Found 34 hits of ki for UniProtKB: Q8TCC7 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM82898
((6R,7R)-3-(acetoxymethyl)-8-keto-7-[[2-(2-thienyl)...)Show SMILES CC(=O)OCC1=C(N2[C@H](SC1)[C@H](NC(=O)Cc1cccs1)C2=O)C(O)=O |t:5| Show InChI InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| DrugBank PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 438: 137-42 (2002)
BindingDB Entry DOI: 10.7270/Q2N87C2C |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50350468
(CEFAMANDOLE)Show SMILES Cn1nnnc1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](O)c1ccccc1)C2=O)C(O)=O |r,t:9| Show InChI InChI=1S/C18H18N6O5S2/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29)/t11-,13-,16-/m1/s1 | Reactome pathway KEGG
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| DrugBank PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 438: 137-42 (2002)
BindingDB Entry DOI: 10.7270/Q2N87C2C |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50335523
((6R,7R)-3-(acetoxymethyl)-7-(2-(2-aminothiazol-4-y...)Show SMILES CO\N=C(\C(=O)N[C@H]1[C@H]2SCC(COC(C)=O)=C(N2C1=O)C(O)=O)c1csc(N)n1 |r,c:16| Show InChI InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9+/t10-,14-/m1/s1 | Reactome pathway KEGG
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| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 438: 137-42 (2002)
BindingDB Entry DOI: 10.7270/Q2N87C2C |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50370587
(CEFAZOLIN)Show SMILES Cc1nnc(SCC2=C(N3[C@H](SC2)[C@H](NC(=O)Cn2cnnn2)C3=O)C(O)=O)s1 |r,t:7| Show InChI InChI=1S/C14H14N8O4S3/c1-6-17-18-14(29-6)28-4-7-3-27-12-9(11(24)22(12)10(7)13(25)26)16-8(23)2-21-5-15-19-20-21/h5,9,12H,2-4H2,1H3,(H,16,23)(H,25,26)/t9-,12-/m1/s1 | Reactome pathway KEGG
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| DrugBank PubMed
| 550 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 438: 137-42 (2002)
BindingDB Entry DOI: 10.7270/Q2N87C2C |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50390999
(CEFOPERAZONE)Show SMILES CCN1CCN(C(=O)N[C@@H](C(=O)N[C@H]2[C@H]3SCC(CSc4nnnn4C)=C(N3C2=O)C(O)=O)c2ccc(O)cc2)C(=O)C1=O |c:26| Show InChI InChI=1S/C25H27N9O8S2/c1-3-32-8-9-33(21(39)20(32)38)24(42)27-15(12-4-6-14(35)7-5-12)18(36)26-16-19(37)34-17(23(40)41)13(10-43-22(16)34)11-44-25-28-29-30-31(25)2/h4-7,15-16,22,35H,3,8-11H2,1-2H3,(H,26,36)(H,27,42)(H,40,41)/t15-,16-,22-/m1/s1 | Reactome pathway KEGG
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MCE KEGG PC cid PC sid UniChem
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| PubMed
| 1.89E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 438: 137-42 (2002)
BindingDB Entry DOI: 10.7270/Q2N87C2C |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50538736
(CHEMBL4640580)Show InChI InChI=1S/C14H10Br2N2O3/c15-9-5-8(6-10(16)13(9)19)14(20)18-3-4-21-12-1-2-17-7-11(12)18/h1-2,5-7,19H,3-4H2 | Reactome pathway KEGG
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| Article PubMed
| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
West China Hospital of Sichuan University
Curated by ChEMBL
| Assay Description Inhibition of human OAT3 |
Eur J Med Chem 166: 186-196 (2019)
Article DOI: 10.1016/j.ejmech.2019.01.043 BindingDB Entry DOI: 10.7270/Q20C50BS |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50350473
(Aliporina | CEFALORIDINE)Show SMILES [O-]C(=O)C1=C(C[n+]2ccccc2)CS[C@@H]2[C@@H](NC(=O)Cc3cccs3)C(=O)N12 |r,c:3| Show InChI InChI=1S/C19H17N3O4S2/c23-14(9-13-5-4-8-27-13)20-15-17(24)22-16(19(25)26)12(11-28-18(15)22)10-21-6-2-1-3-7-21/h1-8,15,18H,9-11H2,(H-,20,23,25,26)/t15-,18+/m0/s1 | Reactome pathway KEGG
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| PubMed
| 2.46E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 438: 137-42 (2002)
BindingDB Entry DOI: 10.7270/Q2N87C2C |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50003019
(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)Show SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)C12CC3CC1CC(C2)C3 |THB:22:21:18:24.23.25,22:23:18:21.20| Show InChI InChI=1S/C20H28N4O2/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12/h12-14H,3-11H2,1-2H3,(H,21,22) | Reactome pathway KEGG
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| 3.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 419: 113-20 (2001)
BindingDB Entry DOI: 10.7270/Q2S183SP |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50049707
