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Compile Data Set for Download or QSAR

Found 41 hits of ki for UniProtKB: P09619   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50237710
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C28H22F3N7O/c1-17-5-6-19(10-25(17)37-27-33-9-7-24(36-27)20-4-3-8-32-14-20)26(39)35-22-11-21(28(29,30)31)12-23(13-22)38-15-18(2)34-16-38/h3-16H,1-2H3,(H,35,39)(H,33,36,37)
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2n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM13530
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
Show InChI InChI=1S/C29H31N7O/c1-21-5-10-25(18-27(21)34-29-31-13-11-26(33-29)24-4-3-12-30-19-24)32-28(37)23-8-6-22(7-9-23)20-36-16-14-35(2)15-17-36/h3-13,18-19H,14-17,20H2,1-2H3,(H,32,37)(H,31,33,34)
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3n/an/an/an/an/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 103: 3153-8 (2006)


Article DOI: 10.1073/pnas.0511292103
BindingDB Entry DOI: 10.7270/Q21Z430B
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM4814
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12-
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8n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to PDGFR-beta (unknown origin)


Eur J Med Chem 82: 139-51 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.051
BindingDB Entry DOI: 10.7270/Q2F1918D
More data for this
Ligand-Target Pair
PDGFR-beta/Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))
BDBM50039655
PNG
(5,7-Dimethoxy-3-pyridin-4-yl-quinoline | CHEMBL684...)
Show SMILES COc1cc(OC)c2cc(cnc2c1)-c1ccncc1
Show InChI InChI=1S/C16H14N2O2/c1-19-13-8-15-14(16(9-13)20-2)7-12(10-18-15)11-3-5-17-6-4-11/h3-10H,1-2H3
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14n/an/an/an/an/an/an/an/a



Sterling Winthrop Pharmaceuticals Research Division

Curated by ChEMBL


Assay Description
Inhibition of PDGF-stimulated autophosphorylation of PDGF-receptor


J Med Chem 37: 2627-9 (1994)


BindingDB Entry DOI: 10.7270/Q2CR5SDD
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139621
PNG
(US8889870, 169 | US9388176, 169 | US9820989, 169)
Show SMILES COC(=O)c1cncc2CN(CCc12)c1cccc(c1)C(=O)Nc1cccc(c1)C(C)C
Show InChI InChI=1S/C26H27N3O3/c1-17(2)18-6-4-8-21(12-18)28-25(30)19-7-5-9-22(13-19)29-11-10-23-20(16-29)14-27-15-24(23)26(31)32-3/h4-9,12-15,17H,10-11,16H2,1-3H3,(H,28,30)
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15n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50020310
PNG
(CHEMBL3288854)
Show SMILES CN1CCN(CCC(=O)Nc2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c2C)CC1
Show InChI InChI=1S/C23H28FN5O2/c1-14-20(13-18-17-12-16(24)4-5-19(17)26-23(18)31)25-15(2)22(14)27-21(30)6-7-29-10-8-28(3)9-11-29/h4-5,12-13,25H,6-11H2,1-3H3,(H,26,31)(H,27,30)/b18-13-
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19n/an/an/an/an/an/an/an/a



Qilu Pharmaceutical Co, Ltd

Curated by ChEMBL


Assay Description
Binding affinity to PDGFR-beta (unknown origin)


Eur J Med Chem 82: 139-51 (2014)


Article DOI: 10.1016/j.ejmech.2014.05.051
BindingDB Entry DOI: 10.7270/Q2F1918D
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139601
PNG
(US8889870, 147 | US9820989, 147)
Show SMILES Cc1ccc(cc1N1CCc2nc(N)ncc2C1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H20F3N5O/c1-13-5-6-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-19(13)30-8-7-18-15(12-30)11-27-21(26)29-18/h2-6,9-11H,7-8,12H2,1H3,(H,28,31)(H2,26,27,29)
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20n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM308058
PNG
(US9650366, 9)
Show SMILES Cc1ccoc1C(=O)Nc1cccc(c1)C#Cc1cncc(c1)-c1nnn(CCCO)n1
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21n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9650366 (2017)


