Found 154 hits of ec50 data for polymerid = 50006415 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437979
(CHEMBL2409110)Show InChI InChI=1S/C18H16F2N4O/c1-12-9-17(24(23-12)11-13-5-3-2-4-6-13)22-18(25)21-14-7-8-15(19)16(20)10-14/h2-10H,11H2,1H3,(H2,21,22,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 110 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593405
(CHEMBL5178783)Show SMILES Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCC(F)(F)CC1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 145 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593381
(CHEMBL5192713)Show SMILES Cc1cc(NC(=O)COc2ccc(Br)cc2Br)n(n1)C1CCS(=O)(=O)C1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 229 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50439410
(CHEMBL2420532)Show InChI InChI=1S/C15H10Cl2F3NO/c16-12-4-2-1-3-9(12)7-14(22)21-10-5-6-13(17)11(8-10)15(18,19)20/h1-6,8H,7H2,(H,21,22) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 240 | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay |
Bioorg Med Chem Lett 23: 5195-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.07.002
BindingDB Entry DOI: 10.7270/Q28K7BG1 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532008
(CHEMBL4453946)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H23N7O/c1-14-12-17(26(22-14)16-10-6-3-7-11-16)20-18(27)13-25-23-19(21-24-25)15-8-4-2-5-9-15/h2,4-5,8-9,12,16H,3,6-7,10-11,13H2,1H3,(H,20,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 259 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532012
(CHEMBL4461542)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(F)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H22FN7O/c1-13-10-17(27(23-13)16-8-3-2-4-9-16)21-18(28)12-26-24-19(22-25-26)14-6-5-7-15(20)11-14/h5-7,10-11,16H,2-4,8-9,12H2,1H3,(H,21,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 264 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532037
(CHEMBL4457178)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(CC2CCCCC2)n1 Show InChI InChI=1S/C20H25N7O/c1-15-12-18(26(23-15)13-16-8-4-2-5-9-16)21-19(28)14-27-24-20(22-25-27)17-10-6-3-7-11-17/h3,6-7,10-12,16H,2,4-5,8-9,13-14H2,1H3,(H,21,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 283 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532041
(CHEMBL4447978)Show SMILES COc1cccc(c1)-c1nnn(CC(=O)Nc2cc(C)nn2C2CCCCC2)n1 Show InChI InChI=1S/C20H25N7O2/c1-14-11-18(27(23-14)16-8-4-3-5-9-16)21-19(28)13-26-24-20(22-25-26)15-7-6-10-17(12-15)29-2/h6-7,10-12,16H,3-5,8-9,13H2,1-2H3,(H,21,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 299 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437970
(CHEMBL2409132)Show SMILES Fc1ccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)cc1Cl Show InChI InChI=1S/C20H18ClFN4O/c21-16-10-15(8-9-17(16)22)23-20(27)24-19-11-18(14-6-7-14)25-26(19)12-13-4-2-1-3-5-13/h1-5,8-11,14H,6-7,12H2,(H2,23,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593378
(CHEMBL5202704)Show SMILES Cc1cc(NC(=O)COc2ccc(Br)cc2Cl)n(n1)C1CCS(=O)(=O)C1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 335 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532046
(CHEMBL4453299)Show SMILES Cc1cc(NC(=O)Cn2cc(cn2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C21H25N5O/c1-16-12-20(26(24-16)19-10-6-3-7-11-19)23-21(27)15-25-14-18(13-22-25)17-8-4-2-5-9-17/h2,4-5,8-9,12-14,19H,3,6-7,10-11,15H2,1H3,(H,23,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 348 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593394
(CHEMBL5209446)Show SMILES CCc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCS(=O)(=O)C1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 360 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593406
(CHEMBL5206362) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 371 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532034
(CHEMBL4435859)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCC(F)(F)CC1 Show InChI InChI=1S/C19H21F2N7O/c1-13-11-16(28(24-13)15-7-9-19(20,21)10-8-15)22-17(29)12-27-25-18(23-26-27)14-5-3-2-4-6-14/h2-6,11,15H,7-10,12H2,1H3,(H,22,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 383 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532013
(CHEMBL4549232)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(F)c(F)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H21F2N7O/c1-12-9-17(28(24-12)14-5-3-2-4-6-14)22-18(29)11-27-25-19(23-26-27)13-7-8-15(20)16(21)10-13/h7-10,14H,2-6,11H2,1H3,(H,22,29) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 392 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532045
