Found 3 hits of ic50 data for polymerid = 50006222 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Histone-lysine N-methyltransferase 2B
(Homo sapiens (Human)) | BDBM50572749
(CHEMBL4854710) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of MLL4 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by HTRF metho... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2021.113592 BindingDB Entry DOI: 10.7270/Q2HQ43QP |
More data for this Ligand-Target Pair | |
Histone-lysine N-methyltransferase 2B
(Homo sapiens (Human)) | BDBM50606100
(CHEMBL5173004)Show SMILES C[C@H](Oc1ccc(cc1)-c1cc2c(ncnc2[nH]1)C1=CCNCC1)c1ccccc1 |r,t:21| | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00398 BindingDB Entry DOI: 10.7270/Q20K2DNQ |
More data for this Ligand-Target Pair | |
Histone-lysine N-methyltransferase 2B
(Homo sapiens (Human)) | BDBM50400778
(CHEMBL2204995)Show SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccnc(c1)N1CCN(C)CC1 Show InChI InChI=1S/C31H39N7O2/c1-6-7-23-14-21(4)35-31(40)26(23)18-33-30(39)25-15-24(16-28-27(25)19-34-38(28)20(2)3)22-8-9-32-29(17-22)37-12-10-36(5)11-13-37/h8-9,14-17,19-20H,6-7,10-13,18H2,1-5H3,(H,33,39)(H,35,40) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of MLL4 using core histone as substrate preincubated for 10 mins followed by addition of [3H]SAM and incubated for 60 mins |
ACS Med Chem Lett 3: 1091-1096 (2012)
Article DOI: 10.1021/ml3003346 BindingDB Entry DOI: 10.7270/Q2NK3G60 |
More data for this Ligand-Target Pair | |