Compile Data Set for Download or QSAR

Found 28 hits of ic50 for UniProtKB: P12497   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM2483 ((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...) Show SMILES FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1 |r| Show InChI InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	8.1	37
University of Siena					Assay Description RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Cc1nc2ccc(Br)cc2c(-c2ccc(Cl)cc2)c1C(OC(C)(C)C)C(O)=O Show InChI InChI=1S/C22H21BrClNO3/c1-12-18(20(21(26)27)28-22(2,3)4)19(13-5-8-15(24)9-6-13)16-11-14(23)7-10-17(16)25-12/h5-11,20H,1-4H3,(H,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM188497 (2-(6-bromo-4-(4-chlorophenyl)-2-methylquinolin-3-y...) Show SMILES Cc1nc2ccc(Br)cc2c(-c2ccc(Cl)cc2)c1C(OC(C)(C)C)C(O)=O Show InChI InChI=1S/C22H21BrClNO3/c1-12-18(20(21(26)27)28-22(2,3)4)19(13-5-8-15(24)9-6-13)16-11-14(23)7-10-17(16)25-12/h5-11,20H,1-4H3,(H,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM93213 (Benzimidazole Inhibitor, 6) Show SMILES OC(=O)c1ccc(cc1)-c1ccc2n(CCCNC3CCCCC3)c(nc2c1)-c1c[nH]nc1-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C32H31Cl2N5O2/c33-26-13-11-23(17-27(26)34)30-25(19-36-38-30)31-37-28-18-22(20-7-9-21(10-8-20)32(40)41)12-14-29(28)39(31)16-4-15-35-24-5-2-1-3-6-24/h7-14,17-19,24,35H,1-6,15-16H2,(H,36,38)(H,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	500	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim (Canada) Ltd					Assay Description In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly.				ACS Chem Biol 8: 1074-82 (2013) Article DOI: 10.1021/cb400075f BindingDB Entry DOI: 10.7270/Q2W094JX
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM50103642 (4-(6-amino-5-bromo-2-(4-cyanophenylamino)pyrimidin...) Show SMILES Cc1cc(cc(C)c1Oc1nc(Nc2ccc(cc2)C#N)nc(N)c1Br)C#N Show InChI InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	37
Shandong University					Assay Description A reverse transcriptase (RT) assay kit produced by Roche was selected for the RT inhibition assay. All the reagents for performing the RT reaction ...				Chem Biol Drug Des 88: 241-53 (2016) Article DOI: 10.1111/cbdd.12751 BindingDB Entry DOI: 10.7270/Q2X065VJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM50011132 (ALLINI-1 | CHEMBL3259891) Show SMILES COC(C(O)=O)c1c(C)nc2ccc(Br)cc2c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H15BrClNO3/c1-10-16(18(25-2)19(23)24)17(11-3-6-13(21)7-4-11)14-9-12(20)5-8-15(14)22-10/h3-9,18H,1-2H3,(H,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM93212 (Benzimidazole Inhibitor, 5) Show SMILES OC(=O)c1ccc(cc1)-c1ccc2n(CCCN3CCCCC3)c(nc2c1)-c1c[nH]nc1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C32H30F3N5O2/c33-32(34,35)25-12-9-22(10-13-25)29-26(20-36-38-29)30-37-27-19-24(21-5-7-23(8-6-21)31(41)42)11-14-28(27)40(30)18-4-17-39-15-2-1-3-16-39/h5-14,19-20H,1-4,15-18H2,(H,36,38)(H,41,42)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	670	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim (Canada) Ltd					Assay Description In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly.				ACS Chem Biol 8: 1074-82 (2013) Article DOI: 10.1021/cb400075f BindingDB Entry DOI: 10.7270/Q2W094JX
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM1434 (11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...) Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12 Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	n/a	37
