Compile Data Set for Download or QSAR

Found 306 hits of ec50 data for polymerid = 5598   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372992 (US10597366, Compound 64 | US9896418, Compound 64) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)CF |r| Show InChI InChI=1S/C16H11F5O4S/c17-7-26(23,24)13-2-1-12(11-6-16(20,21)15(22)14(11)13)25-10-4-8(18)3-9(19)5-10/h1-5,15,22H,6-7H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372992 (US10597366, Compound 64 | US9896418, Compound 64) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)CF |r| Show InChI InChI=1S/C16H11F5O4S/c17-7-26(23,24)13-2-1-12(11-6-16(20,21)15(22)14(11)13)25-10-4-8(18)3-9(19)5-10/h1-5,15,22H,6-7H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372992 (US10597366, Compound 64 | US9896418, Compound 64) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)CF |r| Show InChI InChI=1S/C16H11F5O4S/c17-7-26(23,24)13-2-1-12(11-6-16(20,21)15(22)14(11)13)25-10-4-8(18)3-9(19)5-10/h1-5,15,22H,6-7H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM566629 (3-fluoro-5-(((1R,2S,2aS)-1,2,3,3,4,4-hexafluoro- 2...) Show SMILES O[C@]12[C@H](F)[C@H](F)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...				Citation and Details BindingDB Entry DOI: 10.7270/Q2474F3H
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373015 (US10597366, Compound 185 | US9896418, Compound 185) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C17H9F6NO4S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(26,27)17(21,22)23)14-11(12)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373015 (US10597366, Compound 185 | US9896418, Compound 185) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C17H9F6NO4S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(26,27)17(21,22)23)14-11(12)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373015 (US10597366, Compound 185 | US9896418, Compound 185) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C17H9F6NO4S/c18-9-3-8(7-24)4-10(5-9)28-12-1-2-13(29(26,27)17(21,22)23)14-11(12)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373004 (US10597366, Compound 158 | US9896418, Compound 158) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(Cl)c1)ccc2S(=O)(=O)C(F)F |r| Show InChI InChI=1S/C16H10ClF5O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373004 (US10597366, Compound 158 | US9896418, Compound 158) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(Cl)c1)ccc2S(=O)(=O)C(F)F |r| Show InChI InChI=1S/C16H10ClF5O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372966 (US10597366, Compound 9 | US9896418, Compound 9) Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372966 (US10597366, Compound 9 | US9896418, Compound 9) Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373004 (US10597366, Compound 158 | US9896418, Compound 158) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(Cl)c1)ccc2S(=O)(=O)C(F)F |r| Show InChI InChI=1S/C16H10ClF5O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM566616 (3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a- hy...) Show SMILES O[C@]12C[C@H](F)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...				Citation and Details BindingDB Entry DOI: 10.7270/Q2474F3H
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM566616 (3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a- hy...) Show SMILES O[C@]12C[C@H](F)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...				Citation and Details BindingDB Entry DOI: 10.7270/Q2474F3H
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372966 (US10597366, Compound 9 | US9896418, Compound 9) Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(F)c1)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C16H10F6O4S/c17-7-3-8(18)5-9(4-7)26-11-1-2-12(27(24,25)15(19)20)13-10(11)6-16(21,22)14(13)23/h1-5,14-15,23H,6H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373041 (US10597366, Compound 292 | US9896418, Compound 292) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12 |r| Show InChI InChI=1S/C17H11F4NO4S/c1-27(24,25)12-3-2-11(13-14(12)16(23)17(20,21)15(13)19)26-10-5-8(7-22)4-9(18)6-10/h2-6,15-16,23H,1H3/t15-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373042 (US10597366, Compound 273 | US9896418, Compound 273) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2C(F)(F)F |r| Show InChI InChI=1S/C17H9F6NO2/c18-9-3-8(7-24)4-10(5-9)26-13-2-1-12(17(21,22)23)14-11(13)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373041 (US10597366, Compound 292 | US9896418, Compound 292) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12 |r| Show InChI InChI=1S/C17H11F4NO4S/c1-27(24,25)12-3-2-11(13-14(12)16(23)17(20,21)15(13)19)26-10-5-8(7-22)4-9(18)6-10/h2-6,15-16,23H,1H3/t15-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373042 (US10597366, Compound 273 | US9896418, Compound 273) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2C(F)(F)F |r| Show InChI InChI=1S/C17H9F6NO2/c18-9-3-8(7-24)4-10(5-9)26-13-2-1-12(17(21,22)23)14-11(13)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373041 (US10597366, Compound 292 | US9896418, Compound 292) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12 |r| Show InChI InChI=1S/C17H11F4NO4S/c1-27(24,25)12-3-2-11(13-14(12)16(23)17(20,21)15(13)19)26-10-5-8(7-22)4-9(18)6-10/h2-6,15-16,23H,1H3/t15-,16+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373042 (US10597366, Compound 273 | US9896418, Compound 273) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2C(F)(F)F |r| Show InChI InChI=1S/C17H9F6NO2/c18-9-3-8(7-24)4-10(5-9)26-13-2-1-12(17(21,22)23)14-11(13)6-16(19,20)15(14)25/h1-5,15,25H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	6.20	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM566628 ((R)-3-fluoro-5-((3,3,4,4-tetrafluoro-2a-hydroxy-1-...) Show SMILES O[C@]12CC(=C)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...				Citation and Details BindingDB Entry DOI: 10.7270/Q2474F3H
