Compile Data Set for Download or QSAR

Found 502 hits of ic50 for UniProtKB: P00749   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50147093 (6-Carbamimidoyl-4-(pyrimidin-2-ylamino)-naphthalen...) Show SMILES NCc1ccc(NC(=O)c2cc(Nc3ncccn3)c3cc(ccc3c2)C(N)=N)cc1 Show InChI InChI=1S/C23H21N7O/c24-13-14-2-6-18(7-3-14)29-22(31)17-10-15-4-5-16(21(25)26)11-19(15)20(12-17)30-23-27-8-1-9-28-23/h1-12H,13,24H2,(H3,25,26)(H,29,31)(H,27,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
University of Wollongong Curated by ChEMBL					Assay Description Inhibition of uPA (unknown origin)				J Med Chem 61: 8299-8320 (2018) Article DOI: 10.1021/acs.jmedchem.8b00838 BindingDB Entry DOI: 10.7270/Q2QF8WH4
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194745 (CHEMBL385900 | diphenyl 1-[(N-2-thiophenesulfonyl-...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1cccs1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C31H35N6O8PS2/c1-21(34-30(40)26(20-38)37-48(42,43)28-13-8-18-47-28)29(39)36-27(19-22-14-16-23(17-15-22)35-31(32)33)46(41,44-24-9-4-2-5-10-24)45-25-11-6-3-7-12-25/h2-18,21,26-27,37-38H,19-20H2,1H3,(H,34,40)(H,36,39)(H4,32,33,35)/t21-,26+,27?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194741 (CHEMBL385158 | diphenyl 1-[(N-benzenesulfonyl-D-se...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1ccccc1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C33H37N6O8PS/c1-23(36-32(42)29(22-40)39-49(44,45)28-15-9-4-10-16-28)31(41)38-30(21-24-17-19-25(20-18-24)37-33(34)35)48(43,46-26-11-5-2-6-12-26)47-27-13-7-3-8-14-27/h2-20,23,29-30,39-40H,21-22H2,1H3,(H,36,42)(H,38,41)(H4,34,35,37)/t23-,29+,30?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228418 (CHEMBL393591 | methyl 1-(diphenoxyphosphoryl)-2-(4...) Show SMILES [#6]-[#8]-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C23H25N4O5P/c1-30-23(28)27-21(16-17-12-14-18(15-13-17)26-22(24)25)33(29,31-19-8-4-2-5-9-19)32-20-10-6-3-7-11-20/h2-15,21H,16H2,1H3,(H,27,28)(H4,24,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50088982 (CHEMBL160253 | CHEMBL367004 | N-[1-(1-Carbamimidoy...) Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)CCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C20H32N6O6S/c1-13(17(28)24-15-8-5-10-26(19(15)30)20(21)22)23-18(29)16(12-27)25-33(31,32)11-9-14-6-3-2-4-7-14/h2-4,6-7,13,15-16,19,25,27,30H,5,8-12H2,1H3,(H3,21,22)(H,23,29)(H,24,28)/t13-,15-,16+,19?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228412 (CHEMBL393979 | methyl 1-(bis(4-acetamidophenoxy)ph...) Show SMILES [#6]-[#8]-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccc(-[#7]-[#6](-[#6])=O)cc1)[#8]-c1ccc(-[#7]-[#6](-[#6])=O)cc1 Show InChI InChI=1S/C27H31N6O7P/c1-17(34)30-20-8-12-23(13-9-20)39-41(37,40-24-14-10-21(11-15-24)31-18(2)35)25(33-27(36)38-3)16-19-4-6-22(7-5-19)32-26(28)29/h4-15,25H,16H2,1-3H3,(H,30,34)(H,31,35)(H,33,36)(H4,28,29,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194743 (CHEMBL214814 | diphenyl 1-[(N-alpha-toluenesulfony...