BindingDB PrimarySearch

Found 12 hits of ec50 data for polymerid = 50006227
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
GTPase KRas (Homo sapiens (Human))	BDBM50586341 (CHEMBL5077647) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.30	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRAS G12C mutant in human HCC1171 cells assessed as effect on cell alkylation measured after 18 hrs by western blot analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00152 BindingDB Entry DOI: 10.7270/Q23R0XR5
TBA					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50586342 (CHEMBL5092687) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRAS G12C mutant in human HCC1171 cells assessed as effect on cell alkylation measured after 18 hrs by western blot analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00152 BindingDB Entry DOI: 10.7270/Q23R0XR5
TBA					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50586343 (CHEMBL5074707) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<6.10	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRAS G12C mutant in human HCC1171 cells assessed as effect on cell alkylation measured after 18 hrs by western blot analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00152 BindingDB Entry DOI: 10.7270/Q23R0XR5
TBA					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50586344 (CHEMBL5073894) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	6.60	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRAS G12C mutant in human HCC1171 cells assessed as effect on cell alkylation measured after 18 hrs by western blot analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00152 BindingDB Entry DOI: 10.7270/Q23R0XR5
TBA					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50539763 (Adagrasib \| Mrtx-849 \| Mrtx849) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1016/j.ejmech.2020.113006 BindingDB Entry DOI: 10.7270/Q2G44VBP
TBA					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50586345 (CHEMBL5090056) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	40	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRAS G12C mutant in human HCC1171 cells assessed as effect on cell alkylation measured after 18 hrs by western blot analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00152 BindingDB Entry DOI: 10.7270/Q23R0XR5
TBA					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50549221 (CHEMBL4293433) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRas G12C mutant in human NCI-H1792 cells assessed as antiproliferative activity incubated for 3 days by CellTiter-Glo assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01312 BindingDB Entry DOI: 10.7270/Q2T1578S
TBA					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50139187 (4-(2-cyclohexylethyl)-23-oxo-8-oxa-1,15,17,21-tetr...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.07E+3	n/a	n/a	n/a	n/a
Universite£ de Sherbrooke Curated by ChEMBL					Assay Description Inhibition of Ki-Ras				J Med Chem 54: 1961-2004 (2011) Article DOI: 10.1021/jm1012374 BindingDB Entry DOI: 10.7270/Q28C9XDV
Universite£ de Sherbrooke Curated by ChEMBL					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50586346 (CHEMBL5079099) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.00E+3	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRAS G12C mutant in human HCC1171 cells assessed as effect on cell alkylation measured after 18 hrs by western blot analysis				Citation and Details Article DOI: 10.1021/acsmedchemlett.2c00152 BindingDB Entry DOI: 10.7270/Q23R0XR5
TBA					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50101929 (3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Universite£ de Sherbrooke Curated by ChEMBL					Assay Description Inhibition of Ki-Ras				J Med Chem 54: 1961-2004 (2011) Article DOI: 10.1021/jm1012374 BindingDB Entry DOI: 10.7270/Q28C9XDV
Universite£ de Sherbrooke Curated by ChEMBL					More data for this Ligand-Target Pair
GTPase KRas (Homo sapiens (Human))	BDBM50436053 (CHEMBL2396992) Show SMILES Cc1[nH]c2cc(Cl)cc(Cl)c2c1CCN Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRas activation in HEK 293T-REx Flp-In cells harboring Venus-RBD-CRD/mCherry-CAAX assessed as reduction in Venus-RBD-CRD recruitment to...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01312 BindingDB Entry DOI: 10.7270/Q2T1578S
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
GTPase KRas (Homo sapiens (Human))	BDBM50549220 (CHEMBL4795772) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	2.66E+4	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of KRas G12C mutant in human H358 cells assessed as antiproliferative activity incubated for 3 days by CellTiter-Glo assay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01312 BindingDB Entry DOI: 10.7270/Q2T1578S
TBA					More data for this Ligand-Target Pair