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373005 (US10597366, Compound 159 | US9896418, Compound 159) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)C(O)c12 Show InChI InChI=1S/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373005 (US10597366, Compound 159 | US9896418, Compound 159) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)C(O)c12 Show InChI InChI=1S/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373005 (US10597366, Compound 159 | US9896418, Compound 159) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)C(O)c12 Show InChI InChI=1S/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	7	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM282572 ((R)-3-((4-(difluoromethyl)-2,2-difluoro-3-hydroxy-...) Show SMILES O[C@@H]1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F |r| Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H/t14-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
PELOTON THERAPEUTICS, INC. US Patent					Assay Description About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				US Patent US9884843 (2018) BindingDB Entry DOI: 10.7270/Q2HQ41Z0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM282656 (4-(Difluoromethyl)-5-(3,5-difluorophenoxy)-2,2- di...) Show SMILES OC1c2c(ccc(Oc3cc(F)cc(F)c3)c2C(F)F)S(=O)(=O)C1(F)F Show InChI InChI=1S/C15H8F6O4S/c16-6-3-7(17)5-8(4-6)25-9-1-2-10-12(11(9)14(18)19)13(22)15(20,21)26(10,23)24/h1-5,13-14,22H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9	n/a	n/a	n/a	n/a
PELOTON THERAPEUTICS, INC. US Patent					Assay Description About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				US Patent US9884843 (2018) BindingDB Entry DOI: 10.7270/Q2HQ41Z0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM566615 (3-fluoro-5-((1,3,3,4,4-pentafluoro-2a-hydroxy- 2,2...) Show SMILES OC12CC(F)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	10	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...				Citation and Details BindingDB Entry DOI: 10.7270/Q2474F3H
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM566630 (3-fluoro-5-(((1R,2R,2aS)-1,2,3,3,4,4-hexafluoro- 2...) Show SMILES O[C@]12[C@@H](F)[C@H](F)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...				Citation and Details BindingDB Entry DOI: 10.7270/Q2474F3H
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373006 (US10597366, Compound 161 | US9896418, Compound 161) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)[C@@H](O)c12 |r| Show InChI InChI=1S/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373006 (US10597366, Compound 161 | US9896418, Compound 161) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)[C@@H](O)c12 |r| Show InChI InChI=1S/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373006 (US10597366, Compound 161 | US9896418, Compound 161) Show SMILES CS(=O)(=O)c1ccc(Oc2cc(F)cc(F)c2)c2CC(F)(F)[C@@H](O)c12 |r| Show InChI InChI=1S/C16H12F4O4S/c1-25(22,23)13-3-2-12(11-7-16(19,20)15(21)14(11)13)24-10-5-8(17)4-9(18)6-10/h2-6,15,21H,7H2,1H3/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM566614 (3-fluoro-5-((3,3,4,4-tetrafluoro-2a-hydroxy-1- met...) Show SMILES OC12CC(=C)c3c1c(ccc3Oc1cc(F)cc(c1)C#N)C(F)(F)C2(F)F Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
TBA					Assay Description The ability of the disclosed compounds to inhibit HIF-2α was measured by determining VEGF expression in 786-O cells. About 7500 786-O cells were...				Citation and Details BindingDB Entry DOI: 10.7270/Q2474F3H
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373016 (US10597366, Compound 186 | US9896418, Compound 186) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(Cl)c1)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C15H9ClF5NO4S/c16-7-3-8(6-22-5-7)26-10-1-2-11(27(24,25)15(19,20)21)12-9(10)4-14(17,18)13(12)23/h1-3,5-6,13,23H,4H2/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372976 (US10597366, Compound 15 | US9896418, Compound 15) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F |r| Show InChI InChI=1S/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372976 (US10597366, Compound 15 | US9896418, Compound 15) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F |r| Show InChI InChI=1S/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372976 (US10597366, Compound 15 | US9896418, Compound 15) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F |r| Show InChI InChI=1S/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373016 (US10597366, Compound 186 | US9896418, Compound 186) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(Cl)c1)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C15H9ClF5NO4S/c16-7-3-8(6-22-5-7)26-10-1-2-11(27(24,25)15(19,20)21)12-9(10)4-14(17,18)13(12)23/h1-3,5-6,13,23H,4H2/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373016 (US10597366, Compound 186 | US9896418, Compound 186) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cncc(Cl)c1)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C15H9ClF5NO4S/c16-7-3-8(6-22-5-7)26-10-1-2-11(27(24,25)15(19,20)21)12-9(10)4-14(17,18)13(12)23/h1-3,5-6,13,23H,4H2/t13-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM438062 (US10597366, Compound 317 | US10597366, Compound 32...) Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@H](F)C(F)(F)[C@H](O)c12 |r| Show InChI InChI=1S/C18H11F4N3O3S/c1-29(27,25-8-24)13-3-2-12(14-15(13)17(26)18(21,22)16(14)20)28-11-5-9(7-23)4-10(19)6-11/h2-6,16-17,26H,1H3/t16-,17+,29?/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373050 (US10597366, Compound 316 | US9896418, Compound 316...) Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12 |r| Show InChI InChI=1S/C18H11F4N3O3S/c1-29(27,25-8-24)13-3-2-12(14-15(13)17(26)18(21,22)16(14)20)28-11-5-9(7-23)4-10(19)6-11/h2-6,16-17,26H,1H3/t16-,17+,29?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM282685 (3-((4-(Difluoromethyl)-2,2-difluoro-3-hydroxy-1,1-...) Show SMILES OC1c2c(ccc(Oc3cc(F)cc(c3)C#N)c2C(F)F)S(=O)(=O)C1(F)F Show InChI InChI=1S/C16H8F5NO4S/c17-8-3-7(6-22)4-9(5-8)26-10-1-2-11-13(12(10)15(18)19)14(23)16(20,21)27(11,24)25/h1-5,14-15,23H	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
PELOTON THERAPEUTICS, INC. US Patent					Assay Description About 7500 of 786-O cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				US Patent US9884843 (2018) BindingDB Entry DOI: 10.7270/Q2HQ41Z0
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373050 (US10597366, Compound 316 | US9896418, Compound 316...) Show SMILES CS(=O)(=NC#N)c1ccc(Oc2cc(F)cc(c2)C#N)c2[C@@H](F)C(F)(F)[C@@H](O)c12 |r| Show InChI InChI=1S/C18H11F4N3O3S/c1-29(27,25-8-24)13-3-2-12(14-15(13)17(26)18(21,22)16(14)20)28-11-5-9(7-23)4-10(19)6-11/h2-6,16-17,26H,1H3/t16-,17+,29?/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373028 (US10597366, Compound 233 | US9896418, Compound 233) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C16H9F7O4S/c17-9-2-1-7(5-10(9)18)27-11-3-4-12(28(25,26)16(21,22)23)13-8(11)6-15(19,20)14(13)24/h1-5,14,24H,6H2/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372972 (US10597366, Compound 11 | US9896418, Compound 11) Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372972 (US10597366, Compound 11 | US9896418, Compound 11) Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM372972 (US10597366, Compound 11 | US9896418, Compound 11) Show SMILES OC1c2c(CC1(F)F)c(Oc1cc(F)cc(c1)C#N)ccc2S(=O)(=O)C(F)F Show InChI InChI=1S/C17H10F5NO4S/c18-9-3-8(7-23)4-10(5-9)27-12-1-2-13(28(25,26)16(19)20)14-11(12)6-17(21,22)15(14)24/h1-5,15-16,24H,6H2	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373028 (US10597366, Compound 233 | US9896418, Compound 233) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C16H9F7O4S/c17-9-2-1-7(5-10(9)18)27-11-3-4-12(28(25,26)16(21,22)23)13-8(11)6-15(19,20)14(13)24/h1-5,14,24H,6H2/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Research Triangle Institute					Assay Description Four hours later, serial dilutions of 10× compound stocks were made in growth medium from 500×DMSO stocks, and 20 μL of those 10× stocks were ad...				J Med Chem 50: 3686-95 (2007) BindingDB Entry DOI: 10.7270/Q2QC05TR
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373028 (US10597366, Compound 233 | US9896418, Compound 233) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1ccc(F)c(F)c1)ccc2S(=O)(=O)C(F)(F)F |r| Show InChI InChI=1S/C16H9F7O4S/c17-9-2-1-7(5-10(9)18)27-11-3-4-12(28(25,26)16(21,22)23)13-8(11)6-15(19,20)14(13)24/h1-5,14,24H,6H2/t14-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	15	n/a	n/a	n/a	n/a
Peloton Therapeutics, Inc. US Patent					Assay Description VEGF: Four hours later, serial dilutions of 10x compound stocks were made in growth medium from 500xDMSO stocks, and 20 uL of those 10x stocks were a...				US Patent US10597366 (2020) BindingDB Entry DOI: 10.7270/Q2M32ZSW
					More data for this Ligand-Target Pair
Vascular endothelial growth factor A (Homo sapiens (Human))	BDBM373031 (US10597366, Compound 236 | US9896418, Compound 236) Show SMILES O[C@H]1c2c(CC1(F)F)c(Oc1cccc(c1)C#N)ccc2S(=O)(=O)C(F)F |r| Show InChI InChI=1S/C17H11F4NO4S/c18-16(19)27(24,25)13-5-4-12(11-7-17(20,21)15(23)14(11)13)26-10-3-1-2-9(6-10)8-22/h1-6,15-16,23H,7H2/t15-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	16	n/a	n/a	n/a	n/a
The Scripps Research Institute					Assay Description About 7500 of 786-0 cells in 180 μL of growth medium were seeded into each well of a 96 well plate with white clear bottom on the first day (07-...				J Med Chem 50: 3359-68 (2007) BindingDB Entry DOI: 10.7270/Q2FN18HM
					More data for this Ligand-Target Pair

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