Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50532381 (CHEMBL4538666) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Eastern Finland Curated by ChEMBL | Assay Description Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation counting | J Med Chem 59: 5740-51 (2016) Article DOI: 10.1021/acs.jmedchem.6b00190 BindingDB Entry DOI: 10.7270/Q27084W4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50532381 (CHEMBL4538666) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Eastern Finland Curated by ChEMBL | Assay Description Inhibition of [14C]-L-leucine uptake at LAT1 in human HT-29 cells after 1 hr by liquid scintillation counting | J Med Chem 59: 5740-51 (2016) Article DOI: 10.1021/acs.jmedchem.6b00190 BindingDB Entry DOI: 10.7270/Q27084W4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50532381 (CHEMBL4538666) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Eastern Finland Curated by ChEMBL | Assay Description Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation counting | J Med Chem 59: 5740-51 (2016) Article DOI: 10.1021/acs.jmedchem.6b00190 BindingDB Entry DOI: 10.7270/Q27084W4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50532381 (CHEMBL4538666) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 790 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Eastern Finland Curated by ChEMBL | Assay Description Inhibition of [14C]-L-leucine uptake at LAT1 in human YD-38 cells after 1 hr by liquid scintillation counting | J Med Chem 59: 5740-51 (2016) Article DOI: 10.1021/acs.jmedchem.6b00190 BindingDB Entry DOI: 10.7270/Q27084W4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50528545 (CHEMBL4526588) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
Maharaja Ranjit Singh Punjab Technical University Curated by ChEMBL | Assay Description Inhibition of recombinant human LAT1 | Eur J Med Chem 180: 486-508 (2019) Article DOI: 10.1016/j.ejmech.2019.07.043 BindingDB Entry DOI: 10.7270/Q2959N1V | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50540285 (CHEMBL4642431) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Central Florida Curated by ChEMBL | Assay Description Induction of LAT1-mediated polyamine efflux in human L3.6PL cells assessed as reduction in cell viability after 48 hrs by MTS assay | J Med Chem 63: 2814-2832 (2020) Article DOI: 10.1021/acs.jmedchem.9b00568 BindingDB Entry DOI: 10.7270/Q25D8WC1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50174344 (CHEMBL58129) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Kearney Curated by ChEMBL | Assay Description Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i... | Bioorg Med Chem Lett 26: 2616-2621 (2016) Article DOI: 10.1016/j.bmcl.2016.04.023 BindingDB Entry DOI: 10.7270/Q2ZS2ZFD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50174344 (CHEMBL58129) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50174345 (CHEMBL3809112) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Kearney Curated by ChEMBL | Assay Description Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i... | Bioorg Med Chem Lett 26: 2616-2621 (2016) Article DOI: 10.1016/j.bmcl.2016.04.023 BindingDB Entry DOI: 10.7270/Q2ZS2ZFD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50174345 (CHEMBL3809112) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50174343 (CHEMBL3809645) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 9.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska Kearney Curated by ChEMBL | Assay Description Inhibition of human LAT1 expressed in HEK cells assessed as reduction in uptake of [3H]-gabapentin after 3 mins by scintillation counting based cis-i... | Bioorg Med Chem Lett 26: 2616-2621 (2016) Article DOI: 10.1016/j.bmcl.2016.04.023 BindingDB Entry DOI: 10.7270/Q2ZS2ZFD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340672 (US9771316, Example 70) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463188 (CHEMBL4248463) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50532380 (CHEMBL4522605) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Eastern Finland Curated by ChEMBL | Assay Description Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured durin... | J Med Chem 59: 5740-51 (2016) Article DOI: 10.1021/acs.jmedchem.6b00190 BindingDB Entry DOI: 10.7270/Q27084W4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50532380 (CHEMBL4522605) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Eastern Finland Curated by ChEMBL | Assay Description Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured durin... | J Med Chem 59: 5740-51 (2016) Article DOI: 10.1021/acs.jmedchem.6b00190 BindingDB Entry DOI: 10.7270/Q27084W4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50606666 (CHEMBL5219332) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.82E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113806 BindingDB Entry DOI: 10.7270/Q2M61QBT | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM181118 (US9138393, Histidine | US9144538, Histidine) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463321 (CHEMBL4239455) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.77E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Curated by ChEMBL | Assay Description Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting method | Bioorg Med Chem Lett 28: 2856-2860 (2018) Article DOI: 10.1016/j.bmcl.2018.07.030 BindingDB Entry DOI: 10.7270/Q2WM1H2C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463211 (CHEMBL4244215) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463322 (CHEMBL4242544) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Curated by ChEMBL | Assay Description Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting method | Bioorg Med Chem Lett 28: 2856-2860 (2018) Article DOI: 10.1016/j.bmcl.2018.07.030 BindingDB Entry DOI: 10.7270/Q2WM1H2C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463202 (CHEMBL4241703) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340669 (US9771316, Example 68) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.64E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340672 (US9771316, Example 70) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340542 (US9771316, Example 44) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.94E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM36161 (D-phenylalanine) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340549 (US9771316, Example 48) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.66E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340539 (US9771316, Example 26) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340532 (US9771316, Example 1) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340661 (US9771316, Example 66) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.28E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340536 (US9771316, Example 12) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463208 (CHEBI:16414 | L-Valine | NSC-76038 | Valine) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE KEGG PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM18129 ((2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid | L...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska at Kearney Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo... | Bioorg Med Chem Lett 29: 2254-2258 (2019) Article DOI: 10.1016/j.bmcl.2019.06.033 BindingDB Entry DOI: 10.7270/Q21V5JBJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340671 (US9771316, Example 69) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463186 (CHEMBL4242404) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463186 (CHEMBL4242404) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska at Kearney Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo... | Bioorg Med Chem Lett 29: 2254-2258 (2019) Article DOI: 10.1016/j.bmcl.2019.06.033 BindingDB Entry DOI: 10.7270/Q21V5JBJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM18073 ((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340540 (US9771316, Example 29) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 7.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463203 (CHEMBL4242607) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463191 (CHEMBL4251478) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50219348 ((2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leuc...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50219348 ((2S)-2-amino-4-methylpentanoic acid | (S)-(+)-leuc...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human LAT1 expressed in HEK293-T-Rex cells assessed as inhibition of [3H]-gabapentin uptake by scintillation counting cis-inhibition as... | Citation and Details Article DOI: 10.1016/j.bmcl.2016.09.001 BindingDB Entry DOI: 10.7270/Q22F7S4P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340533 (US9771316, Example 6) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8.91E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463201 (CHEMBL4239335) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463196 (CHEMBL4241017) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463200 (CHEMBL4240451) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM340668 (US9771316, Example 67) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Osaka University; KNC Laboratories Co., Ltd. US Patent | Assay Description Expression vector each expressing a gene was inserted using Lipofectamine 2000 (Invitrogen) to cultured cell line HEK293 cell derived from human fetu... | US Patent US9771316 (2017) BindingDB Entry DOI: 10.7270/Q2X0694S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463209 (CHEMBL4249170) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska at Kearney Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 degC follo... | Bioorg Med Chem Lett 29: 2254-2258 (2019) Article DOI: 10.1016/j.bmcl.2019.06.033 BindingDB Entry DOI: 10.7270/Q21V5JBJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM60928 (BDBM50130192 | L-3,4-dihydroxyphenylalanine | L-DO...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florida Curated by ChEMBL | Assay Description Inhibition of LAT1-mediated [14C]-L-leucine uptake in human MCF7 cells after 5 mins by liquid scintillation counting method | Bioorg Med Chem Lett 28: 2856-2860 (2018) Article DOI: 10.1016/j.bmcl.2018.07.030 BindingDB Entry DOI: 10.7270/Q2WM1H2C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Large neutral amino acids transporter small subunit 1 (Homo sapiens (Human)) | BDBM50463209 (CHEMBL4249170) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of California Curated by ChEMBL | Assay Description Cis-inhibition of human LAT1 expressed in TREx HEK293 cells at 200 uM assessed as inhibition of [3H]-gabapentin uptake preincubated for 3 mins at 37 ... | J Med Chem 61: 7358-7373 (2018) Article DOI: 10.1021/acs.jmedchem.8b01007 BindingDB Entry DOI: 10.7270/Q2XK8J66 | |||||||||||
More data for this Ligand-Target Pair |
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