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Compile Data Set for Download or QSAR

Found 165 hits of ec50 data for polymerid = 50006413   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593405
PNG
(CHEMBL5178783)
Show SMILES Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCC(F)(F)CC1
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n/an/an/an/a 33n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593381
PNG
(CHEMBL5192713)
Show SMILES Cc1cc(NC(=O)COc2ccc(Br)cc2Br)n(n1)C1CCS(=O)(=O)C1
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532046
PNG
(CHEMBL4453299)
Show SMILES Cc1cc(NC(=O)Cn2cc(cn2)-c2ccccc2)n(n1)C1CCCCC1
Show InChI InChI=1S/C21H25N5O/c1-16-12-20(26(24-16)19-10-6-3-7-11-19)23-21(27)15-25-14-18(13-22-25)17-8-4-2-5-9-17/h2,4-5,8-9,12-14,19H,3,6-7,10-11,15H2,1H3,(H,23,27)
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n/an/an/an/a 65n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437979
PNG
(CHEMBL2409110)
Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(Cc2ccccc2)n1
Show InChI InChI=1S/C18H16F2N4O/c1-12-9-17(24(23-12)11-13-5-3-2-4-6-13)22-18(25)21-14-7-8-15(19)16(20)10-14/h2-10H,11H2,1H3,(H2,21,22,25)
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n/an/an/an/a 70n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532012
PNG
(CHEMBL4461542)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(F)c2)n(n1)C1CCCCC1
Show InChI InChI=1S/C19H22FN7O/c1-13-10-17(27(23-13)16-8-3-2-4-9-16)21-18(28)12-26-24-19(22-25-26)14-6-5-7-15(20)11-14/h5-7,10-11,16H,2-4,8-9,12H2,1H3,(H,21,28)
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n/an/an/an/a 81n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532034
PNG
(CHEMBL4435859)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCC(F)(F)CC1
Show InChI InChI=1S/C19H21F2N7O/c1-13-11-16(28(24-13)15-7-9-19(20,21)10-8-15)22-17(29)12-27-25-18(23-26-27)14-5-3-2-4-6-14/h2-6,11,15H,7-10,12H2,1H3,(H,22,29)
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n/an/an/an/a 84n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593406
PNG
(CHEMBL5206362)
Show SMILES Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCOCC1
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593403
PNG
(CHEMBL5199523)
Show SMILES Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCCCC1
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532008
PNG
(CHEMBL4453946)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCCC1
Show InChI InChI=1S/C19H23N7O/c1-14-12-17(26(22-14)16-10-6-3-7-11-16)20-18(27)13-25-23-19(21-24-25)15-8-4-2-5-9-15/h2,4-5,8-9,12,16H,3,6-7,10-11,13H2,1H3,(H,20,27)
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University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532045
PNG
(CHEMBL4529550)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(C)cc2)n(n1)C1CCCCC1
Show InChI InChI=1S/C20H25N7O/c1-14-8-10-16(11-9-14)20-22-25-26(24-20)13-19(28)21-18-12-15(2)23-27(18)17-6-4-3-5-7-17/h8-12,17H,3-7,13H2,1-2H3,(H,21,28)
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University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532013
PNG
(CHEMBL4549232)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(F)c(F)c2)n(n1)C1CCCCC1
Show InChI InChI=1S/C19H21F2N7O/c1-12-9-17(28(24-12)14-5-3-2-4-6-14)22-18(29)11-27-25-19(23-26-27)13-7-8-15(20)16(21)10-13/h7-10,14H,2-6,11H2,1H3,(H,22,29)
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n/an/an/an/a 116n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532019
PNG
(CHEMBL4458146)
Show SMILES Cc1cc(NC(=O)Cn2cc(nn2)-c2ccccc2)n(n1)C1CCCCC1
Show InChI InChI=1S/C20H24N6O/c1-15-12-19(26(23-15)17-10-6-3-7-11-17)21-20(27)14-25-13-18(22-24-25)16-8-4-2-5-9-16/h2,4-5,8-9,12-13,17H,3,6-7,10-11,14H2,1H3,(H,21,27)
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University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532041
PNG
(CHEMBL4447978)
Show SMILES COc1cccc(c1)-c1nnn(CC(=O)Nc2cc(C)nn2C2CCCCC2)n1
Show InChI InChI=1S/C20H25N7O2/c1-14-11-18(27(23-14)16-8-4-3-5-9-16)21-19(28)13-26-24-20(22-25-26)15-7-6-10-17(12-15)29-2/h6-7,10-12,16H,3-5,8-9,13H2,1-2H3,(H,21,28)
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University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532002
PNG
(CHEMBL4530409)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(C)c2)n(n1)C1CCCCC1
Show InChI InChI=1S/C20H25N7O/c1-14-7-6-8-16(11-14)20-22-25-26(24-20)13-19(28)21-18-12-15(2)23-27(18)17-9-4-3-5-10-17/h6-8,11-12,17H,3-5,9-10,13H2,1-2H3,(H,21,28)
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n/an/an/an/a 129n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593378
PNG
(CHEMBL5202704)
Show SMILES Cc1cc(NC(=O)COc2ccc(Br)cc2Cl)n(n1)C1CCS(=O)(=O)C1
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593401
PNG
(CHEMBL5192503)
Show SMILES CC(C)n1nc(C)cc1NC(=O)COc1ccc(Cl)cc1Cl
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593373
PNG
(CHEMBL5182581)
Show SMILES Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCS(=O)(=O)C1
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593387
PNG
(CHEMBL5187664)
Show SMILES Cc1cc(NC(=O)COc2ccc(cc2C(F)(F)F)C(F)(F)F)n(n1)C1CCS(=O)(=O)C1
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497414
PNG
(CHEMBL3339145)
Show SMILES CC1CC1c1cc(NC(=O)Nc2ccc(Cl)cc2)n(CC(F)(F)F)n1
Show InChI InChI=1S/C16H16ClF3N4O/c1-9-6-12(9)13-7-14(24(23-13)8-16(18,19)20)22-15(25)21-11-4-2-10(17)3-5-11/h2-5,7,9,12H,6,8H2,1H3,(H2,21,22,25)
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Northwest A&F University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593377
PNG
(CHEMBL5186323)
Show SMILES Cc1cc(NC(=O)COc2cc(Cl)ccc2Cl)n(n1)C1CCS(=O)(=O)C1
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437983
PNG
(CHEMBL2409106)
Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
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n/an/an/an/a 160n/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437983
PNG
(CHEMBL2409106)
Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
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n/an/an/an/a 160n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium flux assay


