Compile Data Set for Download or QSAR

Found 249 hits of ic50 data for polymerid = 50006237   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50511306 (CHEMBL4470115) Show SMILES Nc1ccc(nc1)C#Cc1c(N)nccc1Oc1ccc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)cc1F Show InChI InChI=1S/C30H20F2N6O3/c31-18-3-9-22(10-4-18)38-15-1-2-24(30(38)40)29(39)37-21-8-12-27(25(32)16-21)41-26-13-14-35-28(34)23(26)11-7-20-6-5-19(33)17-36-20/h1-6,8-10,12-17H,33H2,(H2,34,35)(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research & Development Curated by ChEMBL					Assay Description Displacement of fluorescein labeled probe from full length human GST-tagged RIPK3 expressed in Sf9 cells incubated for 60 mins by HTRF assay				ACS Med Chem Lett 11: 266-271 (2020) Article DOI: 10.1021/acsmedchemlett.9b00065 BindingDB Entry DOI: 10.7270/Q2VM4GKH
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50519649 (CHEMBL4439913) Show SMILES CNC(=O)c1ccc2n(cnc2c1)-c1ccc(CC(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C21H23N3O3/c1-21(2,3)27-19(25)11-14-5-8-16(9-6-14)24-13-23-17-12-15(20(26)22-4)7-10-18(17)24/h5-10,12-13H,11H2,1-4H3,(H,22,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of human recombinant RIP3 (2 to 328 residues) expressed in baculovirus by ADP-glo assay				J Med Chem 59: 6629-44 (2016) Article DOI: 10.1021/acs.jmedchem.5b01874 BindingDB Entry DOI: 10.7270/Q2N58QV5
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50519649 (CHEMBL4439913) Show SMILES CNC(=O)c1ccc2n(cnc2c1)-c1ccc(CC(=O)OC(C)(C)C)cc1 Show InChI InChI=1S/C21H23N3O3/c1-21(2,3)27-19(25)11-14-5-8-16(9-6-14)24-13-23-17-12-15(20(26)22-4)7-10-18(17)24/h5-10,12-13H,11H2,1-4H3,(H,22,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
University of Utah Curated by ChEMBL					Assay Description Inhibition of human recombinant RIP3 (2 to 328 residues) expressed in baculovirus by ADP-glo assay				J Med Chem 59: 6629-44 (2016) Article DOI: 10.1021/acs.jmedchem.5b01874 BindingDB Entry DOI: 10.7270/Q2N58QV5
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50322535 (3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of recombinant GST-tagged RIPK3 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 4 hrs by ADP-Glo assay				J Med Chem 63: 1490-1510 (2020) Article DOI: 10.1021/acs.jmedchem.9b01317 BindingDB Entry DOI: 10.7270/Q20K2CZB
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50322535 (3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...) Show SMILES CN1CCN(Cc2ccc(NC(=O)c3ccc(C)c(c3)C#Cc3cnc4cccnn34)cc2C(F)(F)F)CC1 Show InChI InChI=1S/C29H27F3N6O/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01518 BindingDB Entry DOI: 10.7270/Q2QC07MW
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50428286 (DABRAFENIB | GSK2118436A) Show SMILES CC(C)(C)c1nc(c(s1)-c1ccnc(N)n1)-c1cccc(NS(=O)(=O)c2c(F)cccc2F)c1F Show InChI InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Inhibition of human RIPK3 using MBP as substrate by [gamma33-ATP] based radiometric assay				J Med Chem 63: 1490-1510 (2020) Article DOI: 10.1021/acs.jmedchem.9b01317 BindingDB Entry DOI: 10.7270/Q20K2CZB