((6R,7R)-7-{2-(2-Amino-thiazol-4-yl)-2-[(Z)-methoxy...)Show SMILES CO\N=C(/C(=O)N[C@H]1[C@H]2SCC(CSc3nc(=O)c(=O)[nH]n3C)=C(N2C1=O)C(O)=O)c1csc(N)n1 |r,c:23| Show InChI InChI=1S/C18H18N8O7S3/c1-25-18(22-12(28)13(29)23-25)36-4-6-3-34-15-9(14(30)26(15)10(6)16(31)32)21-11(27)8(24-33-2)7-5-35-17(19)20-7/h5,9,15H,3-4H2,1-2H3,(H2,19,20)(H,21,27)(H,23,29)(H,31,32)/b24-8-/t9-,15-/m1/s1 | Reactome pathway KEGG
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| DrugBank PubMed
| 4.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 438: 137-42 (2002)
BindingDB Entry DOI: 10.7270/Q2N87C2C |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50206509
(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)Show InChI InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16) | Reactome pathway KEGG
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| DrugBank Article PubMed
| 4.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells |
Life Sci 69: 2123-35 (2001)
Article DOI: 10.1016/s0024-3205(01)01296-6 BindingDB Entry DOI: 10.7270/Q2XD14JB |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM85245
(CAS_36322-90-4 | NSC_4856 | Piroxicam)Show SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O |t:12| Show InChI InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20) | Reactome pathway KEGG
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| DrugBank Article PubMed
| 4.88E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells |
Life Sci 69: 2123-35 (2001)
Article DOI: 10.1016/s0024-3205(01)01296-6 BindingDB Entry DOI: 10.7270/Q2XD14JB |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM17638
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(O)=O)c2c1 Show InChI InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23) | Reactome pathway KEGG
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| DrugBank Article PubMed
| 5.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells |
J Pharmacol Exp Ther 302: 666-71 (2002)
Article DOI: 10.1124/jpet.102.034330 BindingDB Entry DOI: 10.7270/Q2HH6MBN |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50485608
(CHEBI:28837 | Caprylic acid | EDENOR C 8-98-100 | ...)Show InChI InChI=1S/C8H16O2/c1-2-3-4-5-6-7-8(9)10/h2-7H2,1H3,(H,9,10) | Reactome pathway KEGG
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| Article PubMed
| 8.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells |
Life Sci 69: 2123-35 (2001)
Article DOI: 10.1016/s0024-3205(01)01296-6 BindingDB Entry DOI: 10.7270/Q2XD14JB |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50350467
(BL-S578 | CEFADROXIL | Cefadrops)Show SMILES CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c1ccc(O)cc1)C2=O)C(O)=O |r,t:1| Show InChI InChI=1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1 | Reactome pathway KEGG
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| DrugBank PubMed
| 8.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 438: 137-42 (2002)
BindingDB Entry DOI: 10.7270/Q2N87C2C |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50350467
(BL-S578 | CEFADROXIL | Cefadrops)Show SMILES CC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)c1ccc(O)cc1)C2=O)C(O)=O |r,t:1| Show InChI InChI=1S/C16H17N3O5S/c1-7-6-25-15-11(14(22)19(15)12(7)16(23)24)18-13(21)10(17)8-2-4-9(20)5-3-8/h2-5,10-11,15,20H,6,17H2,1H3,(H,18,21)(H,23,24)/t10-,11-,15-/m1/s1 | Reactome pathway KEGG
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| DrugBank Article PubMed
| 8.62E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wilkes University
Curated by ChEMBL
| Assay Description Inhibition of human OAT3 using estrone-3-sulfate as substrate |
Drug Metab Dispos 41: 791-800 (2013)
Article DOI: 10.1124/dmd.112.049569 BindingDB Entry DOI: 10.7270/Q2TF003W |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50206509
(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)Show InChI InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16) | Reactome pathway KEGG
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| DrugBank PubMed
| 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 419: 113-20 (2001)
BindingDB Entry DOI: 10.7270/Q2S183SP |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50344961
(CHEMBL510139 | citrinin)Show SMILES C[C@H]1OC=C2C(=O)C(C(O)=O)C(=O)C(C)=C2[C@@H]1C |r,c:14,t:3| Show InChI InChI=1S/C13H14O5/c1-5-7(3)18-4-8-9(5)6(2)11(14)10(12(8)15)13(16)17/h4-5,7,10H,1-3H3,(H,16,17)/t5-,7-,10?/m1/s1 | Reactome pathway KEGG
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| Article PubMed
| 1.54E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells |