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437983
PNG
(CHEMBL2409106)
Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
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Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by cell-based thallium flux assay


Bioorg Med Chem Lett 23: 5195-8 (2013)


Article DOI: 10.1016/j.bmcl.2013.07.002
BindingDB Entry DOI: 10.7270/Q28K7BG1
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532007
PNG
(CHEMBL4473433)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCC1
Show InChI InChI=1S/C18H21N7O/c1-13-11-16(25(21-13)15-9-5-6-10-15)19-17(26)12-24-22-18(20-23-24)14-7-3-2-4-8-14/h2-4,7-8,11,15H,5-6,9-10,12H2,1H3,(H,19,26)
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n/an/an/an/a 163n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593371
PNG
(CHEMBL5189637)
Show SMILES Cc1cc(NC(=O)Cc2ccc(F)c(Cl)c2)n(n1)C1CCCCC1
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n/an/an/an/a 165n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532005
PNG
(CHEMBL4543208)
Show SMILES COc1ccc(cc1)-c1nnn(CC(=O)Nc2cc(C)nn2C2CCCCC2)n1
Show InChI InChI=1S/C20H25N7O2/c1-14-12-18(27(23-14)16-6-4-3-5-7-16)21-19(28)13-26-24-20(22-25-26)15-8-10-17(29-2)11-9-15/h8-12,16H,3-7,13H2,1-2H3,(H,21,28)
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n/an/an/an/a 175n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532037
PNG
(CHEMBL4457178)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(CC2CCCCC2)n1
Show InChI InChI=1S/C20H25N7O/c1-15-12-18(26(23-15)13-16-8-4-2-5-9-16)21-19(28)14-27-24-20(22-25-27)17-10-6-3-7-11-17/h3,6-7,10-12,16H,2,4-5,8-9,13-14H2,1H3,(H,21,28)
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n/an/an/an/a 176n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532025
PNG
(CHEMBL4450006)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(F)cc2)n(n1)C1CCCCC1
Show InChI InChI=1S/C19H22FN7O/c1-13-11-17(27(23-13)16-5-3-2-4-6-16)21-18(28)12-26-24-19(22-25-26)14-7-9-15(20)10-8-14/h7-11,16H,2-6,12H2,1H3,(H,21,28)
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n/an/an/an/a 180n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532048
PNG
(CHEMBL4536665)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(c2)C#N)n(n1)C1CCCCC1
Show InChI InChI=1S/C20H22N8O/c1-14-10-18(28(24-14)17-8-3-2-4-9-17)22-19(29)13-27-25-20(23-26-27)16-7-5-6-15(11-16)12-21/h5-7,10-11,17H,2-4,8-9,13H2,1H3,(H,22,29)
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n/an/an/an/a 183n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532042
PNG
(CHEMBL4518000)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(c2)C(F)(F)F)n(n1)C1CCCCC1
Show InChI InChI=1S/C20H22F3N7O/c1-13-10-17(30(26-13)16-8-3-2-4-9-16)24-18(31)12-29-27-19(25-28-29)14-6-5-7-15(11-14)20(21,22)23/h5-7,10-11,16H,2-4,8-9,12H2,1H3,(H,24,31)
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n/an/an/an/a 183n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593394
PNG
(CHEMBL5209446)
Show SMILES CCc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCS(=O)(=O)C1
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Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532040
PNG
(CHEMBL4522066)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2F)n(n1)C1CCCCC1
Show InChI InChI=1S/C19H22FN7O/c1-13-11-17(27(23-13)14-7-3-2-4-8-14)21-18(28)12-26-24-19(22-25-26)15-9-5-6-10-16(15)20/h5-6,9-11,14H,2-4,7-8,12H2,1H3,(H,21,28)
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n/an/an/an/a 187n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437981
PNG
(CHEMBL2409108)
Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H13F3N4O/c1-10-8-16(24(23-10)13-5-2-11(18)3-6-13)22-17(25)21-12-4-7-14(19)15(20)9-12/h2-9H,1H3,(H2,21,22,25)