Shandong University					Assay Description A reverse transcriptase (RT) assay kit produced by Roche was selected for the RT inhibition assay. All the reagents for performing the RT reaction ...				Chem Biol Drug Des 88: 241-53 (2016) Article DOI: 10.1111/cbdd.12751 BindingDB Entry DOI: 10.7270/Q2X065VJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM93214 (Benzodiazepine Inhibitor, 7) Show SMILES COCCN=CC1C(=O)N(C)c2ccc(cc2N(c2ccccc2)C1=O)C(F)(F)F |w:5.5| Show InChI InChI=1S/C21H20F3N3O3/c1-26-17-9-8-14(21(22,23)24)12-18(17)27(15-6-4-3-5-7-15)20(29)16(19(26)28)13-25-10-11-30-2/h3-9,12-13,16H,10-11H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim (Canada) Ltd					Assay Description In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly.				ACS Chem Biol 8: 1074-82 (2013) Article DOI: 10.1021/cb400075f BindingDB Entry DOI: 10.7270/Q2W094JX
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM50011132 (ALLINI-1 | CHEMBL3259891) Show SMILES COC(C(O)=O)c1c(C)nc2ccc(Br)cc2c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C19H15BrClNO3/c1-10-16(18(25-2)19(23)24)17(11-3-6-13(21)7-4-11)14-9-12(20)5-8-15(14)22-10/h3-9,18H,1-2H3,(H,23,24)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	910	n/a	n/a	n/a	n/a	n/a	n/a
The Ohio State University					Assay Description A recently reported time-resolved fluorescence assay [J. Biol. Chem. 287: 21189-21203] was used to quantify IN 3'-processing and strand transfer ...				J Biol Chem 288: 15813-20 (2013) Article DOI: 10.1074/jbc.M112.443390 BindingDB Entry DOI: 10.7270/Q23R0RP6
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM93211 (Benzimidazole Inhibitor, 4) Show SMILES OC(=O)c1ccc(cc1)-c1ccc2n(CCCn3ccnc3)c(nc2c1)-c1c[nH]nc1-c1cccc(Cl)c1 Show InChI InChI=1S/C29H23ClN6O2/c30-23-4-1-3-22(15-23)27-24(17-32-34-27)28-33-25-16-21(19-5-7-20(8-6-19)29(37)38)9-10-26(25)36(28)13-2-12-35-14-11-31-18-35/h1,3-11,14-18H,2,12-13H2,(H,32,34)(H,37,38)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim (Canada) Ltd					Assay Description In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly.				ACS Chem Biol 8: 1074-82 (2013) Article DOI: 10.1021/cb400075f BindingDB Entry DOI: 10.7270/Q2W094JX
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM93209 (Benzimidazole Inhibitor, 2) Show SMILES CN(C)CCCn1c(nc2cc(ccc12)-c1ccc(cc1)C(O)=O)-c1c[nH]nc1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C29H26F3N5O2/c1-36(2)14-3-15-37-25-13-10-21(18-4-6-20(7-5-18)28(38)39)16-24(25)34-27(37)23-17-33-35-26(23)19-8-11-22(12-9-19)29(30,31)32/h4-13,16-17H,3,14-15H2,1-2H3,(H,33,35)(H,38,39)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	4.30E+3	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim (Canada) Ltd					Assay Description In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly.				ACS Chem Biol 8: 1074-82 (2013) Article DOI: 10.1021/cb400075f BindingDB Entry DOI: 10.7270/Q2W094JX
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM93210 (Benzimidazole Inhibitor, 3) Show SMILES OC(=O)c1ccc(cc1)-c1ccc2n(CCCn3ccnc3)c(nc2c1)-c1c[nH]nc1-c1ccc(cc1)C(F)(F)F Show InChI InChI=1S/C30H23F3N6O2/c31-30(32,33)23-9-6-20(7-10-23)27-24(17-35-37-27)28-36-25-16-22(19-2-4-21(5-3-19)29(40)41)8-11-26(25)39(28)14-1-13-38-15-12-34-18-38/h2-12,15-18H,1,13-14H2,(H,35,37)(H,40,41)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	8.00E+3	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim (Canada) Ltd					Assay Description In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly.				ACS Chem Biol 8: 1074-82 (2013) Article DOI: 10.1021/cb400075f BindingDB Entry DOI: 10.7270/Q2W094JX
