Found 19 hits of ec50 for UniProtKB: P31751 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591174
(CHEMBL5192394)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(CCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:51:52:49.50.55:56,THB:51:50:56:57.52.53,53:52:49:55.54.56,53:54:49:57.51.52| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | 82 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50188913
(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN)Cc1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H19Cl2N5OS/c1-23-19-24-7-6-15(26-19)16-4-5-17(28-16)18(27)25-13(10-22)8-11-2-3-12(20)9-14(11)21/h2-7,9,13H,8,10,22H2,1H3,(H,25,27)(H,23,24,26)/t13-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Chiron Corporation
Curated by ChEMBL
| Assay Description
Activity against AKT-mediated PRAS40 T246P phosphorylation in human DOV13 cell line |
Bioorg Med Chem Lett 16: 4163-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C |
More data for this
Ligand-Target Pair | |
RAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50188913
(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN)Cc1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H19Cl2N5OS/c1-23-19-24-7-6-15(26-19)16-4-5-17(28-16)18(27)25-13(10-22)8-11-2-3-12(20)9-14(11)21/h2-7,9,13H,8,10,22H2,1H3,(H,25,27)(H,23,24,26)/t13-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a |
Chiron Corporation
Curated by ChEMBL
| Assay Description
Activity against AKT-mediated GSK3 S9P phosphorylation in human DOV13 cell line |
Bioorg Med Chem Lett 16: 4163-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C |
More data for this
Ligand-Target Pair | |
RAC-alpha/RAC-beta/RAC-gamma serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50188913
(CHEMBL213618 | N-((S)-1-amino-3-(2,4-dichloropheny...)Show SMILES CNc1nccc(n1)-c1ccc(s1)C(=O)N[C@H](CN)Cc1ccc(Cl)cc1Cl Show InChI InChI=1S/C19H19Cl2N5OS/c1-23-19-24-7-6-15(26-19)16-4-5-17(28-16)18(27)25-13(10-22)8-11-2-3-12(20)9-14(11)21/h2-7,9,13H,8,10,22H2,1H3,(H,25,27)(H,23,24,26)/t13-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | 370 | n/a | n/a | n/a | n/a |
Chiron Corporation
Curated by ChEMBL
| Assay Description
Activity against AKT-mediated S6RP S235/236P phosphorylation in human DOV13 cell line |
Bioorg Med Chem Lett 16: 4163-8 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591178
(CHEMBL5203483)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(CCOCCOCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:51:52:49.50.55:56,THB:51:50:56:57.52.53,53:52:49:55.54.56,53:54:49:57.52.51| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50131841
(CHEMBL3633143)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(C)CC1 Show InChI InChI=1S/C29H31N7O3/c1-5-26(37)31-20-7-6-8-22(16-20)36-27(38)15-19(2)23-18-30-29(33-28(23)36)32-24-10-9-21(17-25(24)39-4)35-13-11-34(3)12-14-35/h5-10,15-18H,1,11-14H2,2-4H3,(H,31,37)(H,30,32,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
PDB
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591180
(CHEMBL5200575)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(N)c3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:51:52:49.50.55:56,THB:51:50:56:57.52.53,53:52:49:55.54.56,53:54:49:57.52.51| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591181
(CHEMBL5172728)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(C)=O)c3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:54:55:52.53.58:59,THB:54:53:59:60.55.56,56:55:52:58.57.59,56:57:52:60.55.54| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591182
(CHEMBL5187719)Show SMILES CCC(=O)Nc1cccc(c1)-n1c2nc(Nc3ccc(cc3OC)N3CCN(CCCCCCCCCCCCNC(=O)CC45CC6CC(CC(C6)C4)C5)CC3)ncc2c(C)cc1=O |TLB:47:48:45.46.51:52,THB:47:46:52:53.48.49,49:48:45:51.50.52,49:50:45:53.48.47| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591183
(CHEMBL5170694)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C(C)C)c3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:56:57:54.55.60:61,THB:58:57:54:60.59.61,58:59:54:62.57.56,56:55:61:62.57.58| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591184
(CHEMBL5172973)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C4CC4)c3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:56:57:54.55.60:61,THB:58:57:54:60.59.61,58:59:54:62.57.56,56:55:61:62.57.58| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591185
(CHEMBL5176956)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C(C)(C)C)c3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:57:58:55.56.61:62,THB:59:58:55:61.60.62,59:60:55:63.58.57,57:56:62:63.58.59| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591186
(CHEMBL5204086)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3ccc(NC(=O)C=C)cc3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:55:56:53.54.59:60,THB:55:54:60:61.56.57,57:56:53:59.58.60,57:58:53:61.56.55| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591187
(CHEMBL5197756)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3ccc(NC(=O)C4CC4)cc3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:56:57:54.55.60:61,THB:58:57:54:60.59.61,58:59:54:62.57.56,56:55:61:62.57.58| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591177
(CHEMBL5172011)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(CCCCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:57:58:55.56.61:62,THB:59:58:55:61.60.62,59:60:55:63.58.57,57:56:62:63.58.59| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591176
(CHEMBL5183997)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(CCCCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:55:56:53.54.59:60,THB:55:54:60:61.56.57,57:56:53:59.58.60,57:58:53:61.55.56| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591175
(CHEMBL5178991)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(CCCCCCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:53:54:51.52.57:58,THB:53:52:58:59.54.55,55:54:51:57.56.58,55:56:51:59.53.54| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591173
(CHEMBL5171347)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(CCCCCCNC(=O)CC23CC4CC(CC(C4)C2)C3)CC1 |TLB:49:50:47.48.53:54,THB:49:48:54:55.50.51,51:50:47:53.52.54,51:52:47:55.49.50| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
RAC-beta serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50591179
(CHEMBL5181769)Show SMILES COc1cc(ccc1Nc1ncc2c(C)cc(=O)n(-c3cccc(NC(=O)C=C)c3)c2n1)N1CCN(CC1)C(=O)CCCCCCCCCCCNC(=O)CC12CC3CC(CC(C3)C1)C2 |TLB:58:59:56.57.62:63,THB:60:59:56:62.61.63,60:61:56:64.59.58,58:57:63:64.59.60| | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01246
BindingDB Entry DOI: 10.7270/Q2FX7FG8 |
More data for this
Ligand-Target Pair | |
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