Found 185 hits of ic50 data for polymerid = 50006059,50006915 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425531
(CHEMBL2313646)Show InChI InChI=1S/C15H19NO2S/c1-10-6-12(3)15(13(4)7-10)19(17,18)16-9-11(2)8-14(16)5/h6-9H,1-5H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425555
(CHEMBL2313653)Show InChI InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of EPAC2 (unknown origin) |
J Med Chem 57: 3651-65 (2014)
Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175143
(CHEMBL3809313)Show InChI InChI=1S/C18H23N/c1-11-7-13(3)17(14(4)8-11)19-18-15(5)9-12(2)10-16(18)6/h7-10,19H,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175225
(CHEMBL3808606)Show InChI InChI=1S/C16H15ClF3N/c1-9-6-10(2)15(11(3)7-9)21-12-4-5-14(17)13(8-12)16(18,19)20/h4-8,21H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425541
(CHEMBL2313637)Show InChI InChI=1S/C15H15Cl2N/c1-9-6-10(2)15(11(3)7-9)18-14-8-12(16)4-5-13(14)17/h4-8,18H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175226
(CHEMBL3808936)Show InChI InChI=1S/C16H18ClN/c1-10-8-11(2)16(12(3)9-10)18-15-7-5-6-14(17)13(15)4/h5-9,18H,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425555
(CHEMBL2313653)Show InChI InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425539
(CHEMBL2313639)Show InChI InChI=1S/C15H19NO2S/c1-5-14-7-6-8-16(14)19(17,18)15-12(3)9-11(2)10-13(15)4/h6-10H,5H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175266
(CHEMBL3808997)Show InChI InChI=1S/C16H15ClF3N/c1-9-4-10(2)15(11(3)5-9)21-14-7-12(16(18,19)20)6-13(17)8-14/h4-8,21H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175100
(CHEMBL3809121)Show SMILES Cc1cc(C)c(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(C)c1 Show InChI InChI=1S/C17H15F6N/c1-9-4-10(2)15(11(3)5-9)24-14-7-12(16(18,19)20)6-13(8-14)17(21,22)23/h4-8,24H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50011368
(CHEMBL3260989)Show InChI InChI=1S/C17H24N2OS.HI/c1-12-9-13(2)16(14(3)10-12)18-17-19(7-6-8-20-5)15(4)11-21-17;/h9-11H,6-8H2,1-5H3;1H | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of EPAC2 (unknown origin) |
J Med Chem 57: 3651-65 (2014)
Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175228
(CHEMBL3808792)Show InChI InChI=1S/C16H17Cl2N/c1-9-5-10(2)15(11(3)6-9)19-16-12(4)7-13(17)8-14(16)18/h5-8,19H,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425554
(CHEMBL2313654)Show InChI InChI=1S/C18H22O2S/c1-11-7-15(5)18(16(6)8-11)21(19,20)17-10-13(3)12(2)9-14(17)4/h7-10H,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098793
(CHEMBL3593342)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse EPAC2 by fluorescence assay |
Bioorg Med Chem Lett 27: 1633-1639 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098793
(CHEMBL3593342)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)c(Cl)c(Cl)c1)\C#N Show InChI InChI=1S/C16H13Cl3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425542
(CHEMBL2313636)Show InChI InChI=1S/C15H15Cl2N/c1-9-4-10(2)15(11(3)5-9)18-14-7-12(16)6-13(17)8-14/h4-8,18H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175273
(CHEMBL3808989)Show InChI InChI=1S/C17H21N/c1-11-9-13(3)17(14(4)10-11)18-16-8-6-7-12(2)15(16)5/h6-10,18H,1-5H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175225
(CHEMBL3808606)Show InChI InChI=1S/C16H15ClF3N/c1-9-6-10(2)15(11(3)7-9)21-12-4-5-14(17)13(8-12)16(18,19)20/h4-8,21H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of EPAC2 (unknown origin) assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal tru... |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175270
(CHEMBL3808484)Show InChI InChI=1S/C15H14Cl3N/c1-8-4-9(2)15(10(3)5-8)19-11-6-12(16)14(18)13(17)7-11/h4-7,19H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098792
(CHEMBL3593343)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(F)c(F)c(F)c1)\C#N Show InChI InChI=1S/C16H13F3N4O2/c1-16(2,3)13-6-11(23-25-13)15(24)12(7-20)22-21-8-4-9(17)14(19)10(18)5-8/h4-6,21H,1-3H3/b22-12+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175227
(CHEMBL3809399)Show InChI InChI=1S/C15H15Cl2N/c1-9-6-10(2)15(11(3)7-9)18-12-4-5-13(16)14(17)8-12/h4-8,18H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM89901
(1-(2,4,6-Trimethyl-benzenesulfonyl)-1H-indole | 1-...)Show InChI InChI=1S/C17H17NO2S/c1-12-10-13(2)17(14(3)11-12)21(19,20)18-9-8-15-6-4-5-7-16(15)18/h4-11H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50452020
