BindingDB PrimarySearch

Found 46 hits of kd data for polymerid = 5625
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566086 (CHEMBL4793441) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566082 (CHEMBL4779359) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	2.40	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50359044 (CHEMBL1922178) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.45	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50021403 (Ganoderic Acid F) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	2.69	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	3.81	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566088 (CHEMBL4793924) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566087 (CHEMBL4787790) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	7.30	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50359040 (CHEMBL1922174) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50359037 (CHEMBL602899) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50356915 (GANODERIC ACID B) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50552392 (CHEMBL4743779) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human TNF measured after 2 hrs by surface plasmon resonance				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01608 BindingDB Entry DOI: 10.7270/Q25D8WHT
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50021401 (CHEMBL3289609) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50356920 (CHEMBL1915761) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50021402 (Ganoderic Acid D) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566081 (CHEMBL4778232) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	74	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM228654 ((E)-4-(2-(4-chloro-3-nitrophenyl)) (C87)) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	110	n/a	n/a	n/a	7.0	n/a
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College					Assay Description Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...				J Biol Chem 289: 12457-66 (2014) Article DOI: 10.1074/jbc.M113.521708 BindingDB Entry DOI: 10.7270/Q2J9658M
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50378582 (APIGETRIN \| Apigenin 7-O-β-D-glucoside (8) \| ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50241242 (2-(3,4-dihydroxyphenyl)-5-hydroxy-4-oxo-4H-chromen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	790	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50021397 (CHEMBL3289608) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	1.82E+3	n/a	n/a	n/a	n/a	n/a
The Second People's Hospital of Fujian Provinc Curated by ChEMBL					Assay Description Binding affinity to TNF-alpha (unknown origin)				Eur J Med Chem 83: 294-306 (2014) Article DOI: 10.1016/j.ejmech.2014.06.037 BindingDB Entry DOI: 10.7270/Q2NG4S7H
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566080 (CHEMBL4783333) Show SMILES N#CCc1ccc(cc1)-c1cccc2ccncc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	KEGG PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50545753 (CHEMBL4649816) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.26E+3	n/a	n/a	n/a	n/a	n/a
Huazhong University of Science and Technology Curated by ChEMBL					Assay Description Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as Kd for TNF-alpha-TNFR1 binding at 10 u...				J Med Chem 63: 8146-8156 (2020) Article DOI: 10.1021/acs.jmedchem.0c00377 BindingDB Entry DOI: 10.7270/Q2JQ14MX
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50575321 (CHEMBL4851618) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to TNF (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01693 BindingDB Entry DOI: 10.7270/Q2H135TK
TBA					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50575304 (CHEMBL4877313) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to TNF (unknown origin)				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01693 BindingDB Entry DOI: 10.7270/Q2H135TK
TBA					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	5.36E+3	n/a	n/a	n/a	6.5	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha in 10 mM citrate-phosphate at pH 6.5 by fluorescence assay				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	5.36E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % DMSO as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMSO as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	5.75E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % PEG3350 as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	6.18E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % PEG3350 as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	7.34E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % DMSO as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	7.51E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % DMF as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 2.5 % MeOH as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	8.44E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % PEG3350 as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50103596 ((E)-2-hydroxy-5-((4-(N-pyridin-2-ylsulfamoyl)-phen...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	9.00E+3	n/a	n/a	n/a	7.0	n/a
