Found 515 hits of ic50 for UniProtKB: O96017 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163251
(2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(O)cc2)cc1 Show InChI InChI=1S/C20H15N3O2S/c21-19(25)13-3-10-17-18(11-13)23-20(22-17)12-1-6-15(7-2-12)26-16-8-4-14(24)5-9-16/h1-11,24H,(H2,21,25)(H,22,23) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant Chk2 |
Bioorg Med Chem Lett 17: 6467-71 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.098 BindingDB Entry DOI: 10.7270/Q2KP81XB |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM601450
(US11634424, Compound 16)Show SMILES COc1cccc(F)c1-c1cc(Nc2cnc3c(F)cn(C4CCNCC4)c3n2)n[nH]1 | PDB MMDB
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| | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T43Z1M |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163251
(2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(O)cc2)cc1 Show InChI InChI=1S/C20H15N3O2S/c21-19(25)13-3-10-17-18(11-13)23-20(22-17)12-1-6-15(7-2-12)26-16-8-4-14(24)5-9-16/h1-11,24H,(H2,21,25)(H,22,23) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50335684
(4-FLUORO-2-(4-{[(3S,4R)-4-(1-HYDROXY-1-METHYLETHYL...)Show SMILES COc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O |r| Show InChI InChI=1S/C23H27FN4O4/c1-23(2,30)15-10-25-11-17(15)27-21-13-8-19(31-3)20(32-4)9-16(13)26-22(28-21)14-7-12(24)5-6-18(14)29/h5-9,15,17,25,29-30H,10-11H2,1-4H3,(H,26,27,28)/t15-,17-/m1/s1 | PDB MMDB
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| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CHK2 by DELFIA assay |
J Med Chem 54: 580-90 (2011)
Article DOI: 10.1021/jm101150b BindingDB Entry DOI: 10.7270/Q2DF6RHX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Bologna
Curated by ChEMBL
| Assay Description Inhibition of CHK2 using biotinylated substrate preincubated for 15 mins before substrate addition measured after 30 mins by fluorescence microplate ... |
Eur J Med Chem 46: 4311-23 (2011)
Article DOI: 10.1016/j.ejmech.2011.07.001 BindingDB Entry DOI: 10.7270/Q2NG4R1D |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163246
(2-[4-(3,4-Dichloro-phenylsulfamoyl)-phenyl]-1H-ben...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C20H14Cl2N4O3S/c21-15-7-4-13(10-16(15)22)26-30(28,29)14-5-1-11(2-6-14)20-24-17-8-3-12(19(23)27)9-18(17)25-20/h1-10,26H,(H2,23,27)(H,24,25) | PDB MMDB
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| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163259
(2-[4-(3-Chloro-4-methyl-phenoxy)-phenyl]-1H-benzoi...)Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)cc1Cl Show InChI InChI=1S/C21H16ClN3O2/c1-12-2-6-16(11-17(12)22)27-15-7-3-13(4-8-15)21-24-18-9-5-14(20(23)26)10-19(18)25-21/h2-11H,1H3,(H2,23,26)(H,24,25) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163254
(2-[4-(4-Chloro-3-trifluoromethyl-phenoxy)-phenyl]-...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)c(c2)C(F)(F)F)cc1 Show InChI InChI=1S/C21H13ClF3N3O2/c22-16-7-6-14(10-15(16)21(23,24)25)30-13-4-1-11(2-5-13)20-27-17-8-3-12(19(26)29)9-18(17)28-20/h1-10H,(H2,26,29)(H,27,28) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
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| Article PubMed
| n/a | n/a | 4.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Korea Institute of Science and Technology (KIST)
Curated by ChEMBL
| Assay Description Inhibition of CHK2 (unknown origin) |
Eur J Med Chem 141: 657-675 (2017)
Article DOI: 10.1016/j.ejmech.2017.10.003 BindingDB Entry DOI: 10.7270/Q2CV4M86 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50335683