BindingDB Entry DOI: 10.7270/Q2QN68VG
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139542
PNG
(US8889870, 2 | US9388176, 2 | US9820989, 2)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C23H25N5O/c1-15(2)16-5-3-7-19(11-16)26-22(29)17-6-4-8-20(12-17)28-10-9-21-18(14-28)13-25-23(24)27-21/h3-8,11-13,15H,9-10,14H2,1-2H3,(H,26,29)(H2,24,25,27)
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21n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139552
PNG
(US8889870, 12 | US9388176, 12 | US9820989, 12)
Show SMILES CC(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C23H25N5O/c1-15(2)16-6-8-19(9-7-16)26-22(29)17-4-3-5-20(12-17)28-11-10-21-18(14-28)13-25-23(24)27-21/h3-9,12-13,15H,10-11,14H2,1-2H3,(H,26,29)(H2,24,25,27)
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24n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139545
PNG
(US8889870, 5 | US9388176, 5 | US9820989, 5)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C21H18F3N5O/c22-21(23,24)15-4-2-5-16(10-15)27-19(30)13-3-1-6-17(9-13)29-8-7-18-14(12-29)11-26-20(25)28-18/h1-6,9-11H,7-8,12H2,(H,27,30)(H2,25,26,28)
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26n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139603
PNG
(US8889870, 149 | US9388176, 149 | US9820989, 149)
Show SMILES CC(C)c1cccc(NC(=O)c2ccc(C)c(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C24H27N5O/c1-15(2)17-5-4-6-20(11-17)27-23(30)18-8-7-16(3)22(12-18)29-10-9-21-19(14-29)13-26-24(25)28-21/h4-8,11-13,15H,9-10,14H2,1-3H3,(H,27,30)(H2,25,26,28)
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30n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139550
PNG
(US8889870, 10 | US9388176, 10 | US9820989, 10)
Show SMILES CCCc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C23H25N5O/c1-2-4-16-7-9-19(10-8-16)26-22(29)17-5-3-6-20(13-17)28-12-11-21-18(15-28)14-25-23(24)27-21/h3,5-10,13-14H,2,4,11-12,15H2,1H3,(H,26,29)(H2,24,25,27)
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32n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139618
PNG
(US8889870, 166 | US9388176, 166 | US9820989, 166)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(N3CCc4ccncc4C3)c(C)c2)c1
Show InChI InChI=1S/C23H24N4O/c1-16-4-3-5-20(12-16)25-23(28)26-21-6-7-22(17(2)13-21)27-11-9-18-8-10-24-14-19(18)15-27/h3-8,10,12-14H,9,11,15H2,1-2H3,(H2,25,26,28)
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36n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139620
PNG
(US8889870, 168 | US9388176, 168 | US9820989, 168)
Show SMILES CC(C)c1cccc(NC(=O)c2cccc(c2)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C24H25N3O/c1-17(2)19-5-3-7-22(13-19)26-24(28)20-6-4-8-23(14-20)27-12-10-18-9-11-25-15-21(18)16-27/h3-9,11,13-15,17H,10,12,16H2,1-2H3,(H,26,28)
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40n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139549
PNG
(US8889870, 9 | US9388176, 9 | US9820989, 9)
Show SMILES CCc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C22H23N5O/c1-2-15-5-3-7-18(11-15)25-21(28)16-6-4-8-19(12-16)27-10-9-20-17(14-27)13-24-22(23)26-20/h3-8,11-13H,2,9-10,14H2,1H3,(H,25,28)(H2,23,24,26)
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52n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139604
PNG
(US8889870, 150 | US9388176, 150 | US9820989, 150)