(CHEMBL4213611)Show SMILES Clc1cc(Cl)cc(N\N=C(/C#N)C(=O)c2ccc3CCCCc3c2)c1 Show InChI InChI=1S/C19H15Cl2N3O/c20-15-8-16(21)10-17(9-15)23-24-18(11-22)19(25)14-6-5-12-3-1-2-4-13(12)7-14/h5-10,23H,1-4H2/b24-18+ | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant full length EPAC2 (unknown origin) assessed as inhibition of cAMP-mediated Rap1b-BODIPY GDP nucleotide exchange ac... |
Bioorg Med Chem Lett 27: 5163-5166 (2017)
Article DOI: 10.1016/j.bmcl.2017.10.056 BindingDB Entry DOI: 10.7270/Q2TB19FF |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM517717
(US11124489, Entry 32 | ZL0524)Show SMILES Clc1cc(Cl)cc(NNC(C#N)C(=O)c2ccc3CCCCc3c2)c1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2FR00SJ |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425532
(CHEMBL2313645)Show InChI InChI=1S/C14H17NO2S/c1-4-13-6-5-9-15(13)18(16,17)14-8-7-11(2)10-12(14)3/h5-10H,4H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175100
(CHEMBL3809121)Show SMILES Cc1cc(C)c(Nc2cc(cc(c2)C(F)(F)F)C(F)(F)F)c(C)c1 Show InChI InChI=1S/C17H15F6N/c1-9-4-10(2)15(11(3)5-9)24-14-7-12(16(18,19)20)6-13(8-14)17(21,22)23/h4-8,24H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of EPAC2 (unknown origin) assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal tru... |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175265
(CHEMBL3808689)Show InChI InChI=1S/C16H18ClN/c1-10-7-12(3)16(13(4)8-10)18-15-9-14(17)6-5-11(15)2/h5-9,18H,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175267
(CHEMBL3809943)Show InChI InChI=1S/C15H16BrN/c1-10-7-11(2)15(12(3)8-10)17-14-6-4-5-13(16)9-14/h4-9,17H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098713
(CHEMBL3593335)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C17H14ClF3N4O2/c1-16(2,3)14-7-12(25-27-14)15(26)13(8-22)24-23-11-5-9(17(19,20)21)4-10(18)6-11/h4-7,23H,1-3H3/b24-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175268
(CHEMBL3809058)Show InChI InChI=1S/C15H16BrN/c1-10-8-11(2)15(12(3)9-10)17-14-6-4-13(16)5-7-14/h4-9,17H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175070
(CHEMBL3809465)Show InChI InChI=1S/C17H21N/c1-11-6-12(2)10-16(9-11)18-17-14(4)7-13(3)8-15(17)5/h6-10,18H,1-5H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175143
(CHEMBL3809313)Show InChI InChI=1S/C18H23N/c1-11-7-13(3)17(14(4)8-11)19-18-15(5)9-12(2)10-16(18)6/h7-10,19H,1-6H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of EPAC2 (unknown origin) assessed as reduction in cAMP-mediated guanine nucleotide exchange factor activity in presence of C-terminal tru... |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50326557
((E)-5-((2-hydroxynaphthalen-1-yl)diazenyl)naphthal...)Show SMILES Oc1ccc2ccccc2c1N=Nc1cccc2cc(ccc12)S(O)(=O)=O |w:12.14| Show InChI InChI=1S/C20H14N2O4S/c23-19-11-8-13-4-1-2-6-17(13)20(19)22-21-18-7-3-5-14-12-15(27(24,25)26)9-10-16(14)18/h1-12,23H,(H,24,25,26) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis |
J Med Chem 57: 3651-65 (2014)
Article DOI: 10.1021/jm401425e BindingDB Entry DOI: 10.7270/Q2WH2RJW |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175069
(CHEMBL3808996)Show InChI InChI=1S/C17H21N/c1-11-6-7-13(3)16(10-11)18-17-14(4)8-12(2)9-15(17)5/h6-10,18H,1-5H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175264
(CHEMBL3810082)Show InChI InChI=1S/C16H18ClN/c1-10-7-12(3)16(13(4)8-10)18-14-6-5-11(2)15(17)9-14/h5-9,18H,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175071
(CHEMBL3809991)Show InChI InChI=1S/C18H21N/c1-12-9-13(2)18(14(3)10-12)19-17-8-7-15-5-4-6-16(15)11-17/h7-11,19H,4-6H2,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175101
(CHEMBL3810034)Show InChI InChI=1S/C17H21N/c1-5-15-7-6-8-16(11-15)18-17-13(3)9-12(2)10-14(17)4/h6-11,18H,5H2,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50425550
(CHEMBL2313658)Show InChI InChI=1S/C16H18O3S/c1-11-9-12(2)16(13(3)10-11)20(17,18)15-7-5-14(19-4)6-8-15/h5-10H,1-4H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay |
J Med Chem 56: 952-62 (2013)
Article DOI: 10.1021/jm3014162 BindingDB Entry DOI: 10.7270/Q2D21ZX3 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098719
(CHEMBL3593329)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay |
J Med Chem 58: 6033-47 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00635 BindingDB Entry DOI: 10.7270/Q29025JD |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM517689