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189356 (N-(2-Bromo-4-sulfonamido-phenyl)-2-(1-(4-cycloprop...) Show SMILES NS(=O)(=O)c1ccc(NC(=O)CSc2nc3ncccc3n2-c2ccc(C3CC3)c3ccccc23)c(Br)c1 |(10,-.03,;8.67,.74,;9.44,2.07,;7.9,-.59,;7.34,1.51,;6,.74,;4.67,1.51,;4.67,3.05,;3.34,3.82,;2,3.05,;2,1.51,;.67,3.82,;-.67,3.05,;-2,3.82,;-2.48,5.28,;-4.02,5.28,;-5.05,6.43,;-6.55,6.11,;-7.03,4.64,;-6,3.5,;-4.49,3.82,;-3.25,2.91,;-3.25,1.37,;-4.58,.6,;-4.58,-.94,;-3.25,-1.71,;-3.25,-3.25,;-4.02,-4.58,;-2.48,-4.58,;-1.91,-.94,;-.58,-1.71,;.76,-.94,;.76,.6,;-.58,1.37,;-1.91,.6,;6,3.82,;6,5.36,;7.34,3.05,)| Show InChI InChI=1S/C27H22BrN5O3S2/c28-21-14-17(38(29,35)36)9-11-22(21)31-25(34)15-37-27-32-26-24(6-3-13-30-26)33(27)23-12-10-18(16-7-8-16)19-4-1-2-5-20(19)23/h1-6,9-14,16H,7-8,15H2,(H,31,34)(H2,29,35,36)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	37
Shandong University					Assay Description A reverse transcriptase (RT) assay kit produced by Roche was selected for the RT inhibition assay. All the reagents for performing the RT reaction ...				Chem Biol Drug Des 88: 241-53 (2016) Article DOI: 10.1111/cbdd.12751 BindingDB Entry DOI: 10.7270/Q2X065VJ
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM93208 (Benzimidazole Inhibitor, 1) Show SMILES CN(C)CCCn1c(nc2cc(ccc12)-c1ccc(cc1)C(O)=O)-c1c[nH]nc1-c1ccccc1 Show InChI InChI=1S/C28H27N5O2/c1-32(2)15-6-16-33-25-14-13-22(19-9-11-21(12-10-19)28(34)35)17-24(25)30-27(33)23-18-29-31-26(23)20-7-4-3-5-8-20/h3-5,7-14,17-18H,6,15-16H2,1-2H3,(H,29,31)(H,34,35)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	4.30E+4	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim (Canada) Ltd					Assay Description In vitro capsid assembly assay (CAA) was used in a HTS to identify potential inhibitors of capsid assembly.				ACS Chem Biol 8: 1074-82 (2013) Article DOI: 10.1021/cb400075f BindingDB Entry DOI: 10.7270/Q2W094JX
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189342 (RDS1759) Show SMILES CCOC(=O)C(=O)CC(=O)\C=C\c1cccn1Cc1ccccc1Cl Show InChI InChI=1S/C19H18ClNO4/c1-2-25-19(24)18(23)12-16(22)10-9-15-7-5-11-21(15)13-14-6-3-4-8-17(14)20/h3-11H,2,12-13H2,1H3/b10-9+	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	7.8	37
University of Siena					Assay Description HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189337 (STOCK5S-18255 (2)) Show SMILES CCCCCn1c(=O)n(C)c2nc3N(CCCn3c2c1=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H29N5O3/c1-3-4-8-16-31-24(32)22-23(28(2)26(31)33)27-25-29(17-9-18-30(22)25)19-12-14-21(15-13-19)34-20-10-6-5-7-11-20/h5-7,10-15H,3-4,8-9,16-18H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	7.8	37
University of Siena					Assay Description HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189341 (STOCK4S-60534 (6)) Show SMILES CCOc1ccc(cc1)N1CC(O)Cn2c1nc1n(C)c(=O)n(CC(=O)OCc3ccccc3)c(=O)c21 Show InChI InChI=1S/C26H27N5O6/c1-3-36-20-11-9-18(10-12-20)29-13-19(32)14-30-22-23(27-25(29)30)28(2)26(35)31(24(22)34)15-21(33)37-16-17-7-5-4-6-8-17/h4-12,19,32H,3,13-16H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.85E+4	n/a	n/a	n/a	n/a	8.1	37
University of Siena					Assay Description RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189341 (STOCK4S-60534 (6)) Show SMILES CCOc1ccc(cc1)N1CC(O)Cn2c1nc1n(C)c(=O)n(CC(=O)OCc3ccccc3)c(=O)c21 Show InChI InChI=1S/C26H27N5O6/c1-3-36-20-11-9-18(10-12-20)29-13-19(32)14-30-22-23(27-25(29)30)28(2)26(35)31(24(22)34)15-21(33)37-16-17-7-5-4-6-8-17/h4-12,19,32H,3,13-16H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.30E+4	n/a	n/a	n/a	n/a	7.8	37
University of Siena					Assay Description HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189337 (STOCK5S-18255 (2)) Show SMILES CCCCCn1c(=O)n(C)c2nc3N(CCCn3c2c1=O)c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H29N5O3/c1-3-4-8-16-31-24(32)22-23(28(2)26(31)33)27-25-29(17-9-18-30(22)25)19-12-14-21(15-13-19)34-20-10-6-5-7-11-20/h5-7,10-15H,3-4,8-9,16-18H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.90E+4	n/a	n/a	n/a	n/a	8.1	37
