45.88,;46.26,-41.41,;48.15,-38.22,;50.19,-38.22,;47.05,-35.91,;45.48,-36.01,;44.58,-34.7,;43,-34.7,;42.23,-33.32,;42.2,-36.08,;47.71,-34.5,;46.82,-33.25,;45.29,-33.35,;47.5,-31.88,;49.02,-31.71,;49.9,-33.02,;51.45,-32.86,;52.3,-34.13,;53.88,-34.01,;46.61,-30.57,;47.28,-29.18,;48.81,-29.04,;46.4,-27.9,;44.85,-28.05,;47.1,-26.52,;46.18,-25.27,;44.66,-25.37,;46.88,-23.89,;48.41,-23.75,;45.97,-22.6,;46.65,-21.19,;48.2,-21.08,;45.79,-19.94,;44.22,-20.08,;43.56,-21.45,;42.02,-21.57,;41.15,-20.3,;41.38,-22.93,;46.44,-18.58,;45.53,-17.27,;44.01,-17.37,;46.23,-15.88,;45.34,-14.62,;46.02,-13.23,;47.54,-13.1,;45.15,-11.97,;43.61,-12.08,;42.91,-13.45,;41.38,-13.59,;40.52,-12.3,;40.73,-14.97,;45.81,-10.56,;44.94,-9.3,;43.4,-9.41,;45.62,-7.92,;47.14,-7.76,;47.99,-9.02,;47.37,-10.45,;49.57,-8.92,;44.71,-6.63,;45.37,-5.25,;46.93,-5.14,;44.5,-3.99,;43,-4.11,;42.31,-5.49,;43.19,-6.74,;42.53,-8.16,;40.99,-8.27,;40.3,-9.63,;40.07,-6.99,;40.77,-5.6,;45.15,-2.58,;44.28,-1.32,;43.19,-2.21,;44.97,.09,;46.51,.19,;47.37,-1.06,;44.05,1.35,;42.74,.58,;42.74,-.96,;41.38,1.35,;41.38,2.88,;42.74,3.65,;40.07,.58,;38.72,1.35,;38.72,2.88,;37.4,.58,;36.05,1.35,;34.73,.58,;34.73,-.96,;33.4,1.35,;33.4,2.88,;34.73,3.65,;36.05,2.88,;34.73,5.21,;32.06,.58,;30.7,1.35,;30.7,2.88,;29.39,.58,;29.39,-.96,;30.7,-1.72,;28.01,1.35,;26.72,.58,;26.72,-.96,;25.34,1.35,;24.03,.58,;22.71,1.35,;22.71,2.88,;21.34,.58,;21.34,-.96,;22.71,-1.72,;24.03,-.96,;25.34,-1.72,;25.34,-3.24,;24.03,-4.06,;22.71,-3.24,;20.04,1.35,;18.69,.58,;18.69,-.96,;17.34,1.35,;16,.58,;14.66,1.35,;14.66,2.88,;13.31,.58,;11.99,1.35,;10.66,.58,;10.66,-.96,;9.3,1.35,;9.3,2.88,;10.66,3.65,;10.66,5.21,;9.3,5.97,;11.99,5.97,;7.98,.58,;6.63,1.35,;6.63,2.88,;5.32,.58,;5.32,-.96,;3.97,1.35,;2.61,.58,;2.61,-.96,;1.3,1.35,;-.02,.58,;1.3,2.88,;2.61,3.65,;4.03,3.04,;5.09,4.18,;4.29,5.54,;2.79,5.21,;17.34,2.88,;16,3.65,;18.69,3.65,;25.34,2.88,;24.03,3.65,;26.72,3.65,;37.4,-.96,;36.05,-1.72,;38.72,-1.72,;39.51,-41.81,;39.42,-43.34,;38.22,-40.98,;36.86,-41.69,;36.79,-43.21,;35.55,-40.81,;35.64,-39.3,;34.19,-41.52,;32.88,-40.66,;32.98,-39.14,;31.68,-38.27,;30.24,-38.81,;29.25,-37.61,;30.14,-36.35,;29.72,-34.87,;30.8,-33.77,;32.32,-34.17,;32.71,-35.65,;31.62,-36.77,;31.52,-41.36,;31.41,-42.91,;30.21,-40.54,;28.83,-41.24,;28.76,-42.74,;27.37,-43.45,;27.31,-44.97,;26.09,-42.6,;27.52,-40.38,;27.62,-38.81,;26.16,-41.08,;24.85,-40.23,;24.97,-38.71,;23.66,-37.83,;26.33,-37.99,;23.49,-40.94,;23.42,-42.46,;22.22,-40.07,;20.82,-40.78,;20.71,-42.3,;19.35,-43.02,;19.28,-44.54,;17.91,-45.25,;17.83,-46.77,;19.51,-39.93,;19.62,-38.38,;18.15,-40.65,;16.87,-39.79,;15.48,-40.49,;15.41,-42.03,;14.17,-39.63,;12.81,-40.33,;12.72,-41.87,;11.36,-42.58,;11.27,-44.1,;9.89,-44.8,;9.8,-46.34,;8.44,-47.05,;11.1,-47.16,;11.5,-39.5,;11.6,-37.94,;10.17,-40.21,;8.86,-39.35,;7.45,-40.07,;6.14,-39.2,;7.38,-41.57,)| Show InChI InChI=1S/C151H228N40O47/c1-17-77(10)121(148(236)169-81(14)127(215)177-105(60-87-63-160-92-36-25-24-35-90(87)92)138(226)179-101(56-74(4)5)139(227)188-119(75(6)7)146(234)176-94(37-26-28-52-152)130(218)161-65-111(199)170-93(39-30-54-159-151(156)157)129(217)164-68-118(210)211)190-140(228)103(57-84-31-20-18-21-32-84)180-135(223)99(47-51-116(206)207)175-134(222)95(38-27-29-53-153)172-125(213)79(12)166-124(212)78(11)168-133(221)98(44-48-110(155)198)171-112(200)66-162-132(220)97(46-50-115(204)205)174-136(224)100(55-73(2)3)178-137(225)102(59-86-40-42-89(197)43-41-86)181-143(231)107(69-192)184-145(233)109(71-194)185-147(235)120(76(8)9)189-142(230)106(62-117(208)209)182-144(232)108(70-193)186-150(238)123(83(16)196)191-141(229)104(58-85-33-22-19-23-34-85)183-149(237)122(82(15)195)187-113(201)67-163-131(219)96(45-49-114(202)203)173-126(214)80(13)167-128(216)91(154)61-88-64-158-72-165-88/h18-25,31-36,40-43,63-64,72-83,91,93-109,119-123,160,192-197H,17,26-30,37-39,44-62,65-71,152-154H2,1-16H3,(H2,155,198)(H,158,165)(H,161,218)(H,162,220)(H,163,219)(H,164,217)(H,166,212)(H,167,216)(H,168,221)(H,169,236)(H,170,199)(H,171,200)(H,172,213)(H,173,214)(H,174,224)(H,175,222)(H,176,234)(H,177,215)(H,178,225)(H,179,226)(H,180,223)(H,181,231)(H,182,232)(H,183,237)(H,184,233)(H,185,235)(H,186,238)(H,187,201)(H,188,227)(H,189,230)(H,190,228)(H,191,229)(H,202,203)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H4,156,157,159)/t77-,78-,79-,80-,81-,82+,83+,91-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,119-,120-,121-,122-,123-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121536
(CHEMBL3616717)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C185H289N45O57/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-139(239)209-126(181(281)282)60-65-138(238)194-72-74-284-76-79-287-98-144(244)195-73-75-285-77-78-286-97-143(243)193-69-42-41-51-121(164(264)212-125(63-68-147(249)250)165(265)217-130(82-110-45-34-32-35-46-110)170(270)228-152(104(11)20-2)178(278)206-107(14)157(257)214-132(85-113-88-198-118-50-40-39-49-116(113)118)168(268)216-128(81-101(5)6)169(269)226-150(102(7)8)176(276)213-120(53-44-71-197-184(190)191)160(260)199-90-140(240)207-119(52-43-70-196-183(188)189)159(259)202-93-149(253)254)210-156(256)106(13)204-155(255)105(12)205-163(263)124(59-64-137(187)237)208-141(241)91-200-161(261)122(61-66-145(245)246)211-166(266)127(80-100(3)4)215-167(267)129(84-112-55-57-115(236)58-56-112)218-173(273)134(94-231)221-175(275)136(96-233)222-177(277)151(103(9)10)227-172(272)133(87-148(251)252)219-174(274)135(95-232)223-180(280)154(109(16)235)229-171(271)131(83-111-47-36-33-37-48-111)220-179(279)153(108(15)234)225-142(242)92-201-162(262)123(62-67-146(247)248)224-182(283)185(17,18)230-158(258)117(186)86-114-89-192-99-203-114/h32-37,39-40,45-50,55-58,88-89,99-109,117,119-136,150-154,198,231-236H,19-31,38,41-44,51-54,59-87,90-98,186H2,1-18H3,(H2,187,237)(H,192,203)(H,193,243)(H,194,238)(H,195,244)(H,199,260)(H,200,261)(H,201,262)(H,202,259)(H,204,255)(H,205,263)(H,206,278)(H,207,240)(H,208,241)(H,209,239)(H,210,256)(H,211,266)(H,212,264)(H,213,276)(H,214,257)(H,215,267)(H,216,268)(H,217,265)(H,218,273)(H,219,274)(H,220,279)(H,221,275)(H,222,277)(H,223,280)(H,224,283)(H,225,242)(H,226,269)(H,227,272)(H,228,270)(H,229,271)(H,230,258)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,281,282)(H4,188,189,196)(H4,190,191,197)/t104-,105-,106-,107-,108+,109+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,150-,151-,152-,153-,154-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121433
