Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neutrophil elastase (Homo sapiens (Human)) | BDBM50583309 (CHEMBL4204851) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.0340 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human neutrophil elastase | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01583 BindingDB Entry DOI: 10.7270/Q2R78K38 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50096484 ((4S,6R)-6-Allyl-4-(naphthalene-2-sulfonyl)-5-oxo-h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0360 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Medicines Research Centre Curated by ChEMBL | Assay Description In vitro inhibitory activity against human neutrophil elastase (HNE) | Bioorg Med Chem Lett 11: 243-6 (2001) BindingDB Entry DOI: 10.7270/Q2K074SH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50066997 ((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.0470 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Medicines Research Centre Curated by ChEMBL | Assay Description In vitro inhibitory activity against human neutrophil elastase (HNE) | Bioorg Med Chem Lett 11: 243-6 (2001) BindingDB Entry DOI: 10.7270/Q2K074SH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50120437 (CHEMBL3617973) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0650 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate measured after 60 mins by fluorescence method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00960 BindingDB Entry DOI: 10.7270/Q29W0K46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50120437 (CHEMBL3617973) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.0650 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Florence Curated by ChEMBL | Assay Description Inhibition of human neutrophil elastase | Bioorg Med Chem 26: 5583-5595 (2018) Article DOI: 10.1016/j.bmc.2018.09.034 BindingDB Entry DOI: 10.7270/Q2M32ZGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50058495 (3-{2-[2-(Thiophene-2-carbonylsulfanyl)-propionylam...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherche Servier Curated by ChEMBL | Assay Description Inhibitory concentration against Human Leukocyte Elastase from human sputum | J Med Chem 40: 1906-18 (1997) Article DOI: 10.1021/jm960772z BindingDB Entry DOI: 10.7270/Q2MS3RW1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50120428 (CHEMBL3617966) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 0.210 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare AG Curated by ChEMBL | Assay Description Inhibition of human neutrophil elastase | Bioorg Med Chem Lett 25: 4370-81 (2015) Article DOI: 10.1016/j.bmcl.2015.08.049 BindingDB Entry DOI: 10.7270/Q29Z96PX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50556037 (CHEMBL4744163) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate measured after 60 mins by fluorescence method | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00960 BindingDB Entry DOI: 10.7270/Q29W0K46 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189814 (US9174997, 14) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189815 (US9174997, 18) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189818 (US9174997, 27) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189819 (US9174997, 32) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189820 (US9174997, 33) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189821 (US9174997, 36) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189822 (US9174997, 41) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189823 (US9174997, 43 (Diastereomer 1)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189831 (US9174997, 51) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189835 (US9174997, 55) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189860 (US9174997, 80) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189865 (US9174997, 85) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189871 (US9174997, 91) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189876 (US9174997, 96) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189883 (US9174997, 103) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189896 (US9174997, 116) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189900 (US9174997, 120) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189908 (US9174997, 128) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189921 (US9174997, 141) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189924 (US9174997, 144) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM211514 (US9290457, Example 1.56) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach... | US Patent US9290457 (2016) BindingDB Entry DOI: 10.7270/Q2QJ7G4W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189813 (US9174997, 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189812 (US9174997, 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM104826 (US8569314, 56) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH US Patent | Assay Description In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido... | US Patent US8569314 (2013) BindingDB Entry DOI: 10.7270/Q2FJ2FF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM104825 (US8569314, 53) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | KEGG PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH US Patent | Assay Description In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido... | US Patent