(CHEMBL4529550)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(C)cc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H25N7O/c1-14-8-10-16(11-9-14)20-22-25-26(24-20)13-19(28)21-18-12-15(2)23-27(18)17-6-4-3-5-7-17/h8-12,17H,3-7,13H2,1-2H3,(H,21,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 408 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532019
(CHEMBL4458146)Show SMILES Cc1cc(NC(=O)Cn2cc(nn2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H24N6O/c1-15-12-19(26(23-15)17-10-6-3-7-11-17)21-20(27)14-25-13-18(22-24-25)16-8-4-2-5-9-16/h2,4-5,8-9,12-13,17H,3,6-7,10-11,14H2,1H3,(H,21,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 412 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593403
(CHEMBL5199523) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 430 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532002
(CHEMBL4530409)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(C)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H25N7O/c1-14-7-6-8-16(11-14)20-22-25-26(24-20)13-19(28)21-18-12-15(2)23-27(18)17-9-4-3-5-10-17/h6-8,11-12,17H,3-5,9-10,13H2,1-2H3,(H,21,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 435 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532040
(CHEMBL4522066)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2F)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H22FN7O/c1-13-11-17(27(23-13)14-7-3-2-4-8-14)21-18(28)12-26-24-19(22-25-26)15-9-5-6-10-16(15)20/h5-6,9-11,14H,2-4,7-8,12H2,1H3,(H,21,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 447 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532017
(CHEMBL4529580)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(cc2)C(F)(F)F)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H22F3N7O/c1-13-11-17(30(26-13)16-5-3-2-4-6-16)24-18(31)12-29-27-19(25-28-29)14-7-9-15(10-8-14)20(21,22)23/h7-11,16H,2-6,12H2,1H3,(H,24,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 448 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437981
(CHEMBL2409108)Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C17H13F3N4O/c1-10-8-16(24(23-10)13-5-2-11(18)3-6-13)22-17(25)21-12-4-7-14(19)15(20)9-12/h2-9H,1H3,(H2,21,22,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 540 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593377
(CHEMBL5186323)Show SMILES Cc1cc(NC(=O)COc2cc(Cl)ccc2Cl)n(n1)C1CCS(=O)(=O)C1 | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 563 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437971
(CHEMBL2409131)Show InChI InChI=1S/C20H19FN4O/c21-16-8-10-17(11-9-16)22-20(26)23-19-12-18(15-6-7-15)24-25(19)13-14-4-2-1-3-5-14/h1-5,8-12,15H,6-7,13H2,(H2,22,23,26) | Reactome pathway
KEGG
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| CHEMBL
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PC sid
UniChem
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| n/a | n/a | n/a | n/a | 570 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593376
(CHEMBL5180586)Show SMILES Cc1cc(NC(=O)COc2cccc(Cl)c2Cl)n(n1)C1CCS(=O)(=O)C1 | Reactome pathway
KEGG
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TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593401
(CHEMBL5192503) | Reactome pathway
KEGG
UniProtKB/SwissProt
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UniChem
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TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532007
(CHEMBL4473433)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(n1)C1CCCC1 Show InChI InChI=1S/C18H21N7O/c1-13-11-16(25(21-13)15-9-5-6-10-15)19-17(26)12-24-22-18(20-23-24)14-7-3-2-4-8-14/h2-4,7-8,11,15H,5-6,9-10,12H2,1H3,(H,19,26) | Reactome pathway
KEGG
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UniChem
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| n/a | n/a | n/a | n/a | 612 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532048
(CHEMBL4536665)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(c2)C#N)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H22N8O/c1-14-10-18(28(24-14)17-8-3-2-4-9-17)22-19(29)13-27-25-20(23-26-27)16-7-5-6-15(11-16)12-21/h5-7,10-11,17H,2-4,8-9,13H2,1H3,(H,22,29) | Reactome pathway
KEGG
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 619 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532025
(CHEMBL4450006)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccc(F)cc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H22FN7O/c1-13-11-17(27(23-13)16-5-3-2-4-6-16)21-18(28)12-26-24-19(22-25-26)14-7-9-15(20)10-8-14/h7-11,16H,2-6,12H2,1H3,(H,21,28) | Reactome pathway
KEGG
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UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 634 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437975