(CHEMBL3616759)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C186H291N45O57/c1-18-106(10)154(180(281)208-109(13)159(260)215-133(87-115-90-200-120-51-40-39-50-118(115)120)170(271)217-129(83-103(4)5)171(272)227-152(104(6)7)178(279)214-122(54-44-73-199-185(191)192)162(263)201-92-141(241)209-121(53-43-72-198-184(189)190)161(262)204-95-151(256)257)229-172(273)131(84-112-46-33-31-34-47-112)218-167(268)127(65-69-149(252)253)213-166(267)123(52-41-42-70-195-144(244)99-287-80-79-286-77-75-197-145(245)100-288-81-78-285-76-74-196-140(240)56-45-71-194-139(239)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-146(246)247)211-158(259)108(12)206-157(258)107(11)207-165(266)126(62-66-138(188)238)210-142(242)93-202-163(264)124(63-67-147(248)249)212-168(269)128(82-102(2)3)216-169(270)130(86-114-58-60-117(237)61-59-114)219-175(276)135(96-232)222-177(278)137(98-234)223-179(280)153(105(8)9)228-174(275)134(89-150(254)255)220-176(277)136(97-233)224-182(283)156(111(15)236)230-173(274)132(85-113-48-35-32-36-49-113)221-181(282)155(110(14)235)226-143(243)94-203-164(265)125(64-68-148(250)251)225-183(284)186(16,17)231-160(261)119(187)88-116-91-193-101-205-116/h31-36,39-40,46-51,58-61,90-91,101-111,119,121-137,152-156,200,232-237H,18-30,37-38,41-45,52-57,62-89,92-100,187H2,1-17H3,(H2,188,238)(H,193,205)(H,194,239)(H,195,244)(H,196,240)(H,197,245)(H,201,263)(H,202,264)(H,203,265)(H,204,262)(H,206,258)(H,207,266)(H,208,281)(H,209,241)(H,210,242)(H,211,259)(H,212,269)(H,213,267)(H,214,279)(H,215,260)(H,216,270)(H,217,271)(H,218,268)(H,219,276)(H,220,277)(H,221,282)(H,222,278)(H,223,280)(H,224,283)(H,225,284)(H,226,243)(H,227,272)(H,228,275)(H,229,273)(H,230,274)(H,231,261)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H4,189,190,198)(H4,191,192,199)/t106-,107-,108-,109-,110+,111+,119-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121529
(CHEMBL3616763)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C191H299N45O59/c1-18-109(10)158(184(286)212-112(13)163(265)220-137(90-118-93-204-123-54-44-43-53-121(118)123)174(276)222-133(86-106(4)5)175(277)232-156(107(6)7)182(284)219-125(57-48-76-203-190(196)197)166(268)205-95-145(246)213-124(56-47-75-202-189(194)195)165(267)208-98-155(261)262)234-176(278)135(87-115-49-37-35-38-50-115)223-171(273)130(68-73-153(257)258)218-170(272)126(55-45-46-74-199-148(249)102-294-83-82-293-80-78-201-149(250)103-295-84-81-292-79-77-200-143(244)70-65-131(187(289)290)215-144(245)58-41-33-31-29-27-25-23-21-19-20-22-24-26-28-30-32-34-42-59-150(251)252)216-162(264)111(12)210-161(263)110(11)211-169(271)129(64-69-142(193)243)214-146(247)96-206-167(269)127(66-71-151(253)254)217-172(274)132(85-105(2)3)221-173(275)134(89-117-60-62-120(242)63-61-117)224-179(281)139(99-237)227-181(283)141(101-239)228-183(285)157(108(8)9)233-178(280)138(92-154(259)260)225-180(282)140(100-238)229-186(288)160(114(15)241)235-177(279)136(88-116-51-39-36-40-52-116)226-185(287)159(113(14)240)231-147(248)97-207-168(270)128(67-72-152(255)256)230-188(291)191(16,17)236-164(266)122(192)91-119-94-198-104-209-119/h35-40,43-44,49-54,60-63,93-94,104-114,122,124-141,156-160,204,237-242H,18-34,41-42,45-48,55-59,64-92,95-103,192H2,1-17H3,(H2,193,243)(H,198,209)(H,199,249)(H,200,244)(H,201,250)(H,205,268)(H,206,269)(H,207,270)(H,208,267)(H,210,263)(H,211,271)(H,212,286)(H,213,246)(H,214,247)(H,215,245)(H,216,264)(H,217,274)(H,218,272)(H,219,284)(H,220,265)(H,221,275)(H,222,276)(H,223,273)(H,224,281)(H,225,282)(H,226,287)(H,227,283)(H,228,285)(H,229,288)(H,230,291)(H,231,248)(H,232,277)(H,233,280)(H,234,278)(H,235,279)(H,236,266)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,289,290)(H4,194,195,202)(H4,196,197,203)/t109-,110-,111-,112-,113+,114+,122-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50120388
(CHEMBL3616750)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(N)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C175H270N44O52/c1-18-95(10)142(168(266)195-98(13)147(245)203-123(78-104-81-187-109-50-40-39-49-107(104)109)158(256)205-119(74-92(4)5)159(257)215-140(93(6)7)166(264)202-111(53-44-72-186-174(181)182)150(248)188-83-132(230)196-110(52-43-71-185-173(179)180)149(247)191-86-139(241)242)217-160(258)121(75-101-45-33-31-34-46-101)206-155(253)116(64-69-137(237)238)201-154(252)112(51-41-42-70-184-130(228)66-61-117(171(269)270)198-131(229)55-38-30-28-26-24-22-20-19-21-23-25-27-29-37-54-128(177)226)199-146(244)97(12)193-145(243)96(11)194-153(251)115(60-65-129(178)227)197-133(231)84-189-151(249)113(62-67-135(233)234)200-156(254)118(73-91(2)3)204-157(255)120(77-103-56-58-106(225)59-57-103)207-163(261)125(87-220)210-165(263)127(89-222)211-167(265)141(94(8)9)216-162(260)124(80-138(239)240)208-164(262)126(88-221)212-170(268)144(100(15)224)218-161(259)122(76-102-47-35-32-36-48-102)209-169(267)143(99(14)223)214-134(232)85-190-152(250)114(63-68-136(235)236)213-172(271)175(16,17)219-148(246)108(176)79-105-82-183-90-192-105/h31-36,39-40,45-50,56-59,81-82,90-100,108,110-127,140-144,187,220-225H,18-30,37-38,41-44,51-55,60-80,83-89,176H2,1-17H3,(H2,177,226)(H2,178,227)(H,183,192)(H,184,228)(H,188,248)(H,189,249)(H,190,250)(H,191,247)(H,193,243)(H,194,251)(H,195,266)(H,196,230)(H,197,231)(H,198,229)(H,199,244)(H,200,254)(H,201,252)(H,202,264)(H,203,245)(H,204,255)(H,205,256)(H,206,253)(H,207,261)(H,208,262)(H,209,267)(H,210,263)(H,211,265)(H,212,268)(H,213,271)(H,214,232)(H,215,257)(H,216,260)(H,217,258)(H,218,259)(H,219,246)(H,233,234)(H,235,236)(H,237,238)(H,239,240)(H,241,242)(H,269,270)(H4,179,180,185)(H4,181,182,186)/t95-,96-,97-,98-,99+,100+,108-,110-,111-,112-,113-,114-,115-,116-,117+,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,140-,141-,142-,143-,144-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121523
