Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase (Trypanosoma brucei) | BDBM50148195 (CHEMBL3765188) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50427452 (CHEMBL2326941) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50427452 (CHEMBL2326941) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei full length PDEB1 expressed in insect SF21 cells using cAMP as substrate by scintillation proximity assay | J Med Chem 56: 2087-96 (2013) Article DOI: 10.1021/jm3017877 BindingDB Entry DOI: 10.7270/Q2319X7M | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50427452 (CHEMBL2326941) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50441529 (CHEMBL2436771) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei PDEB1 | Bioorg Med Chem Lett 23: 5971-4 (2013) Article DOI: 10.1016/j.bmcl.2013.08.057 BindingDB Entry DOI: 10.7270/Q22B90GC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397108 (CHEMBL85005) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei TbrPDEB1 | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148237 (CHEMBL3763233) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148238 (CHEMBL3765037) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148239 (CHEMBL3764370) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397078 (CHEMBL2171452) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397078 (CHEMBL2171452) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei His-tagged catalytic domains of TbrPDEB1 expressed in Escherichia coli BL21 assessed as conversion of cAMP to AMP af... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148255 (CHEMBL3765786) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148247 (CHEMBL3765010) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148254 (CHEMBL3765606) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148249 (CHEMBL3763352) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148250 (CHEMBL3765222) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 79 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148248 (CHEMBL3765581) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148252 (CHEMBL3764909) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148251 (CHEMBL3765225) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 126 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Leishmania major) | BDBM50397078 (CHEMBL2171452) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Leishmania major recombinant PDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation proxim... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148253 (CHEMBL3765733) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 158 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397079 (CHEMBL2171451) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397082 (CHEMBL2171460) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50441528 (CHEMBL2436772) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 278 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei PDEB1 | Bioorg Med Chem Lett 23: 5971-4 (2013) Article DOI: 10.1016/j.bmcl.2013.08.057 BindingDB Entry DOI: 10.7270/Q22B90GC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148194 (CHEMBL3763456) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148240 (CHEMBL3763271) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 316 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397086 (CHEMBL2171456) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397106 (CHEMBL2171660) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397081 (CHEMBL2171461) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397102 (CHEMBL2171664) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397080 (CHEMBL2171462) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397083 (CHEMBL2171459) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397084 (CHEMBL2171458) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397090 (CHEMBL2171658) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397091 (CHEMBL2171657) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 830 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50058062 (CHEMBL3323128) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Northeastern University Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant PDEB1 pre-incubated for 5 mins prior to substrate addition | Bioorg Med Chem Lett 24: 4084-9 (2014) Article DOI: 10.1016/j.bmcl.2014.07.063 BindingDB Entry DOI: 10.7270/Q26D5VNC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397085 (CHEMBL2171457) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397103 (CHEMBL2171663) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148244 (CHEMBL3763547) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.59E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50148246 (CHEMBL3764415) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Mercachem Curated by ChEMBL | Assay Description Inhibition of recombinant Trypanosoma brucei PDEB1 using [3H]-cAMP as substrate after 15 mins by scintillation proximity assay | Bioorg Med Chem 24: 1573-81 (2016) Article DOI: 10.1016/j.bmc.2016.02.032 BindingDB Entry DOI: 10.7270/Q22V2J07 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397092 (CHEMBL2171656) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397097 (CHEMBL2171651) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397093 (CHEMBL2171655) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397094 (CHEMBL2171654) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM50397089 (CHEMBL2171453) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
VU University Amsterdam Curated by ChEMBL | Assay Description Inhibition of Trypanosoma brucei recombinant TbrPDEB1 expressed in Sf21 insect cells assessed as reduction of [3H]-cAMP hydrolysis by scintillation p... | J Med Chem 55: 8745-56 (2012) Article DOI: 10.1021/jm301059b BindingDB Entry DOI: 10.7270/Q2SF2X96 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM153391 (3-(3-carbamoyl-4-(3-methoxyphenylamino)-8-methylqu...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Northeastern University | Assay Description In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci... | Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM153402 (4-((3-Methoxyphenyl)amino)-8-methyl-6-(1-methyl-1H...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Northeastern University | Assay Description In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci... | Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM153408 (8-Methyl-6-(1-methyl-1H-indazol-6-yl)-4-(m-tolylam...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Northeastern University | Assay Description In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci... | Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM153390 (Methyl 3-(3-carbamoyl-4-(3-methoxyphenylamino)-8-m...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Northeastern University | Assay Description In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci... | Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase (Trypanosoma brucei) | BDBM153407 (4-(3-Ethylphenylamino)-8-methyl-6-(1-methyl-1H-ind...) | PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.50E+3 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Northeastern University | Assay Description In short, recombinant TbrPDEB1 and TbrPDEB2 were assayed in 10 mM Tris pH 7.4, bovine serum albumin (0.2 mg/mL), 10 mM MgCl2, 25然 cAMP (Enzo Lifesci... | Chem Biol Drug Des 85: 549-64 (2015) Article DOI: 10.1111/cbdd.12443 BindingDB Entry DOI: 10.7270/Q2FF3R28 | |||||||||||
More data for this Ligand-Target Pair |
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