Found 10 hits of ic50 data for polymerid = 50006428 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50440527
(CHEMBL2426164)Show InChI InChI=1S/C15H9BrN6OS/c16-12-2-1-11(7-10(12)8-17)19-14(23)20-15-22-21-13(24-15)9-3-5-18-6-4-9/h1-7H,(H2,19,20,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay |
Bioorg Med Chem Lett 23: 5660-6 (2013)
Checked by Author Article DOI: 10.1016/j.bmcl.2013.08.025 BindingDB Entry DOI: 10.7270/Q2KK9D78 |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50440514
(CHEMBL2426190)Show InChI InChI=1S/C15H9ClN6OS/c16-12-2-1-11(7-10(12)8-17)19-14(23)20-15-22-21-13(24-15)9-3-5-18-6-4-9/h1-7H,(H2,19,20,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay |
Bioorg Med Chem Lett 23: 5660-6 (2013)
Checked by Author Article DOI: 10.1016/j.bmcl.2013.08.025 BindingDB Entry DOI: 10.7270/Q2KK9D78 |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50440533
(CHEMBL2426169)Show InChI InChI=1S/C15H9FN6OS/c16-12-2-1-11(7-10(12)8-17)19-14(23)20-15-22-21-13(24-15)9-3-5-18-6-4-9/h1-7H,(H2,19,20,22,23) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay |
Bioorg Med Chem Lett 23: 5660-6 (2013)
Checked by Author Article DOI: 10.1016/j.bmcl.2013.08.025 BindingDB Entry DOI: 10.7270/Q2KK9D78 |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50440531
(CHEMBL2426168)Show SMILES Fc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C(F)(F)F Show InChI InChI=1S/C15H9F4N5OS/c16-11-2-1-9(7-10(11)15(17,18)19)21-13(25)22-14-24-23-12(26-14)8-3-5-20-6-4-8/h1-7H,(H2,21,22,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay |
Bioorg Med Chem Lett 23: 5660-6 (2013)
Checked by Author Article DOI: 10.1016/j.bmcl.2013.08.025 BindingDB Entry DOI: 10.7270/Q2KK9D78 |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50440524
(CHEMBL2426161)Show InChI InChI=1S/C14H9Br2N5OS/c15-10-2-1-9(7-11(10)16)18-13(22)19-14-21-20-12(23-14)8-3-5-17-6-4-8/h1-7H,(H2,18,19,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay |
Bioorg Med Chem Lett 23: 5660-6 (2013)
Checked by Author Article DOI: 10.1016/j.bmcl.2013.08.025 BindingDB Entry DOI: 10.7270/Q2KK9D78 |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50044626
(CHEMBL1374426)Show InChI InChI=1S/C8H9NO4/c1-2-8(12)13-5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of recombinant WRN (unknown origin) helicase activity expressed in baculovirus expression system using forked duplex DNA as substrate afte... |
J Med Chem 60: 2169-2192 (2017)
Article DOI: 10.1021/acs.jmedchem.6b00966 BindingDB Entry DOI: 10.7270/Q2CR5WMB |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM48721
(1-(3,4-Dichloro-phenyl)-3-(5-pyridin-4-yl-[1,3,4]t...)Show InChI InChI=1S/C14H9Cl2N5OS/c15-10-2-1-9(7-11(10)16)18-13(22)19-14-21-20-12(23-14)8-3-5-17-6-4-8/h1-7H,(H2,18,19,21,22) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay |
Bioorg Med Chem Lett 23: 5660-6 (2013)
Checked by Author Article DOI: 10.1016/j.bmcl.2013.08.025 BindingDB Entry DOI: 10.7270/Q2KK9D78 |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50440531
(CHEMBL2426168)Show SMILES Fc1ccc(NC(=O)Nc2nnc(s2)-c2ccncc2)cc1C(F)(F)F Show InChI InChI=1S/C15H9F4N5OS/c16-11-2-1-9(7-10(11)15(17,18)19)21-13(25)22-14-24-23-12(26-14)8-3-5-20-6-4-8/h1-7H,(H2,21,22,24,25) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine
Curated by ChEMBL
| Assay Description Inhibition of WRN helicase (unknown origin) |
Bioorg Med Chem Lett 24: 3006-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7 |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50440538
(CHEMBL2426174)Show SMILES O=C(Nc1nnc(s1)-c1ccncc1)Nc1ccc(-c2cn[nH]c2)c(c1)C#N Show InChI InChI=1S/C18H12N8OS/c19-8-12-7-14(1-2-15(12)13-9-21-22-10-13)23-17(27)24-18-26-25-16(28-18)11-3-5-20-6-4-11/h1-7,9-10H,(H,21,22)(H2,23,24,26,27) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
National Center for Advancing Translational Sciences
Curated by ChEMBL
| Assay Description Inhibition of WRN (unknown origin) by gel-based DNA unwinding assay |
Bioorg Med Chem Lett 23: 5660-6 (2013)
Checked by Author Article DOI: 10.1016/j.bmcl.2013.08.025 BindingDB Entry DOI: 10.7270/Q2KK9D78 |
More data for this Ligand-Target Pair | |
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN
(Homo sapiens (Human)) | BDBM50044626
(CHEMBL1374426)Show InChI InChI=1S/C8H9NO4/c1-2-8(12)13-5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Drexel University College of Medicine
Curated by ChEMBL
| Assay Description Inhibition of WRN helicase (unknown origin) |
Bioorg Med Chem Lett 24: 3006-13 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.088 BindingDB Entry DOI: 10.7270/Q2NV9KW7 |
More data for this Ligand-Target Pair | |