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College					Assay Description Surface plasmon resonance (SPR) assays were carried out on a BIAcore 3000 instrument (Biacore, Inc). Briefly, purified hTNFα was dissolved at 32...				J Biol Chem 289: 12457-66 (2014) Article DOI: 10.1074/jbc.M113.521708 BindingDB Entry DOI: 10.7270/Q2J9658M
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	9.77E+3	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 5 % MeOH as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	n/a
The Centre for Research and Technology of Thessaly (CE.RE.TE.TH.) , 3rd km Karditsa-Mitropolis, Karditsa 43100, Greece. Curated by ChEMBL					Assay Description Binding affinity to GST-tagged human TNF-alpha by fluorescence assay in presence of 10 % MeOH as solvent				ACS Med Chem Lett 4: 137-41 (2013) Article DOI: 10.1021/ml300380h BindingDB Entry DOI: 10.7270/Q2W66N4P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a	n/a
University of California at San Francisco Curated by ChEMBL					Assay Description Binding affinity to TNF				Nature 450: 1001-1009 (2007) Article DOI: 10.1038/nature06526 BindingDB Entry DOI: 10.7270/Q24Q7VTV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566085 (CHEMBL4779860) Show SMILES CC1(C)N(Cc2ccccc2OC(F)F)c2ccccc2C1=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50545753 (CHEMBL4649816) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.96E+4	n/a	n/a	n/a	n/a	n/a
Huazhong University of Science and Technology Curated by ChEMBL					Assay Description Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as Kd for TNF-alpha-TNFR1 binding at 100 ...				J Med Chem 63: 8146-8156 (2020) Article DOI: 10.1021/acs.jmedchem.0c00377 BindingDB Entry DOI: 10.7270/Q2JQ14MX
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM56191 (MLS000063267 \| SMR000074865 \| [1-(2,5-dimethylbenz...) Show SMILES Cc1ccc(C)c(Cn2c(CO)nc3ccccc23)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human TNF measured after 6 mins by surface plasmon resonance				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01608 BindingDB Entry DOI: 10.7270/Q25D8WHT
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566079 (CHEMBL4793685) Show SMILES c1ccc(cc1)-c1cccc2ccncc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	6.00E+4	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50545753 (CHEMBL4649816) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	8.21E+4	n/a	n/a	n/a	n/a	n/a
Huazhong University of Science and Technology Curated by ChEMBL					Assay Description Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by MST assay				J Med Chem 63: 8146-8156 (2020) Article DOI: 10.1021/acs.jmedchem.0c00377 BindingDB Entry DOI: 10.7270/Q2JQ14MX
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50373071 (CHEMBL255489) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	n/a	9.17E+4	n/a	n/a	n/a	n/a	n/a
Huazhong University of Science and Technology Curated by ChEMBL					Assay Description Binding affinity to recombinant TNFalpha (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 10 mins by MST assay				J Med Chem 63: 8146-8156 (2020) Article DOI: 10.1021/acs.jmedchem.0c00377 BindingDB Entry DOI: 10.7270/Q2JQ14MX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50525149 (CHEMBL4457006) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	9.36E+4	n/a	n/a	n/a	n/a	n/a
Shanghai Jiaotong University School of Medicine Curated by ChEMBL					Assay Description Binding affinity to human TNFalpha by surface plasmon resonance analysis				J Med Chem 62: 5370-5381 (2019) Article DOI: 10.1021/acs.jmedchem.8b02027 BindingDB Entry DOI: 10.7270/Q21R6TZ8
					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566083 (CHEMBL4777805) Show SMILES Cc1ccc(Cn2cnc3ccccc23)c(C)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	1.06E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair
Tumor necrosis factor (Homo sapiens (Human))	BDBM3787 (1-Phenylbenzimidazole deriv. 4 \| 1-benzyl-1H-1,3-b...) Show SMILES C(c1ccccc1)n1cnc2ccccc12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair				3D Structure (crystal)
Tumor necrosis factor (Homo sapiens (Human))	BDBM50566084 (CHEMBL1507048) Show SMILES Cc1nc2ccccc2n1Cc1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	3.25E+5	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to biotinylated human TNFalpha trimer (77 to 233 residues) expressed in Escherichia coli BL21(DE3) by SPR analysis				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01280 BindingDB Entry DOI: 10.7270/Q2DZ0D2V
TBA					More data for this Ligand-Target Pair