Life Sci 69: 2123-35 (2001)
Article DOI: 10.1016/s0024-3205(01)01296-6 BindingDB Entry DOI: 10.7270/Q2XD14JB |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50240008
(Aminohippuric Acid | CHEBI:104011 | PAHA | Para-Am...)Show InChI InChI=1S/C9H10N2O3/c10-7-3-1-6(2-4-7)9(14)11-5-8(12)13/h1-4H,5,10H2,(H,11,14)(H,12,13) | Reactome pathway KEGG
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| Article PubMed
| 1.96E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Ochratoxin A uptake in OAT3-expressing S2 cells |
Life Sci 69: 2123-35 (2001)
Article DOI: 10.1016/s0024-3205(01)01296-6 BindingDB Entry DOI: 10.7270/Q2XD14JB |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50206509
(4-Dipropylsulfamoyl-benzoic acid | 4-Dipropylsulfa...)Show InChI InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16) | Reactome pathway KEGG
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| DrugBank Article PubMed
| 2.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells |
J Pharmacol Exp Ther 302: 666-71 (2002)
Article DOI: 10.1124/jpet.102.034330 BindingDB Entry DOI: 10.7270/Q2HH6MBN |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50009999
(CHEMBL461 | N-benzoylglycine)Show InChI InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12) | Reactome pathway KEGG
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| Article PubMed
| 3.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of benzylpenicillin uptake in OAT3-expressing HEK293 cells |
Kidney Int 65: 162-74 (2004)
Article DOI: 10.1111/j.1523-1755.2004.00354.x BindingDB Entry DOI: 10.7270/Q29026N5 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50022309
(3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine | 4-b...)Show InChI InChI=1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,22H,2-3,14H2,1H3 | Reactome pathway KEGG
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Patents
Similars
| Article PubMed
| 3.47E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells |
J Pharmacol Exp Ther 302: 666-71 (2002)
Article DOI: 10.1124/jpet.102.034330 BindingDB Entry DOI: 10.7270/Q2HH6MBN |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50344964
(Betamipron | CHEMBL1231530 | N-(phenylcarbonyl)-be...)Show InChI InChI=1S/C10H11NO3/c12-9(13)6-7-11-10(14)8-4-2-1-3-5-8/h1-5H,6-7H2,(H,11,14)(H,12,13) | Reactome pathway KEGG
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| 4.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 419: 113-20 (2001)
BindingDB Entry DOI: 10.7270/Q2S183SP |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM22889
((Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidaz...)Show InChI InChI=1S/C10H16N6S/c1-8-9(16-7-15-8)5-17-4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14) | Reactome pathway KEGG
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Similars
| Article PubMed
| 5.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of E1S uptake in OAT3 expressing oocytes |
Eur J Pharmacol 503: 25-30 (2004)
Article DOI: 10.1016/j.ejphar.2004.09.032 BindingDB Entry DOI: 10.7270/Q2TD9ZDK |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50022787
((+)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-...)Show SMILES CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O |r| Show InChI InChI=1S/C16H18N2O4S/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t11-,12+,14-/m1/s1 | Reactome pathway KEGG
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| DrugBank Article PubMed
| 9.76E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells |
J Pharmacol Exp Ther 302: 666-71 (2002)
Article DOI: 10.1124/jpet.102.034330 BindingDB Entry DOI: 10.7270/Q2HH6MBN |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50420185
(CHEMBL1233636)Show InChI InChI=1S/C8H7NO4S/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8/h1-5,9H,(H,10,11,12) | Reactome pathway KEGG
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| 1.69E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of E1S uptake (E1S: 5 uM, indoxyl sulfate:500 uM) in S2 cells expressing human-OAT3 |
Eur J Pharmacol 466: 13-20 (2003)
BindingDB Entry DOI: 10.7270/Q23R0V48 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50420185
(CHEMBL1233636)Show InChI InChI=1S/C8H7NO4S/c10-14(11,12)13-8-5-9-7-4-2-1-3-6(7)8/h1-5,9H,(H,10,11,12) | Reactome pathway KEGG
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| 1.69E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Nagoya University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: uptake&inhibition of estrone sulfate in OAT3-S2 cells |