(CHEMBL2409127)Show SMILES FC(F)(F)c1cccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2)c1 Show InChI InChI=1S/C21H19F3N4O/c22-21(23,24)16-7-4-8-17(11-16)25-20(29)26-19-12-18(15-9-10-15)27-28(19)13-14-5-2-1-3-6-14/h1-8,11-12,15H,9-10,13H2,(H2,25,26,29) | Reactome pathway
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Similars
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PubMed
| n/a | n/a | n/a | n/a | 650 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532028
(CHEMBL4586820)Show SMILES O=C(Cn1nnc(n1)-c1ccccc1)Nc1cc(nn1C1CCCCC1)C1CC1 Show InChI InChI=1S/C21H25N7O/c29-20(14-27-25-21(23-26-27)16-7-3-1-4-8-16)22-19-13-18(15-11-12-15)24-28(19)17-9-5-2-6-10-17/h1,3-4,7-8,13,15,17H,2,5-6,9-12,14H2,(H,22,29) | Reactome pathway
KEGG
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| PC cid
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UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 659 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532026
(CHEMBL4533916)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(Cl)c2)n(n1)C1CCCCC1 Show InChI InChI=1S/C19H22ClN7O/c1-13-10-17(27(23-13)16-8-3-2-4-9-16)21-18(28)12-26-24-19(22-25-26)14-6-5-7-15(20)11-14/h5-7,10-11,16H,2-4,8-9,12H2,1H3,(H,21,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 662 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50115223
(1-(5-Methyl-2-phenyl-2H-pyrazol-3-yl)-3-phenyl-ure...)Show InChI InChI=1S/C17H16N4O/c1-13-12-16(21(20-13)15-10-6-3-7-11-15)19-17(22)18-14-8-4-2-5-9-14/h2-12H,1H3,(H2,18,19,22) | Reactome pathway
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| n/a | n/a | n/a | n/a | 690 | n/a | n/a | n/a | n/a |
Vanderbilt University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay |
Bioorg Med Chem Lett 23: 5195-8 (2013)
Article DOI: 10.1016/j.bmcl.2013.07.002
BindingDB Entry DOI: 10.7270/Q28K7BG1 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50115223
(1-(5-Methyl-2-phenyl-2H-pyrazol-3-yl)-3-phenyl-ure...)Show InChI InChI=1S/C17H16N4O/c1-13-12-16(21(20-13)15-10-6-3-7-11-15)19-17(22)18-14-8-4-2-5-9-14/h2-12H,1H3,(H2,18,19,22) | Reactome pathway
KEGG
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CHEMBL
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PubMed
| n/a | n/a | n/a | n/a | 690 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593373
(CHEMBL5182581)Show SMILES Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCS(=O)(=O)C1 | Reactome pathway
KEGG
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UniChem
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| n/a | n/a | n/a | n/a | 702 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593371
(CHEMBL5189637) | Reactome pathway
KEGG
UniProtKB/SwissProt
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TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437976
(CHEMBL2409120)Show InChI InChI=1S/C19H17ClN4O/c20-14-5-4-6-15(11-14)21-19(25)22-18-12-17(13-9-10-13)23-24(18)16-7-2-1-3-8-16/h1-8,11-13H,9-10H2,(H2,21,22,25) | Reactome pathway
KEGG
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PC sid
UniChem
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PubMed
| n/a | n/a | n/a | n/a | 720 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50593387
(CHEMBL5187664)Show SMILES Cc1cc(NC(=O)COc2ccc(cc2C(F)(F)F)C(F)(F)F)n(n1)C1CCS(=O)(=O)C1 | Reactome pathway
KEGG
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TBA
| |
Citation and Details
Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532005
(CHEMBL4543208)Show SMILES COc1ccc(cc1)-c1nnn(CC(=O)Nc2cc(C)nn2C2CCCCC2)n1 Show InChI InChI=1S/C20H25N7O2/c1-14-12-18(27(23-14)16-6-4-3-5-7-16)21-19(28)13-26-24-20(22-25-26)15-8-10-17(29-2)11-9-15/h8-12,16H,3-7,13H2,1-2H3,(H,21,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 779 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437974
(CHEMBL2409128)Show InChI InChI=1S/C20H19FN4O/c21-16-7-4-8-17(11-16)22-20(26)23-19-12-18(15-9-10-15)24-25(19)13-14-5-2-1-3-6-14/h1-8,11-12,15H,9-10,13H2,(H2,22,23,26) | Reactome pathway
KEGG
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 780 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437973
(CHEMBL2409129)Show InChI InChI=1S/C20H19BrN4O/c21-16-7-4-8-17(11-16)22-20(26)23-19-12-18(15-9-10-15)24-25(19)13-14-5-2-1-3-6-14/h1-8,11-12,15H,9-10,13H2,(H2,22,23,26) | Reactome pathway
KEGG
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 790 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532027