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50511307 (CHEMBL4455682) Show SMILES Fc1ccc(cc1)-n1cccc(C(=O)Nc2ccc(Oc3ccnc(NC(=O)C4CC4)c3)c(F)c2)c1=O Show InChI InChI=1S/C27H20F2N4O4/c28-17-5-8-19(9-6-17)33-13-1-2-21(27(33)36)26(35)31-18-7-10-23(22(29)14-18)37-20-11-12-30-24(15-20)32-25(34)16-3-4-16/h1-2,5-16H,3-4H2,(H,31,35)(H,30,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research & Development Curated by ChEMBL					Assay Description Displacement of fluorescein labeled ATP probe from full length His/GST-tagged RIPK3 (unknown origin) incubated for 60 mins by HTRF assay				ACS Med Chem Lett 11: 266-271 (2020) Article DOI: 10.1021/acsmedchemlett.9b00065 BindingDB Entry DOI: 10.7270/Q2VM4GKH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50511302 (CHEMBL4476485) Show SMILES Cc1cc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)ccc1Oc1ccnc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C28H23FN4O4/c1-17-15-20(8-11-24(17)37-22-12-13-30-25(16-22)32-26(34)18-4-5-18)31-27(35)23-3-2-14-33(28(23)36)21-9-6-19(29)7-10-21/h2-3,6-16,18H,4-5H2,1H3,(H,31,35)(H,30,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research & Development Curated by ChEMBL					Assay Description Displacement of fluorescein labeled ATP probe from full length His/GST-tagged RIPK3 (unknown origin) incubated for 60 mins by HTRF assay				ACS Med Chem Lett 11: 266-271 (2020) Article DOI: 10.1021/acsmedchemlett.9b00065 BindingDB Entry DOI: 10.7270/Q2VM4GKH
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50519646 (CHEMBL4464634) Show SMILES Cc1ccc(CCCCN2C(=O)N[C@H](Cc3c[nH]c4c(Cl)cccc34)C2=O)cc1C#Cc1cnc2cccnn12 |r| Show InChI InChI=1S/C31H27ClN6O2/c1-20-10-11-21(16-22(20)12-13-24-19-33-28-9-5-14-35-38(24)28)6-2-3-15-37-30(39)27(36-31(37)40)17-23-18-34-29-25(23)7-4-8-26(29)32/h4-5,7-11,14,16,18-19,27,34H,2-3,6,15,17H2,1H3,(H,36,40)/t27-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c01518 BindingDB Entry DOI: 10.7270/Q2QC07MW
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50511310 (CHEMBL4552106) Show SMILES CC#Cc1c(N)nccc1Oc1ccc(NC(=O)c2cccn(-c3ccc(F)cc3)c2=O)cc1F Show InChI InChI=1S/C26H18F2N4O3/c1-2-4-19-22(12-13-30-24(19)29)35-23-11-8-17(15-21(23)28)31-25(33)20-5-3-14-32(26(20)34)18-9-6-16(27)7-10-18/h3,5-15H,1H3,(H2,29,30)(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research & Development Curated by ChEMBL					Assay Description Displacement of fluorescein labeled ATP probe from full length His/GST-tagged RIPK3 (unknown origin) incubated for 60 mins by HTRF assay				ACS Med Chem Lett 11: 266-271 (2020) Article DOI: 10.1021/acsmedchemlett.9b00065 BindingDB Entry DOI: 10.7270/Q2VM4GKH
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM50184765 (CHEMBL3823499) Show SMILES CC(C)(C)S(=O)(=O)c1ccc2nccc(Nc3n[nH]c4ccc(F)cc34)c2c1 Show InChI InChI=1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of RIPK3 (unknown origin) preincubated for 10 mins followed by addition of fluorescent-labeled 2-Methyl-5-(2-propen-l-yloxy)aniline measur...				J Med Chem 59: 4867-80 (2016) Article DOI: 10.1021/acs.jmedchem.6b00211 BindingDB Entry DOI: 10.7270/Q2G162SQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392902 (US10301306, Example 100 | US10301306, Example 161) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(F)cc1C#N)-c1ccc(F)cc1 Show InChI InChI=1S/C28H21F2N5O2/c1-16(36)34-24-13-18(8-10-32-24)27-25(17-2-5-21(29)6-3-17)26-23(9-11-33-28(26)37)35(27)15-19-4-7-22(30)12-20(19)14-31/h2-8,10,12-13H,9,11,15H2,1H3,(H,33,37)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392966 (US10301306, Example 164) Show SMILES