(CHEMBL3616742)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C191H300N46O60/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-144(246)216-131(187(289)290)60-65-143(245)200-72-75-292-78-82-296-102-149(251)202-74-77-294-80-83-297-103-150(252)201-73-76-293-79-81-295-101-148(250)199-69-42-41-51-126(170(272)219-130(63-68-153(257)258)171(273)224-135(86-115-45-34-32-35-46-115)176(278)235-158(109(11)20-2)184(286)213-112(14)163(265)221-137(89-118-92-205-123-50-40-39-49-121(118)123)174(276)223-133(85-106(5)6)175(277)233-156(107(7)8)182(284)220-125(53-44-71-204-190(196)197)166(268)206-94-145(247)214-124(52-43-70-203-189(194)195)165(267)209-97-155(261)262)217-162(264)111(13)211-161(263)110(12)212-169(271)129(59-64-142(193)244)215-146(248)95-207-167(269)127(61-66-151(253)254)218-172(274)132(84-105(3)4)222-173(275)134(88-117-55-57-120(243)58-56-117)225-179(281)139(98-238)228-181(283)141(100-240)229-183(285)157(108(9)10)234-178(280)138(91-154(259)260)226-180(282)140(99-239)230-186(288)160(114(16)242)236-177(279)136(87-116-47-36-33-37-48-116)227-185(287)159(113(15)241)232-147(249)96-208-168(270)128(62-67-152(255)256)231-188(291)191(17,18)237-164(266)122(192)90-119-93-198-104-210-119/h32-37,39-40,45-50,55-58,92-93,104-114,122,124-141,156-160,205,238-243H,19-31,38,41-44,51-54,59-91,94-103,192H2,1-18H3,(H2,193,244)(H,198,210)(H,199,250)(H,200,245)(H,201,252)(H,202,251)(H,206,268)(H,207,269)(H,208,270)(H,209,267)(H,211,263)(H,212,271)(H,213,286)(H,214,247)(H,215,248)(H,216,246)(H,217,264)(H,218,274)(H,219,272)(H,220,284)(H,221,265)(H,222,275)(H,223,276)(H,224,273)(H,225,281)(H,226,282)(H,227,287)(H,228,283)(H,229,285)(H,230,288)(H,231,291)(H,232,249)(H,233,277)(H,234,280)(H,235,278)(H,236,279)(H,237,266)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,289,290)(H4,194,195,203)(H4,196,197,204)/t109-,110-,111-,112-,113+,114+,122-,124-,125-,126-,127-,128-,129-,130-,131+,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
MMDB
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM559791
(2-[[4-[6-[(4-cyano-2-fluoro-phenyl)methoxy]-5-fluo...)Show SMILES OC(=O)c1cc(F)c2nc(CN3CCN(CC3)c3ccc(F)c(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2c1 |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| WIPO WO2022109182
| n/a | n/a | 0.220 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
GLP-1R activation by small molecule agonists is quantified by measuring cAMP increase in CHO cells stably expressing GLP-1R (MultiSpan product # C126... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q27D2ZC6 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM559784
(WO2022109182, Example 15)Show SMILES CC(C)(Cn1c(CN2CCC(CC2)c2cccc(OCc3ccc(cc3F)C#N)n2)nc2c(F)cc(cc12)C(O)=O)C#N | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| WIPO WO2022109182
| n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
GLP-1R activation by a compound of the present disclosure was quantified by measuring cAMP increase in CHO cells stably expressing GLP-1R (MultiSpan ... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q27D2ZC6 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121394
(CHEMBL3616711)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C151H228N42O47/c1-17-76(10)120(147(238)171-80(14)126(217)179-104(59-86-62-162-91-35-25-24-34-89(86)91)137(228)181-100(55-73(4)5)138(229)190-118(74(6)7)145(236)178-93(38-29-53-161-151(157)158)129(220)163-64-110(201)172-92(37-28-52-160-150(155)156)128(219)166-67-117(212)213)192-139(230)102(56-83-30-20-18-21-31-83)182-134(225)98(46-50-115(208)209)177-133(224)94(36-26-27-51-152)174-124(215)78(12)168-123(214)77(11)170-132(223)97(43-47-109(154)200)173-111(202)65-164-131(222)96(45-49-114(206)207)176-135(226)99(54-72(2)3)180-136(227)101(58-85-39-41-88(199)42-40-85)183-142(233)106(68-194)186-144(235)108(70-196)187-146(237)119(75(8)9)191-141(232)105(61-116(210)211)184-143(234)107(69-195)188-149(240)122(82(16)198)193-140(231)103(57-84-32-22-19-23-33-84)185-148(239)121(81(15)197)189-112(203)66-165-130(221)95(44-48-113(204)205)175-125(216)79(13)169-127(218)90(153)60-87-63-159-71-167-87/h18-25,30-35,39-42,62-63,71-82,90,92-108,118-122,162,194-199H,17,26-29,36-38,43-61,64-70,152-153H2,1-16H3,(H2,154,200)(H,159,167)(H,163,220)(H,164,222)(H,165,221)(H,166,219)(H,168,214)(H,169,218)(H,170,223)(H,171,238)(H,172,201)(H,173,202)(H,174,215)(H,175,216)(H,176,226)(H,177,224)(H,178,236)(H,179,217)(H,180,227)(H,181,228)(H,182,225)(H,183,233)(H,184,234)(H,185,239)(H,186,235)(H,187,237)(H,188,240)(H,189,203)(H,190,229)(H,191,232)(H,192,230)(H,193,231)(H,204,205)(H,206,207)(H,208,209)(H,210,211)(H,212,213)(H4,155,156,160)(H4,157,158,161)/t76-,77-,78-,79-,80-,81+,82+,90-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,118-,119-,120-,121-,122-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121435
(CHEMBL3616756)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C192H299N47O61/c1-18-107(10)158(184(289)214-110(13)163(268)223-136(88-116-91-206-121-50-40-39-49-119(116)121)174(279)225-132(84-104(4)5)175(280)235-156(105(6)7)182(287)222-123(53-44-74-205-191(198)199)166(271)208-94-146(251)215-122(52-43-73-204-190(196)197)165(270)207-93-142(195)247)237-176(281)134(85-113-45-33-31-34-46-113)226-171(276)128(65-71-154(262)263)221-170(275)124(51-41-42-72-201-149(254)100-299-81-80-298-78-76-203-150(255)101-300-82-79-297-77-75-202-143(248)67-61-129(187(292)293)218-145(250)68-62-130(188(294)295)217-144(249)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-151(256)257)219-162(267)109(12)212-161(266)108(11)213-169(274)127(60-66-141(194)246)216-147(252)95-209-167(272)125(63-69-152(258)259)220-172(277)131(83-103(2)3)224-173(278)133(87-115-56-58-118(245)59-57-115)227-179(284)138(97-240)230-181(286)140(99-242)231-183(288)157(106(8)9)236-178(283)137(90-155(264)265)228-180(285)139(98-241)232-186(291)160(112(15)244)238-177(282)135(86-114-47-35-32-36-48-114)229-185(290)159(111(14)243)234-148(253)96-210-168(273)126(64-70-153(260)261)233-189(296)192(16,17)239-164(269)120(193)89-117-92-200-102-211-117/h31-36,39-40,45-50,56-59,91-92,102-112,120,122-140,156-160,206,240-245H,18-30,37-38,41-44,51-55,60-90,93-101,193H2,1-17H3,(H2,194,246)(H2,195,247)(H,200,211)(H,201,254)(H,202,248)(H,203,255)(H,207,270)(H,208,271)(H,209,272)(H,210,273)(H,212,266)(H,213,274)(H,214,289)(H,215,251)(H,216,252)(H,217,249)(H,218,250)(H,219,267)(H,220,277)(H,221,275)(H,222,287)(H,223,268)(H,224,278)(H,225,279)(H,226,276)(H,227,284)(H,228,285)(H,229,290)(H,230,286)(H,231,288)(H,232,291)(H,233,296)(H,234,253)(H,235,280)(H,236,283)(H,237,281)(H,238,282)(H,239,269)(H,256,257)(H,258,259)(H,260,261)(H,262,263)(H,264,265)(H,292,293)(H,294,295)(H4,196,197,204)(H4,198,199,205)/t107-,108-,109-,110-,111+,112+,120-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,156-,157-,158-,159-,160-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121530