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H39N6O8PS/c1-24(37-33(43)30(22-41)40-50(45,46)23-26-11-5-2-6-12-26)32(42)39-31(21-25-17-19-27(20-18-25)38-34(35)36)49(44,47-28-13-7-3-8-14-28)48-29-15-9-4-10-16-29/h2-20,24,30-31,40-41H,21-23H2,1H3,(H,37,43)(H,39,42)(H4,35,36,38)/t24-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228425 (CHEMBL239118 | di-(4-acetamidophenyl) 1-(methylsul...) Show SMILES [#6]-[#6](=O)-[#7]-c1ccc(-[#8]P(=O)([#8]-c2ccc(-[#7]-[#6](-[#6])=O)cc2)[#6](-[#6]-c2ccc(cc2)\[#7]=[#6](\[#7])-[#7])-[#7]S([#6])(=O)=O)cc1 Show InChI InChI=1S/C26H31N6O7PS/c1-17(33)29-20-8-12-23(13-9-20)38-40(35,39-24-14-10-21(11-15-24)30-18(2)34)25(32-41(3,36)37)16-19-4-6-22(7-5-19)31-26(27)28/h4-15,25,32H,16H2,1-3H3,(H,29,33)(H,30,34)(H4,27,28,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194743 (CHEMBL214814 | diphenyl 1-[(N-alpha-toluenesulfony...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H39N6O8PS/c1-24(37-33(43)30(22-41)40-50(45,46)23-26-11-5-2-6-12-26)32(42)39-31(21-25-17-19-27(20-18-25)38-34(35)36)49(44,47-28-13-7-3-8-14-28)48-29-15-9-4-10-16-29/h2-20,24,30-31,40-41H,21-23H2,1H3,(H,37,43)(H,39,42)(H4,35,36,38)/t24-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228420 (CHEMBL391968 | di-(4-acetamidophenyl) 1-(benzyloxy...) Show SMILES [#6]-[#6](=O)-[#7]-c1ccc(-[#8]P(=O)([#8]-c2ccc(-[#7]-[#6](-[#6])=O)cc2)[#6](-[#6]-c2ccc(cc2)\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#8]-[#6]-c2ccccc2)cc1 Show InChI InChI=1S/C33H35N6O7P/c1-22(40)36-26-12-16-29(17-13-26)45-47(43,46-30-18-14-27(15-19-30)37-23(2)41)31(20-24-8-10-28(11-9-24)38-32(34)35)39-33(42)44-21-25-6-4-3-5-7-25/h3-19,31H,20-21H2,1-2H3,(H,36,40)(H,37,41)(H,39,42)(H4,34,35,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50145689 (CHEMBL80844 | [1-[(S)-2-((R)-2-Benzyloxycarbonylam...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-[#8]-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](/[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C35H39N6O8P/c1-24(38-33(44)30(22-42)40-35(45)47-23-26-11-5-2-6-12-26)32(43)41-31(21-25-17-19-27(20-18-25)39-34(36)37)50(46,48-28-13-7-3-8-14-28)49-29-15-9-4-10-16-29/h2-20,24,30-31,42H,21-23H2,1H3,(H,38,44)(H,40,45)(H,41,43)(H4,36,37,39)/t24-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.30	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194737 (CHEMBL384263 | diphenyl 1-[(N-o-methylbenzoyl-D-se...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-c1cccc(-[#6])c1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C35H39N6O7P/c1-23-10-9-11-26(20-23)33(44)40-30(22-42)34(45)38-24(2)32(43)41-31(21-25-16-18-27(19-17-25)39-35(36)37)49(46,47-28-12-5-3-6-13-28)48-29-14-7-4-8-15-29/h3-20,24,30-31,42H,21-22H2,1-2H3,(H,38,45)(H,40,44)(H,41,43)(H4,36,37,39)/t24-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.40	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194742 (CHEMBL263977 | diphenyl 1-[(N-benzyl-D-seryl)-L-al...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-c1ccccc1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H37N6O7P/c1-23(37-33(44)29(22-41)39-32(43)25-11-5-2-6-12-25)31(42)40-30(21-24-17-19-26(20-18-24)38-34(35)36)48(45,46-27-13-7-3-8-14-27)47-28-15-9-4-10-16-28/h2-20,23,29-30,41H,21-22H2,1H3,(H,37,44)(H,39,43)(H,40,42)(H4,35,36,38)/t23-,29+,30?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194746 (CHEMBL405546 | diphenyl 1-[(N-o-methylbenzoyl-D-se...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-c1ccccc1-[#6])-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C35H39N6O7P/c1-23-11-9-10-16-29(23)33(44)40-30(22-42)34(45)38-24(2)32(43)41-31(21-25-17-19-26(20-18-25)39-35(36)37)49(46,47-27-12-5-3-6-13-27)48-28-14-7-4-8-15-28/h3-20,24,30-31,42H,21-22H2,1-2H3,(H,38,45)(H,40,44)(H,41,43)(H4,36,37,39)/t24-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50088978 (CHEMBL176515 | N-[1-(1-Carbamimidoyl-2-hydroxy-pip...) Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C19H30N6O6S/c1-12(16(27)23-14-8-5-9-25(18(14)29)19(20)21)22-17(28)15(10-26)24-32(30,31)11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,24,26,29H,5,8-11H2,1H3,(H3,20,21)(H,22,28)(H,23,27)/t12-,14-,15+,18?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.10	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194744 (CHEMBL385897 | diphenyl 1-[(N-naphthalenesulfonyl-...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1cccc2ccccc12)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C37H39N6O8PS/c1-25(40-36(46)32(24-44)43-53(48,49)33-18-10-12-27-11-8-9-17-31(27)33)35(45)42-34(23-26-19-21-28(22-20-26)41-37(38)39)52(47,50-29-13-4-2-5-14-29)51-30-15-6-3-7-16-30/h2-22,25,32,34,43-44H,23-24H2,1H3,(H,40,46)(H,42,45)(H4,38,39,41)/t25-,32+,34?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194734 (CHEMBL386275 | diphenyl 1-[(N-p-methoxybenzenesulf...) Show SMILES [#6]-[#8]-c1ccc(cc1)S(=O)(=O)[#7]-[#6@H](-[#6]-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H39N6O9PS/c1-23(37-33(43)30(22-41)40-51(45,46)29-19-17-26(47-2)18-20-29)32(42)39-31(21-24-13-15-25(16-14-24)38-34(35)36)50(44,48-27-9-5-3-6-10-27)49-28-11-7-4-8-12-28/h3-20,23,30-31,40-41H,21-22H2,1-2H3,(H,37,43)(H,39,42)(H4,35,36,38)/t23-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194736 (CHEMBL189823 | diphenyl 1-[(N-o,o-dimethylbenzoyl-...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-c1c(-[#6])cccc1-[#6])-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C36H41N6O7P/c1-23-11-10-12-24(2)32(23)35(46)41-30(22-43)34(45)39-25(3)33(44)42-31(21-26-17-19-27(20-18-26)40-36(37)38)50(47,48-28-13-6-4-7-14-28)49-29-15-8-5-9-16-29/h4-20,25,30-31,43H,21-22H2,1-3H3,(H,39,45)(H,41,46)(H,42,44)(H4,37,38,40)/t25-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194735 (CHEMBL215961 | diphenyl 1-[(N-p-cyanobenzenesulfon...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1ccc(cc1)C#N)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C34H36N7O8PS/c1-23(38-33(44)30(22-42)41-51(46,47)29-18-14-25(21-35)15-19-29)32(43)40-31(20-24-12-16-26(17-13-24)39-34(36)37)50(45,48-27-8-4-2-5-9-27)49-28-10-6-3-7-11-28/h2-19,23,30-31,41-42H,20,22H2,1H3,(H,38,44)(H,40,43)(H4,36,37,39)/t23-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194738 (CHEMBL386249 | diphenyl 1-[(N-p-bromobenzenesulfon...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]S(=O)(=O)c1ccc(Br)cc1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C33H36BrN6O8PS/c1-22(37-32(43)29(21-41)40-50(45,46)28-18-14-24(34)15-19-28)31(42)39-30(20-23-12-16-25(17-13-23)38-33(35)36)49(44,47-26-8-4-2-5-9-26)48-27-10-6-3-7-11-27/h2-19,22,29-30,40-41H,20-21H2,1H3,(H,37,43)(H,39,42)(H4,35,36,38)/t22-,29+,30?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM92479 (Tannic Acid, A | Tannic acid) Show SMILES Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OCC1OC(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1 Show InChI InChI=1S/C76H52O46/c77-32-1-22(2-33(78)53(32)92)67(103)113-47-16-27(11-42(87)58(47)97)66(102)112-21-52-63(119-72(108)28-12-43(88)59(98)48(17-28)114-68(104)23-3-34(79)54(93)35(80)4-23)64(120-73(109)29-13-44(89)60(99)49(18-29)115-69(105)24-5-36(81)55(94)37(82)6-24)65(121-74(110)30-14-45(90)61(100)50(19-30)116-70(106)25-7-38(83)56(95)39(84)8-25)76(118-52)122-75(111)31-15-46(91)62(101)51(20-31)117-71(107)26-9-40(85)57(96)41(86)10-26/h1-20,52,63-65,76-101H,21H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	7.8	23