(4-fluoro-2-(4-((3S,4R)-4-(2-hydroxypropan-2-yl)pyr...)Show SMILES COCCOc1cc2nc(nc(N[C@@H]3CNC[C@H]3C(C)(C)O)c2cc1OC)-c1cc(F)ccc1O |r| Show InChI InChI=1S/C25H31FN4O5/c1-25(2,32)17-12-27-13-19(17)29-23-15-10-21(34-4)22(35-8-7-33-3)11-18(15)28-24(30-23)16-9-14(26)5-6-20(16)31/h5-6,9-11,17,19,27,31-32H,7-8,12-13H2,1-4H3,(H,28,29,30)/t17-,19-/m1/s1 | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CHK2 by DELFIA assay |
J Med Chem 54: 580-90 (2011)
Article DOI: 10.1021/jm101150b BindingDB Entry DOI: 10.7270/Q2DF6RHX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50601440
(CHEMBL5176837)Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cnn(C)c1 | PDB MMDB
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| PC cid PC sid PDB UniChem
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| n/a | n/a | 5.10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01851 BindingDB Entry DOI: 10.7270/Q25Q515Z |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163266
(2-[4-(3,4-Dichloro-phenoxy)-phenyl]-1H-benzoimidaz...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)c(Cl)c2)cc1 Show InChI InChI=1S/C20H13Cl2N3O2/c21-15-7-6-14(10-16(15)22)27-13-4-1-11(2-5-13)20-24-17-8-3-12(19(23)26)9-18(17)25-20/h1-10H,(H2,23,26)(H,24,25) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Patents
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| Article PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252231
(CHEMBL4072515)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(=O)NCc2ccccc2)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C31H24N6O4/c1-20-28(37(39)40)31(36(35-20)24-10-6-3-7-11-24)41-25-15-12-22(13-16-25)29-33-26-17-14-23(18-27(26)34-29)30(38)32-19-21-8-4-2-5-9-21/h2-18H,19H2,1H3,(H,32,38)(H,33,34) | PDB MMDB
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| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.5 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090 BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50292371
(CHEMBL4171617)Show SMILES CCOC(=O)CSc1nc(Sc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(N)=O)c(C#N)c(n1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C29H21ClN6O3S2/c1-2-39-24(37)15-40-29-35-25(16-3-8-19(30)9-4-16)21(14-31)28(36-29)41-20-10-5-17(6-11-20)27-33-22-12-7-18(26(32)38)13-23(22)34-27/h3-13H,2,15H2,1H3,(H2,32,38)(H,33,34) | PDB MMDB
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Similars
| Article PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats |
Eur J Med Chem 146: 687-708 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.072 BindingDB Entry DOI: 10.7270/Q2TQ643K |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50291874
(CHEMBL4159805)Show SMILES CCOC(=O)CSc1nc(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(O)=O)c(C#N)c(n1)-c1ccc(F)cc1 Show InChI InChI=1S/C29H20FN5O5S/c1-2-39-24(36)15-41-29-34-25(16-3-8-19(30)9-4-16)21(14-31)27(35-29)40-20-10-5-17(6-11-20)26-32-22-12-7-18(28(37)38)13-23(22)33-26/h3-13H,2,15H2,1H3,(H,32,33)(H,37,38) | PDB MMDB
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Similars
| Article PubMed
| n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description Inhibition of Chk2 (unknown origin) assessed as decrease in Cdc25C phosphorylation at Ser216 by ELISA based spectrophotometric analysis |
Eur J Med Chem 146: 687-708 (2018)
Article DOI: 10.1016/j.ejmech.2018.01.072 BindingDB Entry DOI: 10.7270/Q2TQ643K |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
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| Article PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human CHK2 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163264
(2-[4-(4-Chloro-benzenesulfonyl)-phenyl]-1H-benzoim...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)S(=O)(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H14ClN3O3S/c21-14-4-8-16(9-5-14)28(26,27)15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) | PDB MMDB
