Compile Data Set for Download or QSAR

Found 201 hits of ic50 data for polymerid = 50006087   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Anoctamin-1 (Homo sapiens (Human))	BDBM50503445 (CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...) Show SMILES Cc1cc(Cl)ccc1OCC(=O)N\N=C\c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14ClF3N2O3/c1-11-8-13(18)6-7-14(11)25-10-16(24)23-22-9-12-4-2-3-5-15(12)26-17(19,20)21/h2-9H,10H2,1H3,(H,23,24)/b22-9+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GT5RDM
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50503445 (CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...) Show SMILES Cc1cc(Cl)ccc1OCC(=O)N\N=C\c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14ClF3N2O3/c1-11-8-13(18)6-7-14(11)25-10-16(24)23-22-9-12-4-2-3-5-15(12)26-17(19,20)21/h2-9H,10H2,1H3,(H,23,24)/b22-9+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching method				Eur J Med Chem 160: 245-255 (2018) Article DOI: 10.1016/j.ejmech.2018.10.002 BindingDB Entry DOI: 10.7270/Q24T6NMB
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50503445 (CHEMBL4445544 | US11274074, Example 1 [Chemical Fo...) Show SMILES Cc1cc(Cl)ccc1OCC(=O)N\N=C\c1ccccc1OC(F)(F)F Show InChI InChI=1S/C17H14ClF3N2O3/c1-11-8-13(18)6-7-14(11)25-10-16(24)23-22-9-12-4-2-3-5-15(12)26-17(19,20)21/h2-9H,10H2,1H3,(H,23,24)/b22-9+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiologica...				Eur J Med Chem 160: 245-255 (2018) Article DOI: 10.1016/j.ejmech.2018.10.002 BindingDB Entry DOI: 10.7270/Q24T6NMB
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50594075 (CHEMBL5186789) Show SMILES OC(=O)c1c(NC(=O)c2cc(F)ccc2F)scc1-c1ccc(Cl)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114413 BindingDB Entry DOI: 10.7270/Q2GX4GK6
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM11242 (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenza...) Show SMILES Oc1ccc(Cl)cc1C(=O)Nc1ccc(cc1Cl)[N+]([O-])=O Show InChI InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114413 BindingDB Entry DOI: 10.7270/Q2GX4GK6
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50594073 (CHEMBL5206041) Show SMILES OC(=O)c1c(NC(=O)c2cc(Cl)ccc2Br)scc1-c1ccc(Cl)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	29	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114413 BindingDB Entry DOI: 10.7270/Q2GX4GK6
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239459 (CHEMBL4074929) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCCCc12 Show InChI InChI=1S/C19H19BrF2N2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114413 BindingDB Entry DOI: 10.7270/Q2GX4GK6
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239459 (CHEMBL4074929) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCCCc12 Show InChI InChI=1S/C19H19BrF2N2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description In vitro inhibition of [3H]norepinephrine uptake in rat brain synaptosomes				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239459 (CHEMBL4074929) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCCCc12 Show InChI InChI=1S/C19H19BrF2N2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of ANO1 channel (unknown origin)				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112688 BindingDB Entry DOI: 10.7270/Q2N58R1T
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239465 (CHEMBL4080525 | US11274074, Control [Ani9]) Show SMILES COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C Show InChI InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human ANO1 channel expressed in HEK293 cells incubated for 10 mins by FLIPR assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112688 BindingDB Entry DOI: 10.7270/Q2N58R1T
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239465 (CHEMBL4080525 | US11274074, Control [Ani9]) Show SMILES COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C Show InChI InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human ANO1 expressed in FRT cells assessed as inhibition of ATP-induced channel current treated 20 mins prior to ATP challenge and meas...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112688 BindingDB Entry DOI: 10.7270/Q2N58R1T