University of Michigan					Assay Description Enzyme activity assay using human and murine PAI-1.				J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228421 (CHEMBL238493 | diphenyl 1-(methylsulfonylamino)-2-...) Show SMILES [#6]S(=O)(=O)[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 |w:5.4| Show InChI InChI=1S/C22H25N4O5PS/c1-33(28,29)26-21(16-17-12-14-18(15-13-17)25-22(23)24)32(27,30-19-8-4-2-5-9-19)31-20-10-6-3-7-11-20/h2-15,21,26H,16H2,1H3,(H4,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194732 (CHEMBL214539 | di-(4-acetamidophenyl) 1-[(N-benzyl...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-[#8]-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccc(-[#7]-[#6](-[#6])=O)cc1)[#8]-c1ccc(-[#7]-[#6](-[#6])=O)cc1 Show InChI InChI=1S/C39H45N8O10P/c1-24(42-37(52)34(22-48)46-39(53)55-23-28-7-5-4-6-8-28)36(51)47-35(21-27-9-11-31(12-10-27)45-38(40)41)58(54,56-32-17-13-29(14-18-32)43-25(2)49)57-33-19-15-30(16-20-33)44-26(3)50/h4-20,24,34-35,48H,21-23H2,1-3H3,(H,42,52)(H,43,49)(H,44,50)(H,46,53)(H,47,51)(H4,40,41,45)/t24-,34+,35?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP incorporation into biotin-linked K-ras decapeptide (CVIM) by bovine farnesyltransferase				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194739 (CHEMBL213216 | diphenyl 1-[(N-2-thienyl-D-seryl)-L...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-c1cccs1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C32H35N6O7PS/c1-21(35-30(41)26(20-39)37-31(42)27-13-8-18-47-27)29(40)38-28(19-22-14-16-23(17-15-22)36-32(33)34)46(43,44-24-9-4-2-5-10-24)45-25-11-6-3-7-12-25/h2-18,21,26,28,39H,19-20H2,1H3,(H,35,41)(H,37,42)(H,38,40)(H4,33,34,36)/t21-,26+,28?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228410 (CHEMBL239535 | diphenyl 1-(benzyloxycarbonylamino)...) Show SMILES [#7]\[#6](-[#7])=[#7]\c1ccc(-[#6]-[#6](-[#7]-[#6](=O)-[#8]-[#6]-c2ccccc2)P(=O)([#8]-c2ccccc2)[#8]-c2ccccc2)cc1 Show InChI InChI=1S/C29H29N4O5P/c30-28(31)32-24-18-16-22(17-19-24)20-27(33-29(34)36-21-23-10-4-1-5-11-23)39(35,37-25-12-6-2-7-13-25)38-26-14-8-3-9-15-26/h1-19,27H,20-21H2,(H,33,34)(H4,30,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194740 (CHEMBL404226 | diphenyl 1-[(N-p-methylbenzoyl-D-se...) Show SMILES [#6]-[#6@H](-[#7]-[#6](=O)-[#6@@H](-[#6]-[#8])-[#7]-[#6](=O)-c1ccc(-[#6])cc1)-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C35H39N6O7P/c1-23-13-17-26(18-14-23)33(44)40-30(22-42)34(45)38-24(2)32(43)41-31(21-25-15-19-27(20-16-25)39-35(36)37)49(46,47-28-9-5-3-6-10-28)48-29-11-7-4-8-12-29/h3-20,24,30-31,42H,21-22H2,1-2H3,(H,38,45)(H,40,44)(H,41,43)(H4,36,37,39)/t24-,30+,31?