US8569314 (2013) BindingDB Entry DOI: 10.7270/Q2FJ2FF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM104824 (US8569314, 50) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH US Patent | Assay Description In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido... | US Patent US8569314 (2013) BindingDB Entry DOI: 10.7270/Q2FJ2FF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM104823 (US8569314, 35) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH US Patent | Assay Description In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido... | US Patent US8569314 (2013) BindingDB Entry DOI: 10.7270/Q2FJ2FF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM104822 (US8569314, 23) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH US Patent | Assay Description In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido... | US Patent US8569314 (2013) BindingDB Entry DOI: 10.7270/Q2FJ2FF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM104820 (US8569314, 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH US Patent | Assay Description In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido... | US Patent US8569314 (2013) BindingDB Entry DOI: 10.7270/Q2FJ2FF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM104821 (US8569314, 9) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Intellectual Property GmbH US Patent | Assay Description In vitro HNE inhibition assay. The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amido... | US Patent US8569314 (2013) BindingDB Entry DOI: 10.7270/Q2FJ2FF4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50120436 (CHEMBL3617972) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | <0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare AG Curated by ChEMBL | Assay Description Inhibition of human neutrophil elastase using MeOSuc-AAPV-AMC as substrate after 60 mins by fluorescence assay | Bioorg Med Chem Lett 25: 4370-81 (2015) Article DOI: 10.1016/j.bmcl.2015.08.049 BindingDB Entry DOI: 10.7270/Q29Z96PX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50066999 ((S)-3,3-Diethyl-2-[4-(4-methyl-piperazine-1-carbon...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | PubMed | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Medicines Research Centre Curated by ChEMBL | Assay Description In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10 | Bioorg Med Chem Lett 11: 243-6 (2001) BindingDB Entry DOI: 10.7270/Q2K074SH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189817 (US9174997, 22) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.450 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189811 (US9174997, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50120429 (CHEMBL3617965) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare AG Curated by ChEMBL | Assay Description Inhibition of human neutrophil elastase | Bioorg Med Chem Lett 25: 4370-81 (2015) Article DOI: 10.1016/j.bmcl.2015.08.049 BindingDB Entry DOI: 10.7270/Q29Z96PX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50096486 (CHEMBL2367646 | benzyl (3aS,6aR)-4-acetyl-6-allyl-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.690 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Medicines Research Centre Curated by ChEMBL | Assay Description In vitro inhibitory activity against human neutrophil elastase (HNE) | Bioorg Med Chem Lett 11: 243-6 (2001) BindingDB Entry DOI: 10.7270/Q2K074SH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM50120424 (CHEMBL3617970) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer HealthCare AG Curated by ChEMBL | Assay Description Inhibition of human neutrophil elastase | Bioorg Med Chem Lett 25: 4370-81 (2015) Article DOI: 10.1016/j.bmcl.2015.08.049 BindingDB Entry DOI: 10.7270/Q29Z96PX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM189849 (US9174997, 69) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.900 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Bayer Intellectual Property GmbH US Patent | Assay Description The potency of the compounds of the invention is ascertained in an in vitro inhibition assay. The HNE-mediated amidolytic cleavage of a suitable pept... | US Patent US9174997 (2015) BindingDB Entry DOI: 10.7270/Q2GT5KZQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM211459 (US9290457, Example 1.1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach... | US Patent US9290457 (2016) BindingDB Entry DOI: 10.7270/Q2QJ7G4W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM211460 (US9290457, Example 1.2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach... | US Patent US9290457 (2016) BindingDB Entry DOI: 10.7270/Q2QJ7G4W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM211462 (US9290457, Example 1.4) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach... | US Patent US9290457 (2016) BindingDB Entry DOI: 10.7270/Q2QJ7G4W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neutrophil elastase (Homo sapiens (Human)) | BDBM211463 (US9290457, Example 1.5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Boehringer Ingelheim International GmbH US Patent | Assay Description Materials: Human neutrophil elastase was purchased from Calbiochem (Cat. No.: 324681) and the elastase substrate MeOSuc-Ala-Ala-Pro-Val-AMC from Bach... | US Patent US9290457 (2016) BindingDB Entry DOI: 10.7270/Q2QJ7G4W | |||||||||||
More data for this Ligand-Target Pair |
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