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| CHEMBL PC cid PC sid UniChem
Patents
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| Article PubMed
| n/a | n/a | 6.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
National Cancer Institute
Curated by ChEMBL
| Assay Description Inhibition of CHK2 |
J Med Chem 52: 3191-204 (2009)
Article DOI: 10.1021/jm800861c BindingDB Entry DOI: 10.7270/Q23J3DWT |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50252253
(CHEMBL4093249)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(=O)NC2CCCCC2)c1[N+]([O-])=O)-c1ccccc1 Show InChI InChI=1S/C30H28N6O4/c1-19-27(36(38)39)30(35(34-19)23-10-6-3-7-11-23)40-24-15-12-20(13-16-24)28-32-25-17-14-21(18-26(25)33-28)29(37)31-22-8-4-2-5-9-22/h3,6-7,10-18,22H,2,4-5,8-9H2,1H3,(H,31,37)(H,32,33) | PDB MMDB
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Similars
| Article PubMed
| n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description Inhibition of Chk2 (unknown origin) by ELISA based spectrophotometric analysis |
Eur J Med Chem 134: 392-405 (2017)
Article DOI: 10.1016/j.ejmech.2017.03.090 BindingDB Entry DOI: 10.7270/Q27P91T8 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50149481
(5-[2-Amino-5-oxo-1,5-dihydro-imidazol-(4Z)-ylidene...)Show SMILES Nc1nc(O)c([nH]1)C1=C2C(=Nc3ccccc23)C(=O)NCC1 |c:10,t:8| Show InChI InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,22H,5-6H2,(H,17,21)(H3,16,19,20) | PDB MMDB
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Michigan State University
Curated by ChEMBL
| Assay Description In vitro inhibitory concentration against checkpoint kinase 2 (Chk2) by using [gamma-33P]-ATP] as radioligand |
Bioorg Med Chem Lett 14: 4319-21 (2004)
Article DOI: 10.1016/j.bmcl.2004.05.079 BindingDB Entry DOI: 10.7270/Q2ZP45MV |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50524300
(LY2606368 | Prexasertib | US11564920, Example Prex...)Show SMILES COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1 Show InChI InChI=1S/C18H19N7O2/c1-26-14-4-2-5-15(27-7-3-6-19)18(14)13-8-16(25-24-13)23-17-11-21-12(9-20)10-22-17/h2,4-5,8,10-11H,3,6-7,19H2,1H3,(H2,22,23,24,25) | PDB MMDB
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TBA
| |
Citation and Details
Article DOI: 10.1016/j.ejmech.2022.114109 BindingDB Entry DOI: 10.7270/Q2XK8KKJ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50256044
(5-(2-amino-4-oxo-1H-imidazol-5(4H)-ylidene)-2,3,4,...)Show SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]c3ccccc3c12 |w:3.2,t:1| Show InChI InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,18H,5-6H2,(H,17,21)(H3,16,19,20,22) | PDB MMDB
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TBA
Curated by ChEMBL
| Assay Description Inhibition of Chk2 |
Eur J Med Chem 56: 246-253 (2012)
Article DOI: 10.1016/j.ejmech.2012.08.022 BindingDB Entry DOI: 10.7270/Q2639R1G |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50025098
(CHEMBL332551)Show SMILES Nc1nc(c(O)[nH]1)C1=C2C(=Nc3ccccc23)C(=O)NCC1 |c:10,t:8| Show InChI InChI=1S/C15H13N5O2/c16-15-19-11(14(22)20-15)8-5-6-17-13(21)12-10(8)7-3-1-2-4-9(7)18-12/h1-4,22H,5-6H2,(H,17,21)(H3,16,19,20) | PDB MMDB
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Michigan State University
Curated by ChEMBL
| Assay Description Inhibition of human Chk2 using STK1 as substrate after 10 mins by HTRF assay |
Bioorg Med Chem 20: 1475-81 (2012)
Article DOI: 10.1016/j.bmc.2011.12.054 BindingDB Entry DOI: 10.7270/Q20865RK |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50335687
(2-(4-((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3...)Show SMILES CC(C)(O)[C@@H]1CNC[C@H]1Nc1nc(nc2ccccc12)-c1cc(ccc1O)-c1cc[nH]n1 |r| Show InChI InChI=1S/C24H26N6O2/c1-24(2,32)17-12-25-13-20(17)28-22-15-5-3-4-6-19(15)27-23(29-22)16-11-14(7-8-21(16)31)18-9-10-26-30-18/h3-11,17,20,25,31-32H,12-13H2,1-2H3,(H,26,30)(H,27,28,29)/t17-,20-/m1/s1 | PDB MMDB