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228414 (CHEMBL239747 | diphenyl 1-acetamido-2-(4-guanidino...) Show SMILES [#6]-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 |w:4.3| Show InChI InChI=1S/C23H25N4O4P/c1-17(28)26-22(16-18-12-14-19(15-13-18)27-23(24)25)32(29,30-20-8-4-2-5-9-20)31-21-10-6-3-7-11-21/h2-15,22H,16H2,1H3,(H,26,28)(H4,24,25,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.20	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228417 (CHEMBL238491 | diphenyl 1-(o-toluenesulfonylamino)...) Show SMILES [#7]\[#6](-[#7])=[#7]\c1ccc(-[#6]-[#6](-[#7]S(=O)(=O)[#6]-c2ccccc2)P(=O)([#8]-c2ccccc2)[#8]-c2ccccc2)cc1 |w:9.9| Show InChI InChI=1S/C28H29N4O5PS/c29-28(30)31-24-18-16-22(17-19-24)20-27(32-39(34,35)21-23-10-4-1-5-11-23)38(33,36-25-12-6-2-7-13-25)37-26-14-8-3-9-15-26/h1-19,27,32H,20-21H2,(H4,29,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228423 (CHEMBL239536 | ethyl 1-(diphenoxyphosphoryl)-2-(4-...) Show SMILES [#6]-[#6]-[#8]-[#6](=O)-[#7]-[#6](-[#6]-c1ccc(cc1)\[#7]=[#6](\[#7])-[#7])P(=O)([#8]-c1ccccc1)[#8]-c1ccccc1 Show InChI InChI=1S/C24H27N4O5P/c1-2-31-24(29)28-22(17-18-13-15-19(16-14-18)27-23(25)26)34(30,32-20-9-5-3-6-10-20)33-21-11-7-4-8-12-21/h3-16,22H,2,17H2,1H3,(H,28,29)(H4,25,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50194733 (CHEMBL411215 | diphenyl 1-[(N-1-adamantanyl-D-sery...) Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccc(NC(N)=N)cc1)P(=O)(Oc1ccccc1)Oc1ccccc1 |TLB:17:16:20:13.12.11,THB:18:16:13:20.19.11| Show InChI InChI=1S/C38H47N6O7P/c1-23(41-36(47)32(22-45)43-37(48)34-27-17-25-16-26(19-27)20-28(34)18-25)35(46)44-33(21-24-12-14-29(15-13-24)42-38(39)40)52(49,50-30-8-4-2-5-9-30)51-31-10-6-3-7-11-31/h2-15,23,25-28,32-34,45H,16-22H2,1H3,(H,41,47)(H,43,48)(H,44,46)(H4,39,40,42)/t23-,25?,26?,27?,28?,32+,33?,34?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 49: 5785-93 (2006) Article DOI: 10.1021/jm060622g BindingDB Entry DOI: 10.7270/Q2SF2VT3
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50088984 (2-Benzenesulfonylamino-N-[1-(1-carbamimidoyl-2-hyd...) Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C18H28N6O6S/c1-11(15(26)22-13-8-5-9-24(17(13)28)18(19)20)21-16(27)14(10-25)23-31(29,30)12-6-3-2-4-7-12/h2-4,6-7,11,13-14,17,23,25,28H,5,8-10H2,1H3,(H3,19,20)(H,21,27)(H,22,26)/t11-,13-,14+,17?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM92485 (CDE-066 | US9120744, CDE-066) Show SMILES Oc1cc(cc(O)c1O)C(=O)OC[C@H]1OC(OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1 |r,w:15.16| Show InChI InChI=1S/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33+,34+,35-,41?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.8	23
University of Michigan					Assay Description Enzyme activity assay using human and murine PAI-1.				J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50088979 (CHEMBL366666 | {(R)-2-[2-((S)-1-Carbamimidoyl-2-hy...) Show SMILES NC(=N)N1CCC[C@H](NC(=O)C2CCN2C(=O)[C@@H](CO)NC(=O)OCc2ccccc2)C1O Show InChI InChI=1S/C21H30N6O6/c22-20(23)27-9-4-7-14(18(27)30)24-17(29)16-8-10-26(16)19(31)15(11-28)25-21(32)33-12-13-5-2-1-3-6-13/h1-3,5-6,14-16,18,28,30H,4,7-12H2,(H3,22,23)(H,24,29)(H,25,32)/t14-,15+,16?,18?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50088985 (CHEMBL369042 | {2-[2-(1-Carbamimidoyl-2-hydroxy-pi...) Show SMILES NC(=N)N1CCCC(NC(=O)[C@H]2CCCN2C(=O)C(CO)NC(=O)OCc2ccccc2)C1O Show InChI InChI=1S/C22H32N6O6/c23-21(24)28-11-4-8-15(19(28)31)25-18(30)17-9-5-10-27(17)20(32)16(12-29)26-22(33)34-13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,29,31H,4-5,8-13H2,(H3,23,24)(H,25,30)(H,26,33)/t15?,16?,17-,19?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM92486 (CDE-082 | US9120744, CDE-082) Show SMILES Oc1cc(cc(O)c1O)C(=O)OCC(COC(=O)c1cc(O)c(O)c(O)c1)OC(=O)c1cc(O)c(O)c(O)c1 Show InChI InChI=1S/C24H20O15/c25-13-1-9(2-14(26)19(13)31)22(34)37-7-12(39-24(36)11-5-17(29)21(33)18(30)6-11)8-38-23(35)10-3-15(27)20(32)16(28)4-10/h1-6,12,25-33H,7-8H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.8	23