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239465 (CHEMBL4080525 | US11274074, Control [Ani9]) Show SMILES COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C Show InChI InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of ANO1 (unknown origin) expressed in FRT cells assessed as reduction in ATP-induced chloride current after 20 mins by electrophysiologica...				Eur J Med Chem 160: 245-255 (2018) Article DOI: 10.1016/j.ejmech.2018.10.002 BindingDB Entry DOI: 10.7270/Q24T6NMB
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239465 (CHEMBL4080525 | US11274074, Control [Ani9]) Show SMILES COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C Show InChI InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	77	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 20 mins followed by ...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239467 (CHEMBL4086165) Show SMILES COc1cc(Nc2ccc(cc2C(O)=O)[N+]([O-])=O)cc2ccccc12 Show InChI InChI=1S/C18H14N2O5/c1-25-17-9-12(8-11-4-2-3-5-14(11)17)19-16-7-6-13(20(23)24)10-15(16)18(21)22/h2-10,19H,1H3,(H,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of TMEM16A (unknown origin) expressed in Xenopus laevis oocytes at -60 mV holding potential by voltage-clamp assay				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239459 (CHEMBL4074929) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCCCc12 Show InChI InChI=1S/C19H19BrF2N2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	83	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239465 (CHEMBL4080525 | US11274074, Control [Ani9]) Show SMILES COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C Show InChI InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	US Patent	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GT5RDM
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239465 (CHEMBL4080525 | US11274074, Control [Ani9]) Show SMILES COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C Show InChI InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching method				Eur J Med Chem 160: 245-255 (2018) Article DOI: 10.1016/j.ejmech.2018.10.002 BindingDB Entry DOI: 10.7270/Q24T6NMB
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239465 (CHEMBL4080525 | US11274074, Control [Ani9]) Show SMILES COc1ccccc1\C=N\NC(=O)COc1ccc(Cl)cc1C Show InChI InChI=1S/C17H17ClN2O3/c1-12-9-14(18)7-8-15(12)23-11-17(21)20-19-10-13-5-3-4-6-16(13)22-2/h3-10H,11H2,1-2H3,(H,20,21)/b19-10+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239433 (CHEMBL3134585) Show SMILES FC(F)(F)C(=O)Nc1sc2CCCCCc2c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H17F3N2O2S/c19-18(20,21)17(25)23-16-14(12-9-5-2-6-10-13(12)26-16)15(24)22-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2,(H,22,24)(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239428 (CHEMBL4104024) Show SMILES Fc1ccc(NC(=O)c2c(NC(=O)C(F)(F)I)sc3CCCCCc23)cc1 Show InChI InChI=1S/C18H16F3IN2O2S/c19-10-6-8-11(9-7-10)23-15(25)14-12-4-2-1-3-5-13(12)27-16(14)24-17(26)18(20,21)22/h6-9H,1-5H2,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239446 (CHEMBL4069503) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)F)sc2CCCCc12 Show InChI InChI=1S/C18H17F3N2O2S/c1-10-6-2-4-8-12(10)22-15(24)14-11-7-3-5-9-13(11)26-16(14)23-17(25)18(19,20)21/h2,4,6,8H,3,5,7,9H2,1H3,(H,22,24)(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239457 (CHEMBL4071143) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Cl)sc2CCCCCc12 Show InChI InChI=1S/C19H19ClF2N2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50503455 (CHEMBL4448175 | US11274074, Example 5 [Chemical Fo...) Show SMILES Cc1cc(Cl)ccc1OCC(=O)N\N=C\c1ccccc1C(F)(F)F Show InChI InChI=1S/C17H14ClF3N2O2/c1-11-8-13(18)6-7-15(11)25-10-16(24)23-22-9-12-4-2-3-5-14(12)17(19,20)21/h2-9H,10H2,1H3,(H,23,24)/b22-9+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	US Patent	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GT5RDM
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50503455 (CHEMBL4448175 | US11274074, Example 5 [Chemical Fo...) Show SMILES Cc1cc(Cl)ccc1OCC(=O)N\N=C\c1ccccc1C(F)(F)F Show InChI InChI=1S/C17H14ClF3N2O2/c1-11-8-13(18)6-7-15(11)25-10-16(24)23-22-9-12-4-2-3-5-14(12)17(19,20)21/h2-9H,10H2,1H3,(H,23,24)/b22-9+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching method				Eur J Med Chem 160: 245-255 (2018) Article DOI: 10.1016/j.ejmech.2018.10.002 BindingDB Entry DOI: 10.7270/Q24T6NMB