Show SMILES CC(C)c1cccc(NC(=O)c2cc(C)cc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C24H27N5O/c1-15(2)17-5-4-6-20(11-17)27-23(30)18-9-16(3)10-21(12-18)29-8-7-22-19(14-29)13-26-24(25)28-22/h4-6,9-13,15H,7-8,14H2,1-3H3,(H,27,30)(H2,25,26,28)
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59n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139628
PNG
(US8889870, 176 | US9388176, 176 | US9820989, 176)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)Nc1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H17F4N5O/c22-17-5-4-14(9-16(17)21(23,24)25)28-19(31)12-2-1-3-15(8-12)30-7-6-18-13(11-30)10-27-20(26)29-18/h1-5,8-10H,6-7,11H2,(H,28,31)(H2,26,27,29)
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61n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139546
PNG
(US8889870, 6 | US9388176, 6 | US9820989, 6)
Show SMILES Cc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C21H21N5O/c1-14-5-7-17(8-6-14)24-20(27)15-3-2-4-18(11-15)26-10-9-19-16(13-26)12-23-21(22)25-19/h2-8,11-12H,9-10,13H2,1H3,(H,24,27)(H2,22,23,25)
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90n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139544
PNG
(US8889870, 4 | US9388176, 4 | US9820989, 4)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C24H27N5O/c1-24(2,3)18-7-9-19(10-8-18)27-22(30)16-5-4-6-20(13-16)29-12-11-21-17(15-29)14-26-23(25)28-21/h4-10,13-14H,11-12,15H2,1-3H3,(H,27,30)(H2,25,26,28)
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109n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139543
PNG
(US8889870, 3 | US9388176, 3 | US9820989, 3)
Show SMILES Cc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C21H21N5O/c1-14-4-2-6-17(10-14)24-20(27)15-5-3-7-18(11-15)26-9-8-19-16(13-26)12-23-21(22)25-19/h2-7,10-12H,8-9,13H2,1H3,(H,24,27)(H2,22,23,25)
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116n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139548
PNG
(US8889870, 8 | US9388176, 8 | US9820989, 8)
Show SMILES CCc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C22H23N5O/c1-2-15-6-8-18(9-7-15)25-21(28)16-4-3-5-19(12-16)27-11-10-20-17(14-27)13-24-22(23)26-20/h3-9,12-13H,2,10-11,14H2,1H3,(H,25,28)(H2,23,24,26)
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134n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139560
PNG
(US8889870, 20 | US9388176, 20 | US9820989, 20)
Show SMILES CC(C)(C)CCNC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C20H27N5O/c1-20(2,3)8-9-22-18(26)14-5-4-6-16(11-14)25-10-7-17-15(13-25)12-23-19(21)24-17/h4-6,11-12H,7-10,13H2,1-3H3,(H,22,26)(H2,21,23,24)
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164n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50355491
PNG
(CHEMBL1835870)
Show SMILES Nc1nc(Nc2ccc(cc2)[C@H]2CC[C@@H](CC2)N2CCOCC2)nn1-c1ccccn1 |r,wU:11.11,wD:14.18,(-9.05,.18,;-7.58,.64,;-7.09,2.1,;-5.55,2.08,;-4.8,3.43,;-3.26,3.44,;-2.48,2.12,;-.94,2.14,;-.18,3.48,;-.98,4.81,;-2.52,4.79,;1.35,3.5,;2.1,4.85,;3.65,4.86,;4.44,3.53,;3.68,2.19,;2.14,2.18,;5.97,3.55,;6.75,2.22,;8.29,2.23,;9.05,3.57,;8.27,4.9,;6.73,4.89,;-5.09,.62,;-6.35,-.28,;-6.36,-1.81,;-5.04,-2.59,;-5.05,-4.13,;-6.39,-4.89,;-7.72,-4.11,;-7.71,-2.57,)|
Show InChI InChI=1S/C23H29N7O/c24-22-27-23(28-30(22)21-3-1-2-12-25-21)26-19-8-4-17(5-9-19)18-6-10-20(11-7-18)29-13-15-31-16-14-29/h1-5,8-9,12,18,20H,6-7,10-11,13-16H2,(H3,24,26,27,28)/t18-,20-
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200n/an/an/an/an/an/an/an/a