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Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CHK2 by DELFIA assay |
J Med Chem 54: 580-90 (2011)
Article DOI: 10.1021/jm101150b BindingDB Entry DOI: 10.7270/Q2DF6RHX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163255
(2-[4-(4-Chloro-phenylsulfanyl)-phenyl]-1H-benzoimi...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Sc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C20H14ClN3OS/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) | PDB MMDB
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Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50335662
((S)-4-(1H-pyrazol-3-yl)-2-(4-(pyrrolidin-3-ylamino...)Show SMILES Oc1ccc(cc1-c1nc(N[C@H]2CCNC2)c2ccccc2n1)-c1cc[nH]n1 |r| Show InChI InChI=1S/C21H20N6O/c28-19-6-5-13(17-8-10-23-27-17)11-16(19)21-25-18-4-2-1-3-15(18)20(26-21)24-14-7-9-22-12-14/h1-6,8,10-11,14,22,28H,7,9,12H2,(H,23,27)(H,24,25,26)/t14-/m0/s1 | PDB MMDB
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Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CHK2 by DELFIA assay |
J Med Chem 54: 580-90 (2011)
Article DOI: 10.1021/jm101150b BindingDB Entry DOI: 10.7270/Q2DF6RHX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM2579
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 | PDB MMDB
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University of Florida
Curated by ChEMBL
| Assay Description Inhibition of human CHK2 using KKKVSRSGLYRSPSMPENLNRPR as substrate by [gamma-33P]-ATP assay |
Eur J Med Chem 161: 456-467 (2019)
Article DOI: 10.1016/j.ejmech.2018.10.052 BindingDB Entry DOI: 10.7270/Q2W380MT |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163282
(2-[4-(4-Chloro-3-hydroxy-phenoxy)-phenyl]-1H-benzo...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)c(O)c2)cc1 Show InChI InChI=1S/C20H14ClN3O3/c21-15-7-6-14(10-18(15)25)27-13-4-1-11(2-5-13)20-23-16-8-3-12(19(22)26)9-17(16)24-20/h1-10,25H,(H2,22,26)(H,23,24) | PDB MMDB
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Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50291408
(CHEMBL4165600)Show SMILES COc1ccc(N\N=C\c2c(C)nn(c2Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(O)=O)-c2ccccc2)cc1 Show InChI InChI=1S/C32H26N6O4/c1-20-27(19-33-36-23-11-15-25(41-2)16-12-23)31(38(37-20)24-6-4-3-5-7-24)42-26-13-8-21(9-14-26)30-34-28-17-10-22(32(39)40)18-29(28)35-30/h3-19,36H,1-2H3,(H,34,35)(H,39,40)/b33-19+ | PDB MMDB
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National Research Centre
Curated by ChEMBL
| Assay Description Inhibition of Chk2 (unknown origin) by spectrophotometric analysis |
Eur J Med Chem 144: 859-873 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.023 BindingDB Entry DOI: 10.7270/Q2KD21F1 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50280450
(18-hydroxy-3-methoxy-2-methyl-4-methylamino-(2R,3S...)Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C28H26N4O4/c1-28-25(35-3)15(29-2)12-18(36-28)31-16-10-6-4-8-13(16)19-21-22(27(34)30-26(21)33)20-14-9-5-7-11-17(14)32(28)24(20)23(19)31/h4-11,15,18,25,27,29,34H,12H2,1-3H3,(H,30,33)/t15-,18-,25-,27+,28+/m1/s1 | PDB MMDB
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AstraZeneca R&D Boston
Curated by ChEMBL
| Assay Description Inhibition of CHK2 |
Bioorg Med Chem Lett 20: 5133-8 (2010)
Article DOI: 10.1016/j.bmcl.2010.07.015 BindingDB Entry DOI: 10.7270/Q2FF3SJZ |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50389803
(AZD7762 | CHEMBL2041933)Show SMILES NC(=O)Nc1cc(sc1C(=O)N[C@H]1CCCNC1)-c1cccc(F)c1 |r| Show InChI InChI=1S/C17H19FN4O2S/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24)/t12-/m0/s1 | PDB MMDB
