Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92479 (Tannic Acid, A | Tannic acid) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7 | n/a | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92485 (CDE-066 | US9120744, CDE-066) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132862 (4-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assay | Bioorg Med Chem Lett 13: 3361-5 (2003) BindingDB Entry DOI: 10.7270/Q28W3CQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132855 (1-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assay | Bioorg Med Chem Lett 13: 3361-5 (2003) BindingDB Entry DOI: 10.7270/Q28W3CQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM175525 (US9120744, CDE-001 (or 073)) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM175528 (US9120744, CDE-004) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM175526 (US9120744, CDE-002) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM175527 (US9120744, CDE-003) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127745 ((E)-3-[3-(4-Chloro-phenoxy)-5,6-bis-(4-phenylsulfa...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM175544 (US9120744, CDE-058) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM175546 (US9120744, CDE-061) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM175558 (US9120744, CDE-075) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 70 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM175548 (US9120744, CDE-059) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 90 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50070942 ((-)-Epigallocatechin gallate | (-)-Epigallocatechi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 91 | n/a | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132853 (3-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined by inhibition of Urokinase-type plasminogen activator using primary assay | Bioorg Med Chem Lett 13: 3361-5 (2003) BindingDB Entry DOI: 10.7270/Q28W3CQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132856 (3-Hydroxy-4-[(4-{[2-((1R,2S,5R)-2-isopropyl-5-meth...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assay | Bioorg Med Chem Lett 13: 3361-5 (2003) BindingDB Entry DOI: 10.7270/Q28W3CQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127733 ((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-phenoxy-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127735 ((E)-3-[3-(4-Chloro-phenoxy)-5,6-bis-(4-phenoxy-ben...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127743 ((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127732 ((E)-3-[3-(4-Chloro-phenoxy)-5,6-bis-(4'-methoxy-bi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50104502 (8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity of compound against Plasminogen activator inhibitor-1 | Bioorg Med Chem Lett 11: 2589-92 (2001) BindingDB Entry DOI: 10.7270/Q20865TG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50111316 (8-[4-(3,6-Dioxo-5-{4-[(thiophene-2-carbonyl)-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay. | Bioorg Med Chem Lett 12: 1063-6 (2002) BindingDB Entry DOI: 10.7270/Q2W958HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127742 ((E)-3-[5,6-Bis-(biphenyl-3-ylmethoxy)-3-(4-chloro-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127726 ((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(3-fluoro-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50104502 (8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 260 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Tissue plasminogen activator generation in plasmin was evaluated by measuring the ability to inhibit Plasminogen activator inhibitor-1 through fibrin... | Bioorg Med Chem Lett 11: 2589-92 (2001) BindingDB Entry DOI: 10.7270/Q20865TG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127730 ((E)-3-[5,6-Bis-(4-benzyl-benzyloxy)-3-(4-chloro-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92487 (CDE-031 | US9120744, CDE-031) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 280 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50310309 (CHEMBL596879 | N-(3,4-dihydroxyphenylsulfonyl)-N-h...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 284 | n/a | n/a | n/a | n/a | n/a | n/a |
Eastern Michigan University Curated by ChEMBL | Assay Description Inhibition of human recombinant PAI1 assessed as rate of AMC release after 30 mins | Bioorg Med Chem Lett 20: 966-70 (2010) Article DOI: 10.1016/j.bmcl.2009.12.051 BindingDB Entry DOI: 10.7270/Q24M94P3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50111273 (6-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2-dihydr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 290 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay. | Bioorg Med Chem Lett 12: 1063-6 (2002) BindingDB Entry DOI: 10.7270/Q2W958HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50111280 (1-(4-Chloro-phenyl)-4-hydroxy-2-oxo-2,5-dihydro-1H...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay. | Bioorg Med Chem Lett 12: 1063-6 (2002) BindingDB Entry DOI: 10.7270/Q2W958HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50116764 (3-[1-Pyridin-2-yl-meth-(Z)-ylidene]-6-[1-[4-(3-pyr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration required against Plasminogen activator inhibitor 1. | Bioorg Med Chem Lett 12: 2367-70 (2002) BindingDB Entry DOI: 10.7270/Q2319V6B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50111298 (8-{4-[(7-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay. | Bioorg Med Chem Lett 12: 1063-6 (2002) BindingDB Entry DOI: 10.7270/Q2W958HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92480 (Epigallocatechin-3,5-Digallate, C) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 330 | n/a | n/a | n/a | n/a | 7.8 | 23 |
