Found 23 hits of ic50 for UniProtKB: Q92830 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50028142
(CHEMBL2177300)Show SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/m0/s1 | PDB
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| n/a | n/a | <316 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline R&D
Curated by ChEMBL
| Assay Description
Inhibition of human GCN5 by BROMOscan assay |
J Med Chem 57: 8111-31 (2014)
Article DOI: 10.1021/jm5010539
BindingDB Entry DOI: 10.7270/Q23R0VGR |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50256397
(CHEMBL4088466)Show SMILES Cn1cc(-c2cc(ccc2Oc2ccc(F)cc2F)S(C)(=O)=O)c2cc[nH]c(=O)c12 Show InChI InChI=1S/C21H16F2N2O4S/c1-25-11-16(14-7-8-24-21(26)20(14)25)15-10-13(30(2,27)28)4-6-18(15)29-19-5-3-12(22)9-17(19)23/h3-11H,1-2H3,(H,24,26) | PDB
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| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL 60064, USA.
Curated by ChEMBL
| Assay Description
Inhibition of human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay |
Bioorg Med Chem Lett 27: 2225-2233 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.057
BindingDB Entry DOI: 10.7270/Q20P12FJ |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM342597
(N-[3-(3-methyl-4-oxo-4,5,6,7-tetrahydro-2H-isoindo...)Show SMILES Cc1[nH]c(c2CCCC(=O)c12)-c1cc(NS(C)(=O)=O)ccc1Oc1ccccc1 Show InChI InChI=1S/C22H22N2O4S/c1-14-21-17(9-6-10-19(21)25)22(23-14)18-13-15(24-29(2,26)27)11-12-20(18)28-16-7-4-3-5-8-16/h3-5,7-8,11-13,23-24H,6,9-10H2,1-2H3 | PDB
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AbbVie Inc., Oncology Discovery, 1 North Waukegan Rd., North Chicago, IL 60064, USA.
Curated by ChEMBL
| Assay Description
Inhibition of human GCN5L2 (E726 to K837 residues) expressed in bacterial expression system by BROMOscan assay |
Bioorg Med Chem Lett 27: 2225-2233 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.057
BindingDB Entry DOI: 10.7270/Q20P12FJ |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50346554
(CHEMBL106011)Show InChI InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H | PDB
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| n/a | n/a | 8.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human C-terminal FLAG-tagged GCN5 HAT domain (362 to 837 residues) expressed in baculovirus infected Sf9 cells using histon... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112861
BindingDB Entry DOI: 10.7270/Q2CC14D7 |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50346554
(CHEMBL106011)Show InChI InChI=1S/C12H7FN2OS/c13-8-3-5-9(6-4-8)15-12(16)10-2-1-7-14-11(10)17-15/h1-7H | PDB
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| n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant C-terminal FLAG-tagged human GCN5 expressed in a Baculovirus-infected Sf9 cell expression system |
Bioorg Med Chem 26: 5397-5407 (2018)
Article DOI: 10.1016/j.bmc.2018.07.048
BindingDB Entry DOI: 10.7270/Q2ZW1PM0 |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50506380
(CHEMBL4587968)Show SMILES Cn1cc(cn1)-c1ccc2c(CC[C@]22NC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C(F)(F)F)C2=O)c1 |r| Show InChI InChI=1S/C27H23F4N5O4/c1-34-11-18(10-32-34)15-2-4-20-16(8-15)6-7-26(20)24(38)36(25(39)33-26)13-23(37)35-12-17-9-19(28)3-5-21(17)40-14-22(35)27(29,30)31/h2-5,8-11,22H,6-7,12-14H2,1H3,(H,33,39)/t22-,26-/m0/s1 | PDB
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Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of GCN5 (unknown origin) |
J Med Chem 63: 1337-1360 (2020)
Article DOI: 10.1021/acs.jmedchem.9b01721
BindingDB Entry DOI: 10.7270/Q25Q50C7 |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50269849
(CHEMBL4076748)Show SMILES CC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C27H32F2N6O2/c1-17(36)33-9-5-24-23(16-33)27(31-35(24)20-6-10-37-11-7-20)34-8-3-4-18-12-21(19-14-30-32(2)15-19)22(26(28)29)13-25(18)34/h12-15,20,26H,3-11,16H2,1-2H3 | PDB
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Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Curated by ChEMBL
| Assay Description
Displacement of biotinylated histone H3K14 peptide ligand from recombinant His-tagged human GCN5L2 measured after 10 mins by TR-FRET assay |
J Med Chem 60: 9162-9183 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00796