(CHEMBL3616773)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C188H296N46O57/c1-18-107(10)155(181(282)210-110(13)160(261)218-135(88-116-91-202-121-52-40-39-51-119(116)121)171(272)220-131(84-104(4)5)172(273)230-153(105(6)7)179(280)217-123(56-46-74-201-187(194)195)163(264)204-93-142(243)211-122(55-45-73-200-186(192)193)162(263)203-95-144(245)213-129(184(285)286)54-42-44-72-197-146(247)100-290-81-80-289-78-76-199-147(248)101-291-82-79-288-77-75-198-141(242)57-37-29-27-25-23-21-19-20-22-24-26-28-30-38-58-148(249)250)232-173(274)133(85-113-47-33-31-34-48-113)221-168(269)128(66-70-151(255)256)216-167(268)124(53-41-43-71-189)214-159(260)109(12)208-158(259)108(11)209-166(267)127(63-67-140(191)241)212-143(244)94-205-164(265)125(64-68-149(251)252)215-169(270)130(83-103(2)3)219-170(271)132(87-115-59-61-118(240)62-60-115)222-176(277)137(97-235)225-178(279)139(99-237)226-180(281)154(106(8)9)231-175(276)136(90-152(257)258)223-177(278)138(98-236)227-183(284)157(112(15)239)233-174(275)134(86-114-49-35-32-36-50-114)224-182(283)156(111(14)238)229-145(246)96-206-165(266)126(65-69-150(253)254)228-185(287)188(16,17)234-161(262)120(190)89-117-92-196-102-207-117/h31-36,39-40,47-52,59-62,91-92,102-112,120,122-139,153-157,202,235-240H,18-30,37-38,41-46,53-58,63-90,93-101,189-190H2,1-17H3,(H2,191,241)(H,196,207)(H,197,247)(H,198,242)(H,199,248)(H,203,263)(H,204,264)(H,205,265)(H,206,266)(H,208,259)(H,209,267)(H,210,282)(H,211,243)(H,212,244)(H,213,245)(H,214,260)(H,215,270)(H,216,268)(H,217,280)(H,218,261)(H,219,271)(H,220,272)(H,221,269)(H,222,277)(H,223,278)(H,224,283)(H,225,279)(H,226,281)(H,227,284)(H,228,287)(H,229,246)(H,230,273)(H,231,276)(H,232,274)(H,233,275)(H,234,262)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,192,193,200)(H4,194,195,201)/t107-,108-,109-,110-,111+,112+,120-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,153-,154-,155-,156-,157-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.270 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121533
(CHEMBL3616716)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C186H289N45O59/c1-17-104(10)154(181(282)208-108(14)160(261)217-133(85-114-88-199-119-49-39-38-48-117(114)119)171(272)219-129(81-101(4)5)172(273)228-152(102(6)7)179(280)216-121(52-43-71-198-186(191)192)163(264)200-90-141(241)209-120(51-42-70-197-185(189)190)162(263)203-93-151(256)257)230-173(274)131(82-111-44-32-30-33-45-111)220-168(269)126(63-68-149(252)253)215-167(268)122(50-40-41-69-194-144(244)97-289-78-77-288-75-73-196-145(245)98-290-79-76-287-74-72-195-139(239)65-60-127(184(285)286)211-140(240)53-36-28-26-24-22-20-18-19-21-23-25-27-29-37-54-146(246)247)212-158(259)106(12)205-157(258)105(11)207-166(267)125(59-64-138(188)238)210-142(242)91-201-165(266)124(62-67-148(250)251)214-169(270)128(80-100(2)3)218-170(271)130(84-113-55-57-116(237)58-56-113)221-176(277)135(94-232)224-178(279)137(96-234)225-180(281)153(103(8)9)229-175(276)134(87-150(254)255)222-177(278)136(95-233)226-183(284)156(110(16)236)231-174(275)132(83-112-46-34-31-35-47-112)223-182(283)155(109(15)235)227-143(243)92-202-164(265)123(61-66-147(248)249)213-159(260)107(13)206-161(262)118(187)86-115-89-193-99-204-115/h30-35,38-39,44-49,55-58,88-89,99-110,118,120-137,152-156,199,232-237H,17-29,36-37,40-43,50-54,59-87,90-98,187H2,1-16H3,(H2,188,238)(H,193,204)(H,194,244)(H,195,239)(H,196,245)(H,200,264)(H,201,266)(H,202,265)(H,203,263)(H,205,258)(H,206,262)(H,207,267)(H,208,282)(H,209,241)(H,210,242)(H,211,240)(H,212,259)(H,213,260)(H,214,270)(H,215,268)(H,216,280)(H,217,261)(H,218,271)(H,219,272)(H,220,269)(H,221,277)(H,222,278)(H,223,283)(H,224,279)(H,225,281)(H,226,284)(H,227,243)(H,228,273)(H,229,276)(H,230,274)(H,231,275)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,285,286)(H4,189,190,197)(H4,191,192,198)/t104-,105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.280 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM559788
(2-[[4-[6-[(4-cyano-2-fluoro-phenyl)methoxy]-2-pyri...)Show SMILES Cn1cc(cn1)-c1cc(cc2n(C[C@@H]3CCO3)c(CN3CCN(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)nc12)C(O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| WIPO WO2022109182
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
GLP-1R activation by small molecule agonists is quantified by measuring cAMP increase in CHO cells stably expressing GLP-1R (MultiSpan product # C126... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q27D2ZC6 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121404
(CHEMBL3616770)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C176H274N46O51/c1-18-96(10)142(168(268)198-99(13)147(247)206-124(79-105-82-190-110-51-40-39-50-108(105)110)158(258)208-120(75-93(4)5)159(259)218-140(94(6)7)166(266)205-112(54-44-72-188-174(181)182)150(250)192-84-131(231)199-111(53-43-71-187-173(179)180)149(249)191-86-133(233)201-118(171(271)272)52-41-42-70-186-130(230)56-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-135(235)236)220-160(260)122(76-102-46-33-31-34-47-102)209-155(255)117(65-69-138(241)242)204-154(254)113(55-45-73-189-175(183)184)202-146(246)98(12)196-145(245)97(11)197-153(253)116(62-66-129(178)229)200-132(232)85-193-151(251)114(63-67-136(237)238)203-156(256)119(74-92(2)3)207-157(257)121(78-104-58-60-107(228)61-59-104)210-163(263)126(88-223)213-165(265)128(90-225)214-167(267)141(95(8)9)219-162(262)125(81-139(243)244)211-164(264)127(89-224)215-170(270)144(101(15)227)221-161(261)123(77-103-48-35-32-36-49-103)212-169(269)143(100(14)226)217-134(234)87-194-152(252)115(64-68-137(239)240)216-172(273)176(16,17)222-148(248)109(177)80-106-83-185-91-195-106/h31-36,39-40,46-51,58-61,82-83,91-101,109,111-128,140-144,190,223-228H,18-30,37-38,41-45,52-57,62-81,84-90,177H2,1-17H3,(H2,178,229)(H,185,195)(H,186,230)(H,191,249)(H,192,250)(H,193,251)(H,194,252)(H,196,245)(H,197,253)(H,198,268)(H,199,231)(H,200,232)(H,201,233)(H,202,246)(H,203,256)(H,204,254)(H,205,266)(H,206,247)(H,207,257)(H,208,258)(H,209,255)(H,210,263)(H,211,264)(H,212,269)(H,213,265)(H,214,267)(H,215,270)(H,216,273)(H,217,234)(H,218,259)(H,219,262)(H,220,260)(H,221,261)(H,222,248)(H,235,236)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,271,272)(H4,179,180,187)(H4,181,182,188)(H4,183,184,189)/t96-,97-,98-,99-,100+,101+,109-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,140-,141-,142-,143-,144-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.310 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121528