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n/an/an/an/a 190n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437970
PNG
(CHEMBL2409132)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)cc1Cl
Show InChI InChI=1S/C20H18ClFN4O/c21-16-10-15(8-9-17(16)22)23-20(27)24-19-11-18(14-6-7-14)25-26(19)12-13-4-2-1-3-5-13/h1-5,8-11,14H,6-7,12H2,(H2,23,24,27)
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n/an/an/an/a 210n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532049
PNG
(CHEMBL4567000)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCC(C)(C)CC1
Show InChI InChI=1S/C21H27N7O/c1-15-13-18(28(24-15)17-9-11-21(2,3)12-10-17)22-19(29)14-27-25-20(23-26-27)16-7-5-4-6-8-16/h4-8,13,17H,9-12,14H2,1-3H3,(H,22,29)
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n/an/an/an/a>221n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50593376
PNG
(CHEMBL5180586)
Show SMILES Cc1cc(NC(=O)COc2cccc(Cl)c2Cl)n(n1)C1CCS(=O)(=O)C1
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TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532017
PNG
(CHEMBL4529580)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(cc2)C(F)(F)F)n(n1)C1CCCCC1
Show InChI InChI=1S/C20H22F3N7O/c1-13-11-17(30(26-13)16-5-3-2-4-6-16)24-18(31)12-29-27-19(25-28-29)14-7-9-15(10-8-14)20(21,22)23/h7-11,16H,2-6,12H2,1H3,(H,24,31)
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n/an/an/an/a 241n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497384
PNG
(CHEMBL3339128)
Show SMILES CC1CC1c1cc(NC(=O)Nc2cccc(F)c2)n(Cc2ccccc2)n1
Show InChI InChI=1S/C21H21FN4O/c1-14-10-18(14)19-12-20(26(25-19)13-15-6-3-2-4-7-15)24-21(27)23-17-9-5-8-16(22)11-17/h2-9,11-12,14,18H,10,13H2,1H3,(H2,23,24,27)
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n/an/an/an/a 270n/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497390
PNG
(CHEMBL3339144)
Show SMILES CC1CC1c1cc(NC(=O)Nc2ccc(C)cc2)n(CC(F)(F)F)n1
Show InChI InChI=1S/C17H19F3N4O/c1-10-3-5-12(6-4-10)21-16(25)22-15-8-14(13-7-11(13)2)23-24(15)9-17(18,19)20/h3-6,8,11,13H,7,9H2,1-2H3,(H2,21,22,25)
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n/an/an/an/a 270n/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532028
PNG
(CHEMBL4586820)
Show SMILES O=C(Cn1nnc(n1)-c1ccccc1)Nc1cc(nn1C1CCCCC1)C1CC1
Show InChI InChI=1S/C21H25N7O/c29-20(14-27-25-21(23-26-27)16-7-3-1-4-8-16)22-19-13-18(15-11-12-15)24-28(19)17-9-5-2-6-10-17/h1,3-4,7-8,13,15,17H,2,5-6,9-12,14H2,(H,22,29)
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n/an/an/an/a 271n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532026
PNG
(CHEMBL4533916)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(Cl)c2)n(n1)C1CCCCC1
Show InChI InChI=1S/C19H22ClN7O/c1-13-10-17(27(23-13)16-8-3-2-4-9-16)21-18(28)12-26-24-19(22-25-26)14-6-5-7-15(20)11-14/h5-7,10-11,16H,2-4,8-9,12H2,1H3,(H,21,28)
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n/an/an/an/a 300n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497367
PNG
(CHEMBL3339146)
Show SMILES CC1CC1c1cc(NC(=O)Nc2ccc(cc2)C(F)(F)F)n(CC(F)(F)F)n1
Show InChI InChI=1S/C17H16F6N4O/c1-9-6-12(9)13-7-14(27(26-13)8-16(18,19)20)25-15(28)24-11-4-2-10(3-5-11)17(21,22)23/h2-5,7,9,12H,6,8H2,1H3,(H2,24,25,28)
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n/an/an/an/a 310n/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50497391
PNG
(CHEMBL3339147)
Show SMILES CC1CC1c1cc(NC(=O)Nc2cccc(F)c2)n(CC(F)(F)F)n1
Show InChI InChI=1S/C16H16F4N4O/c1-9-5-12(9)13-7-14(24(23-13)8-16(18,19)20)22-15(25)21-11-4-2-3-10(17)6-11/h2-4,6-7,9,12H,5,8H2,1H3,(H2,21,22,25)
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n/an/an/an/a 310n/an/an/an/a