University of Kentucky

Curated by ChEMBL


Assay Description
Inhibition of PDGFR-beta


J Med Chem 55: 725-34 (2012)


Article DOI: 10.1021/jm201198w
BindingDB Entry DOI: 10.7270/Q2GQ6Z6R
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139557
PNG
(US8889870, 17 | US9388176, 17 | US9820989, 17)
Show SMILES CC(C)(C)C1CCC(CC1)NC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1 |(9.34,-.77,;8,-1.54,;8,-3.08,;9.34,-2.31,;6.67,-.77,;5.33,-1.54,;4,-.77,;4,.77,;5.33,1.54,;6.67,.77,;2.67,1.54,;1.33,.77,;1.33,-.77,;,1.54,;,3.08,;-1.33,3.85,;-2.67,3.08,;-2.67,1.54,;-1.33,.77,;-4,.77,;-5.33,1.54,;-6.67,.77,;-6.67,-.77,;-8,-1.54,;-8,-3.08,;-9.34,-3.85,;-6.67,-3.85,;-5.33,-3.08,;-5.33,-1.54,;-4,-.77,)|
Show InChI InChI=1S/C24H33N5O/c1-24(2,3)18-7-9-19(10-8-18)27-22(30)16-5-4-6-20(13-16)29-12-11-21-17(15-29)14-26-23(25)28-21/h4-6,13-14,18-19H,7-12,15H2,1-3H3,(H,27,30)(H2,25,26,28)
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246n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139602
PNG
(US8889870, 148 | US9388176, 148 | US9820989, 148)
Show SMILES Cc1cc(cc(c1)C(=O)Nc1cccc(c1)C(F)(F)F)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C22H20F3N5O/c1-13-7-14(20(31)28-17-4-2-3-16(10-17)22(23,24)25)9-18(8-13)30-6-5-19-15(12-30)11-27-21(26)29-19/h2-4,7-11H,5-6,12H2,1H3,(H,28,31)(H2,26,27,29)
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273n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139558
PNG
(US8889870, 18 | US9388176, 18 | US9820989, 18)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C21H27N5O/c22-21-24-13-17-14-26(10-9-19(17)25-21)18-8-4-7-16(11-18)20(27)23-12-15-5-2-1-3-6-15/h4,7-8,11,13,15H,1-3,5-6,9-10,12,14H2,(H,23,27)(H2,22,24,25)
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602n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139617
PNG
(US8889870, 165 | US9388176, 165 | US9820989, 165)
Show SMILES Cc1ccc(NC(=O)Nc2ccc(cc2)N2CCc3ccncc3C2)cc1
Show InChI InChI=1S/C22H22N4O/c1-16-2-4-19(5-3-16)24-22(27)25-20-6-8-21(9-7-20)26-13-11-17-10-12-23-14-18(17)15-26/h2-10,12,14H,11,13,15H2,1H3,(H2,24,25,27)
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>1.00E+3n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139551
PNG
(US8889870, 11 | US9388176, 11 | US9820989, 11)
Show SMILES CN1CCC(CC1)Oc1ccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)cc1
Show InChI InChI=1S/C26H30N6O2/c1-31-12-9-23(10-13-31)34-22-7-5-20(6-8-22)29-25(33)18-3-2-4-21(15-18)32-14-11-24-19(17-32)16-28-26(27)30-24/h2-8,15-16,23H,9-14,17H2,1H3,(H,29,33)(H2,27,28,30)
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>1.00E+3n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139561
PNG
(US8889870, 21 | US9388176, 21 | US9820989, 21)
Show SMILES CCN(CC)C(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C18H23N5O/c1-3-22(4-2)17(24)13-6-5-7-15(10-13)23-9-8-16-14(12-23)11-20-18(19)21-16/h5-7,10-11H,3-4,8-9,12H2,1-2H3,(H2,19,20,21)
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>1.00E+3n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139619
PNG
(US8889870, 167 | US9388176, 167 | US9820989, 167)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2C)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C23H24N4O/c1-16-4-3-5-20(12-16)25-23(28)26-22-7-6-21(13-17(22)2)27-11-9-18-8-10-24-14-19(18)15-27/h3-8,10,12-14H,9,11,15H2,1-2H3,(H2,25,26,28)
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1.05E+3n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139547
PNG
(US8889870, 7 | US9388176, 7 | US9820989, 7)
Show SMILES COc1cccc(NC(=O)c2cccc(c2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C21H21N5O2/c1-28-18-7-3-5-16(11-18)24-20(27)14-4-2-6-17(10-14)26-9-8-19-15(13-26)12-23-21(22)25-19/h2-7,10-12H,8-9,13H2,1H3,(H,24,27)(H2,22,23,25)
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1.24E+3n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139615
PNG
(US8889870, 163 | US9388176, 163 | US9820989, 163)
Show SMILES Cc1cccc(NC(=O)Nc2ccc(cc2)N2CCc3ccncc3C2)c1
Show InChI InChI=1S/C22H22N4O/c1-16-3-2-4-20(13-16)25-22(27)24-19-5-7-21(8-6-19)26-12-10-17-9-11-23-14-18(17)15-26/h2-9,11,13-14H,10,12,15H2,1H3,(H2,24,25,27)
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1.56E+3n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50198782
PNG
(([7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]tri...)
Show SMILES Cc1cc(cc2nnc(Nc3ccc(OCCN4CCCC4)cc3)nc12)-c1c(Cl)cccc1Cl
Show InChI InChI=1S/C26H25Cl2N5O/c1-17-15-18(24-21(27)5-4-6-22(24)28)16-23-25(17)30-26(32-31-23)29-19-7-9-20(10-8-19)34-14-13-33-11-2-3-12-33/h4-10,15-16H,2-3,11-14H2,1H3,(H,29,30,32)
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2.09E+3n/an/an/an/an/an/an/an/a



TargeGen, Inc.