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AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of CHK2 |
J Med Chem 55: 5130-42 (2012)
Article DOI: 10.1021/jm300025r BindingDB Entry DOI: 10.7270/Q2RV0PR6 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50291372
(CHEMBL4177291)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)[N+]([O-])=O)c1\C=N\NC(N)=S)-c1ccccc1 Show InChI InChI=1S/C25H20N8O3S/c1-15-20(14-27-30-25(26)37)24(32(31-15)17-5-3-2-4-6-17)36-19-10-7-16(8-11-19)23-28-21-12-9-18(33(34)35)13-22(21)29-23/h2-14H,1H3,(H,28,29)(H3,26,30,37)/b27-14+ | PDB MMDB
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National Research Centre
Curated by ChEMBL
| Assay Description Inhibition of Chk2 (unknown origin) by spectrophotometric analysis |
Eur J Med Chem 144: 859-873 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.023 BindingDB Entry DOI: 10.7270/Q2KD21F1 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50291380
(CHEMBL4170221)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(N)=O)c1\C=N\NC(N)=O)-c1ccccc1 Show InChI InChI=1S/C26H22N8O3/c1-15-20(14-29-32-26(28)36)25(34(33-15)18-5-3-2-4-6-18)37-19-10-7-16(8-11-19)24-30-21-12-9-17(23(27)35)13-22(21)31-24/h2-14H,1H3,(H2,27,35)(H,30,31)(H3,28,32,36)/b29-14+ | PDB MMDB
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National Research Centre
Curated by ChEMBL
| Assay Description Inhibition of Chk2 (unknown origin) by spectrophotometric analysis |
Eur J Med Chem 144: 859-873 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.023 BindingDB Entry DOI: 10.7270/Q2KD21F1 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50335681
((S)-4-fluoro-2-(7-(2-methoxyethoxy)-4-(pyrrolidin-...)Show SMILES COCCOc1ccc2c(N[C@H]3CCNC3)nc(nc2c1)-c1cc(F)ccc1O |r| Show InChI InChI=1S/C21H23FN4O3/c1-28-8-9-29-15-3-4-16-18(11-15)25-21(17-10-13(22)2-5-19(17)27)26-20(16)24-14-6-7-23-12-14/h2-5,10-11,14,23,27H,6-9,12H2,1H3,(H,24,25,26)/t14-/m0/s1 | PDB MMDB
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Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CHK2 by DELFIA assay |
J Med Chem 54: 580-90 (2011)
Article DOI: 10.1021/jm101150b BindingDB Entry DOI: 10.7270/Q2DF6RHX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50335685
(4-fluoro-2-(4-((3S,4R)-4-(hydroxymethyl)pyrrolidin...)Show SMILES COc1cc2nc(nc(N[C@@H]3CNC[C@H]3CO)c2cc1OC)-c1cc(F)ccc1O |r| Show InChI InChI=1S/C21H23FN4O4/c1-29-18-6-13-15(7-19(18)30-2)24-21(14-5-12(22)3-4-17(14)28)26-20(13)25-16-9-23-8-11(16)10-27/h3-7,11,16,23,27-28H,8-10H2,1-2H3,(H,24,25,26)/t11-,16+/m0/s1 | PDB MMDB
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Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CHK2 by DELFIA assay |
J Med Chem 54: 580-90 (2011)
Article DOI: 10.1021/jm101150b BindingDB Entry DOI: 10.7270/Q2DF6RHX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50335680
((S)-2-(6,7-dimethoxy-4-(pyrrolidin-3-ylamino)quina...)Show SMILES COc1cc2nc(nc(N[C@H]3CCNC3)c2cc1OC)-c1cc(F)ccc1O |r| Show InChI InChI=1S/C20H21FN4O3/c1-27-17-8-13-15(9-18(17)28-2)24-20(14-7-11(21)3-4-16(14)26)25-19(13)23-12-5-6-22-10-12/h3-4,7-9,12,22,26H,5-6,10H2,1-2H3,(H,23,24,25)/t12-/m0/s1 | PDB MMDB
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Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CHK2 by DELFIA assay |
J Med Chem 54: 580-90 (2011)
Article DOI: 10.1021/jm101150b BindingDB Entry DOI: 10.7270/Q2DF6RHX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163250
(2-[4-(3,4-Dimethyl-phenoxy)-phenyl]-1H-benzoimidaz...)Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nc3ccc(cc3[nH]2)C(N)=O)cc1C Show InChI InChI=1S/C22H19N3O2/c1-13-3-7-18(11-14(13)2)27-17-8-4-15(5-9-17)22-24-19-10-6-16(21(23)26)12-20(19)25-22/h3-12H,1-2H3,(H2,23,26)(H,24,25) | PDB MMDB