(CHEMBL3616740)Show SMILES CCCCCCCCCCCCCCCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C180H282N44O54/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-135(232)189-70-72-275-74-77-278-96-140(237)190-71-73-276-75-76-277-95-139(236)188-67-42-41-51-119(160(257)206-123(62-66-143(242)243)161(258)211-127(80-108-45-34-32-35-46-108)166(263)222-148(102(11)20-2)174(271)201-105(14)153(250)208-129(83-111-86-193-116-50-40-39-49-114(111)116)164(261)210-125(79-99(5)6)165(262)220-146(100(7)8)172(269)207-118(53-44-69-192-179(185)186)156(253)194-88-136(233)202-117(52-43-68-191-178(183)184)155(252)197-91-145(246)247)204-152(249)104(13)199-151(248)103(12)200-159(256)122(59-63-134(182)231)203-137(234)89-195-157(254)120(60-64-141(238)239)205-162(259)124(78-98(3)4)209-163(260)126(82-110-55-57-113(230)58-56-110)212-169(266)131(92-225)215-171(268)133(94-227)216-173(270)147(101(9)10)221-168(265)130(85-144(244)245)213-170(267)132(93-226)217-176(273)150(107(16)229)223-167(264)128(81-109-47-36-33-37-48-109)214-175(272)149(106(15)228)219-138(235)90-196-158(255)121(61-65-142(240)241)218-177(274)180(17,18)224-154(251)115(181)84-112-87-187-97-198-112/h32-37,39-40,45-50,55-58,86-87,97-107,115,117-133,146-150,193,225-230H,19-31,38,41-44,51-54,59-85,88-96,181H2,1-18H3,(H2,182,231)(H,187,198)(H,188,236)(H,189,232)(H,190,237)(H,194,253)(H,195,254)(H,196,255)(H,197,252)(H,199,248)(H,200,256)(H,201,271)(H,202,233)(H,203,234)(H,204,249)(H,205,259)(H,206,257)(H,207,269)(H,208,250)(H,209,260)(H,210,261)(H,211,258)(H,212,266)(H,213,267)(H,214,272)(H,215,268)(H,216,270)(H,217,273)(H,218,274)(H,219,235)(H,220,262)(H,221,265)(H,222,263)(H,223,264)(H,224,251)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H4,183,184,191)(H4,185,186,192)/t102-,103-,104-,105-,106+,107+,115-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,146-,147-,148-,149-,150-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.320 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121459
(CHEMBL3616757)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CC[C@H](NC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)C(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C197H306N48O64/c1-18-109(10)162(188(296)219-112(13)167(275)229-139(90-118-93-211-123-50-40-39-49-121(118)123)178(286)231-135(86-106(4)5)179(287)241-160(107(6)7)186(294)228-125(53-44-76-210-196(203)204)170(278)213-96-150(258)220-124(52-43-75-209-195(201)202)169(277)212-95-145(200)253)243-180(288)137(87-115-45-33-31-34-46-115)232-175(283)130(66-73-158(269)270)227-174(282)126(51-41-42-74-206-153(261)102-308-83-82-307-80-78-208-154(262)103-309-84-81-306-79-77-207-146(254)68-61-131(191(299)300)223-148(256)70-63-133(193(303)304)224-149(257)69-62-132(192(301)302)222-147(255)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-155(263)264)225-166(274)111(12)217-165(273)110(11)218-173(281)129(60-67-144(199)252)221-151(259)97-214-171(279)127(64-71-156(265)266)226-176(284)134(85-105(2)3)230-177(285)136(89-117-56-58-120(251)59-57-117)233-183(291)141(99-246)236-185(293)143(101-248)237-187(295)161(108(8)9)242-182(290)140(92-159(271)272)234-184(292)142(100-247)238-190(298)164(114(15)250)244-181(289)138(88-116-47-35-32-36-48-116)235-189(297)163(113(14)249)240-152(260)98-215-172(280)128(65-72-157(267)268)239-194(305)197(16,17)245-168(276)122(198)91-119-94-205-104-216-119/h31-36,39-40,45-50,56-59,93-94,104-114,122,124-143,160-164,211,246-251H,18-30,37-38,41-44,51-55,60-92,95-103,198H2,1-17H3,(H2,199,252)(H2,200,253)(H,205,216)(H,206,261)(H,207,254)(H,208,262)(H,212,277)(H,213,278)(H,214,279)(H,215,280)(H,217,273)(H,218,281)(H,219,296)(H,220,258)(H,221,259)(H,222,255)(H,223,256)(H,224,257)(H,225,274)(H,226,284)(H,227,282)(H,228,294)(H,229,275)(H,230,285)(H,231,286)(H,232,283)(H,233,291)(H,234,292)(H,235,297)(H,236,293)(H,237,295)(H,238,298)(H,239,305)(H,240,260)(H,241,287)(H,242,290)(H,243,288)(H,244,289)(H,245,276)(H,263,264)(H,265,266)(H,267,268)(H,269,270)(H,271,272)(H,299,300)(H,301,302)(H,303,304)(H4,201,202,209)(H4,203,204,210)/t109-,110-,111-,112-,113+,114+,122-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,160-,161-,162-,163-,164-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50241203
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)Show SMILES [H][C@](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.398 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00653
BindingDB Entry DOI: 10.7270/Q28K7F3B |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121393