University of Michigan					Assay Description Enzyme activity assay using human and murine PAI-1.				J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50301972 (2-(6-(5-amino-3'-(aminomethyl)biphenyl-3-yloxy)-4-...) Show SMILES CN(C)C1CCN(C1)c1c(F)c(Oc2cc(N)cc(c2)-c2cccc(CN)c2)nc(Oc2cc(C)ccc2C(O)=O)c1F Show InChI InChI=1S/C32H33F2N5O4/c1-18-7-8-25(32(40)41)26(11-18)43-31-28(34)29(39-10-9-23(17-39)38(2)3)27(33)30(37-31)42-24-14-21(13-22(36)15-24)20-6-4-5-19(12-20)16-35/h4-8,11-15,23H,9-10,16-17,35-36H2,1-3H3,(H,40,41)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences Curated by ChEMBL					Assay Description Inhibition of uPA				Bioorg Med Chem Lett 19: 5712-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.008 BindingDB Entry DOI: 10.7270/Q2JQ113Z
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50542728 (CHEMBL4635912) Show SMILES CC1(C)COc2c1cc(cc2COc1ccccc1CC(O)=O)-c1ccc2OC[C@@H](N)c2c1 |r| Show InChI InChI=1S/C27H27NO5/c1-27(2)15-33-26-19(13-31-23-6-4-3-5-17(23)12-25(29)30)9-18(11-21(26)27)16-7-8-24-20(10-16)22(28)14-32-24/h3-11,22H,12-15,28H2,1-2H3,(H,29,30)/t22-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human urokinase using fluorescent peptide as substrate by florescence assay				J Med Chem 63: 8088-8113 (2020) Article DOI: 10.1021/acs.jmedchem.0c00279 BindingDB Entry DOI: 10.7270/Q2KS6W36
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50088977 (CHEMBL177557 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...) Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C20H30N6O6/c1-12(16(28)24-14-8-5-9-26(18(14)30)19(21)22)23-17(29)15(10-27)25-20(31)32-11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,27,30H,5,8-11H2,1H3,(H3,21,22)(H,23,29)(H,24,28)(H,25,31)/t12-,14-,15+,18?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Similars	PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50542732 (CHEMBL4647925) Show SMILES CC(C)c1cc(CCOc2ccccc2C(O)=O)cc(c1)-c1ccc2OC[C@@H](N)c2c1 |r| Show InChI InChI=1S/C26H27NO4/c1-16(2)19-11-17(9-10-30-24-6-4-3-5-21(24)26(28)29)12-20(13-19)18-7-8-25-22(14-18)23(27)15-31-25/h3-8,11-14,16,23H,9-10,15,27H2,1-2H3,(H,28,29)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human uPA using fluorescent peptide as substrate by florescence assay				J Med Chem 63: 8088-8113 (2020) Article DOI: 10.1021/acs.jmedchem.0c00279 BindingDB Entry DOI: 10.7270/Q2KS6W36
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50542731 (CHEMBL4642845) Show SMILES CC(C)c1cc(cc(c1)-c1ccc2OC[C@@H](N)c2c1)[C@@H]1CNc2cccc(CC(O)=O)c2O1 |r| Show InChI InChI=1S/C27H28N2O4/c1-15(2)18-8-19(16-6-7-24-21(11-16)22(28)14-32-24)10-20(9-18)25-13-29-23-5-3-4-17(12-26(30)31)27(23)33-25/h3-11,15,22,25,29H,12-14,28H2,1-2H3,(H,30,31)/t22-,25+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research Curated by ChEMBL					Assay Description Inhibition of human uPA using fluorescent peptide as substrate by florescence assay				J Med Chem 63: 8088-8113 (2020) Article DOI: 10.1021/acs.jmedchem.0c00279 BindingDB Entry DOI: 10.7270/Q2KS6W36