Northwest A&F University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin) by thallium-flux based assay


Bioorg Med Chem Lett 24: 5102-6 (2014)


Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437975
PNG
(CHEMBL2409127)
Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)c1
Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)16-7-4-8-17(11-16)25-20(29)26-19-12-18(15-9-10-15)27-28(19)13-14-5-2-1-3-6-14/h1-8,11-12,15H,9-10,13H2,(H2,25,26,29)
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n/an/an/an/a 340n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437971
PNG
(CHEMBL2409131)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)cc1
Show InChI InChI=1S/C20H19FN4O/c21-16-8-10-17(11-9-16)22-20(26)23-19-12-18(15-6-7-15)24-25(19)13-14-4-2-1-3-5-14/h1-5,8-12,15H,6-7,13H2,(H2,22,23,26)
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n/an/an/an/a 350n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532043
PNG
(CHEMBL4476625)
Show SMILES Cc1cc(NC(=O)Cc2cccc(c2)-c2ccccc2)n(n1)C1CCCCC1
Show InChI InChI=1S/C24H27N3O/c1-18-15-23(27(26-18)22-13-6-3-7-14-22)25-24(28)17-19-9-8-12-21(16-19)20-10-4-2-5-11-20/h2,4-5,8-12,15-16,22H,3,6-7,13-14,17H2,1H3,(H,25,28)
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n/an/an/an/a 370n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532020
PNG
(CHEMBL4451814)
Show SMILES Cc1cc(NC(=O)Cn2nncc2-c2ccccc2)n(n1)C1CCCCC1
Show InChI InChI=1S/C20H24N6O/c1-15-12-19(26(23-15)17-10-6-3-7-11-17)22-20(27)14-25-18(13-21-24-25)16-8-4-2-5-9-16/h2,4-5,8-9,12-13,17H,3,6-7,10-11,14H2,1H3,(H,22,27)
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n/an/an/an/a 375n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437973
PNG
(CHEMBL2409129)
Show SMILES Brc1cccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)c1
Show InChI InChI=1S/C20H19BrN4O/c21-16-7-4-8-17(11-16)22-20(26)23-19-12-18(15-9-10-15)24-25(19)13-14-5-2-1-3-6-14/h1-8,11-12,15H,9-10,13H2,(H2,22,23,26)
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n/an/an/an/a 380n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50437977
PNG
(CHEMBL2409113)
Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2-c2ccccc2)C2CC2)cc1F
Show InChI InChI=1S/C19H16F2N4O/c20-15-9-8-13(10-16(15)21)22-19(26)23-18-11-17(12-6-7-12)24-25(18)14-4-2-1-3-5-14/h1-5,8-12H,6-7H2,(H2,22,23,26)
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n/an/an/an/a 410n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/2 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN
More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 1


(Homo sapiens (Human))
BDBM50532035
PNG
(CHEMBL4451422)
Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCOCC1
Show InChI InChI=1S/C18H21N7O2/c1-13-11-16(25(21-13)15-7-9-27-10-8-15)19-17(26)12-24-22-18(20-23-24)14-5-3-2-4-6-14/h2-6,11,15H,7-10,12H2,1H3,(H,19,26)
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n/an/an/an/a 435n/an/an/an/a



University of Nebraska Medical Center

Curated by ChEMBL


Assay Description
Activation of human GIRK1/2 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay


Bioorg Med Chem Lett 29: 791-796 (2019)


Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47
More data for this
Ligand-Target Pair
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