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Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163270
(2-[4-(2-Fluoro-5-trifluoromethyl-phenoxy)-phenyl]-...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2cc(ccc2F)C(F)(F)F)cc1 Show InChI InChI=1S/C21H13F4N3O2/c22-15-7-4-13(21(23,24)25)10-18(15)30-14-5-1-11(2-6-14)20-27-16-8-3-12(19(26)29)9-17(16)28-20/h1-10H,(H2,26,29)(H,27,28) | PDB MMDB
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Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163278
(2-[4-(Naphthalen-2-yloxy)-phenyl]-1H-benzoimidazol...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc3ccccc3c2)cc1 Show InChI InChI=1S/C24H17N3O2/c25-23(28)18-8-12-21-22(14-18)27-24(26-21)16-6-9-19(10-7-16)29-20-11-5-15-3-1-2-4-17(15)13-20/h1-14H,(H2,25,28)(H,26,27) | PDB MMDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50291376
(CHEMBL4170505)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)[N+]([O-])=O)c1\C=N\Nc1ccccc1)-c1ccccc1 Show InChI InChI=1S/C30H23N7O3/c1-20-26(19-31-34-22-8-4-2-5-9-22)30(36(35-20)23-10-6-3-7-11-23)40-25-15-12-21(13-16-25)29-32-27-17-14-24(37(38)39)18-28(27)33-29/h2-19,34H,1H3,(H,32,33)/b31-19+ | PDB MMDB
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| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description Inhibition of Chk2 (unknown origin) by spectrophotometric analysis |
Eur J Med Chem 144: 859-873 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.023 BindingDB Entry DOI: 10.7270/Q2KD21F1 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM601395
(US11634424, Compound 7)Show SMILES COc1cccc(F)c1-c1cc(Nc2cnc3ccn(C4CCNCC4)c3n2)n[nH]1 | PDB MMDB
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TBA
| |
Citation and Details
BindingDB Entry DOI: 10.7270/Q2T43Z1M |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50291405
(CHEMBL4173655)Show SMILES Cc1nn(c(Oc2ccc(cc2)-c2nc3cc(ccc3[nH]2)C(O)=O)c1\C=N\NC(N)=S)-c1ccccc1 Show InChI InChI=1S/C26H21N7O3S/c1-15-20(14-28-31-26(27)37)24(33(32-15)18-5-3-2-4-6-18)36-19-10-7-16(8-11-19)23-29-21-12-9-17(25(34)35)13-22(21)30-23/h2-14H,1H3,(H,29,30)(H,34,35)(H3,27,31,37)/b28-14+ | PDB MMDB
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| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
National Research Centre
Curated by ChEMBL
| Assay Description Inhibition of Chk2 (unknown origin) by spectrophotometric analysis |
Eur J Med Chem 144: 859-873 (2018)
Article DOI: 10.1016/j.ejmech.2017.12.023 BindingDB Entry DOI: 10.7270/Q2KD21F1 |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50196392
(3-hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenyl...)Show SMILES CC(CO)N=C(N)c1c(Nc2ccc(Nc3ccccc3)cc2)s[nH]c1=O |w:4.3| Show InChI InChI=1S/C19H21N5O2S/c1-12(11-25)21-17(20)16-18(26)24-27-19(16)23-15-9-7-14(8-10-15)22-13-5-3-2-4-6-13/h2-10,12,22-23,25H,11H2,1H3,(H2,20,21)(H,24,26) | PDB MMDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Valeant Pharmaceuticals Research & Development
Curated by ChEMBL
| Assay Description Inhibition of CHK2 |
Bioorg Med Chem Lett 16: 5561-6 (2006)
Article DOI: 10.1016/j.bmcl.2006.08.048 BindingDB Entry DOI: 10.7270/Q2J38S5D |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163269
(2-[4-(4-Chloro-benzenesulfinyl)-phenyl]-1H-benzoim...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)S(=O)c1ccc(Cl)cc1 Show InChI InChI=1S/C20H14ClN3O2S/c21-14-4-8-16(9-5-14)27(26)15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) | PDB MMDB
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| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50163273
(2-[4-(4-Chloro-phenylsulfamoyl)-phenyl]-1H-benzoim...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)cc1 Show InChI InChI=1S/C20H15ClN4O3S/c21-14-4-6-15(7-5-14)25-29(27,28)16-8-1-12(2-9-16)20-23-17-10-3-13(19(22)26)11-18(17)24-20/h1-11,25H,(H2,22,26)(H,23,24) | PDB MMDB
