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Compile Data Set for Download or QSAR

Found 46 hits of ic50 for UniProtKB: P05696   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98660
PNG
(US8497385, 18C)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccc(Br)cc1)=C\C(=O)OC |r,t:36|
Show InChI InChI=1S/C41H59BrO13/c1-5-6-7-8-9-10-35(45)54-39-28(22-36(46)49-4)21-32-24-33(26-43)52-37(47)23-30(44)16-19-50-34(27-11-13-29(42)14-12-27)25-31-17-20-51-38(53-31)15-18-40(2,3)41(39,48)55-32/h11-15,18,22,30-34,38-39,43-44,48H,5-10,16-17,19-21,23-26H2,1-4H3/b18-15+,28-22+/t30-,31+,32+,33-,34+,38+,39+,41-/m1/s1
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n/an/a 1.60n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98659
PNG
(US8497385, 19B.0)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccccc1)=C\C(=O)OC |r,t:36|
Show InChI InChI=1S/C41H60O13/c1-5-6-7-8-12-15-35(44)53-39-29(23-36(45)48-4)22-32-25-33(27-42)51-37(46)24-30(43)17-20-49-34(28-13-10-9-11-14-28)26-31-18-21-50-38(52-31)16-19-40(2,3)41(39,47)54-32/h9-11,13-14,16,19,23,30-34,38-39,42-43,47H,5-8,12,15,17-18,20-22,24-27H2,1-4H3/b19-16+,29-23+/t30-,31+,32+,33-,34+,38+,39+,41-/m1/s1
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n/an/a 2.30n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r|
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282632
PNG
(3-((3aR,10aR)-2-Methyl-2,3,3a,4,10,10a-hexahydro-1...)
Show SMILES CN1C[C@@H]2Cc3c(C4=C(C(=O)NC4=O)c4cn(C)c5ccccc45)c4ccccc4n3C[C@H]2C1 |r,t:7|
Show InChI InChI=1S/C28H26N4O2/c1-30-12-16-11-23-24(19-8-4-6-10-22(19)32(23)14-17(16)13-30)26-25(27(33)29-28(26)34)20-15-31(2)21-9-5-3-7-18(20)21/h3-10,15-17H,11-14H2,1-2H3,(H,29,33,34)/t16-,17+/m0/s1
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n/an/a 2.85n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C alpha


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98661
PNG
(US8497385, 19B.1)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccc(cc1)-c1ccccc1)=C\C(=O)OC |r,t:36|
Show InChI InChI=1S/C47H64O13/c1-5-6-7-8-12-15-41(50)59-45-35(27-42(51)54-4)26-38-29-39(31-48)57-43(52)28-36(49)21-24-55-40(34-18-16-33(17-19-34)32-13-10-9-11-14-32)30-37-22-25-56-44(58-37)20-23-46(2,3)47(45,53)60-38/h9-11,13-14,16-20,23,27,36-40,44-45,48-49,53H,5-8,12,15,21-22,24-26,28-31H2,1-4H3/b23-20+,35-27+/t36-,37+,38+,39-,40+,44+,45+,47-/m1/s1
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n/an/a 3.10n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98662
PNG
(US8497385, 19B.2)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccc(CCCOCCOCC)cc1)=C\C(=O)OC |r,t:36|
Show InChI InChI=1S/C48H74O15/c1-6-8-9-10-11-14-42(51)62-46-36(29-43(52)55-5)28-39-31-40(33-49)60-44(53)30-37(50)20-24-58-41(35-17-15-34(16-18-35)13-12-23-57-27-26-56-7-2)32-38-21-25-59-45(61-38)19-22-47(3,4)48(46,54)63-39/h15-19,22,29,37-41,45-46,49-50,54H,6-14,20-21,23-28,30-33H2,1-5H3/b22-19+,36-29+/t37-,38+,39+,40-,41+,45+,46+,48-/m1/s1
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n/an/a 3.80n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98663
PNG
(US8497385, 19B.3)
Show SMILES CCCCCCCC(=O)O[C@H]1\C(C[C@H]2C[C@H](CO)OC(=O)C[C@H](O)CCO[C@@H](C[C@@H]3CCO[C@@H](O3)\C=C\C(C)(C)[C@]1(O)O2)c1ccc(\C=C\CCCCCC)cc1)=C\C(=O)OC |r,t:36|
Show InChI InChI=1S/C49H74O13/c1-6-8-10-12-14-15-17-35-19-21-36(22-20-35)42-33-39-25-28-58-46(60-39)23-26-48(3,4)49(55)47(61-43(52)18-16-13-11-9-7-2)37(30-44(53)56-5)29-40(62-49)32-41(34-50)59-45(54)31-38(51)24-27-57-42/h15,17,19-23,26,30,38-42,46-47,50-51,55H,6-14,16,18,24-25,27-29,31-34H2,1-5H3/b17-15+,26-23+,37-30+/t38-,39+,40+,41-,42+,46+,47+,49-/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282633
PNG
((S)-3-(8-((dimethylamino)methyl)-6,7,8,9-tetrahydr...)
Show SMILES CN(C)C[C@H]1CCn2c(C1)c(C1=C(C(=O)NC1=O)c1cn(C)c3ccccc13)c1ccccc21 |t:12|
Show InChI InChI=1S/C28H28N4O2/c1-30(2)15-17-12-13-32-22-11-7-5-9-19(22)24(23(32)14-17)26-25(27(33)29-28(26)34)20-16-31(3)21-10-6-4-8-18(20)21/h4-11,16-17H,12-15H2,1-3H3,(H,29,33,34)/t17-/m0/s1
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n/an/a 8.80n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C alpha