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239447 (CHEMBL4090522) Show SMILES Cc1ccc(NC(=O)c2c(NC(=O)C(F)(F)F)sc3CCCCc23)cc1 Show InChI InChI=1S/C18H17F3N2O2S/c1-10-6-8-11(9-7-10)22-15(24)14-12-4-2-3-5-13(12)26-16(14)23-17(25)18(19,20)21/h6-9H,2-5H2,1H3,(H,22,24)(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239461 (CHEMBL4074900) Show SMILES FC(F)(Br)C(=O)Nc1sc2CCCCCc2c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H17BrF2N2O2S/c19-18(20,21)17(25)23-16-14(12-9-5-2-6-10-13(12)26-16)15(24)22-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2,(H,22,24)(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239470 (CHEMBL4095338) Show SMILES FC(F)(I)C(=O)Nc1sc2CCCCCc2c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H17F2IN2O2S/c19-18(20,21)17(25)23-16-14(12-9-5-2-6-10-13(12)26-16)15(24)22-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2,(H,22,24)(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239457 (CHEMBL4071143) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Cl)sc2CCCCCc12 Show InChI InChI=1S/C19H19ClF2N2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239426 (CHEMBL1444023) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)F)sc2CCCCCc12 Show InChI InChI=1S/C19H19F3N2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50594059 (CHEMBL5186589) Show SMILES OC(=O)c1c(NC(=O)c2cc(Cl)ccc2Cl)scc1-c1ccc(Cl)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114413 BindingDB Entry DOI: 10.7270/Q2GX4GK6
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239433 (CHEMBL3134585) Show SMILES FC(F)(F)C(=O)Nc1sc2CCCCCc2c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H17F3N2O2S/c19-18(20,21)17(25)23-16-14(12-9-5-2-6-10-13(12)26-16)15(24)22-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2,(H,22,24)(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50503439 (CHEMBL4515829 | US11274074, Example 6 [Chemical Fo...) Show SMILES C\C(=N/NC(=O)COc1ccc(Cl)cc1C)c1ccccc1OC(F)(F)F Show InChI InChI=1S/C18H16ClF3N2O3/c1-11-9-13(19)7-8-15(11)26-10-17(25)24-23-12(2)14-5-3-4-6-16(14)27-18(20,21)22/h3-9H,10H2,1-2H3,(H,24,25)/b23-12+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The method for inhibiting the expression of ANO1 (TMEM16A) of the present disclosure includes a step of inhibiting the expression of ANO1 (TMEM16A) i...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GT5RDM
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50503439 (CHEMBL4515829 | US11274074, Example 6 [Chemical Fo...) Show SMILES C\C(=N/NC(=O)COc1ccc(Cl)cc1C)c1ccccc1OC(F)(F)F Show InChI InChI=1S/C18H16ClF3N2O3/c1-11-9-13(19)7-8-15(11)26-10-17(25)24-23-12(2)14-5-3-4-6-16(14)27-18(20,21)22/h3-9H,10H2,1-2H3,(H,24,25)/b23-12+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching method				Eur J Med Chem 160: 245-255 (2018) Article DOI: 10.1016/j.ejmech.2018.10.002 BindingDB Entry DOI: 10.7270/Q24T6NMB
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239438 (CHEMBL4099581) Show SMILES Fc1ccc(NC(=O)c2c(NC(=O)C(F)(F)F)sc3CCCCCc23)cc1 Show InChI InChI=1S/C18H16F4N2O2S/c19-10-6-8-11(9-7-10)23-15(25)14-12-4-2-1-3-5-13(12)27-16(14)24-17(26)18(20,21)22/h6-9H,1-5H2,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	320	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of [3H]spiperone binding to Dopamine receptor D2 from rat striatal membranes				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239475 (CHEMBL4082703) Show SMILES FC(F)(F)C(=O)Nc1sc2CCCCc2c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C17H15F3N2O2S/c18-17(19,20)16(24)22-15-13(11-8-4-5-9-12(11)25-15)14(23)21-10-6-2-1-3-7-10/h1-3,6-7H,4-5,8-9H2,(H,21,23)(H,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239469 (CHEMBL4091961) Show SMILES FC(F)(F)Oc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)F)sc2CCCc12 Show InChI InChI=1S/C17H12F6N2O3S/c18-16(19,20)15(27)25-14-12(8-4-3-7-11(8)29-14)13(26)24-9-5-1-2-6-10(9)28-17(21,22)23/h1-2,5-6H,3-4,7H2,(H,24,26)(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239458 (CHEMBL4095365) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)C(F)(F)C(F)(F)F)sc2CCCCCc12 Show InChI InChI=1S/C21H19F7N2O2S/c1-11-7-5-6-9-13(11)29-16(31)15-12-8-3-2-4-10-14(12)33-17(15)30-18(32)19(22,23)20(24,25)21(26,27)28/h5-7,9H,2-4,8,10H2,1H3,(H,29,31)(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	380	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239426 (CHEMBL1444023) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)F)sc2CCCCCc12 Show InChI InChI=1S/C19H19F3N2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50075050 (Alinia | Nitazoxanide | PH-5776) Show SMILES CC(=O)Oc1ccccc1C(=O)Nc1ncc(s1)[N+]([O-])=O Show InChI InChI=1S/C12H9N3O5S/c1-7(16)20-9-5-3-2-4-8(9)11(17)14-12-13-6-10(21-12)15(18)19/h2-6H,1H3,(H,13,14,17)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	424	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114413 BindingDB Entry DOI: 10.7270/Q2GX4GK6