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM92487 (CDE-031 | US9120744, CDE-031) Show SMILES Oc1cc(cc(O)c1O)C(=O)O[C@@H]1CCCC[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1 Show InChI InChI=1S/C20H20O10/c21-11-5-9(6-12(22)17(11)25)19(27)29-15-3-1-2-4-16(15)30-20(28)10-7-13(23)18(26)14(24)8-10/h5-8,15-16,21-26H,1-4H2/t15-,16+	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	7.8	23
University of Michigan					Assay Description Enzyme activity assay using human and murine PAI-1.				J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50231520 ((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...) Show SMILES NC(=N)c1ccc(CNC(=O)[C@H](CO)NC(=O)[C@@H](CO)NS(=O)(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C21H27N5O6S/c22-19(23)16-8-6-14(7-9-16)10-24-20(29)17(11-27)25-21(30)18(12-28)26-33(31,32)13-15-4-2-1-3-5-15/h1-9,17-18,26-28H,10-13H2,(H3,22,23)(H,24,29)(H,25,30)/t17-,18+/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Astex Therapeutics Ltd Curated by ChEMBL					Assay Description Inhibition of uPA				J Med Chem 51: 183-6 (2008) Article DOI: 10.1021/jm701359z BindingDB Entry DOI: 10.7270/Q2XG9QWK
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50301973 (2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-...) Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1 Show InChI InChI=1S/C26H20F2N2O5/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(30-25)34-19-10-17(9-18(31)11-19)16-4-2-3-15(8-16)13-29/h2-12,31H,13,29H2,1H3,(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences Curated by ChEMBL					Assay Description Inhibition of uPA				Bioorg Med Chem Lett 19: 5712-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.008 BindingDB Entry DOI: 10.7270/Q2JQ113Z
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50467209 (CHEMBL4291446) Show SMILES COc1cc(Oc2nc(O[C@@H](C(O)=O)C(C)(C)C)c(F)cc2F)cc(c1)-c1cccc(CN)c1 |r| Show InChI InChI=1S/C25H26F2N2O5/c1-25(2,3)21(24(30)31)34-23-20(27)12-19(26)22(29-23)33-18-10-16(9-17(11-18)32-4)15-7-5-6-14(8-15)13-28/h5-12,21H,13,28H2,1-4H3,(H,30,31)/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Abdulaziz University for Health Sciences Curated by ChEMBL					Assay Description Inhibition of human uPA				Bioorg Med Chem Lett 28: 3372-3375 (2018) Article DOI: 10.1016/j.bmcl.2018.09.001 BindingDB Entry DOI: 10.7270/Q24Q7XNF
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50088987 (CHEMBL174813 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...) Show SMILES CC(C)COC(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H]1CCCN(C1O)C(N)=N Show InChI InChI=1S/C17H32N6O6/c1-9(2)8-29-17(28)22-12(7-24)14(26)20-10(3)13(25)21-11-5-4-6-23(15(11)27)16(18)19/h9-12,15,24,27H,4-8H2,1-3H3,(H3,18,19)(H,20,26)(H,21,25)(H,22,28)/t10-,11-,12+,15?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem	PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Corvas International, Inc. Curated by ChEMBL					Assay Description The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50				Bioorg Med Chem Lett 10: 983-7 (2000) BindingDB Entry DOI: 10.7270/Q2765DKB