BindingDB Entry DOI: 10.7270/Q23F4S4V |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50200385
(CHEMBL3959584)Show InChI InChI=1S/C14H16N4O/c1-10(19)18-8-7-13-12(9-18)14(17-16-13)15-11-5-3-2-4-6-11/h2-6H,7-9H2,1H3,(H2,15,16,17) | PDB
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Genentech
Curated by ChEMBL
| Assay Description
Displacement of biotinylated ligand from recombinant His-tagged GCN5 long isoform (unknown origin) measured after 10 mins by TR-FRET assay |
J Med Chem 59: 10549-10563 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50200384
(CHEMBL3968533 | US9763922, Example 299)Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1F)-c1cnn(C)c1)nn2[C@@H]1CCOC1 |r| Show InChI InChI=1S/C22H25FN6O2/c1-14(30)28-7-5-21-18(12-28)22(26-29(21)17-6-8-31-13-17)25-20-4-3-15(9-19(20)23)16-10-24-27(2)11-16/h3-4,9-11,17H,5-8,12-13H2,1-2H3,(H,25,26)/t17-/m1/s1 | PDB
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Genentech
Curated by ChEMBL
| Assay Description
Displacement of biotinylated ligand from recombinant His-tagged GCN5 long isoform (unknown origin) measured after 10 mins by TR-FRET assay |
J Med Chem 59: 10549-10563 (2016)
Article DOI: 10.1021/acs.jmedchem.6b01022
BindingDB Entry DOI: 10.7270/Q27083DF |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50269847
(CHEMBL4097025)Show SMILES CNC(=O)N1CCc2c(C1)c(nn2C1CCOCC1)N1CCCc2cc(-c3cnn(C)c3)c(cc12)C(F)F Show InChI InChI=1S/C27H33F2N7O2/c1-30-27(37)34-9-5-23-22(16-34)26(32-36(23)19-6-10-38-11-7-19)35-8-3-4-17-12-20(18-14-31-33(2)15-18)21(25(28)29)13-24(17)35/h12-15,19,25H,3-11,16H2,1-2H3,(H,30,37) | PDB
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Genentech, Inc. , 1 DNA Way, South San Francisco, California 94080, United States.
Curated by ChEMBL
| Assay Description
Displacement of biotinylated histone H3K14 peptide ligand from recombinant His-tagged human GCN5L2 measured after 10 mins by TR-FRET assay |
J Med Chem 60: 9162-9183 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00796
BindingDB Entry DOI: 10.7270/Q23F4S4V |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50580965
(CHEMBL5090239)Show SMILES CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N3Cc4cc(F)ccc4OC[C@H]3C3CC3)C2=O)c1 |r| | PDB
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TBA
| Assay Description
Inhibition of GCN5 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmc.2021.116512
BindingDB Entry DOI: 10.7270/Q23B640X |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50151658
(CHEMBL3775671)Show SMILES [#6]-[#8]-c1ccc(cc1)S(=O)(=O)[#8]\[#7]=[#6]-1/[#6]=[#6](-[#6])-[#6](=O)-[#6](-[#6])=[#6]-1 |c:21,t:15| Show InChI InChI=1S/C15H15NO5S/c1-10-8-12(9-11(2)15(10)17)16-21-22(18,19)14-6-4-13(20-3)5-7-14/h4-9H,1-3H3 | PDB
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| n/a | n/a | 3.39E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Freiburg
Curated by ChEMBL
| Assay Description
Inhibition of GCN5 (unknown origin) using N-terminal histone H3 substrate by radiometric filter binding based phenotypic screen in presence of [3H]ac... |
J Med Chem 59: 1249-70 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01502
BindingDB Entry DOI: 10.7270/Q2DV1MRN |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50346552
(CHEMBL1797936)Show SMILES Cc1cc(-c2ccc(C=c3c(=C)[nH]n(-c4ccc(cc4)C(O)=O)c3=O)o2)c(cc1C)[N+]([O-])=O |w:8.7| Show InChI InChI=1S/C24H19N3O6/c1-13-10-20(21(27(31)32)11-14(13)2)22-9-8-18(33-22)12-19-15(3)25-26(23(19)28)17-6-4-16(5-7-17)24(29)30/h4-12,25H,3H2,1-2H3,(H,29,30) | PDB
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| n/a | n/a | 4.74E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128726
BindingDB Entry DOI: 10.7270/Q27W6H8T |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50600305
(CHEMBL5193672)Show SMILES COc1ccc(cc1)C1(CCCC1)C(=O)N1CS(=O)(=O)C[C@@H]1C(=O)Nc1cccc2[nH]ncc12 |r| | PDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.bmcl.2022.128726
BindingDB Entry DOI: 10.7270/Q27W6H8T |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50579798
(CHEMBL5080324)Show SMILES COC1=C(Cc2ccc(s2)-c2cn(C)cc(C(O)=O)c2=O)C(=O)N(C1)c1ccc2ccccc2c1 |c:2| | PDB
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TBA
| Assay Description
Inhibition of GCN5 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128358