Cc1ccc(s1)-c1c2c(CCNC2=O)n(Cc2ccc(Cl)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C24H19ClFN3OS/c1-14-2-5-20(31-14)22-21-19(8-11-28-24(21)30)29(23(22)15-6-9-27-10-7-15)13-16-3-4-17(25)12-18(16)26/h2-7,9-10,12H,8,11,13H2,1H3,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392985 (US10301306, Example 183) Show SMILES COc1cnccc1-c1c(c2c(CCNC2=O)n1Cc1cc(C)nn1C)-c1ccc(F)cc1 |(-2.87,-4.05,;-2.1,-2.72,;-2.87,-1.39,;-4.41,-1.39,;-5.18,-.05,;-4.41,1.28,;-2.87,1.28,;-2.1,-.05,;-.56,-.05,;.34,1.19,;1.81,.72,;1.81,-.82,;3.14,-1.59,;4.47,-.82,;4.47,.72,;3.14,1.49,;3.14,3.03,;.34,-1.3,;-.06,-2.79,;1.03,-3.88,;2.56,-3.71,;3.19,-5.12,;4.7,-5.44,;2.05,-6.15,;.71,-5.38,;-.69,-6.01,;-.06,2.68,;1.03,3.77,;.63,5.26,;-.85,5.66,;-1.25,7.14,;-1.94,4.57,;-1.54,3.08,)| Show InChI InChI=1S/C25H24FN5O2/c1-15-12-18(30(2)29-15)14-31-20-9-11-28-25(32)23(20)22(16-4-6-17(26)7-5-16)24(31)19-8-10-27-13-21(19)33-3/h4-8,10,12-13H,9,11,14H2,1-3H3,(H,28,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392804 (3-((3-(4-Fluorophenyl)-4-oxo-2-(pyridin-4-yl)-4,5,...) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2cccc(c2)C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H19FN4O/c27-21-6-4-19(5-7-21)23-24-22(10-13-30-26(24)32)31(25(23)20-8-11-29-12-9-20)16-18-3-1-2-17(14-18)15-28/h1-9,11-12,14H,10,13,16H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392806 (N-(4-(3-(4-Fluorophenyl)-1-(4-methylbenzyl)-4-oxo-...) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(C)cc1)-c1ccc(F)cc1 Show InChI InChI=1S/C28H25FN4O2/c1-17-3-5-19(6-4-17)16-33-23-12-14-31-28(35)26(23)25(20-7-9-22(29)10-8-20)27(33)21-11-13-30-24(15-21)32-18(2)34/h3-11,13,15H,12,14,16H2,1-2H3,(H,31,35)(H,30,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392810 (N-(4-(1-(2-Fluoro-4-(trifluoromethyl)benzyl)-3-(4-...) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2F)C(F)(F)F)c1-c1ccnc(NC(=O)C2CC2)c1 Show InChI InChI=1S/C30H23F5N4O2/c31-21-7-4-16(5-8-21)25-26-23(10-12-37-29(26)41)39(15-19-3-6-20(14-22(19)32)30(33,34)35)27(25)18-9-11-36-24(13-18)38-28(40)17-1-2-17/h3-9,11,13-14,17H,1-2,10,12,15H2,(H,37,41)(H,36,38,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392815 (3-(4-Fluorophenyl)-1-(4-(3-methyl-1,2,4-oxadiazol-...) Show SMILES Cc1noc(n1)-c1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C28H22FN5O2/c1-17-32-28(36-33-17)21-4-2-18(3-5-21)16-34-23-12-15-31-27(35)25(23)24(19-6-8-22(29)9-7-19)26(34)20-10-13-30-14-11-20/h2-11,13-14H,12,15-16H2,1H3,(H,31,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392816 (5-Fluoro-2-((4-oxo-2-(pyridin-4-yl)-3-(thiophen-2-...) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(-c3cccs3)c2-c2ccncc2)c(c1)C#N Show InChI InChI=1S/C24H17FN4OS/c25-18-4-3-16(17(12-18)13-26)14-29-19-7-10-28-24(30)21(19)22(20-2-1-11-31-20)23(29)15-5-8-27-9-6-15/h1-6,8-9,11-12H,7,10,14H2,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392829 (US10301306, Example 27) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1F |(-1.25,7.14,;-.85,5.66,;.63,5.26,;1.03,3.77,;-.06,2.68,;-1.54,3.08,;-1.94,4.57,;.34,1.19,;1.81,.72,;1.81,-.82,;3.14,-1.59,;4.47,-.82,;4.47,.72,;3.14,1.49,;3.14,3.03,;.34,-1.3,;-.06,-2.79,;1.03,-3.88,;2.52,-3.48,;3.61,-4.57,;3.21,-6.05,;4.3,-7.14,;1.72,-6.45,;.58,-5.38,;-.91,-5.78,;-2.4,-6.17,;-.56,-.05,;-2.1,-.05,;-2.87,1.28,;-4.41,1.28,;-5.18,-.05,;-4.41,-1.39,;-2.87,-1.39,;-2.1,-2.72,)| Show InChI InChI=1S/C26H17F3N4O/c27-18-4-1-15(2-5-18)23-24-22(8-10-32-26(24)34)33(25(23)20-7-9-31-13-21(20)29)14-16-3-6-19(28)11-17(16)12-30/h1-7,9,11,13H,8,10,14H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392836 (US10301306, Example 34) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H18F2N4O/c27-20-4-1-16(2-5-20)23-24-22(9-12-31-26(24)33)32(25(23)17-7-10-30-11-8-17)15-18-3-6-21(28)13-19(18)14-29/h1-8,10-11,13H,9,12,15H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392840 (US10301306, Example 38) Show SMILES COc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C26H22FN3O2/c1-32-21-8-2-17(3-9-21)16-30-22-12-15-29-26(31)24(22)23(18-4-6-20(27)7-5-18)25(30)19-10-13-28-14-11-19/h2-11,13-14H,12,15-16H2,1H3,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392843 (US10301306, Example 41) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2cc(F)cc(c2)C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C26H18F5N3O/c27-19-3-1-16(2-4-19)22-23-21(7-10-33-25(23)35)34(24(22)17-5-8-32-9-6-17)14-15-11-18(26(29,30)31)13-20(28)12-15/h1-6,8-9,11-13H,7,10,14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392845 (US10301306, Example 43) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2F)C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C26H18F5N3O/c27-19-5-2-15(3-6-19)22-23-21(9-12-33-25(23)35)34(24(22)16-7-10-32-11-8-16)14-17-1-4-18(13-20(17)28)26(29,30)31/h1-8,10-11,13H,9,12,14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392846 (US10301306, Example 44) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)cc1 Show InChI InChI=1S/C25H19F2N3O/c26-19-5-1-16(2-6-19)15-30-21-11-14-29-25(31)23(21)22(17-3-7-20(27)8-4-17)24(30)18-9-12-28-13-10-18/h1-10,12-13H,11,14-15H2,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392848 (US10301306, Example 46) Show SMILES Cc1cc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)ccc1F Show InChI InChI=1S/C26H21F2N3O/c1-16-14-17(2-7-21(16)28)15-31-22-10-13-30-26(32)24(22)23(18-3-5-20(27)6-4-18)25(31)19-8-11-29-12-9-19/h2-9,11-12,14H,10,13,15H2,1H3,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392850 (US10301306, Example 48) Show SMILES Cc1nc(no1)-c1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)c(F)c1 Show InChI InChI=1S/C28H21F2N5O2/c1-16-33-27(34-37-16)19-2-3-20(22(30)14-19)15-35-23-10-13-32-28(36)25(23)24(17-4-6-21(29)7-5-17)26(35)18-8-11-31-12-9-18/h2-9,11-12,14H,10,13,15H2,1H3,(H,32,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392853 (US10301306, Example 51) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2F)C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H18F2N4O/c27-20-5-3-17(4-6-20)23-24-22(9-12-31-26(24)33)32(25(23)18-7-10-30-11-8-18)15-19-2-1-16(14-29)13-21(19)28/h1-8,10-11,13H,9,12,15H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392855 (US10301306, Example 53) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(cc2C(F)(F)F)C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C27H18F7N3O/c28-19-5-2-15(3-6-19)22-23-21(9-12-36-25(23)38)37(24(22)16-7-10-35-11-8-16)14-17-1-4-18(26(29,30)31)13-20(17)27(32,33)34/h1-8,10-11,13H,9,12,14H2,(H,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392857 (US10301306, Example 55) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C26H18F5N3O/c27-18-4-1-15(2-5-18)22-23-21(9-12-33-25(23)35)34(24(22)16-7-10-32-11-8-16)14-17-3-6-19(28)13-20(17)26(29,30)31/h1-8,10-11,13H,9,12,14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392866 (US10301306, Example 64) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C25H18F3N3O/c26-18-4-1-15(2-5-18)22-23-21(9-12-30-25(23)32)31(24(22)16-7-10-29-11-8-16)14-17-3-6-19(27)13-20(17)28/h1-8,10-11,13H,9,12,14H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392867 (US10301306, Example 65) Show SMILES Cc1cc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)cc2)n(C)n1 Show InChI InChI=1S/C24H22FN5O/c1-15-13-19(29(2)28-15)14-30-20-9-12-27-24(31)22(20)21(16-3-5-18(25)6-4-16)23(30)17-7-10-26-11-8-17/h3-8,10-11,13H,9,12,14H2,1-2H3,(H,27,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392868 (US10301306, Example 66) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccncc2)c1-c1ccncc1 Show InChI InChI=1S/C24H19FN4O/c25-19-3-1-17(2-4-19)21-22-20(9-14-28-24(22)30)29(15-16-5-10-26-11-6-16)23(21)18-7-12-27-13-8-18/h1-8,10-13H,9,14-15H2,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392870 (US10301306, Example 68) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccccc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H19FN4O/c27-21-7-5-17(6-8-21)23-24-22(11-14-30-26(24)32)31(25(23)18-9-12-29-13-10-18)16-20-4-2-1-3-19(20)15-28/h1-10,12-13H,11,14,16H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392873 (US10301306, Example 71) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2c(F)cc(F)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C25H17F4N3O/c26-16-3-1-14(2-4-16)22-23-21(7-10-31-25(23)33)32(24(22)15-5-8-30-9-6-15)13-18-19(28)11-17(27)12-20(18)29/h1-6,8-9,11-12H,7,10,13H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392875 (US10301306, Example 73) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2c(F)cccc2C(F)(F)F)c1-c1ccncc1 Show InChI InChI=1S/C26H18F5N3O/c27-17-6-4-15(5-7-17)22-23-21(10-13-33-25(23)35)34(24(22)16-8-11-32-12-9-16)14-18-19(26(29,30)31)2-1-3-20(18)28/h1-9,11-12H,10,13-14H2,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392876 (US10301306, Example 74) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2ccc(Cl)cc2F)c1-c1ccncc1 Show InChI InChI=1S/C25H18ClF2N3O/c26-18-4-1-17(20(28)13-18)14-31-21-9-12-30-25(32)23(21)22(15-2-5-19(27)6-3-15)24(31)16-7-10-29-11-8-16/h1-8,10-11,13H,9,12,14H2,(H,30,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392877 (US10301306, Example 75) Show SMILES CC(C)(C)CCn1c2CCNC(=O)c2c(c1-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C24H26FN3O/c1-24(2,3)11-15-28-19-10-14-27-23(29)21(19)20(16-4-6-18(25)7-5-16)22(28)17-8-12-26-13-9-17/h4-9,12-13H,10-11,14-15H2,1-3H3,(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392879 (US10301306, Example 77) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2c(F)cccc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H18F2N4O/c27-19-6-4-16(5-7-19)23-24-22(10-13-31-26(24)33)32(25(23)17-8-11-30-12-9-17)15-20-18(14-29)2-1-3-21(20)28/h1-9,11-12H,10,13,15H2,(H,31,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392880 (US10301306, Example 78) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(CC2CCCC2)c1-c1ccncc1 Show InChI InChI=1S/C24H24FN3O/c25-19-7-5-17(6-8-19)21-22-20(11-14-27-24(22)29)28(15-16-3-1-2-4-16)23(21)18-9-12-26-13-10-18/h5-10,12-13,16H,1-4,11,14-15H2,(H,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392886 (US10301306, Example 84) Show SMILES Fc1ccc(cc1)-c1c2c(CCNC2=O)n(Cc2c(F)cc(cc2F)C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H17F3N4O/c27-18-3-1-16(2-4-18)23-24-22(7-10-32-26(24)34)33(25(23)17-5-8-31-9-6-17)14-19-20(28)11-15(13-30)12-21(19)29/h1-6,8-9,11-12H,7,10,14H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392902 (US10301306, Example 100 | US10301306, Example 161) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(F)cc1C#N)-c1ccc(F)cc1 Show InChI InChI=1S/C28H21F2N5O2/c1-16(36)34-24-13-18(8-10-32-24)27-25(17-2-5-21(29)6-3-17)26-23(9-11-33-28(26)37)35(27)15-19-4-7-22(30)12-20(19)14-31/h2-8,10,12-13H,9,11,15H2,1H3,(H,33,37)(H,32,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392903 (US10301306, Example 101) Show SMILES CC(=O)Nc1cc(ccn1)-c1c(c2c(CCNC2=O)n1Cc1ccc(cc1F)C(F)(F)F)-c1ccc(F)cc1 Show InChI InChI=1S/C28H21F5N4O2/c1-15(38)36-23-12-17(8-10-34-23)26-24(16-3-6-20(29)7-4-16)25-22(9-11-35-27(25)39)37(26)14-18-2-5-19(13-21(18)30)28(31,32)33/h2-8,10,12-13H,9,11,14H2,1H3,(H,35,39)(H,34,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392917 (US10301306, Example 115) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2ccc(F)c(F)c2)c(c1)C#N Show InChI InChI=1S/C26H17F3N4O/c27-19-3-1-17(18(11-19)13-30)14-33-22-7-10-32-26(34)24(22)23(16-2-4-20(28)21(29)12-16)25(33)15-5-8-31-9-6-15/h1-6,8-9,11-12H,7,10,14H2,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392925 (US10301306, Example 123) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(c2-c2ccncc2)-c2cccc(c2)C(F)(F)F)c(c1)C#N Show InChI InChI=1S/C27H18F4N4O/c28-21-5-4-18(19(13-21)14-32)15-35-22-8-11-34-26(36)24(22)23(25(35)16-6-9-33-10-7-16)17-2-1-3-20(12-17)27(29,30)31/h1-7,9-10,12-13H,8,11,15H2,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392926 (US10301306, Example 124) Show SMILES COc1ccc(cn1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H20FN5O2/c1-34-22-5-3-17(14-31-22)23-24-21(8-11-30-26(24)33)32(25(23)16-6-9-29-10-7-16)15-18-2-4-20(27)12-19(18)13-28/h2-7,9-10,12,14H,8,11,15H2,1H3,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392929 (US10301306, Example 127) Show SMILES Oc1cccc(c1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C26H19FN4O2/c27-20-5-4-18(19(12-20)14-28)15-31-22-8-11-30-26(33)24(22)23(17-2-1-3-21(32)13-17)25(31)16-6-9-29-10-7-16/h1-7,9-10,12-13,32H,8,11,15H2,(H,30,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392930 (US10301306, Example 128) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(-c3ccsc3)c2-c2ccncc2)c(c1)C#N Show InChI InChI=1S/C24H17FN4OS/c25-19-2-1-16(18(11-19)12-26)13-29-20-5-9-28-24(30)22(20)21(17-6-10-31-14-17)23(29)15-3-7-27-8-4-15/h1-4,6-8,10-11,14H,5,9,13H2,(H,28,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392932 (US10301306, Example 130) Show SMILES Fc1ccc(Cn2c3CCNC(=O)c3c(-c3ccc(Cl)s3)c2-c2ccncc2)c(c1)C#N Show InChI InChI=1S/C24H16ClFN4OS/c25-20-4-3-19(32-20)22-21-18(7-10-29-24(21)31)30(23(22)14-5-8-28-9-6-14)13-15-1-2-17(26)11-16(15)12-27/h1-6,8-9,11H,7,10,13H2,(H,29,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 3 (Homo sapiens (Human))	BDBM392936 (US10301306, Example 134) Show SMILES OCc1cccc(c1)-c1c2c(CCNC2=O)n(Cc2ccc(F)cc2C#N)c1-c1ccncc1 Show InChI InChI=1S/C27H21FN4O2/c28-22-5-4-20(21(13-22)14-29)15-32-23-8-11-31-27(34)25(23)24(19-3-1-2-17(12-19)16-33)26(32)18-6-9-30-10-7-18/h1-7,9-10,12-13,33H,8,11,15-16H2,(H,31,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<30	n/a	n/a	n/a	n/a	n/a	n/a
GSK					Assay Description The assays were performed in black 1536-well plates. The final assay volume of 2 μl contained a mixture of a fluorescently labeled HTRF probe, T...				Bioorg Med Chem Lett 18: 5018-22 (2008) BindingDB Entry DOI: 10.7270/Q2M90C19
					More data for this Ligand-Target Pair

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