(CHEMBL3616765)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C188H294N44O59/c1-16-107(8)156(182(282)208-110(11)161(261)217-136(89-116-92-200-121-51-38-37-50-119(116)121)173(273)219-132(85-105(4)5)175(275)229-155(106(6)7)181(281)216-123(52-39-42-72-189)164(264)201-94-144(242)209-122(55-45-75-199-187(193)194)163(263)204-97-154(257)258)230-176(276)134(86-113-46-31-29-32-47-113)220-170(270)129(66-71-152(253)254)215-168(268)124(53-40-43-73-190)212-160(260)109(10)206-159(259)108(9)207-167(267)128(62-67-141(192)239)210-145(243)95-202-165(265)126(64-69-150(249)250)214-171(271)131(84-104(2)3)218-172(272)133(88-115-58-60-118(238)61-59-115)221-178(278)138(98-233)225-180(280)139(99-234)224-169(269)125(54-41-44-74-196-147(245)101-290-82-81-289-79-77-198-148(246)102-291-83-80-288-78-76-197-142(240)68-63-130(185(285)286)211-143(241)56-35-27-25-23-21-19-17-18-20-22-24-26-28-36-57-149(247)248)213-174(274)137(91-153(255)256)222-179(279)140(100-235)226-184(284)158(112(13)237)231-177(277)135(87-114-48-33-30-34-49-114)223-183(283)157(111(12)236)228-146(244)96-203-166(266)127(65-70-151(251)252)227-186(287)188(14,15)232-162(262)120(191)90-117-93-195-103-205-117/h29-34,37-38,46-51,58-61,92-93,103-112,120,122-140,155-158,200,233-238H,16-28,35-36,39-45,52-57,62-91,94-102,189-191H2,1-15H3,(H2,192,239)(H,195,205)(H,196,245)(H,197,240)(H,198,246)(H,201,264)(H,202,265)(H,203,266)(H,204,263)(H,206,259)(H,207,267)(H,208,282)(H,209,242)(H,210,243)(H,211,241)(H,212,260)(H,213,274)(H,214,271)(H,215,268)(H,216,281)(H,217,261)(H,218,272)(H,219,273)(H,220,270)(H,221,278)(H,222,279)(H,223,283)(H,224,269)(H,225,280)(H,226,284)(H,227,287)(H,228,244)(H,229,275)(H,230,276)(H,231,277)(H,232,262)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,193,194,199)/t107-,108-,109-,110-,111+,112+,120-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,155-,156-,157-,158-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM559793
(6-(tert-butoxycarbonylamino)-2-[[4-[6-[(4-cyano-2-...)Show SMILES CC(C)(C)OC(=O)Nc1cc2nc(CN3CCC(CC3)c3cccc(OCc4ccc(cc4F)C#N)n3)n(C[C@@H]3CCO3)c2cc1C(O)=O |r| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| WIPO WO2022109182
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
GLP-1R activation by small molecule agonists is quantified by measuring cAMP increase in CHO cells stably expressing GLP-1R (MultiSpan product # C126... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q27D2ZC6 |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121403
(CHEMBL3616769)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C170H262N42O50/c1-18-93(10)138(164(259)189-96(13)143(238)196-120(76-102-79-181-107-50-40-39-49-105(102)107)154(249)198-116(72-90(4)5)155(250)208-136(91(6)7)162(257)195-109(52-43-69-179-168(173)174)146(241)182-81-127(221)190-108(145(240)185-84-135(234)235)51-41-42-68-178-126(220)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-130(224)225)210-156(251)118(73-99-45-33-31-34-46-99)199-151(246)114(63-67-133(230)231)194-150(245)110(53-44-70-180-169(175)176)192-142(237)95(12)187-141(236)94(11)188-149(244)113(60-64-125(172)219)191-128(222)82-183-147(242)111(61-65-131(226)227)193-152(247)115(71-89(2)3)197-153(248)117(75-101-56-58-104(218)59-57-101)200-159(254)122(85-213)203-161(256)124(87-215)204-163(258)137(92(8)9)209-158(253)121(78-134(232)233)201-160(255)123(86-214)205-166(261)140(98(15)217)211-157(252)119(74-100-47-35-32-36-48-100)202-165(260)139(97(14)216)207-129(223)83-184-148(243)112(62-66-132(228)229)206-167(262)170(16,17)212-144(239)106(171)77-103-80-177-88-186-103/h31-36,39-40,45-50,56-59,79-80,88-98,106,108-124,136-140,181,213-218H,18-30,37-38,41-44,51-55,60-78,81-87,171H2,1-17H3,(H2,172,219)(H,177,186)(H,178,220)(H,182,241)(H,183,242)(H,184,243)(H,185,240)(H,187,236)(H,188,244)(H,189,259)(H,190,221)(H,191,222)(H,192,237)(H,193,247)(H,194,245)(H,195,257)(H,196,238)(H,197,248)(H,198,249)(H,199,246)(H,200,254)(H,201,255)(H,202,260)(H,203,256)(H,204,258)(H,205,261)(H,206,262)(H,207,223)(H,208,250)(H,209,253)(H,210,251)(H,211,252)(H,212,239)(H,224,225)(H,226,227)(H,228,229)(H,230,231)(H,232,233)(H,234,235)(H4,173,174,179)(H4,175,176,180)/t93-,94-,95-,96-,97+,98+,106-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,136-,137-,138-,139-,140-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.520 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121532
(CHEMBL3616760)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C185H287N45O57/c1-18-103(10)152(178(280)206-106(13)157(259)214-131(85-112-88-198-117-51-40-39-50-115(112)117)168(270)216-127(81-100(4)5)169(271)226-150(101(6)7)176(278)213-119(54-44-75-197-184(190)191)160(262)199-90-140(241)207-118(53-43-74-196-183(188)189)159(261)202-93-149(255)256)228-170(272)129(82-109-46-33-31-34-47-109)217-165(267)124(66-71-147(251)252)212-164(266)120(52-41-42-72-194-143(244)97-287-79-78-286-77-76-195-138(239)68-63-125(181(283)284)209-139(240)56-45-73-193-137(238)55-37-29-27-25-23-21-19-20-22-24-26-28-30-38-57-144(245)246)210-156(258)105(12)204-155(257)104(11)205-163(265)123(62-67-136(187)237)208-141(242)91-200-161(263)121(64-69-145(247)248)211-166(268)126(80-99(2)3)215-167(269)128(84-111-58-60-114(236)61-59-111)218-173(275)133(94-231)221-175(277)135(96-233)222-177(279)151(102(8)9)227-172(274)132(87-148(253)254)219-174(276)134(95-232)223-180(282)154(108(15)235)229-171(273)130(83-110-48-35-32-36-49-110)220-179(281)153(107(14)234)225-142(243)92-201-162(264)122(65-70-146(249)250)224-182(285)185(16,17)230-158(260)116(186)86-113-89-192-98-203-113/h31-36,39-40,46-51,58-61,88-89,98-108,116,118-135,150-154,198,231-236H,18-30,37-38,41-45,52-57,62-87,90-97,186H2,1-17H3,(H2,187,237)(H,192,203)(H,193,238)(H,194,244)(H,195,239)(H,199,262)(H,200,263)(H,201,264)(H,202,261)(H,204,257)(H,205,265)(H,206,280)(H,207,241)(H,208,242)(H,209,240)(H,210,258)(H,211,268)(H,212,266)(H,213,278)(H,214,259)(H,215,269)(H,216,270)(H,217,267)(H,218,275)(H,219,276)(H,220,281)(H,221,277)(H,222,279)(H,223,282)(H,224,285)(H,225,243)(H,226,271)(H,227,274)(H,228,272)(H,229,273)(H,230,260)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,283,284)(H4,188,189,196)(H4,190,191,197)/t103-,104-,105-,106-,107+,108+,116-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,150-,151-,152-,153-,154-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.580 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121396