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B.MOAD antibodypedia GoogleScholar AffyNet
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| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description Inhibition of recombinant human Chk2 kinase |
J Med Chem 48: 1873-85 (2005)
Article DOI: 10.1021/jm0495935 BindingDB Entry DOI: 10.7270/Q2FQ9W4V |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50363647
(CHEMBL1947251)Show SMILES COc1ccc(cc1)-c1cc2c([nH]1)C(=O)NCCC2=C1NC(N)=NC1=O |w:18.19,c:25| Show InChI InChI=1S/C18H17N5O3/c1-26-10-4-2-9(3-5-10)13-8-12-11(14-17(25)23-18(19)22-14)6-7-20-16(24)15(12)21-13/h2-5,8,21H,6-7H2,1H3,(H,20,24)(H3,19,22,23,25) | PDB MMDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University
Curated by ChEMBL
| Assay Description Inhibition of human Chk2 using STK1 as substrate after 10 mins by HTRF assay |
Bioorg Med Chem 20: 1475-81 (2012)
Article DOI: 10.1016/j.bmc.2011.12.054 BindingDB Entry DOI: 10.7270/Q20865RK |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50335686
(2-(4-((3S,4R)-4-(2-hydroxypropan-2-yl)pyrrolidin-3...)Show SMILES CC(C)(O)[C@@H]1CNC[C@H]1Nc1nc(nc2ccccc12)-c1cc(ccc1O)-c1cn[nH]c1 |r| Show InChI InChI=1S/C24H26N6O2/c1-24(2,32)18-12-25-13-20(18)29-22-16-5-3-4-6-19(16)28-23(30-22)17-9-14(7-8-21(17)31)15-10-26-27-11-15/h3-11,18,20,25,31-32H,12-13H2,1-2H3,(H,26,27)(H,28,29,30)/t18-,20-/m1/s1 | PDB MMDB
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Institute of Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of CHK2 by DELFIA assay |
J Med Chem 54: 580-90 (2011)
Article DOI: 10.1021/jm101150b BindingDB Entry DOI: 10.7270/Q2DF6RHX |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50225014
(2-(4-((1-(4-chlorobenzyl)piperidin-3-yl)methoxy)ph...)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(OCC2CCCN(Cc3ccc(Cl)cc3)C2)cc1 Show InChI InChI=1S/C27H27ClN4O2/c28-22-8-3-18(4-9-22)15-32-13-1-2-19(16-32)17-34-23-10-5-20(6-11-23)27-30-24-12-7-21(26(29)33)14-25(24)31-27/h3-12,14,19H,1-2,13,15-17H2,(H2,29,33)(H,30,31) | PDB MMDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research & Development
Curated by ChEMBL
| Assay Description Inhibition of human recombinant Chk2 |
Bioorg Med Chem Lett 17: 6467-71 (2007)
Article DOI: 10.1016/j.bmcl.2007.09.098 BindingDB Entry DOI: 10.7270/Q2KP81XB |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM50363648
(CHEMBL1947252)Show SMILES COc1ccc(cc1OC)-c1cc2c([nH]1)C(=O)NCCC2=C1NC(N)=NC1=O |w:20.21,c:27| Show InChI InChI=1S/C19H19N5O4/c1-27-13-4-3-9(7-14(13)28-2)12-8-11-10(15-18(26)24-19(20)23-15)5-6-21-17(25)16(11)22-12/h3-4,7-8,22H,5-6H2,1-2H3,(H,21,25)(H3,20,23,24,26) | PDB MMDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Michigan State University
Curated by ChEMBL
| Assay Description Inhibition of human Chk2 using STK1 as substrate after 10 mins by HTRF assay |
Bioorg Med Chem 20: 1475-81 (2012)
Article DOI: 10.1016/j.bmc.2011.12.054 BindingDB Entry DOI: 10.7270/Q20865RK |
More data for this Ligand-Target Pair | |
Serine/threonine-protein kinase Chk2
(Homo sapiens (Human)) | BDBM34064
(2-arylbenzimidazole | CHEMBL179583)Show SMILES NC(=O)c1ccc2nc([nH]c2c1)-c1ccc(Oc2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24) | PDB MMDB
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CHEMBL MMDB PC cid PC sid PDB UniChem
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| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Oxford
Curated by ChEMBL
| Assay Description Inhibition of Chk2 |
Proc Natl Acad Sci USA 104: 20523-8 (2007)
Checked by Author Article DOI: 10.1073/pnas.0708800104 BindingDB Entry DOI: 10.7270/Q2DB82RH |
More data for this Ligand-Target Pair | 3D Structure (crystal) |