Eur J Pharmacol 466: 13-20 (2003)
BindingDB Entry DOI: 10.7270/Q23R0V48 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50367502
(CILASTATIN)Show SMILES CC1(C)C[C@@H]1C(=O)N\C(=C/CCCCSC[C@H](N)C(O)=O)C(O)=O |r| Show InChI InChI=1S/C16H26N2O5S/c1-16(2)8-10(16)13(19)18-12(15(22)23)6-4-3-5-7-24-9-11(17)14(20)21/h6,10-11H,3-5,7-9,17H2,1-2H3,(H,18,19)(H,20,21)(H,22,23)/b12-6-/t10-,11+/m1/s1 | Reactome pathway KEGG
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Similars
| DrugBank PubMed
| 2.31E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of E1S uptake in OAT3-expressing S2 cells |
Eur J Pharmacol 419: 113-20 (2001)
BindingDB Entry DOI: 10.7270/Q2S183SP |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50325824
(1H-purine-2,6,8(3H,7H,9H)-trione | 7,9-Dihydro-3H-...)Show InChI InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12) | Reactome pathway KEGG
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| 2.75E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Georg-August-Universit£t
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of Estrone sulfate in Xenopus laevis oocytes |
Cell Physiol Biochem 13: 249-56 (2003)
Article DOI: 74539 BindingDB Entry DOI: 10.7270/Q2MS3V12 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50036754
((1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)...)Show SMILES [#7]\[#6](-[#7])=[#7]/c1nc(-[#6]-[#16]-[#6]-[#6]-[#6](=[#7])-[#7]S([#7])(=O)=O)cs1 Show InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14) | Reactome pathway KEGG
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| 3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto University Hospital
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of E1S uptake in OAT3 expressing oocytes |
Eur J Pharmacol 503: 25-30 (2004)
Article DOI: 10.1016/j.ejphar.2004.09.032 BindingDB Entry DOI: 10.7270/Q2TD9ZDK |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50420240
(CHEMBL2074590)Show InChI InChI=1S/C10H9NO2/c1-7(12)13-10-6-11-9-5-3-2-4-8(9)10/h2-6,11H,1H3 | Reactome pathway KEGG
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| Article PubMed
| 4.91E+5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tokyo
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of benzylpenicillin uptake in OAT3-expressing HEK293 cells |
Kidney Int 65: 162-74 (2004)
Article DOI: 10.1111/j.1523-1755.2004.00354.x BindingDB Entry DOI: 10.7270/Q29026N5 |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM26193
(2-Hydroxybenzoate, I | 2-hydroxybenzoic acid | CHE...)Show InChI InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10) | Reactome pathway KEGG
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| 1.02E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells |
J Pharmacol Exp Ther 302: 666-71 (2002)
Article DOI: 10.1124/jpet.102.034330 BindingDB Entry DOI: 10.7270/Q2HH6MBN |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50022271
(2-(3-Benzoylphenyl)propionic acid | 2-(3-benzoylph...)Show InChI InChI=1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19) | Reactome pathway KEGG
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| 1.16E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells |
J Pharmacol Exp Ther 302: 666-71 (2002)
Article DOI: 10.1124/jpet.102.034330 BindingDB Entry DOI: 10.7270/Q2HH6MBN |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM50009859
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15) | Reactome pathway KEGG
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| 1.17E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells |
J Pharmacol Exp Ther 302: 666-71 (2002)
Article DOI: 10.1124/jpet.102.034330 BindingDB Entry DOI: 10.7270/Q2HH6MBN |
More data for this Ligand-Target Pair | |
Solute carrier family 22 member 8
(Homo sapiens (Human)) | BDBM85245
(CAS_36322-90-4 | NSC_4856 | Piroxicam)Show SMILES CN1C(C(=O)Nc2ccccn2)=C(O)c2ccccc2S1(=O)=O |t:12| Show InChI InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,19H,1H3,(H,16,17,20) | Reactome pathway KEGG
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| 1.20E+6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Kyorin University School of Medicine
Curated by ChEMBL
| Assay Description TP_TRANSPORTER: inhibition of MTX uptake in OAT3-expressing S2 cells |
J Pharmacol Exp Ther 302: 666-71 (2002)
Article DOI: 10.1124/jpet.102.034330 BindingDB Entry DOI: 10.7270/Q2HH6MBN |
More data for this Ligand-Target Pair | |