Curated by ChEMBL


Assay Description
Inhibition of PDGFRbeta


Bioorg Med Chem Lett 17: 602-8 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.006
BindingDB Entry DOI: 10.7270/Q29024MW
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139616
PNG
(US8889870, 164 | US9388176, 164 | US9820989, 164)
Show SMILES O=C(Nc1ccccc1)Nc1ccc(cc1)N1CCc2ccncc2C1
Show InChI InChI=1S/C21H20N4O/c26-21(23-18-4-2-1-3-5-18)24-19-6-8-20(9-7-19)25-13-11-16-10-12-22-14-17(16)15-25/h1-10,12,14H,11,13,15H2,(H2,23,24,26)
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>1.00E+4n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139559
PNG
(US8889870, 19 | US9388176, 19 | US9820989, 19)
Show SMILES Nc1ncc2CN(CCc2n1)c1cccc(c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C19H23N5O/c20-19-21-11-14-12-24(9-8-17(14)23-19)16-7-3-4-13(10-16)18(25)22-15-5-1-2-6-15/h3-4,7,10-11,15H,1-2,5-6,8-9,12H2,(H,22,25)(H2,20,21,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139556
PNG
(US8889870, 16 | US9388176, 16 | US9820989, 16)
Show SMILES CCCCNC(=O)c1cccc(c1)N1CCc2nc(N)ncc2C1
Show InChI InChI=1S/C18H23N5O/c1-2-3-8-20-17(24)13-5-4-6-15(10-13)23-9-7-16-14(12-23)11-21-18(19)22-16/h4-6,10-11H,2-3,7-9,12H2,1H3,(H,20,24)(H2,19,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139580
PNG
(US8889870, 83 | US9388176, 83 | US9820989, 83)
Show SMILES CC(C)c1ccc(NC(=O)c2cc(ccn2)N2Cc3cnc(N)nc3C2)cc1
Show InChI InChI=1S/C21H22N6O/c1-13(2)14-3-5-16(6-4-14)25-20(28)18-9-17(7-8-23-18)27-11-15-10-24-21(22)26-19(15)12-27/h3-10,13H,11-12H2,1-2H3,(H,25,28)(H2,22,24,26)
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>1.00E+4n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139568
PNG
(US8889870, 37 | US9388176, 37 | US9820989, 37)
Show SMILES Cc1cccc(NC(=O)c2cccc(n2)N2CCc3nc(N)ncc3C2)c1
Show InChI InChI=1S/C20H20N6O/c1-13-4-2-5-15(10-13)23-19(27)17-6-3-7-18(24-17)26-9-8-16-14(12-26)11-22-20(21)25-16/h2-7,10-11H,8-9,12H2,1H3,(H,23,27)(H2,21,22,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta (PDGFR beta)


(Homo sapiens (Human))
BDBM139614
PNG
(US8889870, 162 | US9388176, 162 | US9820989, 162)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(cc1)N1CCc2ccncc2C1
Show InChI InChI=1S/C22H18F3N3O/c23-22(24,25)18-3-1-2-16(12-18)21(29)27-19-4-6-20(7-5-19)28-11-9-15-8-10-26-13-17(15)14-28/h1-8,10,12-13H,9,11,14H2,(H,27,29)
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>1.00E+4n/an/an/an/an/an/an/an/a



ALLERGAN, INC.

US Patent




US Patent US9820989 (2017)

More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50331612
PNG
(CHEMBL1290072 | N-(4-methoxybenzyl)benzofuro[2,3-b...)
Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
Show InChI InChI=1S/C19H16N2O2/c1-22-14-8-6-13(7-9-14)12-21-16-10-11-20-19-18(16)15-4-2-3-5-17(15)23-19/h2-11H,12H2,1H3,(H,20,21)
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>1.00E+6n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of human PDGFR-beta


Bioorg Med Chem Lett 20: 6915-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.10.004
BindingDB Entry DOI: 10.7270/Q2GF0TQS
More data for this
Ligand-Target Pair