Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Voltage-gated sodium channel Nav1.5 cardiac isoform (Canis lupus familiaris) | BDBM50173335 (CHEBI:87690 | CVT-303 | RS-43285-003 | Ranexa | Ra...) | UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc. Curated by ChEMBL | Assay Description Inhibition of canine ventricular myocytes Nav 1.5 assessed as reduction in ATX-2 induced late channel current by manual single-patch clamp assay | Bioorg Med Chem Lett 26: 3202-6 (2016) Article DOI: 10.1016/j.bmcl.2016.03.101 BindingDB Entry DOI: 10.7270/Q21R6SDP | |||||||||||
More data for this Ligand-Target Pair |