Bioorg Med Chem Lett 4: 1303-1308 (1994)


Article DOI: 10.1016/S0960-894X(01)80349-8
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM98664
PNG
(US8497385, 19B.4)
Show SMILES CCCCCCCCCCCC\C=C\c1ccc(cc1)[C@@H]1C[C@@H]2CCO[C@@H](O2)\C=C\C(C)(C)[C@]2(O)O[C@@H](C\C(=C/C(=O)OC)[C@@H]2OC(=O)CCCCCCC)C[C@H](CO)OC(=O)C[C@H](O)CCO1 |r,t:30|
Show InChI InChI=1S/C55H86O13/c1-6-8-10-12-13-14-15-16-17-18-20-21-23-41-25-27-42(28-26-41)48-39-45-31-34-64-52(66-45)29-32-54(3,4)55(61)53(67-49(58)24-22-19-11-9-7-2)43(36-50(59)62-5)35-46(68-55)38-47(40-56)65-51(60)37-44(57)30-33-63-48/h21,23,25-29,32,36,44-48,52-53,56-57,61H,6-20,22,24,30-31,33-35,37-40H2,1-5H3/b23-21+,32-29+,43-36+/t44-,45+,46+,47-,48+,52+,53+,55-/m1/s1
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n/an/a 30n/an/an/an/an/an/a



The Board of Trustees of the Leland Stanford Junior University

US Patent


Assay Description
Binding affinity of protein kinase C (PKC).


US Patent US8497385 (2013)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50136008
PNG
(12-(3-hydroxypropyl)-9-isopropoxymethyl-6,7,12,13-...)
Show SMILES CC(C)OCc1ccc2n(CCCO)c3c4Cc5ccccc5-c4c4C(=O)NCc4c3c2c1
Show InChI InChI=1S/C28H28N2O3/c1-16(2)33-15-17-8-9-23-20(12-17)25-22-14-29-28(32)26(22)24-19-7-4-3-6-18(19)13-21(24)27(25)30(23)10-5-11-31/h3-4,6-9,12,16,31H,5,10-11,13-15H2,1-2H3,(H,29,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Cephalon, Inc

Curated by ChEMBL


Assay Description
Inhibition of rat brain Protein kinase C


J Med Chem 46: 5375-88 (2003)


Article DOI: 10.1021/jm0301641
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92971
PNG
(Amphiphile, VI)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)OC(C[NH+](C)C)C[N+](C)(C)C |t:14|
Show InChI InChI=1S/C36H65N2O2/c1-25(2)12-11-13-26(3)31-16-17-32-30-15-14-28-22-27(18-20-35(28,4)33(30)19-21-36(31,32)5)34(39)40-29(23-37(6)7)24-38(8,9)10/h14,25-27,29-33H,11-13,15-24H2,1-10H3/q+1/p+1
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n/an/a 1.10E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92969
PNG
(Amphiphile, IV)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)NCC[N+](C)(C)C |t:14|
Show InChI InChI=1S/C32H60N2O/c1-23(2)10-9-11-24(3)27-16-21-36-29-13-12-26-22-25(30(35)33-19-20-34(6,7)8)14-17-31(26,4)28(29)15-18-32(27,36)5/h12,23-25,27-29,34H,9-11,13-22H2,1-8H3,(H,33,35)/q+1
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n/an/a 1.20E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92976
PNG
(Amphiphile, XI)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)OC(C[NH+](C)C)C[N+](C)(C)C |t:14|
Show InChI InChI=1S/C36H65N4O5/c1-25(2)11-10-12-31(37)29-17-20-39-34-30(16-19-36(29,39)4)35(3)18-15-27(21-26(35)24-43-34)44-32(41)13-14-33(42)45-28(22-38(5)6)23-40(7,8)9/h24-25,27-31,34H,10-23,37H2,1-9H3/q+1/p+1
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n/an/a 1.50E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus (Rat))
BDBM50009723
PNG
(2,6-Diamino-hexanoic acid (1-tridecanoyl-piperidin...)
Show SMILES CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H50N4O2/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26/h22-23H,2-21,26-27H2,1H3,(H,28,31)/t22?,23-/m0/s1
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n/an/a 1.90E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Effect of PMA on inhibition of PKC alpha (Protein kinase C)