(CHEMBL4529103)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2ccccc2)n(Cc2ccccc2)n1 Show InChI InChI=1S/C20H19N7O/c1-15-12-18(26(23-15)13-16-8-4-2-5-9-16)21-19(28)14-27-24-20(22-25-27)17-10-6-3-7-11-17/h2-12H,13-14H2,1H3,(H,21,28) | Reactome pathway
KEGG
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PC cid
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UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 848 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532042
(CHEMBL4518000)Show SMILES Cc1cc(NC(=O)Cn2nnc(n2)-c2cccc(c2)C(F)(F)F)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H22F3N7O/c1-13-10-17(30(26-13)16-8-3-2-4-9-16)24-18(31)12-29-27-19(25-28-29)14-6-5-7-15(11-14)20(21,22)23/h5-7,10-11,16H,2-4,8-9,12H2,1H3,(H,24,31) | Reactome pathway
KEGG
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 850 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50497393
(CHEMBL3339120)Show SMILES CC1CC1c1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1 Show InChI InChI=1S/C20H18F2N4O/c1-12-9-15(12)18-11-19(26(25-18)14-5-3-2-4-6-14)24-20(27)23-13-7-8-16(21)17(22)10-13/h2-8,10-12,15H,9H2,1H3,(H2,23,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 890 | n/a | n/a | n/a | n/a |
Northwest A&F University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) by thallium-flux based assay |
Bioorg Med Chem Lett 24: 5102-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50497384
(CHEMBL3339128)Show SMILES CC1CC1c1cc(NC(=O)Nc2cccc(F)c2)n(Cc2ccccc2)n1 Show InChI InChI=1S/C21H21FN4O/c1-14-10-18(14)19-12-20(26(25-19)13-15-6-3-2-4-7-15)24-21(27)23-17-9-5-8-16(22)11-17/h2-9,11-12,14,18H,10,13H2,1H3,(H2,23,24,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 910 | n/a | n/a | n/a | n/a |
Northwest A&F University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) by thallium-flux based assay |
Bioorg Med Chem Lett 24: 5102-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50497388
(CHEMBL3339137)Show SMILES Fc1cccc(NC(=O)Nc2cc(nn2Cc2ccccc2)C2CC2(F)F)c1 Show InChI InChI=1S/C20H17F3N4O/c21-14-7-4-8-15(9-14)24-19(28)25-18-10-17(16-11-20(16,22)23)26-27(18)12-13-5-2-1-3-6-13/h1-10,16H,11-12H2,(H2,24,25,28) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 920 | n/a | n/a | n/a | n/a |
Northwest A&F University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) by thallium-flux based assay |
Bioorg Med Chem Lett 24: 5102-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50437972
(CHEMBL2409130)Show InChI InChI=1S/C21H22N4O/c1-15-7-11-18(12-8-15)22-21(26)23-20-13-19(17-9-10-17)24-25(20)14-16-5-3-2-4-6-16/h2-8,11-13,17H,9-10,14H2,1H3,(H2,22,23,26) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 920 | n/a | n/a | n/a | n/a |
Northwest Agriculture& Forestry University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) |
Bioorg Med Chem Lett 23: 4562-6 (2013)
Article DOI: 10.1016/j.bmcl.2013.06.023
BindingDB Entry DOI: 10.7270/Q2R212SN |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532021
(CHEMBL4540010)Show SMILES Cc1cc(NC(=O)Cn2ccc(n2)-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C21H25N5O/c1-16-14-20(26(23-16)18-10-6-3-7-11-18)22-21(27)15-25-13-12-19(24-25)17-8-4-2-5-9-17/h2,4-5,8-9,12-14,18H,3,6-7,10-11,15H2,1H3,(H,22,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 998 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50497391
(CHEMBL3339147)Show SMILES CC1CC1c1cc(NC(=O)Nc2cccc(F)c2)n(CC(F)(F)F)n1 Show InChI InChI=1S/C16H16F4N4O/c1-9-5-12(9)13-7-14(24(23-13)8-16(18,19)20)22-15(25)21-11-4-2-3-10(17)6-11/h2-4,6-7,9,12H,5,8H2,1H3,(H2,21,22,25) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a |
Northwest A&F University
Curated by ChEMBL
| Assay Description
Activation of GIRK1/4 (unknown origin) by thallium-flux based assay |
Bioorg Med Chem Lett 24: 5102-6 (2014)
Article DOI: 10.1016/j.bmcl.2014.08.061
BindingDB Entry DOI: 10.7270/Q2WD43JR |
More data for this
Ligand-Target Pair | |
G protein-activated inward rectifier potassium channel 4
(Homo sapiens (Human)) | BDBM50532020
(CHEMBL4451814)Show SMILES Cc1cc(NC(=O)Cn2nncc2-c2ccccc2)n(n1)C1CCCCC1 Show InChI InChI=1S/C20H24N6O/c1-15-12-19(26(23-15)17-10-6-3-7-11-17)22-20(27)14-25-18(13-21-24-25)16-8-4-2-5-9-16/h2,4-5,8-9,12-13,17H,3,6-7,10-11,14H2,1H3,(H,22,27) | Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 1.03E+3 | n/a | n/a | n/a | n/a |
University of Nebraska Medical Center
Curated by ChEMBL
| Assay Description
Activation of human GIRK1/4 expressed in HEK293 cells co-expressing rat mGlu8 by thallium flux assay |
Bioorg Med Chem Lett 29: 791-796 (2019)
Article DOI: 10.1016/j.bmcl.2019.01.027
BindingDB Entry DOI: 10.7270/Q2BV7M47 |
More data for this
Ligand-Target Pair | |
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