(NY0562 | US11124489, Compound 33)Show SMILES FC(F)(F)c1cc(NNC(C#N)C(=O)c2noc3ccccc23)ccc1Cl | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2FR00SJ |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50098719
(CHEMBL3593329)Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cc(Cl)cc(Cl)c1)\C#N Show InChI InChI=1S/C16H14Cl2N4O2/c1-16(2,3)14-7-12(22-24-14)15(23)13(8-19)21-20-11-5-9(17)4-10(18)6-11/h4-7,20H,1-3H3/b21-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Displacement of 8-NBD-cAMP from mouse EPAC2 by fluorescence assay |
Bioorg Med Chem Lett 27: 1633-1639 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.065 BindingDB Entry DOI: 10.7270/Q2FF3VXQ |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50241952
(CHEMBL4099528)Show SMILES FC(F)(F)c1cc(N\N=C(/C#N)C(=O)c2noc3ccccc23)ccc1Cl Show InChI InChI=1S/C17H8ClF3N4O2/c18-12-6-5-9(7-11(12)17(19,20)21)23-24-13(8-22)16(26)15-10-3-1-2-4-14(10)27-25-15/h1-7,23H/b24-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NB... |
Eur J Med Chem 134: 62-71 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM50175139
(CHEMBL3810304)Show InChI InChI=1S/C16H16F3N/c1-10-7-11(2)15(12(3)8-10)20-14-6-4-5-13(9-14)16(17,18)19/h4-9,20H,1-3H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Inhibition of 8-NBD-cAMP binding to EPAC2 (unknown origin) by microplate reader analysis |
ACS Med Chem Lett 7: 460-4 (2016)
Article DOI: 10.1021/acsmedchemlett.5b00477 BindingDB Entry DOI: 10.7270/Q2NC6335 |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50241961
(CHEMBL4081514)Show SMILES FC(F)(F)c1ccc(N\N=C(/C#N)C(=O)c2noc3ccccc23)cc1Cl Show InChI InChI=1S/C17H8ClF3N4O2/c18-12-7-9(5-6-11(12)17(19,20)21)23-24-13(8-22)16(26)15-10-3-1-2-4-14(10)27-25-15/h1-7,23H/b24-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NB... |
Eur J Med Chem 134: 62-71 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50241967
(CHEMBL4087626)Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(no1)C(=O)C(=N\Nc1ccc(Cl)c(c1)C(F)(F)F)\C#N Show InChI InChI=1S/C23H18ClF3N4O2/c1-22(2,3)14-6-4-13(5-7-14)20-11-18(31-33-20)21(32)19(12-28)30-29-15-8-9-17(24)16(10-15)23(25,26)27/h4-11,29H,1-3H3/b30-19+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NB... |
Eur J Med Chem 134: 62-71 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50241957
(CHEMBL4100650)Show SMILES FC(F)(F)c1cc(Cl)cc(N\N=C(/C#N)C(=O)c2cc(on2)-c2ccco2)c1 Show InChI InChI=1S/C17H8ClF3N4O3/c18-10-4-9(17(19,20)21)5-11(6-10)23-24-13(8-22)16(26)12-7-15(28-25-12)14-2-1-3-27-14/h1-7,23H/b24-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NB... |
Eur J Med Chem 134: 62-71 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM517666
(NY0617 | US11124489, Compound 10)Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(no1)C(=O)C(NNc1ccc(Cl)c(c1)C(F)(F)F)C#N | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2FR00SJ |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM517687
(NY0495 | US11124489, Compound 31)Show SMILES FC(F)(F)c1cc(Cl)cc(NNC(C#N)C(=O)c2noc3ccccc23)c1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2FR00SJ |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Mus musculus) | BDBM50241953
(CHEMBL4091792)Show SMILES FC(F)(F)c1cc(Cl)cc(N\N=C(/C#N)C(=O)c2noc3ccccc23)c1 Show InChI InChI=1S/C17H8ClF3N4O2/c18-10-5-9(17(19,20)21)6-11(7-10)23-24-13(8-22)16(26)15-12-3-1-2-4-14(12)27-25-15/h1-7,23H/b24-13+ | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Medical Branch
Curated by ChEMBL
| Assay Description Antagonist activity at mouse EPAC2 assessed as inhibition of EPAC2-mediated Rap1B (1 to 167 residues)-BODIPY GDP nucleotide exchange activity by 8-NB... |
Eur J Med Chem 134: 62-71 (2017)
Article DOI: 10.1016/j.ejmech.2017.04.001 BindingDB Entry DOI: 10.7270/Q2RR21DK |
More data for this Ligand-Target Pair | |
Rap guanine nucleotide exchange factor 4
(Homo sapiens (Human)) | BDBM517684
(NY0725 | US11124489, Compound 26)Show SMILES FC(F)(F)c1cc(Cl)cc(NNC(C#N)C(=O)c2cc(on2)-c2ccco2)c1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description From the biological results discussed above, compounds 10, 14-15, 23-24, 26-27, and 31-32 were identified as potent EPAC1 inhibitors with IC50 values... |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2FR00SJ |
More data for this Ligand-Target Pair | |