Found 12 hits of ic50 data for polymerid = 50006382 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434750
(CHEMBL2385596)Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc2ccccc12 Show InChI InChI=1S/C26H24N6/c1-30-12-14-31(15-13-30)21-8-6-19(7-9-21)20-16-28-26-24(17-29-32(26)18-20)22-10-11-27-25-5-3-2-4-23(22)25/h2-11,16-18H,12-15H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434748
(CHEMBL2385600)Show InChI InChI=1S/C16H13N5O/c1-22-14-4-2-11(3-5-14)13-6-17-16-15(9-20-21(16)10-13)12-7-18-19-8-12/h2-10H,1H3,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 94 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM102618
(LDN-212854)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 Show InChI InChI=1S/C25H22N6/c1-3-21(22-4-2-10-27-24(22)5-1)23-16-29-31-17-19(15-28-25(23)31)18-6-8-20(9-7-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434751
(CHEMBL2385579)Show SMILES C1CN(CCO1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1cn[nH]c1 Show InChI InChI=1S/C19H18N6O/c1-3-17(24-5-7-26-8-6-24)4-2-14(1)16-9-20-19-18(12-23-25(19)13-16)15-10-21-22-11-15/h1-4,9-13H,5-8H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 141 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50261979
(5-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...)Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cccc2ncccc12 Show InChI InChI=1S/C22H16N4O/c1-27-17-9-7-15(8-10-17)16-12-24-22-20(13-25-26(22)14-16)18-4-2-6-21-19(18)5-3-11-23-21/h2-14H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 152 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434759
(CHEMBL2385588)Show SMILES Clc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCNCC1 Show InChI InChI=1S/C21H19ClN6/c22-20-11-16(5-6-24-20)19-13-26-28-14-17(12-25-21(19)28)15-1-3-18(4-2-15)27-9-7-23-8-10-27/h1-6,11-14,23H,7-10H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 246 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434758
(CHEMBL2385585)Show SMILES C1CN(CCO1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1csc2ccccc12 Show InChI InChI=1S/C24H20N4OS/c1-2-4-23-20(3-1)22(16-30-23)21-14-26-28-15-18(13-25-24(21)28)17-5-7-19(8-6-17)27-9-11-29-12-10-27/h1-8,13-16H,9-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 418 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434757
(CHEMBL2385595)Show SMILES CN1CCN(CC1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccnc(Cl)c1 Show InChI InChI=1S/C22H21ClN6/c1-27-8-10-28(11-9-27)19-4-2-16(3-5-19)18-13-25-22-20(14-26-29(22)15-18)17-6-7-24-21(23)12-17/h2-7,12-15H,8-11H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 523 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434756
(CHEMBL2385581)Show SMILES Clc1cc(ccn1)-c1cnn2cc(cnc12)-c1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C21H18ClN5O/c22-20-11-16(5-6-23-20)19-13-25-27-14-17(12-24-21(19)27)15-1-3-18(4-2-15)26-7-9-28-10-8-26/h1-6,11-14H,7-10H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 529 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434755
(CHEMBL2385592)Show SMILES C1CN(CCN1)c1ccc(cc1)-c1cnc2c(cnn2c1)-c1csc2ccccc12 Show InChI InChI=1S/C24H21N5S/c1-2-4-23-20(3-1)22(16-30-23)21-14-27-29-15-18(13-26-24(21)29)17-5-7-19(8-6-17)28-11-9-25-10-12-28/h1-8,13-16,25H,9-12H2 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434754
(CHEMBL2385578)Show InChI InChI=1S/C20H14N4OS/c1-25-15-4-2-13(3-5-15)14-10-22-20-17(11-23-24(20)12-14)16-6-8-21-18-7-9-26-19(16)18/h2-12H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.57E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
Bone morphogenetic protein 4
(Mus musculus) | BDBM50434753
(CHEMBL2385403)Show SMILES COc1ccc(cc1)-c1cnc2c(cnn2c1)-c1cncc2ccccc12 Show InChI InChI=1S/C22H16N4O/c1-27-18-8-6-15(7-9-18)17-11-24-22-21(13-25-26(22)14-17)20-12-23-10-16-4-2-3-5-19(16)20/h2-14H,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.73E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center
Curated by ChEMBL
| Assay Description
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay |
Bioorg Med Chem Lett 23: 3248-52 (2013)
Article DOI: 10.1016/j.bmcl.2013.03.113
BindingDB Entry DOI: 10.7270/Q2WW7K3P |
More data for this
Ligand-Target Pair | |
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