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239463 (CHEMBL4087641) Show SMILES Fc1ccc(NC(=O)c2c(NC(=O)C(F)(F)Br)sc3CCCCCc23)cc1 Show InChI InChI=1S/C18H16BrF3N2O2S/c19-18(21,22)17(26)24-16-14(12-4-2-1-3-5-13(12)27-16)15(25)23-11-8-6-10(20)7-9-11/h6-9H,1-5H2,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	450	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description In vitro inhibition of [3H]dopamine uptake in rat brain synaptosomes				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239448 (CHEMBL4080209) Show SMILES Fc1ccc(NC(=O)c2c(NC(=O)C(F)(F)F)sc3CCCCc23)cc1 Show InChI InChI=1S/C17H14F4N2O2S/c18-9-5-7-10(8-6-9)22-14(24)13-11-3-1-2-4-12(11)26-15(13)23-16(25)17(19,20)21/h5-8H,1-4H2,(H,22,24)(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	490	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239464 (CHEMBL4085154) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)I)sc2CCCCCc12 Show InChI InChI=1S/C19H19F2IN2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239428 (CHEMBL4104024) Show SMILES Fc1ccc(NC(=O)c2c(NC(=O)C(F)(F)I)sc3CCCCCc23)cc1 Show InChI InChI=1S/C18H16F3IN2O2S/c19-10-6-8-11(9-7-10)23-15(25)14-12-4-2-1-3-5-13(12)27-16(14)24-17(26)18(20,21)22/h6-9H,1-5H2,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239439 (CHEMBL4083154) Show SMILES FC(F)(F)C(=O)Nc1sc2CCCCCc2c1C(=O)Nc1ccccc1Cl Show InChI InChI=1S/C18H16ClF3N2O2S/c19-11-7-4-5-8-12(11)23-15(25)14-10-6-2-1-3-9-13(10)27-16(14)24-17(26)18(20,21)22/h4-5,7-8H,1-3,6,9H2,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239430 (CHEMBL4096263) Show SMILES FC(F)(F)Oc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)Br)sc2CCCc12 Show InChI InChI=1S/C17H12BrF5N2O3S/c18-16(19,20)15(27)25-14-12(8-4-3-7-11(8)29-14)13(26)24-9-5-1-2-6-10(9)28-17(21,22)23/h1-2,5-6H,3-4,7H2,(H,24,26)(H,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239464 (CHEMBL4085154) Show SMILES Cc1ccccc1NC(=O)c1c(NC(=O)C(F)(F)I)sc2CCCCCc12 Show InChI InChI=1S/C19H19F2IN2O2S/c1-11-7-5-6-9-13(11)23-16(25)15-12-8-3-2-4-10-14(12)27-17(15)24-18(26)19(20,21)22/h5-7,9H,2-4,8,10H2,1H3,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	730	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50594049 (CHEMBL5185767) Show SMILES OC(=O)c1c(NC(=O)c2cccc3ccccc23)scc1-c1ccc(Cl)cc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2022.114413 BindingDB Entry DOI: 10.7270/Q2GX4GK6
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239462 (CHEMBL4066286) Show SMILES Fc1ccc(NC(=O)c2c(NC(=O)C(F)(F)Cl)sc3CCCCCc23)cc1 Show InChI InChI=1S/C18H16ClF3N2O2S/c19-18(21,22)17(26)24-16-14(12-4-2-1-3-5-13(12)27-16)15(25)23-11-8-6-10(20)7-9-11/h6-9H,1-5H2,(H,23,25)(H,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	840	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50503453 (CHEMBL4577443) Show SMILES Cc1cc(Cl)ccc1OCC(=O)N\N=C\c1ccccc1F Show InChI InChI=1S/C16H14ClFN2O2/c1-11-8-13(17)6-7-15(11)22-10-16(21)20-19-9-12-4-2-3-5-14(12)18/h2-9H,10H2,1H3,(H,20,21)/b19-9+	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Yonsei University Curated by ChEMBL					Assay Description Inhibition of YFP-fused ANO1 (unknown origin) expressed in FRT cells after 20 mins by fluorescence quenching method				Eur J Med Chem 160: 245-255 (2018) Article DOI: 10.1016/j.ejmech.2018.10.002 BindingDB Entry DOI: 10.7270/Q24T6NMB
					More data for this Ligand-Target Pair
Anoctamin-1 (Homo sapiens (Human))	BDBM50239460 (CHEMBL4103095) Show SMILES FC(F)(Cl)C(=O)Nc1sc2CCCCCc2c1C(=O)Nc1ccccc1 Show InChI InChI=1S/C18H17ClF2N2O2S/c19-18(20,21)17(25)23-16-14(12-9-5-2-6-10-13(12)26-16)15(24)22-11-7-3-1-4-8-11/h1,3-4,7-8H,2,5-6,9-10H2,(H,22,24)(H,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	925	n/a	n/a	n/a	n/a	n/a	n/a
San Francisco State University Curated by ChEMBL					Assay Description Inhibition of human TMEM16A expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in A...				J Med Chem 60: 4626-4635 (2017) Article DOI: 10.1021/acs.jmedchem.7b00020 BindingDB Entry DOI: 10.7270/Q2FT8P5G
					More data for this Ligand-Target Pair

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