BindingDB Entry DOI: 10.7270/Q23R0XQQ |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50579801
(CHEMBL5088992)Show SMILES COC1=C(Cc2ccc(s2)-c2cn(Cc3ccccc3)cc(C(O)=O)c2=O)C(=O)N(C1)c1ccc2ccccc2c1 |c:2| | PDB
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TBA
| Assay Description
Inhibition of GCN5 (unknown origin) |
Citation and Details
Article DOI: 10.1016/j.bmcl.2021.128358
BindingDB Entry DOI: 10.7270/Q23R0XQQ |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50158627
(CHEMBL3787482 | US10023592, Example 81)Show SMILES CCOc1ccc(cc1-c1cn(C)c(=O)c2ccc(cc12)-c1cnn(C)c1)S(=O)(=O)CC Show InChI InChI=1S/C24H25N3O4S/c1-5-31-23-10-8-18(32(29,30)6-2)12-21(23)22-15-26(3)24(28)19-9-7-16(11-20(19)22)17-13-25-27(4)14-17/h7-15H,5-6H2,1-4H3 | PDB
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Celgene Quanticel Research
Curated by ChEMBL
| Assay Description
Inhibition of human GCN5L2 by AlphaScreen assay |
Bioorg Med Chem Lett 28: 1811-1816 (2018)
Article DOI: 10.1016/j.bmcl.2018.04.016
BindingDB Entry DOI: 10.7270/Q20Z75WN |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50346559
(CHEMBL1795624)Show InChI InChI=1S/C14H9F3N2OS/c15-14(16,17)10-5-3-9(4-6-10)8-19-13(20)11-2-1-7-18-12(11)21-19/h1-7H,8H2 | PDB
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| n/a | n/a | 8.74E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description
Inhibition of recombinant human C-terminal FLAG-tagged GCN5 HAT domain (362 to 837 residues) expressed in baculovirus infected Sf9 cells using histon... |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112861
BindingDB Entry DOI: 10.7270/Q2CC14D7 |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50467835
(CHEMBL217676)Show InChI InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GST-tagged Gcn5 using H3 as substrate in presence of [3H]-acetyl-CoA by phosphor image analysis |
Eur J Med Chem 157: 867-876 (2018)
Article DOI: 10.1016/j.ejmech.2018.08.026
BindingDB Entry DOI: 10.7270/Q2CC13DT |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50371233
(CHEMBL3347571)Show InChI InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m0/s1 | PDB
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| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai University
Curated by ChEMBL
| Assay Description
Inhibition of GCN5 (unknown origin) |
Eur J Med Chem 151: 740-751 (2018)
Article DOI: 10.1016/j.ejmech.2018.02.005
BindingDB Entry DOI: 10.7270/Q24J0HPJ |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50238541
(CHEMBL4092336)Show SMILES COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1 Show InChI InChI=1S/C18H17N3O4S/c1-24-11-7-8-14-15(9-11)21-18(20-14)26-10-16(22)19-13-6-4-3-5-12(13)17(23)25-2/h3-9H,10H2,1-2H3,(H,19,22)(H,20,21) | PDB
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| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shandong University
Curated by ChEMBL
| Assay Description
Inhibition of GCN5 (unknown origin) using H3 as substrate and Ac-CoA as cofactor preincubated for 10 mins followed by substrate/cofactor addition mea... |
J Med Chem 60: 6289-6304 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00587
BindingDB Entry DOI: 10.7270/Q2D220XW |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50151657
(CHEMBL3775750)Show InChI InChI=1S/C9H12O4/c1-3-4-6-5(2)9(12)13-7(6)8(10)11/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7-/m1/s1 | PDB
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UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Freiburg
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GST-tagged GCN5 expressed in bacterial system using histone H3 as substrate preincubated for 20 mins followed by subs... |
J Med Chem 59: 1249-70 (2016)
Article DOI: 10.1021/acs.jmedchem.5b01502
BindingDB Entry DOI: 10.7270/Q2DV1MRN |
More data for this
Ligand-Target Pair | |
Histone acetyltransferase KAT2A
(Homo sapiens (Human)) | BDBM50467835
(CHEMBL217676)Show InChI InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human GCN5 using histone peptide as substrate in presence of [14C]-acetyl CoA by microbeta counting method |
Bioorg Med Chem 26: 5397-5407 (2018)
Article DOI: 10.1016/j.bmc.2018.07.048
BindingDB Entry DOI: 10.7270/Q2ZW1PM0 |
More data for this
Ligand-Target Pair | |
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