(CHEMBL3616712)Show SMILES CCCCCCCCCCCCCCCCCC(=O)N[C@H](CCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C174H269N43O51/c1-18-20-21-22-23-24-25-26-27-28-29-30-31-32-39-55-131(226)197-118(172(267)268)61-66-130(225)182-70-43-42-52-113(155(250)201-117(64-69-137(234)235)156(251)206-122(75-102-46-35-33-36-47-102)161(256)216-142(95(11)19-2)169(264)194-99(15)148(243)203-124(78-105-81-185-110-51-41-40-50-108(105)110)159(254)205-120(74-92(5)6)160(255)214-140(93(7)8)167(262)202-112(54-45-72-184-174(179)180)151(246)186-83-132(227)195-111(53-44-71-183-173(177)178)150(245)189-86-139(238)239)198-146(241)97(13)191-145(240)96(12)193-154(249)116(60-65-129(176)224)196-133(228)84-187-153(248)115(63-68-136(232)233)200-157(252)119(73-91(3)4)204-158(253)121(77-104-56-58-107(223)59-57-104)207-164(259)126(87-218)210-166(261)128(89-220)211-168(263)141(94(9)10)215-163(258)125(80-138(236)237)208-165(260)127(88-219)212-171(266)144(101(17)222)217-162(257)123(76-103-48-37-34-38-49-103)209-170(265)143(100(16)221)213-134(229)85-188-152(247)114(62-67-135(230)231)199-147(242)98(14)192-149(244)109(175)79-106-82-181-90-190-106/h33-38,40-41,46-51,56-59,81-82,90-101,109,111-128,140-144,185,218-223H,18-32,39,42-45,52-55,60-80,83-89,175H2,1-17H3,(H2,176,224)(H,181,190)(H,182,225)(H,186,246)(H,187,248)(H,188,247)(H,189,245)(H,191,240)(H,192,244)(H,193,249)(H,194,264)(H,195,227)(H,196,228)(H,197,226)(H,198,241)(H,199,242)(H,200,252)(H,201,250)(H,202,262)(H,203,243)(H,204,253)(H,205,254)(H,206,251)(H,207,259)(H,208,260)(H,209,265)(H,210,261)(H,211,263)(H,212,266)(H,213,229)(H,214,255)(H,215,258)(H,216,256)(H,217,257)(H,230,231)(H,232,233)(H,234,235)(H,236,237)(H,238,239)(H,267,268)(H4,177,178,183)(H4,179,180,184)/t95-,96-,97-,98-,99-,100+,101+,109-,111-,112-,113-,114-,115-,116-,117-,118+,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,140-,141-,142-,143-,144-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50241203
(CHEMBL414357 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGS...)Show SMILES [H][C@](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)Cc1cnc[nH]1)([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@]([H])([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N1CCC[C@@]1([H])C(=O)N[C@@H](CO)C(N)=O |r| Show InChI InChI=1S/C184H282N50O60S/c1-16-94(10)147(178(289)213-114(52-58-144(257)258)163(274)218-121(73-101-77-195-105-39-24-23-38-103(101)105)168(279)215-116(68-90(2)3)165(276)205-107(41-26-28-61-186)158(269)219-122(75-134(189)243)154(265)198-79-135(244)196-83-139(248)231-63-30-43-129(231)175(286)225-127(87-238)174(285)223-125(85-236)155(266)200-80-136(245)202-96(12)181(292)233-65-32-45-131(233)183(294)234-66-33-46-132(234)182(293)232-64-31-44-130(232)176(287)222-124(84-235)150(190)261)229-170(281)119(71-99-34-19-17-20-35-99)217-166(277)117(69-91(4)5)214-159(270)108(42-29-62-194-184(191)192)212-177(288)146(93(8)9)228-151(262)95(11)203-156(267)111(49-55-141(251)252)208-161(272)112(50-56-142(253)254)209-162(273)113(51-57-143(255)256)210-164(275)115(59-67-295-15)211-160(271)110(47-53-133(188)242)207-157(268)106(40-25-27-60-185)206-172(283)126(86-237)224-167(278)118(70-92(6)7)216-169(280)123(76-145(259)260)220-173(284)128(88-239)226-180(291)149(98(14)241)230-171(282)120(72-100-36-21-18-22-37-100)221-179(290)148(97(13)240)227-138(247)82-199-153(264)109(48-54-140(249)250)204-137(246)81-197-152(263)104(187)74-102-78-193-89-201-102/h17-24,34-39,77-78,89-98,104,106-132,146-149,195,235-241H,16,25-33,40-76,79-88,185-187H2,1-15H3,(H2,188,242)(H2,189,243)(H2,190,261)(H,193,201)(H,196,244)(H,197,263)(H,198,265)(H,199,264)(H,200,266)(H,202,245)(H,203,267)(H,204,246)(H,205,276)(H,206,283)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,271)(H,212,288)(H,213,289)(H,214,270)(H,215,279)(H,216,280)(H,217,277)(H,218,274)(H,219,269)(H,220,284)(H,221,290)(H,222,287)(H,223,285)(H,224,278)(H,225,286)(H,226,291)(H,227,247)(H,228,262)(H,229,281)(H,230,282)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,259,260)(H4,191,192,194)/t94-,95-,96-,97+,98+,104-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,146-,147-,148-,149-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 0.660 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen, Inc.
Curated by ChEMBL
| Assay Description
Displacement of [125I]GLP1 from human GLP1R expressed in CHOK1 cells |
J Med Chem 51: 2758-65 (2008)
Article DOI: 10.1021/jm701522b
BindingDB Entry DOI: 10.7270/Q2736QPR |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121460
(CHEMBL3616754)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C193H302N46O62/c1-18-110(10)160(186(290)215-113(13)165(269)223-138(90-119-93-207-124-50-40-39-49-122(119)124)176(280)225-134(86-107(4)5)177(281)235-158(108(6)7)184(288)222-126(53-44-72-206-192(198)199)168(272)208-95-146(249)216-125(52-43-71-205-191(196)197)167(271)211-98-157(265)266)237-178(282)136(87-116-45-33-31-34-46-116)226-173(277)131(64-69-155(261)262)221-172(276)127(51-41-42-70-201-149(252)102-299-82-80-297-77-74-203-151(254)104-301-84-81-298-78-75-204-150(253)103-300-83-79-296-76-73-202-144(247)66-61-132(189(293)294)218-145(248)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-152(255)256)219-164(268)112(12)213-163(267)111(11)214-171(275)130(60-65-143(195)246)217-147(250)96-209-169(273)128(62-67-153(257)258)220-174(278)133(85-106(2)3)224-175(279)135(89-118-56-58-121(245)59-57-118)227-181(285)140(99-240)230-183(287)142(101-242)231-185(289)159(109(8)9)236-180(284)139(92-156(263)264)228-182(286)141(100-241)232-188(292)162(115(15)244)238-179(283)137(88-117-47-35-32-36-48-117)229-187(291)161(114(14)243)234-148(251)97-210-170(274)129(63-68-154(259)260)233-190(295)193(16,17)239-166(270)123(194)91-120-94-200-105-212-120/h31-36,39-40,45-50,56-59,93-94,105-115,123,125-142,158-162,207,240-245H,18-30,37-38,41-44,51-55,60-92,95-104,194H2,1-17H3,(H2,195,246)(H,200,212)(H,201,252)(H,202,247)(H,203,254)(H,204,253)(H,208,272)(H,209,273)(H,210,274)(H,211,271)(H,213,267)(H,214,275)(H,215,290)(H,216,249)(H,217,250)(H,218,248)(H,219,268)(H,220,278)(H,221,276)(H,222,288)(H,223,269)(H,224,279)(H,225,280)(H,226,277)(H,227,285)(H,228,286)(H,229,291)(H,230,287)(H,231,289)(H,232,292)(H,233,295)(H,234,251)(H,235,281)(H,236,284)(H,237,282)(H,238,283)(H,239,270)(H,255,256)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H,293,294)(H4,196,197,205)(H4,198,199,206)/t110-,111-,112-,113-,114+,115+,123-,125-,126-,127-,128-,129-,130-,131-,132+,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,158-,159-,160-,161-,162-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.710 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121528