University of Michigan | Assay Description Enzyme activity assay using human and murine PAI-1. | J Biol Chem 285: 7892-902 (2010) Article DOI: 10.1074/jbc.M109.067967 BindingDB Entry DOI: 10.7270/Q2ZC81FC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM92482 (CDE-008 | US9120744, CDE-008) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 370 | n/a | n/a | n/a | n/a | 7.8 | 23 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY US Patent | Assay Description To determine the efficacy of various synthesized PAI-1 inhibitor compounds, a fluorometric plate assay was carried out to measure the half maximal in... | US Patent US9120744 (2015) BindingDB Entry DOI: 10.7270/Q2QF8RN8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132862 (4-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined using plasma clot lysis assay | Bioorg Med Chem Lett 13: 3361-5 (2003) BindingDB Entry DOI: 10.7270/Q28W3CQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132862 (4-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Inhibitory concentration against plasminogen activator inhibitor-1 (PAI-1) | Bioorg Med Chem Lett 14: 761-5 (2004) BindingDB Entry DOI: 10.7270/Q26T0M23 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50104505 (9-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity of compound against Plasminogen activator inhibitor-1 | Bioorg Med Chem Lett 11: 2589-92 (2001) BindingDB Entry DOI: 10.7270/Q20865TG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132853 (3-{3-[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined by inhibition of Urokinase-type plasminogen activator using primary assay | Bioorg Med Chem Lett 13: 3361-5 (2003) BindingDB Entry DOI: 10.7270/Q28W3CQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127741 ((E)-3-[5,6-Bis-benzyloxy-3-(4-chloro-phenoxy)-benz...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127727 ((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(4-chloro-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50139534 (2-[2-Methoxy-6-({3-trifluoromethyl-4-[4-(3-trifluo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Zydus Research Centre Curated by ChEMBL | Assay Description Inhibition of human Plasminogen activator inhibitor 1 using HRP substrate after 30 mins by chromogenic assay | Bioorg Med Chem Lett 21: 5701-6 (2011) Article DOI: 10.1016/j.bmcl.2011.08.031 BindingDB Entry DOI: 10.7270/Q2B858JV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132863 (2-{2-[(4-{[2-((1R,2S,5R)-2-Isopropyl-5-methyl-cycl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined by inhibition of Urokinase-type plasminogen activator using primary assay | Bioorg Med Chem Lett 13: 3361-5 (2003) BindingDB Entry DOI: 10.7270/Q28W3CQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50111292 (8-{4-[(6-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay. | Bioorg Med Chem Lett 12: 1063-6 (2002) BindingDB Entry DOI: 10.7270/Q2W958HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50139534 (2-[2-Methoxy-6-({3-trifluoromethyl-4-[4-(3-trifluo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Inhibitory concentration against plasminogen activator inhibitor-1 (PAI-1) | Bioorg Med Chem Lett 14: 761-5 (2004) BindingDB Entry DOI: 10.7270/Q26T0M23 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50111309 (8-{4-[(6-Benzo[b]thiophen-3-yl-4-hydroxy-2-oxo-1,2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by chromogenic assay. | Bioorg Med Chem Lett 12: 1063-6 (2002) BindingDB Entry DOI: 10.7270/Q2W958HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50111316 (8-[4-(3,6-Dioxo-5-{4-[(thiophene-2-carbonyl)-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity against human plasminogen activator inhibitor-1(PAI-1) evaluated by complex assay. | Bioorg Med Chem Lett 12: 1063-6 (2002) BindingDB Entry DOI: 10.7270/Q2W958HQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50104502 (8-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 510 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Tissue plasminogen activator generation in plasmin was evaluated by measuring the ability to inhibit Plasminogen activator inhibitor-1 through comple... | Bioorg Med Chem Lett 11: 2589-92 (2001) BindingDB Entry DOI: 10.7270/Q20865TG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50104511 (7-{4-[3,6-Dioxo-5-[1-{4-[(thiophene-2-carbonyl)-am...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 520 | n/a | n/a | n/a | n/a | n/a | n/a |
Xenova Limited Curated by ChEMBL | Assay Description Inhibitory activity of compound against Plasminogen activator inhibitor-1 | Bioorg Med Chem Lett 11: 2589-92 (2001) BindingDB Entry DOI: 10.7270/Q20865TG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50132874 (3-Hydroxy-4-({6-[2-((1R,2S,5R)-2-isopropyl-5-methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Berlex Biosciences Curated by ChEMBL | Assay Description Plasminogen Activator Inhibitor-1 (PAI-1) activity was determined by inhibition of Urokinase-type plasminogen activator using primary assay | Bioorg Med Chem Lett 13: 3361-5 (2003) BindingDB Entry DOI: 10.7270/Q28W3CQ5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Plasminogen activator inhibitor 1 (Homo sapiens (Human)) | BDBM50127739 ((E)-3-[5,6-Bis-(biphenyl-4-ylmethoxy)-3-(3,4-diflu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier Curated by ChEMBL | Assay Description Inhibitory activity against plasminogen activator inhibitor 1 (PAI-1) was evaluated by inhibition of tissue plasminogen activator/PAI-1 complex forma... | Bioorg Med Chem Lett 13: 1705-8 (2003) BindingDB Entry DOI: 10.7270/Q2J965SB | |||||||||||
More data for this Ligand-Target Pair |
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