J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92978
PNG
(Amphiphile, XIII)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)OCC[NH+](C)CC[N+](C)(C)C |t:14|
Show InChI InChI=1S/C36H65N4O5/c1-26(2)10-9-11-31(37)29-16-19-39-34-30(15-18-36(29,39)4)35(3)17-14-28(24-27(35)25-44-34)45-33(42)13-12-32(41)43-23-21-38(5)20-22-40(6,7)8/h25-26,28-31,34H,9-24,37H2,1-8H3/q+1/p+1
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n/an/a 2.00E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50009723
PNG
(2,6-Diamino-hexanoic acid (1-tridecanoyl-piperidin...)
Show SMILES CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H50N4O2/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26/h22-23H,2-21,26-27H2,1H3,(H,28,31)/t22?,23-/m0/s1
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n/an/a 2.00E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229926
PNG
(CHEMBL319584)
Show SMILES [H][C@](N)(CCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
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n/an/a 2.30E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Rattus norvegicus (Rat))
BDBM50009723
PNG
(2,6-Diamino-hexanoic acid (1-tridecanoyl-piperidin...)
Show SMILES CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H50N4O2/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26/h22-23H,2-21,26-27H2,1H3,(H,28,31)/t22?,23-/m0/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92979
PNG
(Amphiphile, XVI)
Show SMILES CCCCCCCCCCCCCCCCCCCCCC(=O)OC(C[NH+](C)C)C[N+](C)(C)C
Show InChI InChI=1S/C30H63N2O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-30(33)34-29(27-31(2)3)28-32(4,5)6/h29H,7-28H2,1-6H3/q+1/p+1
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n/an/a 2.60E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229931
PNG
(CHEMBL100713)
Show SMILES [H][C@@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
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n/an/a 3.40E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229920
PNG
(CHEMBL101142)
Show SMILES [H][C@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCCCCCCC
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n/an/a 3.60E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229930
PNG
(CHEMBL97997)
Show SMILES CCCCCCCCCCCCCC(=O)N1CCCCC1CN
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n/an/a 3.60E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229928
PNG
(CHEMBL97998)
Show SMILES [H][C@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCCCC
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n/an/a 3.80E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92980
PNG
(Amphiphile, XVII)
Show SMILES CCCCCCCCCCCCCCCCCCCCCCCC(=O)OC(C[NH+](C)C)C[N+](C)(C)C
Show InChI InChI=1S/C32H67N2O2/c1-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-25-26-27-28-32(35)36-31(29-33(2)3)30-34(4,5)6/h31H,7-30H2,1-6H3/q+1/p+1
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n/an/a 4.00E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229917
PNG
(CHEMBL100289)
Show SMILES [H][C@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCCCCC
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n/an/a 4.50E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229921
PNG
(CHEMBL99372)
Show SMILES [H][C@](N)(CO)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
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n/an/a 4.50E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229932
PNG
(CHEMBL97921)
Show SMILES [H][C@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCCCCCC
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n/an/a 4.60E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229922
PNG
(CHEMBL98968)
Show SMILES [H][C@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCCC
PDB

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n/an/a 4.80E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Inhibition of [3H]-phorbol dibutyrate binding to Protein kinase C alpha


J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229924
PNG
(CHEMBL99156)
Show SMILES CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)CN
PDB

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n/an/a 5.10E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229929
PNG
(CHEMBL98337)
Show SMILES [H][C@@](C)(N)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
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n/an/a 5.20E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM83205
PNG
((E,2S,3R)-2-amino-4-octadecene-1,3-diol | (E,2S,3R...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)CO
Show InChI InChI=1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
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n/an/a 5.70E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92974
PNG
(Amphiphile, IX)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)NCC[N+](C)(C)C |t:14|
Show InChI InChI=1S/C33H58N4O4/c1-23(2)9-8-10-28(34)26-15-19-36-31-27(14-17-33(26,36)4)32(3)16-13-25(21-24(32)22-40-31)41-30(39)12-11-29(38)35-18-20-37(5,6)7/h22-23,25-28,31H,8-21,34H2,1-7H3/p+1
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n/an/a 5.90E+4n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229927
PNG
(CHEMBL319666)
Show SMILES [H][C@](N)(Cc1ncc[nH]1)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
PDB