(CHEMBL3616740)Show SMILES CCCCCCCCCCCCCCCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O |r| Show InChI InChI=1S/C180H282N44O54/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-135(232)189-70-72-275-74-77-278-96-140(237)190-71-73-276-75-76-277-95-139(236)188-67-42-41-51-119(160(257)206-123(62-66-143(242)243)161(258)211-127(80-108-45-34-32-35-46-108)166(263)222-148(102(11)20-2)174(271)201-105(14)153(250)208-129(83-111-86-193-116-50-40-39-49-114(111)116)164(261)210-125(79-99(5)6)165(262)220-146(100(7)8)172(269)207-118(53-44-69-192-179(185)186)156(253)194-88-136(233)202-117(52-43-68-191-178(183)184)155(252)197-91-145(246)247)204-152(249)104(13)199-151(248)103(12)200-159(256)122(59-63-134(182)231)203-137(234)89-195-157(254)120(60-64-141(238)239)205-162(259)124(78-98(3)4)209-163(260)126(82-110-55-57-113(230)58-56-110)212-169(266)131(92-225)215-171(268)133(94-227)216-173(270)147(101(9)10)221-168(265)130(85-144(244)245)213-170(267)132(93-226)217-176(273)150(107(16)229)223-167(264)128(81-109-47-36-33-37-48-109)214-175(272)149(106(15)228)219-138(235)90-196-158(255)121(61-65-142(240)241)218-177(274)180(17,18)224-154(251)115(181)84-112-87-187-97-198-112/h32-37,39-40,45-50,55-58,86-87,97-107,115,117-133,146-150,193,225-230H,19-31,38,41-44,51-54,59-85,88-96,181H2,1-18H3,(H2,182,231)(H,187,198)(H,188,236)(H,189,232)(H,190,237)(H,194,253)(H,195,254)(H,196,255)(H,197,252)(H,199,248)(H,200,256)(H,201,271)(H,202,233)(H,203,234)(H,204,249)(H,205,259)(H,206,257)(H,207,269)(H,208,250)(H,209,260)(H,210,261)(H,211,258)(H,212,266)(H,213,267)(H,214,272)(H,215,268)(H,216,270)(H,217,273)(H,218,274)(H,219,235)(H,220,262)(H,221,265)(H,222,263)(H,223,264)(H,224,251)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H4,183,184,191)(H4,185,186,192)/t102-,103-,104-,105-,106+,107+,115-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,146-,147-,148-,149-,150-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121395
(CHEMBL3616766)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)C(C)(C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NC(C)(C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCNC(=O)COCCOCCNC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C184H290N42O53/c1-22-104(10)148(174(270)200-107(13)153(249)206-132(89-113-92-195-118-57-44-43-56-116(113)118)162(258)208-128(85-101(4)5)163(259)220-146(102(6)7)172(268)204-121(59-46-49-77-186)170(266)225-183(18,19)179(276)216-120(61-51-79-194-181(189)190)158(254)205-126(177(273)274)60-47-50-78-192-140(236)98-279-83-82-278-81-80-193-138(234)62-41-33-31-29-27-25-23-24-26-28-30-32-34-42-63-141(237)238)222-164(260)130(86-110-52-37-35-38-53-110)209-159(255)123(70-74-143(241)242)202-157(253)119(58-45-48-76-185)201-152(248)106(12)198-151(247)105(11)199-156(252)124(68-72-137(188)233)218-180(277)184(20,21)226-171(267)125(71-75-144(243)244)203-160(256)127(84-100(2)3)207-161(257)129(88-112-64-66-115(232)67-65-112)210-167(263)134(95-227)213-169(265)136(97-229)214-173(269)147(103(8)9)221-166(262)133(91-145(245)246)211-168(264)135(96-228)215-176(272)150(109(15)231)223-165(261)131(87-111-54-39-36-40-55-111)212-175(271)149(108(14)230)219-139(235)94-196-155(251)122(69-73-142(239)240)217-178(275)182(16,17)224-154(250)117(187)90-114-93-191-99-197-114/h35-40,43-44,52-57,64-67,92-93,99-109,117,119-136,146-150,195,227-232H,22-34,41-42,45-51,58-63,68-91,94-98,185-187H2,1-21H3,(H2,188,233)(H,191,197)(H,192,236)(H,193,234)(H,196,251)(H,198,247)(H,199,252)(H,200,270)(H,201,248)(H,202,253)(H,203,256)(H,204,268)(H,205,254)(H,206,249)(H,207,257)(H,208,258)(H,209,255)(H,210,263)(H,211,264)(H,212,271)(H,213,265)(H,214,269)(H,215,272)(H,216,276)(H,217,275)(H,218,277)(H,219,235)(H,220,259)(H,221,262)(H,222,260)(H,223,261)(H,224,250)(H,225,266)(H,226,267)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,273,274)(H4,189,190,194)/t104-,105-,106-,107-,108+,109+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,146-,147-,148-,149-,150-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121397
(CHEMBL3616753)Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](NC(=O)CCCCCCCCCCCCCCCCC(O)=O)C(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(N)=O |r| Show InChI InChI=1S/C187H292N46O58/c1-18-105(10)154(180(282)209-108(13)159(261)217-133(86-114-89-201-119-50-40-39-49-117(114)119)170(272)219-129(82-102(4)5)171(273)229-152(103(6)7)178(280)216-121(53-44-72-200-186(193)194)162(264)203-92-142(244)210-120(52-43-71-199-185(191)192)161(263)202-91-139(190)241)231-172(274)131(83-111-45-33-31-34-46-111)220-167(269)126(64-69-150(255)256)215-166(268)122(51-41-42-70-196-145(247)98-290-79-78-289-76-74-198-146(248)99-291-80-77-288-75-73-197-140(242)66-61-127(183(285)286)212-141(243)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-147(249)250)213-158(260)107(12)207-157(259)106(11)208-165(267)125(60-65-138(189)240)211-143(245)93-204-163(265)123(62-67-148(251)252)214-168(270)128(81-101(2)3)218-169(271)130(85-113-56-58-116(239)59-57-113)221-175(277)135(95-234)224-177(279)137(97-236)225-179(281)153(104(8)9)230-174(276)134(88-151(257)258)222-176(278)136(96-235)226-182(284)156(110(15)238)232-173(275)132(84-112-47-35-32-36-48-112)223-181(283)155(109(14)237)228-144(246)94-205-164(266)124(63-68-149(253)254)227-184(287)187(16,17)233-160(262)118(188)87-115-90-195-100-206-115/h31-36,39-40,45-50,56-59,89-90,100-110,118,120-137,152-156,201,234-239H,18-30,37-38,41-44,51-55,60-88,91-99,188H2,1-17H3,(H2,189,240)(H2,190,241)(H,195,206)(H,196,247)(H,197,242)(H,198,248)(H,202,263)(H,203,264)(H,204,265)(H,205,266)(H,207,259)(H,208,267)(H,209,282)(H,210,244)(H,211,245)(H,212,243)(H,213,260)(H,214,270)(H,215,268)(H,216,280)(H,217,261)(H,218,271)(H,219,272)(H,220,269)(H,221,277)(H,222,278)(H,223,283)(H,224,279)(H,225,281)(H,226,284)(H,227,287)(H,228,246)(H,229,273)(H,230,276)(H,231,274)(H,232,275)(H,233,262)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H,257,258)(H,285,286)(H4,191,192,199)(H4,193,194,200)/t105-,106-,107-,108-,109+,110+,118-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,152-,153-,154-,155-,156-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description
Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726
BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this
Ligand-Target Pair | |
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