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50301982 (2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-4-(3-(dime...) Show SMILES CN(C)C1CCN(C1)c1c(F)c(Oc2cccc(c2)-c2cccc(CN)c2)nc(Oc2cc(ccc2C(O)=O)N(C)C)c1F Show InChI InChI=1S/C33H35F2N5O4/c1-38(2)23-11-12-26(33(41)42)27(17-23)44-32-29(35)30(40-14-13-24(19-40)39(3)4)28(34)31(37-32)43-25-10-6-9-22(16-25)21-8-5-7-20(15-21)18-36/h5-12,15-17,24H,13-14,18-19,36H2,1-4H3,(H,41,42)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Berlex Biosciences Curated by ChEMBL					Assay Description Inhibition of uPA				Bioorg Med Chem Lett 19: 5712-5 (2009) Article DOI: 10.1016/j.bmcl.2009.08.008 BindingDB Entry DOI: 10.7270/Q2JQ113Z
					More data for this Ligand-Target Pair				3D Structure (crystal)
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50184648 (CHEMBL378976 | [benzyloxycarbonylamino-(4-guanidin...) Show SMILES [#6]-[#16]-c1ccc(-[#8]P(=O)([#8]-c2ccc(-[#16]-[#6])cc2)[#6](-[#7]-[#6](=O)-[#8]-[#6]-c2ccccc2)-c2ccc(cc2)\[#7]=[#6](\[#7])-[#7])cc1 Show InChI InChI=1S/C30H31N4O5PS2/c1-41-26-16-12-24(13-17-26)38-40(36,39-25-14-18-27(42-2)19-15-25)28(22-8-10-23(11-9-22)33-29(31)32)34-30(35)37-20-21-6-4-3-5-7-21/h3-19,28H,20H2,1-2H3,(H,34,35)(H4,31,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Wroc£?aw University of Technology Curated by ChEMBL					Assay Description Inhibition of human uPA by chromogenic assay using Cbz-Val-Gly-Arg-pNA as chromogenic substrate				Bioorg Med Chem Lett 16: 2886-90 (2006) Article DOI: 10.1016/j.bmcl.2006.03.002 BindingDB Entry DOI: 10.7270/Q22N51WR
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50228426 (CHEMBL391344 | diphenyl 1-(naphthalenesulfonylamin...) Show SMILES [#7]\[#6](-[#7])=[#7]\c1ccc(-[#6]-[#6](-[#7]S(=O)(=O)c2cccc3ccccc23)P(=O)([#8]-c2ccccc2)[#8]-c2ccccc2)cc1 |w:9.9| Show InChI InChI=1S/C31H29N4O5PS/c32-31(33)34-25-20-18-23(19-21-25)22-30(35-42(37,38)29-17-9-11-24-10-7-8-16-28(24)29)41(36,39-26-12-3-1-4-13-26)40-27-14-5-2-6-15-27/h1-21,30,35H,22H2,(H4,32,33,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26.5	n/a	n/a	n/a	n/a	n/a	n/a
University of Antwerp Curated by ChEMBL					Assay Description Inhibition of human uPA				J Med Chem 50: 6638-46 (2007) Article DOI: 10.1021/jm700962j BindingDB Entry DOI: 10.7270/Q2MW2J0J
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50144551 ((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...) Show SMILES CC(C)(C)NC(=O)N1CCN(CC1)C(=O)N1[C@@H]([C@@H](CC2CCNCC2)C1=O)C(O)=O Show InChI InChI=1S/C20H33N5O5/c1-20(2,3)22-18(29)23-8-10-24(11-9-23)19(30)25-15(17(27)28)14(16(25)26)12-13-4-6-21-7-5-13/h13-15,21H,4-12H2,1-3H3,(H,22,29)(H,27,28)/t14-,15+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
The Bristol-Myers Squibb Pharmaceutical Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against Urokinase-type plasminogen activator				Bioorg Med Chem Lett 14: 2233-9 (2004) Article DOI: 10.1016/j.bmcl.2004.02.012 BindingDB Entry DOI: 10.7270/Q2SB4697
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM50467207 (CHEMBL4288828) Show SMILES CC(C)(C)[C@@H](Oc1nc(Oc2cc(cc(c2)-c2cccc(CN)c2)C#N)c(F)cc1F)C(O)=O |r| Show InChI InChI=1S/C25H23F2N3O4/c1-25(2,3)21(24(31)32)34-23-20(27)11-19(26)22(30-23)33-18-9-15(13-29)8-17(10-18)16-6-4-5-14(7-16)12-28/h4-11,21H,12,28H2,1-3H3,(H,31,32)/t21-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Abdulaziz University for Health Sciences Curated by ChEMBL					Assay Description Inhibition of human uPA				Bioorg Med Chem Lett 28: 3372-3375 (2018) Article DOI: 10.1016/j.bmcl.2018.09.001 BindingDB Entry DOI: 10.7270/Q24Q7XNF
					More data for this Ligand-Target Pair

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