University of Siena					Assay Description RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM60932 (STOCK4S-37006 (4)) Show SMILES CCCCCn1c(=O)n(C)c2nc3N(CC(C)Cn3c2c1=O)c1ccc(OC)cc1 Show InChI InChI=1S/C22H29N5O3/c1-5-6-7-12-25-20(28)18-19(24(3)22(25)29)23-21-26(13-15(2)14-27(18)21)16-8-10-17(30-4)11-9-16/h8-11,15H,5-7,12-14H2,1-4H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70E+4	n/a	n/a	n/a	n/a	7.8	37
University of Siena					Assay Description HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189340 (STOCK5S-55040 (5)) Show SMILES CCOc1ccc(cc1)N1CC(O)Cn2c1nc1n(C)c(=O)n(CC(N)=O)c(=O)c21 Show InChI InChI=1S/C19H22N6O5/c1-3-30-13-6-4-11(5-7-13)23-8-12(26)9-24-15-16(21-18(23)24)22(2)19(29)25(17(15)28)10-14(20)27/h4-7,12,26H,3,8-10H2,1-2H3,(H2,20,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	8.1	37
University of Siena					Assay Description RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189340 (STOCK5S-55040 (5)) Show SMILES CCOc1ccc(cc1)N1CC(O)Cn2c1nc1n(C)c(=O)n(CC(N)=O)c(=O)c21 Show InChI InChI=1S/C19H22N6O5/c1-3-30-13-6-4-11(5-7-13)23-8-12(26)9-24-15-16(21-18(23)24)22(2)19(29)25(17(15)28)10-14(20)27/h4-7,12,26H,3,8-10H2,1-2H3,(H2,20,27)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.8	37
University of Siena					Assay Description HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189336 (MAS0 (1)) Show SMILES Cn1c2nc3N(CC(O)Cn3c2c(=O)n(C)c1=O)c1ccc(O)cc1 Show InChI InChI=1S/C16H17N5O4/c1-18-13-12(14(24)19(2)16(18)25)21-8-11(23)7-20(15(21)17-13)9-3-5-10(22)6-4-9/h3-6,11,22-23H,7-8H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	7.8	37
University of Siena					Assay Description HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189336 (MAS0 (1)) Show SMILES Cn1c2nc3N(CC(O)Cn3c2c(=O)n(C)c1=O)c1ccc(O)cc1 Show InChI InChI=1S/C16H17N5O4/c1-18-13-12(14(24)19(2)16(18)25)21-8-11(23)7-20(15(21)17-13)9-3-5-10(22)6-4-9/h3-6,11,22-23H,7-8H2,1-2H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	8.1	37
University of Siena					Assay Description RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM60932 (STOCK4S-37006 (4)) Show SMILES CCCCCn1c(=O)n(C)c2nc3N(CC(C)Cn3c2c1=O)c1ccc(OC)cc1 Show InChI InChI=1S/C22H29N5O3/c1-5-6-7-12-25-20(28)18-19(24(3)22(25)29)23-21-26(13-15(2)14-27(18)21)16-8-10-17(30-4)11-9-16/h8-11,15H,5-7,12-14H2,1-4H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	8.1	37
University of Siena					Assay Description RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189338 (STOCK2S-18057 (3)) Show SMILES CCc1ccc(cc1)N1CC(O)Cn2c1nc1n(C)c(=O)n(C)c(=O)c21 Show InChI InChI=1S/C18H21N5O3/c1-4-11-5-7-12(8-6-11)22-9-13(24)10-23-14-15(19-17(22)23)20(2)18(26)21(3)16(14)25/h5-8,13,24H,4,9-10H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	7.8	37
University of Siena					Assay Description HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair
Gag-Pol polyprotein (Human immunodeficiency virus type 1 group M subtyp...)	BDBM189338 (STOCK2S-18057 (3)) Show SMILES CCc1ccc(cc1)N1CC(O)Cn2c1nc1n(C)c(=O)n(C)c(=O)c21 Show InChI InChI=1S/C18H21N5O3/c1-4-11-5-7-12(8-6-11)22-9-13(24)10-23-14-15(19-17(22)23)20(2)18(26)21(3)16(14)25/h5-8,13,24H,4,9-10H2,1-3H3	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	8.1	37
University of Siena					Assay Description RNA-dependent DNA polymerase (RDDP) activity was measured as described[J. Microbiol. 2015, 53:288-293] in Tris·HCl buffer (25 mL, 60 mm, pH 8.1) con...				Chembiochem 17: 683-8 (2016) Article DOI: 10.1002/cbic.201500668 BindingDB Entry DOI: 10.7270/Q25H7F28
					More data for this Ligand-Target Pair