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n/an/a 6.00E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229916
PNG
(CHEMBL322371)
Show SMILES [H][C@]([#7])([#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])[#6](=O)-[#7]-[#6]-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#7]-1-[#6](=O)-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]-[#6]
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n/an/a 7.20E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229933
PNG
(CHEMBL98542)
Show SMILES [H][C@](N)(CCC(N)=O)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
PDB

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n/an/a 7.20E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229915
PNG
(CHEMBL101358)
Show SMILES [H][C@](N)(CCC(=O)OCc1ccccc1)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
PDB

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n/an/a 9.20E+4n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229925
PNG
(CHEMBL433408)
Show SMILES [H][C@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCC
PDB

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n/an/a 1.02E+5n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229923
PNG
(CHEMBL317827)
Show SMILES [H][C@](N)(CC(C)C)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
PDB

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n/an/a 1.54E+5n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229919
PNG
(CHEMBL101538)
Show SMILES [H][C@](N)(CCSC)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCCCC
PDB

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n/an/a 1.59E+5n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92977
PNG
(Amphiphile, XII)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)OCC[NH+](C)CC[NH+](C)C |t:14|
Show InChI InChI=1S/C35H62N4O5/c1-25(2)9-8-10-30(36)28-15-18-39-33-29(14-17-35(28,39)4)34(3)16-13-27(23-26(34)24-43-33)44-32(41)12-11-31(40)42-22-21-38(7)20-19-37(5)6/h24-25,27-30,33H,8-23,36H2,1-7H3/p+2
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n/an/a 1.64E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92973
PNG
(Amphiphile, VIII)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)NCC[NH+](C)C |t:14|
Show InChI InChI=1S/C32H56N4O4/c1-22(2)8-7-9-27(33)25-14-18-36-30-26(13-16-32(25,36)4)31(3)15-12-24(20-23(31)21-39-30)40-29(38)11-10-28(37)34-17-19-35(5)6/h21-22,24-27,30H,7-20,33H2,1-6H3,(H,34,37)/p+1
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n/an/a 1.91E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92972
PNG
(Amphiphile, VII)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)NCC[NH3+] |t:14|
Show InChI InChI=1S/C30H52N2O/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-23-19-22(28(33)32-18-17-31)13-15-29(23,4)27(24)14-16-30(25,26)5/h9,20-22,24-27H,6-8,10-19,31H2,1-5H3,(H,32,33)/p+1
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n/an/a 2.46E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92968
PNG
(Amphiphile, III)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)NCC[NH+](C)C |t:14|
Show InChI InChI=1S/C32H56N2O/c1-22(2)9-8-10-23(3)27-13-14-28-26-12-11-25-21-24(30(35)33-19-20-34(6)7)15-17-31(25,4)29(26)16-18-32(27,28)5/h11,22-24,26-29H,8-10,12-21H2,1-7H3,(H,33,35)/p+1
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n/an/a 2.58E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C, PKC; classical


(Rattus norvegicus (Rat)-Rattus norvegicus (rat))
BDBM50229918
PNG
(CHEMBL101731)
Show SMILES [H][C@](N)(CCCCN)C(=O)NCC1CCCCN1C(=O)CCCCCCCCCC
PDB

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n/an/a 2.99E+5n/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL




J Med Chem 34: 2928-31 (1991)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92975
PNG
(Amphiphile, X)
Show SMILES CC(C)CCCC(N)C1CCN2C3OC=C4CC(CCC4(C)C3CCC12C)OC(=O)CCC(=O)OC(C[NH+](C)C)C[NH+](C)C |t:14|
Show InChI InChI=1S/C35H62N4O5/c1-24(2)10-9-11-30(36)28-16-19-39-33-29(15-18-35(28,39)4)34(3)17-14-26(20-25(34)23-42-33)43-31(40)12-13-32(41)44-27(21-37(5)6)22-38(7)8/h23-24,26-30,33H,9-22,36H2,1-8H3/p+2
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n/an/a 4.08E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM92970
PNG
(Amphiphile, V)
Show SMILES CC(C)CCCC(C)C1CCC2C3CC=C4CC(CCC4(C)C3CCC12C)C(=O)OC(C[NH+](C)C)C[NH+](C)C |t:14|
Show InChI InChI=1S/C35H62N2O2/c1-24(2)11-10-12-25(3)30-15-16-31-29-14-13-27-21-26(33(38)39-28(22-36(6)7)23-37(8)9)17-19-34(27,4)32(29)18-20-35(30,31)5/h13,24-26,28-32H,10-12,14-23H2,1-9H3/p+2
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n/an/a 6.43E+5n/an/an/an/a7.530



McMaster University



Assay Description
The triton X-100 assay previously described by Bell and co-workers were used to measure enzyme activity.


Biochemistry 31: 9025-30 (1992)

More data for this
Ligand-Target Pair